Patrick J Lustman

..We used bupropion hydrochloride (Wellbutrin XL) to determine whether this improvement could be attributed to changes in anthropometrics or diabetes self-care...

..In patients with diabetes mellitus, depression is a prevalent and recurrent problem that adversely affects the medical prognosis...

..In this study, we applied mediational analysis methods to determine whether the hyperglycemic effect of depression could be mediated by poor diabetes self-care...

..A secondary analysis was performed to assess this effect in younger and older subsets of patients...

..The present study uses a national Veterans Affairs cohort to test whether antidepressants increase or decrease risk of MI and all-cause mortality...

..Depression is a known risk factor for mortality after an acute myocardial infarction. Patients with treatment-responsive depression may have a better prognosis than those with treatment-resistant depression...

..This risk may be due to a greater susceptibility for myocardial infarction (MI) in depressed patients with type 2 diabetes compared with nondepressed patients with type 2 diabetes...

..Additional investigation will be required to determine if depression and anxiety affect the development or progression of NASH and serve as modifiable risk factors...

..CONCLUSIONS In patients with type 2 diabetes, poor initial response to antidepressant medication is predicted by multiple factors. Auxiliary treatment of pain and impairment may be required to achieve better outcomes...

..Additional studies are required to confirm the magnitude of the relationship, to elucidate moderating and causal factors, and to determine whether successful treatment of anxiety improves glycemic control...

....

....

....

....

..This therapeutic option should be further studied in diabetic patients considering the morbidity of chronic vomiting in this population...

..Major depressive disorder (MDD) and type 2 diabetes have independent adverse effects on sexual functioning (SF). Bupropion (BU) reportedly has few sexual side effects, but its use in diabetes has not been studied...

..There has been little research on the treatment of depression after coronary artery bypass surgery...

..Depression predicts onset of and poor outcome from CHD in nondiabetic populations. We hypothesized that the doubled rates of depression in female diabetic patients could help explain the high prevalence of CHD in women with diabetes...

..This commonly overlooked comorbidity affects more than one quarter of the diabetic population, making its recognition and treatment in diabetic patients clinically relevant...

..Depression is a risk factor for incident myocardial infarction (MI), but little is known about the independent or additive risk from anxiety disorders...

..Issues in the management of depression in diabetes are outlined, including interactions of depression and insulin resistance...

....

..Additional epidemiological studies are needed to determine the prevalence of anxiety in the broader population of persons with diabetes...

..45). Overall there is little evidence that common genetic and environmental factors account for the co-occurrence of depression and diabetes in middle aged men. Further research in female twins and larger cohorts is warranted...

..Patients consent to witnessed testing but most tests are unwitnessed. The purpose of the present study was to compare treatment effectiveness estimates derived from witnessed versus unwitnessed urine samples...

..The clinical response to treatment with 2 newer antiepileptic drugs was evaluated retrospectively to see whether they might have a prophylactic role in this syndrome...

..They suggest that pharmacologic and psychological approaches are effective in the face of diabetes, and that successful treatment also produces improvements in glycemic control, overall functioning, and quality of life...