M E Lowe

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Colipase stabilizes the lid domain of pancreatic triglyceride lipase
    M E Lowe
    Washington University School of Medicine, Department of Pediatrics, St Louis Children s Hospital, Missouri 63110, USA
    J Biol Chem 272:9-12. 1997
  2. ncbi Structure and function of pancreatic lipase and colipase
    M E Lowe
    Washington University School of Medicine, Department of Pediatrics, St Louis, Missouri 63110, USA
    Annu Rev Nutr 17:141-58. 1997
  3. ncbi Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles
    W V Crandall
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 276:12505-12. 2001
  4. ncbi Cloning and characterization of human pancreatic lipase cDNA
    M E Lowe
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63114
    J Biol Chem 264:20042-8. 1989
  5. ncbi Rat pancreatic lipase and two related proteins: enzymatic properties and mRNA expression during development
    R M Payne
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Physiol 266:G914-21. 1994
  6. ncbi The human pancreatic lipase-encoding gene: structure and conservation of an Alu sequence in the lipase gene family
    H F Sims
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110
    Gene 131:281-5. 1993
  7. ncbi Expression of a Nagao-type, phosphatidylinositol-glycan anchored alkaline phosphatase in human choriocarcinomas
    M E Lowe
    Department of Pediatrics, Washington University School of Medicine, Louis, Missouri 63114
    Cancer Res 50:3956-62. 1990
  8. ncbi Rat GP-3 is a pancreatic lipase with kinetic properties that differ from colipase-dependent pancreatic lipase
    M L Jennens
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, MO 63110, USA
    J Lipid Res 36:2374-82. 1995
  9. ncbi Cloning and characterization of the human colipase cDNA
    M E Lowe
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63114
    Biochemistry 29:823-8. 1990
  10. ncbi Isolation and characterization of the gene from a human genome encoding 17 beta-estradiol dehydrogenase: a comparison of Jar and BeWo choriocarcinoma cell lines
    C A Long
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110
    Am J Obstet Gynecol 163:1976-81. 1990

Collaborators

  • Y Yang
  • D Sanchez
  • A Nilsson
  • Matthew T Andrews
  • W E Momsen
  • W V Crandall
  • V W Bauer
  • M L Jennens
  • H L Brockman
  • N K Mizuno
  • H F Sims
  • J Kullman
  • L Andersson
  • T L Squire
  • R M Payne
  • F Carriere
  • R Verger
  • C Gisi
  • C A Long
  • A W Strauss
  • G S Bauer
  • M J Gast

