James S Lewis

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint The sinonasal tract: another potential "hot spot" for carcinomas with transcriptionally-active human papillomavirus
    James S Lewis
    Departments of Pathology and Immunology and Otolaryngology Head and Neck Surgery, Division of Anatomic and Molecular Pathology, Washington University School of Medicine, St Louis, MO, USA
    Head Neck Pathol 8:241-9. 2014
  2. pmc HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, Campus Box 8118, St Louis, MO 63110, USA
    Head Neck Pathol 3:186-94. 2009
  3. pmc Human papillomavirus and Epstein Barr virus in head and neck carcinomas: suggestions for the new WHO classification
    James S Lewis
    Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 S Euclid Ave, St Louis, MO, 63110, USA
    Head Neck Pathol 8:50-8. 2014
  4. pmc Non-functional parathyroid carcinoma: a review of the literature and report of a case requiring extensive surgery
    Benjamin J Wilkins
    Head and Neck Pathology Section, Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, P O Box 8118, St Louis, MO 63110 1093, USA
    Head Neck Pathol 3:140-9. 2009
  5. pmc Association between human papillomavirus DNA and temporal arteritis
    Amir Mohammadi
    Department of Pathology and Laboratory Medicine, University of Florida, College of Medicine, Jacksonville, FL, USA
    BMC Musculoskelet Disord 13:132. 2012
  6. pmc Extracapsular extension is a poor predictor of disease recurrence in surgically treated oropharyngeal squamous cell carcinoma
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mod Pathol 24:1413-20. 2011
  7. ncbi request reprint Partial p16 staining in oropharyngeal squamous cell carcinoma: extent and pattern correlate with human papillomavirus RNA status
    James S Lewis
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Mod Pathol 25:1212-20. 2012
  8. pmc Tumor cell anaplasia and multinucleation are predictors of disease recurrence in oropharyngeal squamous cell carcinoma, including among just the human papillomavirus-related cancers
    James S Lewis
    Departments of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Am J Surg Pathol 36:1036-46. 2012
  9. pmc p16 Immunohistochemistry as a standalone test for risk stratification in oropharyngeal squamous cell carcinoma
    James S Lewis
    Department of Pathology and Immunology, Washington University in St Louis, Campus Box 8118, 660 South Euclid Ave, St Louis, MO 63110, USA
    Head Neck Pathol 6:S75-82. 2012
  10. pmc Introduction: Human papillomavirus in head and neck cancer: an update for 2012 with a focus on controversial topics
    James S Lewis
    Department of Pathology and Immunology, Washington University in St Louis, Campus Box 8118, 660 South Euclid Ave, St Louis, MO 63110, USA
    Head Neck Pathol 6:S1-2. 2012

Detail Information

Publications72

  1. ncbi request reprint The sinonasal tract: another potential "hot spot" for carcinomas with transcriptionally-active human papillomavirus
    James S Lewis
    Departments of Pathology and Immunology and Otolaryngology Head and Neck Surgery, Division of Anatomic and Molecular Pathology, Washington University School of Medicine, St Louis, MO, USA
    Head Neck Pathol 8:241-9. 2014
    ....
  2. pmc HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, Campus Box 8118, St Louis, MO 63110, USA
    Head Neck Pathol 3:186-94. 2009
    ..NK SCC histology strongly predicts HPV-association and better patient survival compared to K SCC. Hybrid SCC appears to have an intermediate frequency of HPV-association and patient survival...
  3. pmc Human papillomavirus and Epstein Barr virus in head and neck carcinomas: suggestions for the new WHO classification
    James S Lewis
    Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 S Euclid Ave, St Louis, MO, 63110, USA
    Head Neck Pathol 8:50-8. 2014
    ....
  4. pmc Non-functional parathyroid carcinoma: a review of the literature and report of a case requiring extensive surgery
    Benjamin J Wilkins
    Head and Neck Pathology Section, Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, P O Box 8118, St Louis, MO 63110 1093, USA
    Head Neck Pathol 3:140-9. 2009
    ..While diagnosis has been based on clinical and histological criteria, recent data concerning the molecular underpinnings of parathyroid carcinoma may allow for improved accuracy in distinguishing benign and malignant parathyroid tumors...
