Research Topics
Genomes and Genes | David C LinehanSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Publications
Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinomaUdaya K Liyanage
Laboratory for Biologic Cancer Therapy, Department of Surgery and Alvin J. Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA
J Immunother (1997) 29:416-24. 2006..We conclude that Pan02 tumor promotes the prevalence of Treg, in part through the secretion of TGF-beta, which may result in immune evasion...
Adjuvant interferon-based chemoradiation followed by gemcitabine for resected pancreatic adenocarcinoma: a single-institution phase II studyDavid C Linehan
Department of Surgery, Barnes Jewish Hospital Washington University Medical Center and Siteman Cancer Center, St Louis, Missouri 63110, USA
Ann Surg 248:145-51. 2008..The primary end point was 2-year overall survival, with secondary endpoints being 2-year disease-free survival, and the frequency of grade 3 or 4 toxicity...- CD25+ CD4+ regulatory T-cells in cancerDavid C Linehan
Department of Surgery and Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
Immunol Res 32:155-68. 2005..Our studies focus on further defining these mechanisms with the ultimate goal of designing strategies that block Treg-mediated suppression in cancer patients... - Depletion of CD4+CD25+ regulatory T cells promotes a tumor-specific immune response in pancreas cancer-bearing miceCarsten T Viehl
Department of Surgery, Washington University School of Medicine, Box 8109, 660 S. Euclid Ave, St. Louis, Missouri 63110, USA
Ann Surg Oncol 13:1252-8. 2006..009). CONCLUSIONS: Depletion of T(reg) alone or in combination with a whole tumor cell vaccine promotes a tumor-specific immune response. Thus, strategies incorporating T(reg) depletion might improve the efficacy of cancer vaccines... 
Radiologic and intraoperative detection of need for mesenteric vein resection in patients with adenocarcinoma of the head of the pancreasMatthew R Porembka
Section of Hepato Pancreato Biliary Surgery, Department of Surgery, Barnes Jewish Hospital and Washington University in St Louis, St Louis, MO 63110, USA
HPB (Oxford) 13:633-42. 2011..A single-centre review was performed to determine how efficient these processes are in evaluating the need for MVR...- Chemotherapy-induced normalization of FDG uptake by colorectal liver metastases does not usually indicate complete pathologic responseMarcus C B Tan
Section of Hepato Pancreato Biliary and GI Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Gastrointest Surg 11:1112-9. 2007..Therefore, currently, curative resection of liver metastases in these patients should not be deferred on the basis of FDG-PET findings... - A phase II study of alternating cycles of split course radiation therapy and gemcitabine chemotherapy for inoperable pancreatic or biliary tract carcinomaLilie L Lin
Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Am J Clin Oncol 28:234-41. 2005..Despite the prolongation in radiation treatment time because of split-course treatment, patients with sufficient response were able to undergo resection... - Induction of Th17 cells in the tumor microenvironment improves survival in a murine model of pancreatic cancerJennifer L Gnerlich
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 185:4063-71. 2010..The delayed tumor growth and improved survival suggests that induction of Th17 in the tumor microenvironment produces an antitumor effect... - A tat fusion protein-based tumor vaccine for breast cancerCarsten T Viehl
Department of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Ann Surg Oncol 12:517-25. 2005..001). Similarly, a T-helper type 1 CD4(+) T-cell response was observed. CONCLUSIONS: Protein-transduced DCs may be effective vaccines for the treatment of cancer... - Unique site- and time-specific patterns of recurrence following resection of colorectal carcinoma hepatic metastases in patients staged by FDG-PETSteven E Finkelstein
Section of Hepatobiliary Pancreatic Surgery, Washington University in St Louis and Barnes Jewish Hospital, St Louis, MO, USA
J Hepatobiliary Pancreat Surg 15:483-7. 2008..In this study, the site- and time-specific patterns of recurrence were examined in patients staged by FDG-PET and the results compared to historical literature control data... - Prevention of lymphocyte apoptosis in septic mice with cancer increases mortalityAmy C Fox
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 187:1950-6. 2011..These data demonstrate that, despite overwhelming evidence that prevention of lymphocyte apoptosis is beneficial in septic hosts without comorbidities, the same strategy worsens survival in mice with cancer that are given pneumonia... - Tumor-derived TGF-beta mediates conversion of CD4+Foxp3+ regulatory T cells in a murine model of pancreas cancerTricia A Moo-Young
