David C Linehan

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma
    Udaya K Liyanage
    Laboratory for Biologic Cancer Therapy, Department of Surgery and Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA
    J Immunother 29:416-24. 2006
  2. doi request reprint Adjuvant interferon-based chemoradiation followed by gemcitabine for resected pancreatic adenocarcinoma: a single-institution phase II study
    David C Linehan
    Department of Surgery, Barnes Jewish Hospital Washington University Medical Center and Siteman Cancer Center, St Louis, Missouri 63110, USA
    Ann Surg 248:145-51. 2008
  3. ncbi request reprint CD25+ CD4+ regulatory T-cells in cancer
    David C Linehan
    Department of Surgery and Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:155-68. 2005
  4. ncbi request reprint Depletion of CD4+CD25+ regulatory T cells promotes a tumor-specific immune response in pancreas cancer-bearing mice
    Carsten T Viehl
    Department of Surgery, Washington University School of Medicine, Box 8109, 660 S Euclid Ave, St Louis, Missouri 63110, USA
    Ann Surg Oncol 13:1252-8. 2006
  5. doi request reprint Regional lymphadenectomy is indicated in the surgical treatment of pancreatic neuroendocrine tumors (PNETs)
    Yassar M Hashim
    Department of Surgery and The Alvin J Siteman Cancer Center, Barnes Jewish Hospital and Washington University School of Medicine, St Louis, MO Division of Biostatistics, Washington University School of Medicine, St Louis, MO and Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, and Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University Cancer Hospital, Beijing, China
    Ann Surg 259:197-203. 2014
  6. pmc Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer
    Roheena Z Panni
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Ave, Box 8109, St Louis, MO, 63110, USA
    Cancer Immunol Immunother 63:513-28. 2014
  7. pmc Radiologic and intraoperative detection of need for mesenteric vein resection in patients with adenocarcinoma of the head of the pancreas
    Matthew R Porembka
    Section of Hepato Pancreato Biliary Surgery, Department of Surgery, Barnes Jewish Hospital and Washington University in St Louis, St Louis, MO 63110, USA
    HPB (Oxford) 13:633-42. 2011
  8. ncbi request reprint A phase II study of alternating cycles of split course radiation therapy and gemcitabine chemotherapy for inoperable pancreatic or biliary tract carcinoma
    Lilie L Lin
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Clin Oncol 28:234-41. 2005
  9. ncbi request reprint Chemotherapy-induced normalization of FDG uptake by colorectal liver metastases does not usually indicate complete pathologic response
    Marcus C B Tan
    Section of Hepato Pancreato Biliary and GI Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Gastrointest Surg 11:1112-9. 2007
  10. doi request reprint Unique site- and time-specific patterns of recurrence following resection of colorectal carcinoma hepatic metastases in patients staged by FDG-PET
    Steven E Finkelstein
    Section of Hepatobiliary Pancreatic Surgery, Washington University in St Louis and Barnes Jewish Hospital, St Louis, MO, USA
    J Hepatobiliary Pancreat Surg 15:483-7. 2008

Research Grants

Detail Information

Publications55

  1. ncbi request reprint Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma
    Udaya K Liyanage
    Laboratory for Biologic Cancer Therapy, Department of Surgery and Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA
    J Immunother 29:416-24. 2006
    ..We conclude that Pan02 tumor promotes the prevalence of Treg, in part through the secretion of TGF-beta, which may result in immune evasion...
  2. doi request reprint Adjuvant interferon-based chemoradiation followed by gemcitabine for resected pancreatic adenocarcinoma: a single-institution phase II study
    David C Linehan
    Department of Surgery, Barnes Jewish Hospital Washington University Medical Center and Siteman Cancer Center, St Louis, Missouri 63110, USA
    Ann Surg 248:145-51. 2008
    ..The primary end point was 2-year overall survival, with secondary endpoints being 2-year disease-free survival, and the frequency of grade 3 or 4 toxicity...
  3. ncbi request reprint CD25+ CD4+ regulatory T-cells in cancer
    David C Linehan
    Department of Surgery and Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:155-68. 2005
    ..Our studies focus on further defining these mechanisms with the ultimate goal of designing strategies that block Treg-mediated suppression in cancer patients...
