JOAN L contact LUBY

..These findings provide prospective evidence in humans of the positive effect of early supportive parenting on healthy hippocampal development, a brain region key to memory and stress modulation...

..Based on the finding of a valid preschool depressive syndrome, methods to obtain self-report of symptoms of depression and related anxiety directly from the child are now needed...

..other disorders, as well as depression severity between two depressed sub-groups and other diagnostic comparison groups...

..An investigation of the characteristics of depression among putative bipolar preschoolers may inform the controversial nosologic questions that surround the diagnosis in this young age group...

..Data elucidating this developmental trajectory could then inform the design of earlier potentially preventive interventions that may have implications for the disorder across the lifespan...

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..It also clarifies parameters for the rare situations in which antidepressants may be tried when psychotherapeutic options fail and depression is severe and impairing...

..Therefore, the search for prodromes or early markers of risk for later childhood bipolar disorder may be of great importance for prevention and/or early identification...

..The current study used regression analyses to examine the relationships between family history of mood disorders and stressful life events as risk factors for depression in a preschool sample...

..To investigate the clinical characteristics of depression in preschool children...

..To investigate the validity of developmentally modified DSM-IV criteria for preschool major depressive disorder (MDD)...

..This article reviews the relatively new body of evidence supporting the validity of preschool depression...

..Findings have important clinical implications because they suggest that both external relational and internal child factors may be operating in preschool depression...

..To investigate whether differences in the tantrum behaviors of healthy versus mood and disruptive disordered preschoolers can be detected...

..This study compared the severity of depression in preschoolers diagnosed by standard versus modified DSM-IV criteria for major depression...

..Future studies that directly investigate age-appropriate mania manifestations in preschool samples are now warranted...

..The current study is, to our knowledge, the first investigation of HPA axis reactivity in very young children with a clinical depressive syndrome for which content validity has been established...

..Based on the need for the earliest possible identification of depression, the development of a brief screening measure to capture young children with markers of depression from these community settings was developed and tested...

..These findings demonstrate that atypical sgACC functional connections are evident as early as school age in children with a history of PO-MDD and suggest an association with a very early episode of depression...

..This study investigated whether a melancholic subtype similar to that established in depressed adults can be identified in depressed preschool children...

..Results suggest that the MSSB may be a useful child-informant method for interpreting depressed children's internalization of caregiving relationships...

..This finding was detected in depressed and "at risk for internalizing" boys who were not comorbid for externalizing problems...

..Support for the validity of preschool depression is now available; however, objective evidence of negative behaviors among depressed preschoolers is needed...

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..Previous research has indicated that symptom severity and amygdala reactivity during the viewing of facial expressions of emotion are related in depression. However, it remains unclear how early in development this can be detected...

..CONCLUSION: The findings support the general validity of the parent HBQ for the assessment of young child psychopathology and the hypothesis that it captures more internalizing psychopathology than the DISC-IV in this population...

..To investigate the relations among depressive symptoms, social behavior, and chronic medical illness in preschool children...

..The purpose of this effort is to promote responsible treatment of young children, recognizing that this will sometimes involve the use of medications...

..Our exposition is developed in the specific clinical context of childhood mania to maximize accessibility of the ideas but applies more generally to other chronic mental and physical health disorders that are difficult to treat...

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..Based on the design of the study, we will also have the opportunity to address the role of risk and protective factors in this process including parent child relationship, stressful life events and social support. ..

..Findings would serve to inform the design of future early intervention trials for mood disorders. ..

..This is needed because depression is a serious and chronic disorder for which there are currently few safe and effective treatments established. ..

..The chief study statistician, Dr. Satish lyengar is subcontracted to the coordinating site at Washington U in St. Louis and Dr. Philip Lavori is a major consultant for statistical analyses. ..

..Valid diagnostic criteria are necessary for these future treatment studies and to facilitate investigations of the developmental neurobiology of this disorder. ..

..Findings would serve to inform the design of future early intervention trials for mood disorders. ..