  5. pmc Association between human papillomavirus DNA and temporal arteritis
    Amir Mohammadi
    Department of Pathology and Laboratory Medicine, University of Florida, College of Medicine, Jacksonville, FL, USA
    BMC Musculoskelet Disord 13:132. 2012
    ..To examine the relationship between human papillomavirus (HPV) and giant cell arteritis (GCA) of the temporal artery...
  6. pmc Extracapsular extension is a poor predictor of disease recurrence in surgically treated oropharyngeal squamous cell carcinoma
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mod Pathol 24:1413-20. 2011
    ..The impact of extracapsular extension in nodal metastases is limited in oropharyngeal squamous cell carcinoma. Only extracapsular extension grade 4 associates with poorer outcomes, but not independently of T-stage and other variables...
  7. ncbi request reprint Partial p16 staining in oropharyngeal squamous cell carcinoma: extent and pattern correlate with human papillomavirus RNA status
    James S Lewis
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Mod Pathol 25:1212-20. 2012
    ..These results support that greater than 75% p16 staining or, alternatively, >50% staining combined with >25% confluent areas, are suitable cutoffs for defining positivity...
  8. pmc Tumor cell anaplasia and multinucleation are predictors of disease recurrence in oropharyngeal squamous cell carcinoma, including among just the human papillomavirus-related cancers
    James S Lewis
    Departments of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Am J Surg Pathol 36:1036-46. 2012
    ..In summary, among surgically resectable oropharyngeal SCC (including among just the p16-positive cohort), tumor cell anaplasia and multinucleation independently correlated with disease recurrence and poorer survival...
  9. pmc p16 Immunohistochemistry as a standalone test for risk stratification in oropharyngeal squamous cell carcinoma
    James S Lewis
    Department of Pathology and Immunology, Washington University in St Louis, Campus Box 8118, 660 South Euclid Ave, St Louis, MO 63110, USA
    Head Neck Pathol 6:S75-82. 2012
    ....
  10. pmc Introduction: Human papillomavirus in head and neck cancer: an update for 2012 with a focus on controversial topics
    James S Lewis
    Department of Pathology and Immunology, Washington University in St Louis, Campus Box 8118, 660 South Euclid Ave, St Louis, MO 63110, USA
    Head Neck Pathol 6:S1-2. 2012
    ..This article introduces a series of timely reviews and editorials on this important subject in head and neck oncology...
  11. doi request reprint Transcriptionally-active high-risk human papillomavirus is rare in oral cavity and laryngeal/hypopharyngeal squamous cell carcinomas--a tissue microarray study utilizing E6/E7 mRNA in situ hybridization
    James S Lewis
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Histopathology 60:982-91. 2012
    ..In particular, the significance of finding viral DNA is not known. We sought to evaluate nonoropharyngeal squamous cell carcinomas for transcriptionally-active human papillomavirus and to compare this with the presence of viral DNA...
  12. pmc Recognition of nonkeratinizing morphology in oropharyngeal squamous cell carcinoma - a prospective cohort and interobserver variability study
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Histopathology 60:427-36. 2012
    ....
  13. pmc Large cell neuroendocrine carcinoma of the larynx: definition of an entity
    James S Lewis
    Departments of Pathology and Immunology, Otolaryngology Head and Neck Surgery, Washington University in St Louis, St Louis, MO 63110, USA
    Head Neck Pathol 4:198-207. 2010
    ....
  14. pmc p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 34:1088-96. 2010
    ..Many recommend use of both p16 immunohistochemistry and HPV in situ hybridization (ISH). A significant minority of tumors are p16 positive and HPV ISH negative, the significance of which is unclear...
  15. ncbi request reprint Oral cavity neuroendocrine carcinoma: a comparison study with cutaneous Merkel cell carcinoma and other mucosal head and neck neuroendocrine carcinomas
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110:209-17. 2010
    ..We studied cases of cutaneous MCC and mucosal HGNEC to better distinguish them and to better define oral cases...