  4. ncbi request reprint Depletion of CD4+CD25+ regulatory T cells promotes a tumor-specific immune response in pancreas cancer-bearing mice
    Carsten T Viehl
    Department of Surgery, Washington University School of Medicine, Box 8109, 660 S Euclid Ave, St Louis, Missouri 63110, USA
    Ann Surg Oncol 13:1252-8. 2006
    ..Depletion of T(reg) results in smaller tumors and prolonged host survival. The objective of this study was to evaluate the tumor-specific immune response after depletion of T(reg) alone or in combination with a cancer vaccine...
  5. doi request reprint Regional lymphadenectomy is indicated in the surgical treatment of pancreatic neuroendocrine tumors (PNETs)
    Yassar M Hashim
    Department of Surgery and The Alvin J Siteman Cancer Center, Barnes Jewish Hospital and Washington University School of Medicine, St Louis, MO Division of Biostatistics, Washington University School of Medicine, St Louis, MO and Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, and Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University Cancer Hospital, Beijing, China
    Ann Surg 259:197-203. 2014
    ..To explore the prognostic importance and preoperative predictors of lymph node metastasis in an effort to guide surgical decision making in patients with pancreatic neuroendocrine tumors (PNETs)...
  6. pmc Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer
    Roheena Z Panni
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Ave, Box 8109, St Louis, MO, 63110, USA
    Cancer Immunol Immunother 63:513-28. 2014
    ..Therefore, targeting STAT3 activation may be an effective therapeutic strategy in targeting CSCs in PC. ..
  7. pmc Radiologic and intraoperative detection of need for mesenteric vein resection in patients with adenocarcinoma of the head of the pancreas
    Matthew R Porembka
    Section of Hepato Pancreato Biliary Surgery, Department of Surgery, Barnes Jewish Hospital and Washington University in St Louis, St Louis, MO 63110, USA
    HPB (Oxford) 13:633-42. 2011
    ..A single-centre review was performed to determine how efficient these processes are in evaluating the need for MVR...
  8. ncbi request reprint A phase II study of alternating cycles of split course radiation therapy and gemcitabine chemotherapy for inoperable pancreatic or biliary tract carcinoma
    Lilie L Lin
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Clin Oncol 28:234-41. 2005
    ..Despite the prolongation in radiation treatment time because of split-course treatment, patients with sufficient response were able to undergo resection...
  9. ncbi request reprint Chemotherapy-induced normalization of FDG uptake by colorectal liver metastases does not usually indicate complete pathologic response
    Marcus C B Tan
    Section of Hepato Pancreato Biliary and GI Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Gastrointest Surg 11:1112-9. 2007
    ..Therefore, currently, curative resection of liver metastases in these patients should not be deferred on the basis of FDG-PET findings...
  10. doi request reprint Unique site- and time-specific patterns of recurrence following resection of colorectal carcinoma hepatic metastases in patients staged by FDG-PET
    Steven E Finkelstein
    Section of Hepatobiliary Pancreatic Surgery, Washington University in St Louis and Barnes Jewish Hospital, St Louis, MO, USA
    J Hepatobiliary Pancreat Surg 15:483-7. 2008
    ..In this study, the site- and time-specific patterns of recurrence were examined in patients staged by FDG-PET and the results compared to historical literature control data...
  11. pmc Induction of Th17 cells in the tumor microenvironment improves survival in a murine model of pancreatic cancer
    Jennifer L Gnerlich
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 185:4063-71. 2010
    ..The delayed tumor growth and improved survival suggests that induction of Th17 in the tumor microenvironment produces an antitumor effect...
  12. pmc Prevention of lymphocyte apoptosis in septic mice with cancer increases mortality
    Amy C Fox
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 187:1950-6. 2011
    ..These data demonstrate that, despite overwhelming evidence that prevention of lymphocyte apoptosis is beneficial in septic hosts without comorbidities, the same strategy worsens survival in mice with cancer that are given pneumonia...