Laboratory for Biologic Cancer Therapy, Department of Surgery, Washington University School of Medicine, Saint Louis, MO 63110, USA
J Immunother 32:12-21. 2009..Collectively, these observations further support the role of TGF-beta in the induction of Treg in pancreas adenocarcinoma... - Mesh reinforcement of pancreatic transection decreases incidence of pancreatic occlusion failure for left pancreatectomy: a single-blinded, randomized controlled trialNicholas A Hamilton
Departments of Surgery, Washington University School of Medicine, Saint Louis, MO 63110, USA
Ann Surg 255:1037-42. 2012..We performed a single-blinded, parallel-group, randomized controlled trial comparing stapled left pancreatectomy with stapled left pancreatectomy using mesh reinforcement of the staple line with either Seamguard or Peristrips Dry... - Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancerMarcus C B Tan
Department of Surgery, Barnes Jewish Hospital Washington University Medical Center, St Louis, MO 63110, USA
J Immunol 182:1746-55. 2009..Selective targeting of CCR5/CCL5 signaling may represent a novel immunomodulatory strategy for the treatment of cancer... - Long-term results of resection of adenocarcinoma of the body and tail of the pancreas using radical antegrade modular pancreatosplenectomy procedureJonathan B Mitchem
Section of Hepato Pancreato Biliary Surgery, Washington University in St Louis, St Louis, MO 63110, USA
J Am Coll Surg 214:46-52. 2012..The purpose of this report is to provide long-term survival results... - Circulating mesothelin protein and cellular antimesothelin immunity in patients with pancreatic cancerFabian Mc Johnston
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Clin Cancer Res 15:6511-8. 2009..Mesothelin has also been considered as a target for immune-based therapies. We conducted a study on the potential clinical utility of mesothelin as a biomarker for pancreatic disease and therapeutic target pancreatic cancer... - A prognostic system applicable to patients with resectable liver metastasis from colorectal carcinoma staged by positron emission tomography with [18F]fluoro-2-deoxy-D-glucose: role of primary tumor variablesMarcus C B Tan
Section of Hepato Pancreato Biliary Surgery, Department of Surgery, Washington University in Saint Louis, St Louis, MO 63110, USA
J Am Coll Surg 206:857-68; discussion 868-9. 2008..Data from two institutions were analyzed separately and together to improve general applicability of results... - Effect of steatohepatitis associated with irinotecan or oxaliplatin pretreatment on resectability of hepatic colorectal metastasesFelix G Fernandez
Section of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA
J Am Coll Surg 200:845-53. 2005..It can affect the ability to perform large liver resections. Consideration should be given to performing resections before commencing these agents and to obtaining preoperative biopsy in those who have received these agents... - Microscopic margins and patterns of treatment failure in resected pancreatic adenocarcinomaJennifer L Gnerlich
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Arch Surg 147:753-60. 2012..To correlate microscopic margin status with survival and local control in a large cohort of patients from a high-volume pancreatic cancer center... - Radical antegrade modular pancreatosplenectomy procedure for adenocarcinoma of the body and tail of the pancreas: ability to obtain negative tangential marginsSteven M Strasberg
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Am Coll Surg 204:244-9. 2007..We now present results of treatment of patients with adenocarcinoma using RAMPS with particular reference to the ability of this procedure to obtain negative tangential margin rates... - Induction of antigen-specific CTL by recombinant HIV trans-activating fusion protein-pulsed human monocyte-derived dendritic cellsYoshiyuki Tanaka
Department of Surgery, Biologic Cancer Therapy Program, and Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA
J Immunol 170:1291-8. 2003..Our data suggest that TAT fusion proteins efficiently transduce DC and induce Ag-specific T cells. This could prove to be a useful method for treatment of infectious diseases and cancer... - Resection of tumors of the neck of the pancreas with venous invasion: the "Whipple at the Splenic Artery (WATSA)" procedureSteven M Strasberg
HPB Surgery Section, Department of Surgery, Washington University in Saint Louis, 660 South Euclid Avenue, Box 8109, Saint Louis, MO 63110, USA
J Gastrointest Surg 16:1048-54. 2012..Here, we present our method of resecting such tumors, which we term "Whipple at the Splenic Artery (WATSA)"... - Pattern of venous collateral development after splenic vein occlusion in an extended Whipple procedure : comparison with collateral vein pattern in cases of sinistral portal hypertensionSteven M Strasberg