  16. ncbi request reprint Alternative epithelial markers in sarcomatoid carcinomas of the head and neck, lung, and bladder-p63, MOC-31, and TTF-1
    James S Lewis
    Department of Pathology and Immunology, Division of Anatomic Pathology, Washington University in St Louis, School of Medicine, St Louis, MO, USA
    Mod Pathol 18:1471-81. 2005
    ..In conclusion, immunostaining beyond traditional pan-cytokeratin and epithelial membrane antigen may have diagnostic utility in this context...
  17. pmc Spindle cell lesions--neoplastic or non-neoplastic?: spindle cell carcinoma and other atypical spindle cell lesions of the head and neck
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Head Neck Pathol 2:103-10. 2008
    ..This review will focus on the clinical and diagnostic features of SpCC and the select non-neoplastic or benign lesions which are occasionally hard to distinguish from it...
  18. pmc Not your usual cancer case: variants of laryngeal squamous cell carcinoma
    James S Lewis
    Department of Pathology and Immunology, Division of Anatomic and Molecular Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Head Neck Pathol 5:23-30. 2011
    ..These tumor types will be briefly reviewed with a focus on specific controversies, biological questions, and/or recent advancements in our understanding of them...
  19. pmc A novel RT-PCR method for quantification of human papillomavirus transcripts in archived tissues and its application in oropharyngeal cancer prognosis
    Ge Gao
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
    Int J Cancer 132:882-90. 2013
    ..Thus, p16 mRNA or protein expression signature is a sensitive and specific surrogate marker for HPV transcriptional activity (all genotypes combined)...
  20. ncbi request reprint High-risk human papillomavirus E6/E7 mRNA detection by a novel in situ hybridization assay strongly correlates with p16 expression and patient outcomes in oropharyngeal squamous cell carcinoma
    Odey C Ukpo
    Department of Pathology and Immunology, Washington University, 660 S Euclid Ave, St Louis, MO 63110, USA
    Am J Surg Pathol 35:1343-50. 2011
    ..36, P=0.006; DFS: 0.42, P=0.016). RNA ISH is more sensitive than DNA ISH in detecting HPV in OSCC, and it correlates strongly with p16. Although both tests were comparable, p16 more strongly stratified patient outcomes...
  21. pmc Papillary squamous cell carcinoma of the head and neck: clinicopathologic and molecular features with special reference to human papillomavirus
    Mitra Mehrad
    Departments of Pathology and Immunology Department of Otolaryngology Head and Neck Surgery Division of Biostatistics, Washington University School of Medicine, St Louis, MO Advanced Cell Diagnostics Inc, Hayward, CA
    Am J Surg Pathol 37:1349-56. 2013
    ..Overall survival, disease-specific survival, and disease-free survival were favorable and did not significantly differ by anatomic subsite. However, HPV-related tumors showed a trend toward better survival. ..
  22. pmc A quantitative histomorphometric classifier (QuHbIC) identifies aggressive versus indolent p16-positive oropharyngeal squamous cell carcinoma
    James S Lewis
    Departments of Pathology and Immunology Otolaryngology Head and Neck Surgery Radiation Oncology, Washington University, St Louis, MO Division of Biostatistics Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH
    Am J Surg Pathol 38:128-37. 2014
    ..With prospective validation, this testing may be useful to stratify patients into different treatment groups. ..
  23. doi request reprint Verrucous carcinomas of the head and neck, including those with associated squamous cell carcinoma, lack transcriptionally active high-risk human papillomavirus
    Kalyani R Patel
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 44:2385-92. 2013
    ..These findings argue that verrucous carcinoma and its related squamous cell carcinomas are not HPV-driven tumors. ..
  24. doi request reprint Undifferentiated carcinoma of the oropharynx: a human papillomavirus-associated tumor with a favorable prognosis
    Danielle H Carpenter
    Department of Pathology and Immunology, Division of Anatomic and Molecular Pathology, Washington University, St Louis, MO, USA
    Mod Pathol 24:1306-12. 2011
    ..Disease-specific survival is comparable to published rates for other HPV-related oropharyngeal squamous cell carcinoma variants and is better than that of HPV-negative carcinomas...