  13. pmc Tumor-derived TGF-beta mediates conversion of CD4+Foxp3+ regulatory T cells in a murine model of pancreas cancer
    Tricia A Moo-Young
    Laboratory for Biologic Cancer Therapy, Department of Surgery, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Immunother 32:12-21. 2009
    ..Collectively, these observations further support the role of TGF-beta in the induction of Treg in pancreas adenocarcinoma...
  14. ncbi request reprint A tat fusion protein-based tumor vaccine for breast cancer
    Carsten T Viehl
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Surg Oncol 12:517-25. 2005
    ..This study tested the in vivo efficacy of DC-Tat-ECD in a murine breast cancer model...
  15. pmc Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis
    Dominic E Sanford
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Cancer Res 19:3404-15. 2013
    ..To determine the role of the CCL2/CCR2 axis and inflammatory monocytes (CCR2(+)/CD14(+)) as immunotherapeutic targets in the treatment of pancreatic cancer...
  16. pmc Mesh reinforcement of pancreatic transection decreases incidence of pancreatic occlusion failure for left pancreatectomy: a single-blinded, randomized controlled trial
    Nicholas A Hamilton
    Departments of Surgery, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Ann Surg 255:1037-42. 2012
    ..We performed a single-blinded, parallel-group, randomized controlled trial comparing stapled left pancreatectomy with stapled left pancreatectomy using mesh reinforcement of the staple line with either Seamguard or Peristrips Dry...
  17. pmc Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer
    Marcus C B Tan
    Department of Surgery, Barnes Jewish Hospital Washington University Medical Center, St Louis, MO 63110, USA
    J Immunol 182:1746-55. 2009
    ..Selective targeting of CCR5/CCL5 signaling may represent a novel immunomodulatory strategy for the treatment of cancer...
  18. doi request reprint Long-term results of resection of adenocarcinoma of the body and tail of the pancreas using radical antegrade modular pancreatosplenectomy procedure
    Jonathan B Mitchem
    Section of Hepato Pancreato Biliary Surgery, Washington University in St Louis, St Louis, MO 63110, USA
    J Am Coll Surg 214:46-52. 2012
    ..The purpose of this report is to provide long-term survival results...
  19. doi request reprint A prognostic system applicable to patients with resectable liver metastasis from colorectal carcinoma staged by positron emission tomography with [18F]fluoro-2-deoxy-D-glucose: role of primary tumor variables
    Marcus C B Tan
    Section of Hepato Pancreato Biliary Surgery, Department of Surgery, Washington University in Saint Louis, St Louis, MO 63110, USA
    J Am Coll Surg 206:857-68; discussion 868-9. 2008
    ..Data from two institutions were analyzed separately and together to improve general applicability of results...
  20. pmc Circulating mesothelin protein and cellular antimesothelin immunity in patients with pancreatic cancer
    Fabian Mc Johnston
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 15:6511-8. 2009
    ..Mesothelin has also been considered as a target for immune-based therapies. We conducted a study on the potential clinical utility of mesothelin as a biomarker for pancreatic disease and therapeutic target pancreatic cancer...
  21. ncbi request reprint Effect of steatohepatitis associated with irinotecan or oxaliplatin pretreatment on resectability of hepatic colorectal metastases
    Felix G Fernandez
    Section of Hepatobiliary Pancreatic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Coll Surg 200:845-53. 2005
    ..The objective was to evaluate the effect of preoperative administration of newer chemotherapeutic agents (irinotecan and oxaliplatin) on development of steatohepatitis, which could limit surgical options...
  22. pmc Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth
    Matthew R Porembka
    Department of Surgery, Washington University School of Medicine, 660 S Euclid Avenue, Box 8109, Saint Louis, MO 63110, USA
    Cancer Immunol Immunother 61:1373-85. 2012
    ..Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immunosuppressive cells that are upregulated in cancer. Little is known about the prevalence and importance of MDSC in pancreas adenocarcinoma (PA)...
  23. doi request reprint Microscopic margins and patterns of treatment failure in resected pancreatic adenocarcinoma
    Jennifer L Gnerlich
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Arch Surg 147:753-60. 2012
    ..To correlate microscopic margin status with survival and local control in a large cohort of patients from a high-volume pancreatic cancer center...
