Joseph Lin

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs
    Joseph Lin
    Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 29:2082-91. 2009
  2. pmc Regulated movement of CD4 in and out of the immunological synapse
    Henry Kao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 181:8248-57. 2008
  3. pmc The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization
    Joseph Lin
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Immunol 183:1215-21. 2009
  4. pmc Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells
    Erin L Filbert
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 188:5421-7. 2012
  5. pmc The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse
    Emanuele Giurisato
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 29:1554-64. 2009
  6. pmc The c-SMAC: sorting it all out (or in)
    Joseph Lin
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Cell Biol 170:177-82. 2005
  7. pmc Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling
    Jing W Zhu
    Departments of Medicine and of Microbiology and Immunology, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, CA 94143, USA
    Immunity 28:183-96. 2008
  8. pmc A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant
    Lindzy D Friend
    Program in Immunology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 203:2121-33. 2006
  9. ncbi request reprint Getting downstream without a Raft
    Joseph Lin
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Box 8118, Saint Louis, Missouri 63110, USA
    Cell 121:815-6. 2005
  10. ncbi request reprint Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization
    Michelle R Kuhne
    Department of Medicine, Howard Hughes Medical Institute, Rosalind Russell Center for Medical Research in Arthritis, University of California, San Francisco, CA 94143, USA
    J Immunol 171:860-6. 2003

Collaborators

Detail Information

Publications10

  1. pmc KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs
    Joseph Lin
    Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 29:2082-91. 2009
    ..We conclude that KSR1 plays a central role in determining the sensitivity of T-cell responses and is thus well positioned as a key control point...
  2. pmc Regulated movement of CD4 in and out of the immunological synapse
    Henry Kao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 181:8248-57. 2008
    ..Thus, an important role for PKCtheta in T cell activation involves its recruitment to the IS, where it phosphorylates specific substrates that help to maintain the dynamism of protein turnover at the IS...
  3. pmc The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization
    Joseph Lin
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Immunol 183:1215-21. 2009
    ..Because a dominant-negative form of Par1b blocked TCR-induced MTOC polarization, our data suggest that Par1b functions in the establishment of T cell polarity following engagement to an APC...
  4. pmc Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells
    Erin L Filbert
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 188:5421-7. 2012
    ..These data implicate stathmin as a regulator of the microtubule network during T cell activation...
  5. pmc The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse
    Emanuele Giurisato
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 29:1554-64. 2009
    ..Imaging studies showed that KSR1 is recruited to the immunological synapse during T-cell activation and that membrane recruitment of KSR1 is required for recruitment of active ERK to the synapse...
  6. pmc The c-SMAC: sorting it all out (or in)
    Joseph Lin
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Cell Biol 170:177-82. 2005
    ..Here, we review recently published work and propose several possible functions for the role of the c-SMAC in T cell activation...
  7. pmc Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling
    Jing W Zhu
    Departments of Medicine and of Microbiology and Immunology, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, CA 94143, USA
    Immunity 28:183-96. 2008
    ....
  8. pmc A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant
    Lindzy D Friend
    Program in Immunology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 203:2121-33. 2006
    ..Furthermore, we find an important gene dosage effect on the phenotype of the mutation and provide a mechanistic explanation for the conflicting data on the significance of this motif in CD28 function...
  9. ncbi request reprint Getting downstream without a Raft
    Joseph Lin
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Box 8118, Saint Louis, Missouri 63110, USA
    Cell 121:815-6. 2005
    ..In this issue of Cell, use of single-molecule fluorescence suggests that protein-protein interactions, not detergent insolubility, regulate the assembly of signaling complexes in the plasma membrane...
  10. ncbi request reprint Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization
    Michelle R Kuhne
    Department of Medicine, Howard Hughes Medical Institute, Rosalind Russell Center for Medical Research in Arthritis, University of California, San Francisco, CA 94143, USA
    J Immunol 171:860-6. 2003
    ..Moreover, our studies revealed that a calcium-dependent event not requiring calcineurin or calcium/calmodulin-dependent kinase is required for TCR-induced polarization of the MTOC...