  25. pmc A microRNA expression signature for the prognosis of oropharyngeal squamous cell carcinoma
    Ge Gao
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer 119:72-80. 2013
    ..One important goal is to identify those patients who are likely to fail standard therapy and who could potentially benefit from alternative or targeted treatments...
  26. pmc Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 41:1016-23. 2010
    ..These tumors occur almost exclusively in the oropharynx, are molecularly distinct from their human papillomavirus-negative counterparts, and have a more favorable clinical outcome...
  27. pmc Adenosquamous carcinoma of the head and neck: relationship to human papillomavirus and review of the literature
    Ramya P Masand
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Head Neck Pathol 5:108-16. 2011
    ..Head and neck ADSC appears to be a mixed variant that can be further classified according to its HPV status...
  28. doi request reprint BMP-2 expression correlates with local failure in head and neck squamous cell carcinoma
    Jordan P Sand
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Otolaryngol Head Neck Surg 150:245-50. 2014
    ....
  29. pmc B7-H1 expression model for immune evasion in human papillomavirus-related oropharyngeal squamous cell carcinoma
    Odey C Ukpo
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8118, St Louis, MO 63110, USA
    Head Neck Pathol 7:113-21. 2013
    ..B7-H1 is expressed in the majority of oropharyngeal squamous cell carcinomas with transcriptionally-active HPV. This suggests that B7-H1 expression by tumor cells may play a role in harboring persistent HPV infection...
  30. pmc Cyclin D1-a prognostic marker in oropharyngeal squamous cell carcinoma that is tightly associated with high-risk human papillomavirus status
    Juliette B Scantlebury
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Hum Pathol 44:1672-80. 2013
    ....
  31. pmc Detection and significance of human papillomavirus, CDKN2A(p16) and CDKN1A(p21) expression in squamous cell carcinoma of the larynx
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mod Pathol 26:223-31. 2013
    ..Because of this, CDKN2A(p16) should not be used as a definitive surrogate marker of HPV-driven tumors in the larynx...
  32. pmc Human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and African Americans
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8118, St Louis, MO 63110, USA
    Arch Otolaryngol Head Neck Surg 137:163-9. 2011
    ..To evaluate the frequency of human papillomavirus-related oropharyngeal squamous cell carcinoma in African Americans and whites and to examine patient outcomes in these 2 groups...
  33. pmc ERK1/2 regulation of CD44 modulates oral cancer aggressiveness
    Nancy P Judd
    Department of Otolaryngology and John Cochran VA Medical Center, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 72:365-74. 2012
    ..In summary, our findings identify CD44 as a critical target of ERK1/2 in promoting tumor aggressiveness and offer a preclinical proof-of-concept to target this pathway as a strategy to treat head and neck cancer...
  34. ncbi request reprint Keratinizing-type squamous cell carcinoma of the oropharynx: p16 overexpression is associated with positive high-risk HPV status and improved survival
    Chunyu Cai
    Departments of Pathology and Immunology Otolaryngology Head and Neck Surgery Radiation Oncology, Washington University School of Medicine, St Louis, MO
    Am J Surg Pathol 38:809-15. 2014
    ..046, respectively). These data, although with relatively small patient numbers, suggest that HPV-related SCC in the oropharynx is associated with highly favorable outcomes, regardless of the keratinizing or nonkeratinizing phenotype. ..
  35. doi request reprint Human papillomavirus and oropharynx cancer: biology, detection and clinical implications
    Clint T Allen
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Laryngoscope 120:1756-72. 2010
    ..To review evidence for the role of human papillomavirus (HPV) in the etiology of oropharyngeal cancers, methods of viral detection, and the resulting clinical implications...
  36. ncbi request reprint Extensive HPV-Related Carcinoma In Situ of the Upper Aerodigestive Tract with 'Nonkeratinizing' Histologic Features
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University, St Louis, MO, USA
    Head Neck Pathol 8:322-8. 2014
    ..This case was strongly p16 positive by immunohistochemistry and harbored transcriptionally active HPV as demonstrated by E6/E7 RNA in situ hybridization. Furthermore, the patient had an excellent response to radiation treatment. ..