  24. ncbi request reprint Induction of antigen-specific CTL by recombinant HIV trans-activating fusion protein-pulsed human monocyte-derived dendritic cells
    Yoshiyuki Tanaka
    Department of Surgery, Biologic Cancer Therapy Program, and Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 170:1291-8. 2003
    ..Our data suggest that TAT fusion proteins efficiently transduce DC and induce Ag-specific T cells. This could prove to be a useful method for treatment of infectious diseases and cancer...
  25. ncbi request reprint Radical antegrade modular pancreatosplenectomy procedure for adenocarcinoma of the body and tail of the pancreas: ability to obtain negative tangential margins
    Steven M Strasberg
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Coll Surg 204:244-9. 2007
    ..We now present results of treatment of patients with adenocarcinoma using RAMPS with particular reference to the ability of this procedure to obtain negative tangential margin rates...
  26. doi request reprint Resection of tumors of the neck of the pancreas with venous invasion: the "Whipple at the Splenic Artery (WATSA)" procedure
    Steven M Strasberg
    HPB Surgery Section, Department of Surgery, Washington University in Saint Louis, 660 South Euclid Avenue, Box 8109, Saint Louis, MO 63110, USA
    J Gastrointest Surg 16:1048-54. 2012
    ..Here, we present our method of resecting such tumors, which we term "Whipple at the Splenic Artery (WATSA)"...
  27. doi request reprint Pattern of venous collateral development after splenic vein occlusion in an extended Whipple procedure : comparison with collateral vein pattern in cases of sinistral portal hypertension
    Steven M Strasberg
    Section of HPB Surgery, Department of Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USA
    J Gastrointest Surg 15:2070-9. 2011
    ..Our purpose was to compare the pattern of venous collateral development after splenic vein ligation in an extended Whipple procedure with the pattern of collateral development in cases of sinistral portal hypertension...
  28. ncbi request reprint Human dendritic cells induce tumor-specific apoptosis by soluble factors
    Hong Gu Joo
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Cancer 102:20-8. 2002
    ..Our findings suggest that maturing DCs have the intrinsic ability to induce cell-cycle arrest and apoptosis of breast tumor cells through soluble factors, but not normal cells, in addition to their Ag presentation function...
  29. pmc A single-institution review of 157 patients presenting with benign and malignant tumors of the ampulla of Vater: management and outcomes
    John R Hornick
    Division of Hepatobiliary, Pancreatic, and Gastrointestinal Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Surgery 150:169-76. 2011
    ....
  30. pmc Ki-67 predicts disease recurrence and poor prognosis in pancreatic neuroendocrine neoplasms
    Nicholas A Hamilton
    Department of Surgery, Washington University, Saint Louis, MO, USA
    Surgery 152:107-13. 2012
    ..We sought to test the predictive ability of Ki-67 staining for disease recurrence and overall survival (OS) in pancreatic neuroendocrine neoplasms...
  31. ncbi request reprint Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
    Udaya K Liyanage
    Alvin J Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 169:2756-61. 2002
    ..These T(reg) may mitigate the immune response against cancer, and may partly explain the poor immune response against tumor Ags...
  32. doi request reprint Laparoscopic gastric resection for gastrointestinal stromal tumors
    Jennifer A Sexton
    Department of Surgery, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8109, St Louis, MO 63110, USA
    Surg Endosc 22:2583-7. 2008
    ..This study aimed to review clinical outcomes for patients selected to undergo laparoscopic resection for gastrointestinal stromal tumor (GIST) of the stomach...
  33. doi request reprint Saline-linked surface radiofrequency ablation: a safe and effective method of surface ablation of hepatic metastatic colorectal cancer
    Jennifer L Gnerlich
    Section of Hepatobiliary Pancreatic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Ann Surg 250:96-102. 2009
    ..To determine the safety and efficacy of saline-linked surface radiofrequency ablation (SLSRFA) in a clinical setting...
  34. ncbi request reprint "Sideways": results of repair of biliary injuries using a policy of side-to-side hepatico-jejunostomy
    Emily R Winslow
    Section of Hepato Pancreato Biliary Surgery, Department of Surgery, Mallinckrodt Institute of Radiology, Washington University in Saint Louis, St Louis, Missouri 63110, USA
    Ann Surg 249:426-34. 2009
    ..Compared with end-to-side repairs, side-to-side anastomoses require less dissection, theoretically preserving blood supply to the bile ducts, and usually permit wider anastomoses...
