J Lou

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Involvement of ERK in BMP-2 induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1/2
    J Lou
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochem Biophys Res Commun 268:757-62. 2000
  2. ncbi request reprint BMP-12 gene transfer augmentation of lacerated tendon repair
    J Lou
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, St Louis, MO 63110, USA
    J Orthop Res 19:1199-202. 2001
  3. ncbi request reprint Gene therapy: adenovirus-mediated human bone morphogenetic protein-2 gene transfer induces mesenchymal progenitor cell proliferation and differentiation in vitro and bone formation in vivo
    J Lou
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Orthop Res 17:43-50. 1999
  4. ncbi request reprint In vivo gene transfer and overexpression of focal adhesion kinase (pp125 FAK) mediated by recombinant adenovirus-induced tendon adhesion formation and epitenon cell change
    J Lou
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Orthop Res 15:911-8. 1997
  5. ncbi request reprint In vivo Bcl-2 oncogene neuronal expression in the rat spinal cord
    J Lou
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Spine (Phila Pa 1976) 23:517-23. 1998
  6. ncbi request reprint In vitro and in vivo induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene
    S L Cheng
    Division of Bone and Mineral Diseases, Dept. of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA
    Calcif Tissue Int 68:87-94. 2001
  7. ncbi request reprint Quantitative variation in vascular endothelial growth factor mRNA expression during early flexor tendon healing: an investigation in a canine model
    M I Boyer
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University in Saint Louis, MO 63110, USA
    J Orthop Res 19:869-72. 2001
  8. ncbi request reprint Astrocyte response and transforming growth factor-beta localization in acute spinal cord injury
    L G Lenke
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri
    Spine (Phila Pa 1976) 19:2321-9; discussion 2330. 1994
  9. ncbi request reprint Evaluation of different scaffolds for BMP-2 genetic orthopedic tissue engineering
    X Leon Xu
    Department of Orthopedic Surgery, Ninth People s Hospital, Shanghai Second Medical University, Shanghai, 200011, People s Republic of China
    J Biomed Mater Res B Appl Biomater 75:289-303. 2005
  10. ncbi request reprint Cranial repair using BMP-2 gene engineered bone marrow stromal cells
    Sophia Chia Ning Chang
    Tissue Engineering Center, Department of Plastic Surgery, Chang Gung Memorial Hospital, Chang Gung Institute of Technology, Taipei, Taiwan
    J Surg Res 119:85-91. 2004