Section of HPB Surgery, Department of Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USA
J Gastrointest Surg 15:2070-9. 2011..Our purpose was to compare the pattern of venous collateral development after splenic vein ligation in an extended Whipple procedure with the pattern of collateral development in cases of sinistral portal hypertension... - Human dendritic cells induce tumor-specific apoptosis by soluble factorsHong-Gu Joo
Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA
Int J Cancer 102:20-8. 2002..Our findings suggest that maturing DCs have the intrinsic ability to induce cell-cycle arrest and apoptosis of breast tumor cells through soluble factors, but not normal cells, in addition to their Ag presentation function... - A single-institution review of 157 patients presenting with benign and malignant tumors of the ampulla of Vater: management and outcomesJohn R Hornick
Division of Hepatobiliary, Pancreatic, and Gastrointestinal Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Surgery 150:169-76. 2011.... - Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growthMatthew R Porembka
Department of Surgery, Washington University School of Medicine, 660 S Euclid Avenue, Box 8109, Saint Louis, MO 63110, USA
Cancer Immunol Immunother 61:1373-85. 2012..Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immunosuppressive cells that are upregulated in cancer. Little is known about the prevalence and importance of MDSC in pancreas adenocarcinoma (PA)... - Ki-67 predicts disease recurrence and poor prognosis in pancreatic neuroendocrine neoplasmsNicholas A Hamilton
Department of Surgery, Washington University, Saint Louis, MO, USA
Surgery 152:107-13. 2012..We sought to test the predictive ability of Ki-67 staining for disease recurrence and overall survival (OS) in pancreatic neuroendocrine neoplasms... - "Sideways": results of repair of biliary injuries using a policy of side-to-side hepatico-jejunostomyEmily R Winslow
Section of Hepato Pancreato Biliary Surgery, Department of Surgery, Mallinckrodt Institute of Radiology, Washington University in Saint Louis, St Louis, Missouri 63110, USA
Ann Surg 249:426-34. 2009..Compared with end-to-side repairs, side-to-side anastomoses require less dissection, theoretically preserving blood supply to the bile ducts, and usually permit wider anastomoses... - Saline-linked surface radiofrequency ablation: a safe and effective method of surface ablation of hepatic metastatic colorectal cancerJennifer L Gnerlich
Section of Hepatobiliary Pancreatic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
Ann Surg 250:96-102. 2009..To determine the safety and efficacy of saline-linked surface radiofrequency ablation (SLSRFA) in a clinical setting... - Laparoscopic gastric resection for gastrointestinal stromal tumorsJennifer A Sexton
Department of Surgery, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8109, St Louis, MO 63110, USA
Surg Endosc 22:2583-7. 2008..This study aimed to review clinical outcomes for patients selected to undergo laparoscopic resection for gastrointestinal stromal tumor (GIST) of the stomach... - Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinomaUdaya K Liyanage
Alvin J. Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA
J Immunol 169:2756-61. 2002..These T(reg) may mitigate the immune response against cancer, and may partly explain the poor immune response against tumor Ags... - Pattern of lymph node involvement and prognosis in pancreatic adenocarcinoma: direct lymph node invasion has similar survival to node-negative diseaseRish K Pai
Department of Pathology, Washington University, St Louis, MO, USA
Am J Surg Pathol 35:228-34. 2011..Our results indicate that patients with isolated direct lymph node invasion have a comparable overall survival with patients with node-negative adenocarcinomas as opposed to true lymphatic lymph node metastasis... - Cancer causes increased mortality and is associated with altered apoptosis in murine sepsisAmy C Fox
Departments of Surgery, Washington University School of Medicine, St Louis, MO, USA
Crit Care Med 38:886-93. 2010..Malignancy is the most common comorbidity associated with sepsis. The purpose of this study was to determine whether mice with cancer have a different response to sepsis than healthy animals... - Proteins associated with disease and clinical course in pancreas cancer: a proteomic analysis of plasma in surgical patientsYiing Lin
Departments of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Proteome Res 5:2169-76. 2006..With further identification and validation, the candidate biomarkers which we identify in this study may prove to be useful in the diagnosis, management and prognostication of patients with pancreas cancer... - Extended lymphadenectomy in the surgery of pancreatic adenocarcinoma and its relation to quality improvement issuesChristopher C Rupp