  35. pmc Jaundice: an important, poorly recognized risk factor for diminished survival in patients with adenocarcinoma of the head of the pancreas
    Steven M Strasberg
    Section of Hepato Pancreato Biliary Surgery, Department of Surgery, Washington University in St Louis, St Louis, MO, USA Alvin J Siteman Cancer Center, Washington University in St Louis, St Louis, MO, USA
    HPB (Oxford) 16:150-6. 2014
    ..The purpose of this study was to determine whether there is an association between preoperative jaundice and survival in patients who have undergone resection of such tumours...
  36. pmc Down-regulation of PLCγ2-β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer
    Aude Hélène Capietto
    Department of Orthopedics, 2 Department of Surgery, 3 Department of Medicine, Washington University School of Medicine, St Louis, MO
    J Exp Med 210:2257-71. 2013
    ....
  37. pmc Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses
    Jonathan B Mitchem
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 73:1128-41. 2013
    ..Together, our findings show how targeting TAMs can effectively overcome therapeutic resistance mediated by TICs...
  38. doi request reprint Pattern of lymph node involvement and prognosis in pancreatic adenocarcinoma: direct lymph node invasion has similar survival to node-negative disease
    Rish K Pai
    Department of Pathology, Washington University, St Louis, MO, USA
    Am J Surg Pathol 35:228-34. 2011
    ..Our results indicate that patients with isolated direct lymph node invasion have a comparable overall survival with patients with node-negative adenocarcinomas as opposed to true lymphatic lymph node metastasis...
  39. pmc Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis
    Amy C Fox
    Departments of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 38:886-93. 2010
    ..Malignancy is the most common comorbidity associated with sepsis. The purpose of this study was to determine whether mice with cancer have a different response to sepsis than healthy animals...
  40. ncbi request reprint Extended lymphadenectomy in the surgery of pancreatic adenocarcinoma and its relation to quality improvement issues
    Christopher C Rupp
    Division of General Surgery, Department of Surgery, Section of HPB Surgery, Washington University School of Medicine, St Louis, MO 63110 1010, USA
    J Surg Oncol 99:207-14. 2009
    ..Lymph node status is an important surrogate of survival but is not a driving factor for adjuvant chemotherapy. Quality improvement in pancreatic cancer surgery is discussed, focusing on the impact of lymph nodes in determining prognosis...
  41. ncbi request reprint Proteins associated with disease and clinical course in pancreas cancer: a proteomic analysis of plasma in surgical patients
    Yiing Lin
    Departments of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Proteome Res 5:2169-76. 2006
    ..With further identification and validation, the candidate biomarkers which we identify in this study may prove to be useful in the diagnosis, management and prognostication of patients with pancreas cancer...
  42. ncbi request reprint Absorbable mesh reinforcement of a stapled pancreatic transection line reduces the leak rate with distal pancreatectomy
    Reuben I Thaker
    Department of Surgery, Division of Hepatobiliary, Pancreatic, and Gastrointestinal Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Gastrointest Surg 11:59-65. 2007
    ..Mesh reinforcement was possible with open or laparoscopic resections. No complications were attributable to the use of absorbable mesh...
  43. doi request reprint Isolation of right main and right sectional portal pedicles for liver resection without hepatotomy or inflow occlusion
    Steven M Strasberg
    Section of Hepatobiliary Pancreatic Surgery, Siteman Cancer Center, Washington University in St Louis, Barnes Jewish Hospital, St Louis, MO, USA
    J Am Coll Surg 206:390-6. 2008
  44. doi request reprint A technique of gastrojejunostomy to reduce delayed gastric emptying after pancreatoduodenectomy
    Adeel S Khan
    Section of Hepato Pancreato Biliary Surgery, Department of Surgery, Washington University in Saint Louis, St Louis, MO, 63110, USA
    J Gastrointest Surg 15:1468-71. 2011
    ..Delayed gastric emptying (DGE) through a gastroenterostomy is a clinical problem that affects many patients who have a standard Whipple procedure. A new method, which is associated with a low rate of DGE, is described...