  37. doi request reprint Mammaglobin and S-100 immunoreactivity in salivary gland carcinomas other than mammary analogue secretory carcinoma
    Kalyani R Patel
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 44:2501-8. 2013
    ..This indicates a need for caution in the use of immunohistochemistry for diagnosing MASC, especially in the absence of cytogenetic confirmation. ..
  38. ncbi request reprint Extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma
    Parul Sinha
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer 118:3519-30. 2012
    ..The role of ECS as a prognosticator and adjuvant therapy determinant in surgically resected, human papillomavirus-related oropharyngeal squamous cell carcinoma (OPSCC), however, has never been determined...
  39. doi request reprint Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer: a United States multicenter study
    Bruce H Haughey
    Department of Otolaryngology Head and Neck Surgery Washington University School of Medicine, St Louis, Missouri, USA
    Head Neck 33:1683-94. 2011
    ..Oncologic and functional results have been modest. The aim of our study was to evaluate outcomes of a minimally invasive approach, using transoral laser microsurgery (TLM) as the primary treatment for advanced oropharyngeal carcinoma...
  40. doi request reprint Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck
    Maria F Serrano
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 39:591-8. 2008
    ..We conclude that high molecular weight cytokeratin immunostaining is helpful in distinguishing high-grade neuroendocrine carcinomas from similar tumor types...
  41. ncbi request reprint A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease
    Michael D Onken
    Authors Affiliations Departments of Cell Biology and Physiology, Otolaryngology, Genetics, Pathology and Immunology, and Neurosurgery The Genome Institute, Washington University School of Medicine and John Cochran VA Medical Center, St Louis, Missouri
    Clin Cancer Res 20:2873-84. 2014
    ..Herein, cross-species genomic comparison of carcinogen-induced murine and human OSCCs with indolent or metastatic growth yielded results with surprising translational relevance...
  42. ncbi request reprint Napsin A expression in anaplastic, poorly differentiated, and micropapillary pattern thyroid carcinomas
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg Pathol 37:1215-22. 2013
    ..PAX8 may be diagnostically useful to distinguish these napsin A-positive thyroid carcinomas from lung adenocarcinomas, which are PAX8 negative. ..
  43. doi request reprint Pathology quiz case 2. Alveolar rhabdomyosarcoma
    Michael J Brenner
    Washington University School of Medicine, St Louis, Missouri, USA
    Arch Otolaryngol Head Neck Surg 134:1117, 1118-9. 2008
  44. doi request reprint Absence of Merkel cell polyomavirus in primary parotid high-grade neuroendocrine carcinomas regardless of cytokeratin 20 immunophenotype
    Rebecca D Chernock
    Departments of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg Pathol 35:1806-11. 2011
    ..Furthermore, viral testing may aid in distinguishing the 2 tumor types, as a positive result would favor a metastasis...
  45. doi request reprint A retrospective comparison of 2 methods of intraoperative margin evaluation during partial nephrectomy
    Ian S Hagemann
    Department of Pathology and Immunology, Division of Anatomic and Molecular Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    J Urol 181:500-5. 2009
    ..Alternatively the pathologist may perform prosection of the intact partial nephrectomy specimen and prepare frozen sections of suspicious areas. We determined the sensitivity and specificity of these 2 methods and a combined method...
  46. doi request reprint Terminology and classification of neuroendocrine neoplasms of the larynx
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Laryngoscope 121:1187-93. 2011
    ..To review the history and literature on neuroendocrine neoplasms of the larynx and discuss the terminology and classification of these tumors...
  47. doi request reprint Ex vivo sentinel lymph node mapping in patients undergoing proctectomy for rectal cancer
    Kelly R Finan
    Department of Surgery, Section of Colon and Rectal Surgery, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Dis Colon Rectum 53:243-50. 2010
    ..The purpose of this study was to evaluate the use of ex vivo sentinel lymph node mapping in the setting of proctectomy for rectal cancer, with and without multilevel sectioning and immunohistochemistry...
  48. pmc A microRNA expression signature for cervical cancer prognosis
    Xiaoxia Hu
    Departments of Radiation Oncology, Pathology and Immunology, and Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:1441-8. 2010
    ..In particular, miR-200a is likely to affect the metastatic potential of cervical cancer cells by coordinate suppression of multiple genes controlling cell motility...