Research Grants

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Involvement of ERK in BMP-2 induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1/2
    J Lou
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochem Biophys Res Commun 268:757-62. 2000
    ..These results indicate that Erk is involved in BMP-2 induced osteoblast differentiation. The results also demonstrate that a latent and sustained signaling pattern exists in BMP induced signaling cascade...
  2. ncbi request reprint BMP-12 gene transfer augmentation of lacerated tendon repair
    J Lou
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, St Louis, MO 63110, USA
    J Orthop Res 19:1199-202. 2001
    ..We conclude that BMP-12 gene transfer is a promising procedure for improving the tendon repair process...
  3. ncbi request reprint Gene therapy: adenovirus-mediated human bone morphogenetic protein-2 gene transfer induces mesenchymal progenitor cell proliferation and differentiation in vitro and bone formation in vivo
    J Lou
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Orthop Res 17:43-50. 1999
    ..The results of this study demonstrate the potential for gene therapy by adenovirus-mediated bone morphogenetic-protein gene transfer...
  4. ncbi request reprint In vivo gene transfer and overexpression of focal adhesion kinase (pp125 FAK) mediated by recombinant adenovirus-induced tendon adhesion formation and epitenon cell change
    J Lou
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Orthop Res 15:911-8. 1997
    ..This indicates that FAK and the FAK-related signaling pathway may be involved in the process of tendon adhesion formation. Understanding the details of this process may help to prevent tendon adhesion and improve healing...
  5. ncbi request reprint In vivo Bcl-2 oncogene neuronal expression in the rat spinal cord
    J Lou
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Spine (Phila Pa 1976) 23:517-23. 1998
    ..After Bcl-2 oncogene expression in the rat spinal cord, the zone of microscopic injury was diminished. Further investigation of the Bcl-2 oncogene for potentially enhancing neuronal survival after spinal cord injury appears indicated...
  6. ncbi request reprint In vitro and in vivo induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene
    S L Cheng
    Division of Bone and Mineral Diseases, Dept. of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA
    Calcif Tissue Int 68:87-94. 2001
    ....
  7. ncbi request reprint Quantitative variation in vascular endothelial growth factor mRNA expression during early flexor tendon healing: an investigation in a canine model
    M I Boyer
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University in Saint Louis, MO 63110, USA
    J Orthop Res 19:869-72. 2001
    ..These data suggest that cells within the flexor tendon repair site are involved in molecular processes other than the synthesis of extracellular matrix, such as modulation of angiogenesis...
  8. ncbi request reprint Astrocyte response and transforming growth factor-beta localization in acute spinal cord injury
    L G Lenke
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri
    Spine (Phila Pa 1976) 19:2321-9; discussion 2330. 1994
    ..This study suggests that both astrocytes and TGF-beta are involved in the regulation of spinal cord secondary injury. An improved understanding of their specific roles may result in novel treatments to improve the outcome from SCI...
  9. ncbi request reprint Evaluation of different scaffolds for BMP-2 genetic orthopedic tissue engineering
    X Leon Xu
    Department of Orthopedic Surgery, Ninth People s Hospital, Shanghai Second Medical University, Shanghai, 200011, People s Republic of China
    J Biomed Mater Res B Appl Biomater 75:289-303. 2005
    ..These findings help to elucidate the effects of various scaffold materials for future research in orthopedic tissue engineering using BMP-2 transduced cells...
  10. ncbi request reprint Cranial repair using BMP-2 gene engineered bone marrow stromal cells
    Sophia Chia Ning Chang
    Tissue Engineering Center, Department of Plastic Surgery, Chang Gung Memorial Hospital, Chang Gung Institute of Technology, Taipei, Taiwan
    J Surg Res 119:85-91. 2004
    ..Bone grafts, allografts, and biocompatible artificial bone substitutes all have their shortcomings when used for the repair of cranial bone defects. Tissue engineered bone shows promise as an alternative for the repair of these defects...
  11. ncbi request reprint Adenovirus mediated BMP-13 gene transfer induces chondrogenic differentiation of murine mesenchymal progenitor cells
    Hitoshi Nochi
    Department of Orthopaedic Surgery and Division of Renal Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Bone Miner Res 19:111-22. 2004
    ..BMP-13 supported chondrogenesis but not terminal differentiation, whereas BMP-2 stimulated endochondral ossification. The studies show that BMP-13 may fail to support terminal chondrocyte differentiation...
  12. ncbi request reprint Thoracoscopic intradiscal spine fusion using a minimally invasive gene-therapy technique
    K Daniel Riew
    Department of Orthopaedic Surgery, Barnes Jewish Hospital, and Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Bone Joint Surg Am 85:866-71. 2003
    ..The purpose of the present study was to determine if a gene-therapy technique can be utilized to achieve anterior intradiscal fusion in pigs with use of minimally invasive techniques...
  13. ncbi request reprint Immunomodulatory and osteogenic differentiation effects of mesenchymal stem cells by adenovirus-mediated coexpression of CTLA4Ig and BMP2
    Xiaoling Zhang
    Joint Orthopaedic Laboratory of Institute of Health Sciences and Shanghai Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Chinese Academy of Sciences, 225 South Chongqing Road, Shanghai, People s Republic of China
    J Orthop Res 26:314-21. 2008
    ....
  14. ncbi request reprint Engineered allogeneic mesenchymal stem cells repair femoral segmental defect in rats
    Hiroyuki Tsuchida
    Department of Orthopaedic Surgery, Washington University School of Medicine, Barnes Jewish Hospital at Washington University, One Barnes Hospital Plaza, STE 11300, St Louis, MO 63110, USA
    J Orthop Res 21:44-53. 2003
    ..We also show that allogeneic gene transferred MSC are directly involved in bone repair, in addition to acting as gene deliverers...
  15. ncbi request reprint Bone regeneration by implantation of adipose-derived stromal cells expressing BMP-2
    Huiwu Li
    Department of Orthopaedic Surgery, Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, PR China
    Biochem Biophys Res Commun 356:836-42. 2007
    ..We conclude that ADSCs modified by the BMP-2 gene can enhance the repair of critical-sized bone defects in large animals...
  16. ncbi request reprint Immune response and effect of adenovirus-mediated human BMP-2 gene transfer on the repair of segmental tibial bone defects in goats
    X Leon Xu
    Department of Orthopaedic Surgery, Ninth People s Hospital, Shanghai Second Medical University, Shanghai 200011, P R China
    Acta Orthop 76:637-46. 2005
    ..Tissue-engineered bone may be used for filling bone defects. There are, however, no reports on this technique used in large animals...
  17. ncbi request reprint The role of Sp1 in BMP2-up-regulated Erk2 gene expression
    Xiaoyun Xing
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 297:116-24. 2002
    ..All these results indicate that Sp1-mediated transcription is one of the mechanisms, which is responsible for BMP2-induced up-regulation of Erk2 expression...
  18. ncbi request reprint Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue
    Kotaro Satake
    Department of Orthopaedic Surgery, Washington University in St Louis, MO 63110, USA
    Spine (Phila Pa 1976) 29:1971-9. 2004
    ..Experimental spinal cord injury using a rat model...
  19. ncbi request reprint Optimal treatment timing to attenuate neuronal apoptosis via Bcl-2 gene transfer in vitro and in vivo
    Yasutsugu Yukawa
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurotrauma 19:1091-103. 2002
    ..These results stress important temporal considerations in future gene therapy strategies for spinal cord injury...
  20. ncbi request reprint [Preparation of a biphasic calcined bone of beta-TCP/HAP and its application in BMP-2 gene medicine]
    Xiaoliang Xu
    Department of Orthopaedics, Ninth People s Hospital, Shanghai Second Medical University, Shanghai 200011
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 20:630-3. 2003
    ..The results showed biphasic CB is a superior carrier of cells in BMP-2 gene medicine...
  21. ncbi request reprint Ex vivo gene therapy in autologous critical-size craniofacial bone regeneration
    Sophia Chia Ning Chang
    Department of Plastic Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan
    Plast Reconstr Surg 112:1841-50. 2003
    ..The successful repair of cranial defects in this experiment demonstrates the efficacy of the integration of the autologous stem cell concept, gene medicine, and polymers in producing tissue-engineered bone...
  22. ncbi request reprint Flexor tendon healing in the rat: a histologic and gene expression study
    Wataru Oshiro
    Department of Orthopaedic Surgery, Barnes Jewish Hospital, Washington University, St Louis, MO 63110, USA
    J Hand Surg Am 28:814-23. 2003
    ..To establish a rat flexor tendon laceration and repair model to investigate the molecular mechanisms of flexor tendon healing...

Research Grants1

  1. Bone Repair by Allogenic MSC in Non-ablated Animal
    Jueren Lou; Fiscal Year: 2004
    ..2. To investigate the fate of implanted allogeneic MSC in femur defect site of non-ablated rats. The ultimate goal of this proposal is to develop percutaneous injection procedure to facilitate bone repair. ..