Genomes and Genes
Affiliation: Washington University School of Medicine
- Genomic and gene regulatory signatures of cryptozoic adaptation: Loss of blue sensitive photoreceptors through expansion of long wavelength-opsin expression in the red flour beetle Tribolium castaneumMagdalena Jackowska
Department of Biological Sciences, Wayne State University, Detroit, MI 48202 USA
Front Zool 4:24. 2007..Here, we studied the spatial regulation of the Tribolium single LW- and UV-opsin gene paralogs in comparison to that of the five opsin paralogs in the retina of Drosophila melanogaster...
- Simple copy number determination with reference query pyrosequencing (RQPS)Zhenyi Liu
Department of Developmental Biology, School of Medicine, Washington University, St Louis, Missouri 63110, USA
Cold Spring Harb Protoc 2010:pdb.prot5491. 2010....
- Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney developmentScott C Boyle
Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
Development 141:346-54. 2014..Together, these data demonstrate a unique origin of mesangial cells and demonstrate a novel, redundant function for Notch receptors in mesangial cell specification, proliferation or survival during kidney development. ..
- Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activityZhenyi Liu
Sage Labs, St Louis, MO 63146, USA Department of Developmental Biology, Washington University, St Louis, MO 63110, USA
Development 142:1193-202. 2015....
- The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesisZhenyi Liu
Sage Labs, A Horizon Discovery Group Company, St Louis, MO 63146, USA
Development 142:2452-63. 2015..Reinterpretation of clinical findings based on our analyses suggests that differences in outcome segregating with Notch1 or Notch2 are likely to reflect outcomes dependent on the overall strength of Notch signals. ..
- The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney developmentZhenyi Liu
Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Dev Cell 25:585-98. 2013..This context-specific asymmetry in NICD release efficiency is further enhanced by Fringe. Our results indicate that an elevated N1 surface level could compensate for the loss of N2 signal in specific cell contexts. ..
- Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in miceZhenyi Liu
Department of Developmental Biology, Washington University in St Louis School of Medicine, St Louis, Missouri, USA
J Clin Invest 121:800-8. 2011..Our strategy also can be broadly applied to induce sporadic in vivo loss of heterozygosity of any conditional alleles in progenitors that experience Notch1 activation...
- Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS)Zhenyi Liu
Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Genome Res 19:2081-9. 2009..In addition, we also present a simple pyrosequencing-based protocol that could be used for the enrichment of homologous recombinant embryonic stem (ES) cells...