  45. ncbi request reprint Proposal for definition and severity grading of pancreatic anastomosis failure and pancreatic occlusion failure
    Steven M Strasberg
    Section of Hepatobiliary Pancreatic and Gastrointestinal Surgery, Washington University in St Louis, MO, USA
    Surgery 141:420-6. 2007
  46. ncbi request reprint A new operative approach for type I choledochal cysts
    Linda X Jin
    Washington University in Saint Louis School of Medicine, St Louis, MO, USA
    J Gastrointest Surg 18:1049-53. 2014
    ....
  47. pmc Five-year survival after resection of hepatic metastases from colorectal cancer in patients screened by positron emission tomography with F-18 fluorodeoxyglucose (FDG-PET)
    Felix G Fernandez
    Section of Hepatobiliary Pancreatic Surgery, Department of Surgery, Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Ann Surg 240:438-47; discussion 447-50. 2004
    ..To report the first 5-year overall survival results in patients with colorectal carcinoma metastatic to the liver who have undergone hepatic resection after staging with [18F] fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET)...
  48. ncbi request reprint The accordion severity grading system of surgical complications
    Steven M Strasberg
    Department of Surgery, Washington University in Saint Louis, St Louis, MO 63110, USA
    Ann Surg 250:177-86. 2009
    ..Our purpose was to determine how well T92 and its modifications have functioned as a severity grading system and to develop an improved system for reporting complications...
  49. doi request reprint Colorectal liver metastases: state of the art imaging
    Kathryn Jane Fowler
    Department of Radiology, Washington University, St Louis, MO, USA
    Ann Surg Oncol 20:1185-93. 2013
    ..Particular challenges such as hepatic steatosis, disappearing metastases, and following treated lesions are addressed...
  50. doi request reprint Establishing "normal" values for liver function tests after reconstruction of biliary injuries
    Elizabeth A Fialkowski
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Coll Surg 207:705-9. 2008
    ..This study's aim was to determine LFT reference values after biliary-enteric anastomosis for biliary injury repair in persons who have had an excellent postoperative course for > 6 months...
  51. pmc Utility of the Gyrus open forceps in hepatic parenchymal transection
    Matthew R Porembka
    Section of Hepato Pancreato Biliary Surgery, Department of Surgery, Washington University Saint Louis, MO, USA
    HPB (Oxford) 11:258-63. 2009
    ....
  52. ncbi request reprint Desmoplastic melanoma: a pathologically and clinically distinct form of cutaneous melanoma
    William G Hawkins
    Department of Surgery, Washington University, St Louis, Missouri 63110, USA
    Ann Surg Oncol 12:207-13. 2005
    ..Pathologic heterogeneity within DM may account for the controversy regarding the clinical presentation and prognosis of DM compared with conventional melanoma (CM)...
  53. pmc Utility of staging laparoscopy in subsets of peripancreatic and biliary malignancies
    Charles M Vollmer
    Section of Hepatobiliary Pancreatic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Ann Surg 235:1-7. 2002
    ..To determine the relative benefit of staging laparoscopy in peripancreatic and biliary malignancies...
  54. pmc Targeting tumor-infiltrating macrophages to combat cancer
    Roheena Z Panni
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63132, USA
    Immunotherapy 5:1075-87. 2013
    ....
  55. ncbi request reprint Bile duct injuries in the era of laparoscopic cholecystectomies
    Yuhsin V Wu
    Division of General Surgery, Department of Surgery, Washington University School of Medicine, Surgery House Staff Office, 1701 West Building, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Surg Clin North Am 90:787-802. 2010
    ..Better outcomes are achieved when patients are referred to centers specialized in biliary injury evaluation, treatment, and performing pretreatment planning early...

Research Grants1

  1. Multivalent Dendritic Cell Vaccine in Pancreas Cancer
    David Linehan; Fiscal Year: 2006
    ..3) Test efficacy of peptide-specific CTL generation and toxicity in an HLA-A2 transgenic murine model (4) Conduct a phase I clinical trial of a multivalent DC vaccine in pancreas cancer patients. ..