Detail Information

Publications20

  1. ncbi Colipase stabilizes the lid domain of pancreatic triglyceride lipase
    M E Lowe
    Washington University School of Medicine, Department of Pediatrics, St Louis Children s Hospital, Missouri 63110, USA
    J Biol Chem 272:9-12. 1997
    ..We propose that this function is to stabilize the lid domain of lipase in the open conformation, thereby facilitating lipolysis...
  2. ncbi Structure and function of pancreatic lipase and colipase
    M E Lowe
    Washington University School of Medicine, Department of Pediatrics, St Louis, Missouri 63110, USA
    Annu Rev Nutr 17:141-58. 1997
    ..This review discusses the advances made in protein structure and in understanding the relationships of structure to function of pancreatic triglyceride lipase and colipase...
  3. ncbi Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles
    W V Crandall
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 276:12505-12. 2001
    ..PTL complexes, that bile salt micelles influence that binding, and that the proper interaction of colipase with PTL requires the Glu(64)/Arg(65) binding site...
  4. ncbi Cloning and characterization of human pancreatic lipase cDNA
    M E Lowe
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63114
    J Biol Chem 264:20042-8. 1989
    ..The demonstrated regions of homology with other lipases will aid definition of interactions with substrate and colipase through site-specific mutagenesis...
  5. ncbi Rat pancreatic lipase and two related proteins: enzymatic properties and mRNA expression during development
    R M Payne
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Physiol 266:G914-21. 1994
    ..In contrast, the PL mRNA is low at birth and rises rapidly during the suckling-weanling transition. In conclusion, the rat has at least three genes encoding different lipases, and these related genes have separate regulatory controls...
  6. ncbi The human pancreatic lipase-encoding gene: structure and conservation of an Alu sequence in the lipase gene family
    H F Sims
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110
    Gene 131:281-5. 1993
    ..The gene has 13 exons dispersed in about 20 kb of genomic DNA. A pseudogene of hPL was also partially characterized. An Alu sequence is conserved in the homologous introns of hPL and the lipoprotein lipase-encoding gene...
  7. ncbi Expression of a Nagao-type, phosphatidylinositol-glycan anchored alkaline phosphatase in human choriocarcinomas
    M E Lowe
    Department of Pediatrics, Washington University School of Medicine, Louis, Missouri 63114
    Cancer Res 50:3956-62. 1990
    ..The BeWo AP (Nagao isozyme) is modified with PI-glycan that is added soon after translation, not cotranslationally...
  8. ncbi Rat GP-3 is a pancreatic lipase with kinetic properties that differ from colipase-dependent pancreatic lipase
    M L Jennens
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, MO 63110, USA
    J Lipid Res 36:2374-82. 1995
    ..These findings have important implications for the physiological function of rPLRP2...
  9. ncbi Cloning and characterization of the human colipase cDNA
    M E Lowe
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63114
    Biochemistry 29:823-8. 1990
    ..RNA blot analysis demonstrated tissue-specific expression of colipase mRNA in the pancreas. Thus, we report, for the first time, a cDNA for colipase.(ABSTRACT TRUNCATED AT 250 WORDS)..
  10. ncbi Isolation and characterization of the gene from a human genome encoding 17 beta-estradiol dehydrogenase: a comparison of Jar and BeWo choriocarcinoma cell lines
    C A Long
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110
    Am J Obstet Gynecol 163:1976-81. 1990
    ..1 kilobase was abundantly present in the granulosa cells. Whether these two species of messenger ribonucleic acid are involved in the regulation of the estradiol dehydrogenase genes is yet to be determined...
  11. ncbi Human pancreatic triglyceride lipase expressed in yeast cells: purification and characterization
    Y Yang
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Protein Expr Purif 13:36-40. 1998
    ..This expression system is suitable for the rapid, efficient production of human pancreatic triglyceride lipase in amounts adequate for biophysical studies...
  12. ncbi Dexamethasone-regulated expression of pancreatic lipase and two related proteins in AR42J cells
    J Kullman
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol 270:G746-51. 1996
    ..We conclude that AR42J cells synthesize and secrete PL, PLRP-1, and PLRP-2 and that dexamethasone discoordinately regulates the expression of the three genes...
  13. ncbi Discoordinate expression of pancreatic lipase and two related proteins in the human fetal pancreas
    Y Yang
    Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Pediatr Res 47:184-8. 2000
    ....
  14. ncbi Properties and function of pancreatic lipase related protein 2
    M E Lowe
    Washington University and St Louis Children s Hospital, One Children s Place, St Louis, MO 63141, USA
    Biochimie 82:997-1004. 2000
    ..They also had a defect in T-cell mediated cytotoxicity. Thus, pancreatic lipase related protein 2 is a lipase that participates in the cytotoxic activity of T-cells and plays a critical role in the digestion of breast milk fats...
  15. ncbi Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein
    M E Lowe
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63101
    J Cell Biol 116:799-807. 1992
    ..Substitution of a charged amino acid for a hydrophobic amino acid may be a mechanism for producing membrane bound and secreted forms of the same protein...
  16. ncbi Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice
    M E Lowe
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 273:31215-21. 1998
    ..Our results provide the first evidence of a physiological function for PLRP2. PLRP2 participates in T cell cytotoxicity, and PLRP2 performs a crucial role in the digestion of dietary fats in suckling animals...
  17. ncbi The human colipase gene: isolation, chromosomal location, and tissue-specific expression
    H F Sims
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63101
    Biochemistry 31:7120-5. 1992
    ..These results demonstrate that the isolated gene for human colipase contains tissue-specific promoter activity in the 5'-flanking DNA. The 28-bp region specifically binds to a factor in nuclear extracts...
  18. ncbi Pancreatic lipase-related protein 2 but not classical pancreatic lipase hydrolyzes galactolipids
    L Andersson
    Department of Internal Medicine, University of Lund, Sweden
    Biochim Biophys Acta 1302:236-40. 1996
    ..Also, MGalDG and SQDG were hydrolyzed by GPLRP2 and RPLRP2. These data suggest a possible role of PLRP2 in the digestion of dietary galactolipids...
  19. ncbi Expression of a chimeric retroviral-lipase mRNA confers enhanced lipolysis in a hibernating mammal
    V W Bauer
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695-7614, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1186-92. 2001
    ....
  20. ncbi Real-time measurement of solute partitioning to lipid monolayers
    W E Momsen
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Anal Biochem 346:139-49. 2005
    ..With appropriate instrumental configuration, the method should be adaptable for screening solutes for interaction with planar monolayers having both well-defined composition and adjustable lipid packing density...