  49. pmc Transoral laser microsurgery (TLM) +/- adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors
    Jason T Rich
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Laryngoscope 119:1709-19. 2009
    ..Document survival, prognostic variables, and functional outcomes of patients with AJCC stage III or IV oropharyngeal cancer, treated with transoral laser microsurgery (TLM) +/- adjuvant therapy...
  50. ncbi request reprint Receptor tyrosine kinases in sinonasal undifferentiated carcinomas--evaluation for EGFR, c-KIT, and HER2/neu expression
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Head Neck 31:919-27. 2009
    ..Our objective was to identify the expression of epidermal growth factor receptor (EGFR), c-KIT (CD117), and HER2/neu in sinonasal undifferentiated carcinoma (SNUC)...
  51. ncbi request reprint MRI of the peritoneum: spectrum of abnormalities
    Khaled M Elsayes
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    AJR Am J Roentgenol 186:1368-79. 2006
    ..Our objective was to detail peritoneal anatomy, techniques for optimizing peritoneal MRI, and the MRI characteristics of several disease processes that frequently involve the peritoneum...
  52. ncbi request reprint MR imaging of the spleen: spectrum of abnormalities
    Khaled M Elsayes
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Radiographics 25:967-82. 2005
    ..MR imaging is an excellent tool for diagnosis and evaluation of focal lesions and pathologic conditions of the spleen...
  53. ncbi request reprint Magnetic resonance imaging of adrenal angiomyolipoma
    Khaled M Elsayes
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Comput Assist Tomogr 29:80-2. 2005
    ..Only 2 cases describing adrenal angiomyolipoma were found in the English literature. Neither of these 2 cases was documented in the radiology literature or discussed the MR features of adrenal angiomyolipoma...
  54. ncbi request reprint Adrenal masses: mr imaging features with pathologic correlation
    Khaled M Elsayes
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Radiographics 24:S73-86. 2004
    ..Benign disease is diagnosed if macroscopic fat or a homogeneous cystlike lesion is seen. Recognition of the typical MR imaging features is important because it often changes the treatment approach and may obviate surgery...
  55. pmc Transcriptionally-active human papillomavirus is consistently retained in the distant metastases of primary oropharyngeal carcinomas
    Mitra Mehrad
    Department of Pathology and Immunology, Washington University in St Louis, School of Medicine, Campus Box 8118, 660 S Euclid Ave, St Louis, MO, 63110, USA
    Head Neck Pathol 8:157-63. 2014
    ....
  56. pmc Lipomatous congenital melanocytic nevus presenting as a neck mass in a young adult
    Kalyani R Patel
    Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University in St Louis, St Louis, MO, 63108, USA
    Head Neck Pathol 7:404-8. 2013
    ..This case serves to illustrate the initial diagnostic dilemma as well as the plasticity of the neural crest cells. ..
  57. pmc Transoral laser microsurgery for oral squamous cell carcinoma: oncologic outcomes and prognostic factors
    Parul Sinha
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri
    Head Neck 36:340-51. 2014
    ..Modest survival rates are published for treatment of oral squamous cell carcinoma (OSCC) using conventional approaches. Few cohort studies are available for transoral resection of OSCC...
  58. doi request reprint Prognostic significance of β-human chorionic gonadotropin and PAX8 expression in anaplastic thyroid carcinoma
    Nils Becker
    1 Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri
    Thyroid 24:319-26. 2014
    ..The objectives of this study were to report a case of β-hCG-secreting ATC and to study the expression and significance of β-hCG and PAX8 in an institutional cohort of ATC...
  59. ncbi request reprint Multiple measures of carcinoma extent versus perineural invasion in prostate needle biopsy tissue in prediction of pathologic stage in a screening population
    Tarek A Bismar
    Lauren V Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Surg Pathol 27:432-40. 2003
    ..Reporting of several measures of carcinoma extent in needle biopsy tissue is recommended...
  60. ncbi request reprint Prognostic significance of p16 expression in advanced cervical cancer treated with definitive radiotherapy
    Julie K Schwarz
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, 4921 Parkview Place, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 84:153-7. 2012
    ..The purpose of this study was to evaluate the prognostic significance of p16 immunohistochemistry (IHC) in patients with advanced cervical cancer treated with radiation therapy...