Division of General Surgery, Department of Surgery, Section of HPB Surgery, Washington University School of Medicine, St Louis, MO 63110 1010, USA
J Surg Oncol 99:207-14. 2009..Lymph node status is an important surrogate of survival but is not a driving factor for adjuvant chemotherapy. Quality improvement in pancreatic cancer surgery is discussed, focusing on the impact of lymph nodes in determining prognosis... - A technique of gastrojejunostomy to reduce delayed gastric emptying after pancreatoduodenectomyAdeel S Khan
Section of Hepato Pancreato Biliary Surgery, Department of Surgery, Washington University in Saint Louis, St Louis, MO, 63110, USA
J Gastrointest Surg 15:1468-71. 2011..Delayed gastric emptying (DGE) through a gastroenterostomy is a clinical problem that affects many patients who have a standard Whipple procedure. A new method, which is associated with a low rate of DGE, is described... - Absorbable mesh reinforcement of a stapled pancreatic transection line reduces the leak rate with distal pancreatectomyReuben I Thaker
Department of Surgery, Division of Hepatobiliary, Pancreatic, and Gastrointestinal Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Gastrointest Surg 11:59-65. 2007..Mesh reinforcement was possible with open or laparoscopic resections. No complications were attributable to the use of absorbable mesh... - Isolation of right main and right sectional portal pedicles for liver resection without hepatotomy or inflow occlusionSteven M Strasberg
Section of Hepatobiliary-Pancreatic Surgery, Siteman Cancer Center, Washington University in St Louis, Barnes-Jewish Hospital, St Louis, MO, USA
J Am Coll Surg 206:390-6. 2008 - Proposal for definition and severity grading of pancreatic anastomosis failure and pancreatic occlusion failureSteven M Strasberg
Section of Hepatobiliary-Pancreatic and Gastrointestinal Surgery, Washington University in St. Louis, MO, USA
Surgery 141:420-6. 2007 - The accordion severity grading system of surgical complicationsSteven M Strasberg
Department of Surgery, Washington University in Saint Louis, St Louis, MO 63110, USA
Ann Surg 250:177-86. 2009..Our purpose was to determine how well T92 and its modifications have functioned as a severity grading system and to develop an improved system for reporting complications... - Five-year survival after resection of hepatic metastases from colorectal cancer in patients screened by positron emission tomography with F-18 fluorodeoxyglucose (FDG-PET)Felix G Fernandez
Section of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA
Ann Surg 240:438-47; discussion 447-50. 2004..FDG-PET appears to define a new cohort of patients in whom tumor grade is a very important prognostic variable... - Establishing "normal" values for liver function tests after reconstruction of biliary injuriesElizabeth A Fialkowski
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Am Coll Surg 207:705-9. 2008..This study's aim was to determine LFT reference values after biliary-enteric anastomosis for biliary injury repair in persons who have had an excellent postoperative course for > 6 months... - Utility of the Gyrus open forceps in hepatic parenchymal transectionMatthew R Porembka
Section of Hepato Pancreato Biliary Surgery, Department of Surgery, Washington University Saint Louis, MO, USA
HPB (Oxford) 11:258-63. 2009.... - Desmoplastic melanoma: a pathologically and clinically distinct form of cutaneous melanomaWilliam G Hawkins
Department of Surgery, Washington University, St. Louis, Missouri 63110, USA
Ann Surg Oncol 12:207-13. 2005..Tumors with prominent fibrosis (pure subtype) are unlikely to disseminate to regional lymph nodes and are associated with a favorable outcome when compared with those with mixed desmoplasia or CM... - Utility of staging laparoscopy in subsets of peripancreatic and biliary malignanciesCharles M Vollmer
Section of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA
Ann Surg 235:1-7. 2002..CONCLUSIONS: The utility of staging laparoscopy depends on diagnosis. It is recommended for continued use in pancreatic head and gallbladder cancers but not in ampullary malignancies... - Bile duct injuries in the era of laparoscopic cholecystectomiesYuhsin V Wu
Division of General Surgery, Department of Surgery, Washington University School of Medicine, Surgery House Staff Office, 1701 West Building, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
Surg Clin North Am 90:787-802. 2010..Better outcomes are achieved when patients are referred to centers specialized in biliary injury evaluation, treatment, and performing pretreatment planning early...
Research Grants
- Multivalent Dendritic Cell Vaccine in Pancreas CancerDavid Linehan; Fiscal Year: 2006..3) Test efficacy of peptide-specific CTL generation and toxicity in an HLA-A2 transgenic murine model (4) Conduct a phase I clinical trial of a multivalent DC vaccine in pancreas cancer patients. ..