Yonghe Li

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution
    Yonghe Li
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, MO 63110, USA
    Oncogene 23:9129-35. 2004
  2. ncbi request reprint Striking differences of LDL receptor-related protein 1B expression in mouse and human
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 333:868-73. 2005
  3. ncbi request reprint Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway
    Yonghe Li
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 45:1084-91. 2004
  4. ncbi request reprint Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    FEBS Lett 555:346-50. 2003
  5. ncbi request reprint Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
    Yonghe Li
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Cell Sci 118:5305-14. 2005
  6. ncbi request reprint Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein
    Judy A Cam
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:15464-70. 2005
  7. pmc Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9
    Heesang Song
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:879-86. 2009
  8. pmc Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway
    Lora Melman
    Department of Pediatrics, Washington University School of Medicine, CB 8208, St Louis Children s Hospital, Missouri 63110, USA
    Mol Biol Cell 13:3325-35. 2002
  9. ncbi request reprint Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, Missouri 63110, USA
    J Biol Chem 277:42366-71. 2002
  10. pmc Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation
    Jane M Knisely
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Cell Res 313:3298-307. 2007

Collaborators

Detail Information

Publications20

  1. ncbi request reprint LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution
    Yonghe Li
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, MO 63110, USA
    Oncogene 23:9129-35. 2004
    ..Finally, we demonstrate that LRP6 expression promotes tumorigenesis in vivo. These results thus indicate that LRP6 may function as a potential oncogenic protein by modulating Wnt/beta-catenin signaling...
  2. ncbi request reprint Striking differences of LDL receptor-related protein 1B expression in mouse and human
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 333:868-73. 2005
    ..The broader expression pattern of LRP1B in human tissues suggests that this putative tumor suppressor may play roles in several types of human cancer...
  3. ncbi request reprint Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway
    Yonghe Li
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 45:1084-91. 2004
    ..Taken together, these data demonstrate that the proteasome is the principal degradation pathway for LDLR class 2 mutants...
  4. ncbi request reprint Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    FEBS Lett 555:346-50. 2003
    ..More important, we found that platelet-derived growth factor-dependent cell migration was inhibited in cells transfected with LRP siRNA. These results demonstrate an important role of LRP in smooth muscle cell migration...
  5. ncbi request reprint Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
    Yonghe Li
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Cell Sci 118:5305-14. 2005
    ..Together our results show that in addition to serving as a folding chaperone, Mesd can function as a receptor antagonist by inhibiting ligand binding to mature LRP6...
  6. ncbi request reprint Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein
    Judy A Cam
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:15464-70. 2005
    ..Together, these data establish a relationship between LRP rapid endocytosis and APP trafficking and proteolytic processing to generate Abeta...
  7. pmc Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9
    Heesang Song
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:879-86. 2009
    ..Together, our data strongly suggest that LRP1 promotes glioblastoma cell migration and invasion by regulating the expression and function of MMP2 and MMP9 perhaps via an ERK-dependent signaling pathway...
  8. pmc Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway
    Lora Melman
    Department of Pediatrics, Washington University School of Medicine, CB 8208, St Louis Children s Hospital, Missouri 63110, USA
    Mol Biol Cell 13:3325-35. 2002
    ..e., LRP, is regulated by the proteasomal system, suggesting a broader function of the proteasome in regulating the trafficking of receptors into the degradation pathway...
  9. ncbi request reprint Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, Missouri 63110, USA
    J Biol Chem 277:42366-71. 2002
    ..Taken together, these results demonstrate that LRP1B can function as a negative regulator of uPAR regeneration and cell migration...
  10. pmc Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation
    Jane M Knisely
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Cell Res 313:3298-307. 2007
    ..From these data, we propose that both halves of the LRP1B cytoplasmic tail contribute to a unique global conformation, which results in less efficient recognition by endocytic adaptors and a slow endocytosis rate...
  11. ncbi request reprint Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, MO 63110, USA
    FEBS Lett 580:5423-8. 2006
    ..Our results present novel mechanisms by which Mesd and LRP6 modulate Wnt signaling...
  12. ncbi request reprint Receptor-associated protein facilitates proper folding and maturation of the low-density lipoprotein receptor and its class 2 mutants
    Yonghe Li
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 41:4921-8. 2002
    ..Taken together, our results show that the folding, trafficking, and maturation of the LDLR and its class 2 mutants are promoted by RAP...
  13. ncbi request reprint The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production
    Judy A Cam
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:29639-46. 2004
    ..These findings reveal that LRP1B is a novel binding partner of APP that functions to decrease APP processing to Abeta. Consequently LRP1B expression could function to protect against the pathogenesis of Alzheimer's disease...
  14. pmc Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases
    Guojun Bu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Int J Cancer 123:1034-42. 2008
    ..Taken together, these results suggest that breast cancer-produced Dkk1 may be an important mechanistic link between primary breast tumors and secondary osteolytic bone metastases...
  15. doi request reprint Inhibition of LRP5/6-mediated Wnt/β-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats
    Deepthi Alapati
    Department of Pediatrics, Division of Neonatology, Batchelor Children s Research Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
    Pediatr Res 73:719-25. 2013
    ..We hypothesized that inhibition of LRP5/6 by their universal inhibitor, Mesd, would attenuate hyperoxia-induced lung injury...
  16. ncbi request reprint LRP5, a multifunctional cell surface receptor
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Curr Opin Lipidol 15:361-3. 2004
  17. ncbi request reprint LRP5/6 in Wnt signaling and tumorigenesis
    Yonghe Li
    Southern Research Institute, Biochemistry and Molecular Biology Department, Drug Discovery Division, Birmingham, AL 35255, USA
    Future Oncol 1:673-81. 2005
    ..Furthermore, it has been demonstrated that LRP5 and 6 are potential oncogenic proteins. Thus, blockade of LRP56 function may lead to new strategies in cancer treatment...
  18. ncbi request reprint Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP)
    Hua Poo Su
    Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:11772-9. 2002
    ..These studies suggest a physical link between CED-1 or CD91/LRP and the adapter protein CED-6/GULP during engulfment of apoptotic cells and further elucidate the pathway suggested by the genetic studies...
  19. doi request reprint R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression
    Wenyan Lu
    Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, AL 35255, USA
    FEBS Lett 582:643-50. 2008
    ..Finally, we demonstrated that Rspo1 synergized with Wnt3A to induce primary mouse osteoblast differentiation. Together, these findings suggest that Rpos1 may play an important role in bone remodeling...
  20. ncbi request reprint Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains
    Maria Paz Marzolo
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Traffic 4:273-88. 2003
    ..Additionally, we show that the NPTY motif in LRP is important for basolateral sorting and the megalin transmembrane domain directs association with lipid rafts...