  61. doi request reprint Frozen section analysis of margins for head and neck tumor resections: reduction of sampling errors with a third histologic level
    Stephen M Olson
    Department of Pathology and Immunology, Washington University in St Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mod Pathol 24:665-70. 2011
    ..This difference was statistically significant (P=0.006). Cutting a single additional 'deeper' level at the time of frozen section identifies more tumor-bearing specimens and may reduce the number of sampling errors...
  62. ncbi request reprint Detection of viral pathogens in high grade gliomas from unmapped next-generation sequencing data
    Patrick J Cimino
    Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, United States
    Exp Mol Pathol 96:310-5. 2014
    ..Overall, a similar discovery approach using unmapped non-human NGS reads could be used to discover viral sequences in other cancer types. ..
  63. pmc rhBMP-2 has adverse effects on human oral carcinoma cell lines in vivo
    Natalia A Kokorina
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Laryngoscope 122:95-102. 2012
    ....
  64. pmc Plasmablastic lymphoma of head and neck: report of two new cases and correlation with c-myc and IgVH gene mutation status
    Anjum Hassan
    Department of Pathology and Immunology, Division of Anatomic Pathology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Head Neck Pathol 1:150-5. 2007
    ..The immunophenotype of our second case (BCL-6(-)/CD138(+)/MUM-1(+)) also suggests a post-germinal center B-cell origin. However, IgV(H) hypermutation analysis was not possible in this case...
  65. pmc CXCR3 enhances a T-cell-dependent epidermal proliferative response and promotes skin tumorigenesis
    Ashley E Winkler
    Department of Otolaryngology, and John Cochran VA Medical Center, St Louis, Missouri, USA
    Cancer Res 71:5707-16. 2011
    ..Taken together, our findings establish that CXCR3 promotes epidermal tumorigenesis likely through a T-cell-dependent induction of keratinocyte proliferation...
  66. pmc Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in head and neck cancers
    Ravindra Uppaluri
    Department of Otolaryngology Head and Neck Surgery and John Cochran VA Medical Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Immun 8:16. 2008
    ..Finally, with this perspective, we describe our current understanding of tumor infiltrating lymphocyte data for head and neck cancers...
  67. ncbi request reprint Best cases from the AFIP: Metastatic renal cell carcinoma
    Shao Pow Lin
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Radiographics 27:1801-7. 2007
  68. ncbi request reprint Clinical-pathologic conference in general thoracic surgery: malignant transformation of recurrent respiratory papillomatosis
    Benjamin D Kozower
    Washington University School of Medicine, Department of Cardiothoracic Surgery, Barnes Jewish Hospital, St Louis, MO 63105, USA
    J Thorac Cardiovasc Surg 130:1190-3. 2005
  69. ncbi request reprint MRI of heterotopic pancreatic tissue in the spleen
    Khaled M Elsayes
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    AJR Am J Roentgenol 185:816-7. 2005
  70. ncbi request reprint MRI of adrenal and extraadrenal pheochromocytoma
    Khaled M Elsayes
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    AJR Am J Roentgenol 184:860-7. 2005
  71. ncbi request reprint PCR for the diagnosis of toxoplasmosis after hematopoietic stem cell transplantation
    James S Lewis
    Washington University, Department of Pathology and Immunology, 660 S Euclid Ave, Box 8118, St Louis, MO 63110, USA
    Expert Rev Mol Diagn 2:616-24. 2002
    ..This article reviews the clinical, diagnostic and therapeutic aspects of toxoplasmosis in the setting of hematopoietic stem cell transplantation and the current and future role of PCR-based testing for early detection and diagnosis...
  72. ncbi request reprint Spontaneous regression of cutaneous head and neck melanoma: implications for the immunologic control of neoplasia
    Gavin P Dunn
    Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    Head Neck 30:267-72. 2008
    ..Spontaneous regression of cancer in the head and neck is a rare event. Moreover, there are rare reported cases of spontaneous regression of primary head and neck melanoma with accompanying immunohistochemical analysis of the tumor...