J S Lewis
Affiliation: Washington University School of Medicine
- Workshop on the production, application and clinical translation of ''non-standard'' PET nuclides: a meeting reportJ S Lewis
Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
Q J Nucl Med Mol Imaging 52:101-6. 2008..Also, the translation of these nuclides to the clinic, perhaps the most important goal of this work is discussed in this introductory article...
- Comparative dosimetry of copper-64 and yttrium-90-labeled somatostatin analogs in a tumor-bearing rat modelJ S Lewis
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
Cancer Biother Radiopharm 15:593-604. 2000..90Y-DOTA-Y3-OC and 64Cu-DOTA-Y3-OC were comparable with respect to their tumor-to-normal tissue dose ratios, while 90Y-DOTA-Y3-TATE appeared to have distinct advantages over 64Cu-DOTA-Y3-TATE...
- A novel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity-modulated radiation therapyK S Chao
Radiation Oncology Center, Mallinckrodt Institute of Radiology, Washington University Medical Center, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 49:1171-82. 2001....
- Tumor uptake of copper-diacetyl-bis(N(4)-methylthiosemicarbazone): effect of changes in tissue oxygenationJ S Lewis
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA
J Nucl Med 42:655-61. 2001..Therefore, the possible use of Cu-ATSM PET as a prognostic indicator in the management of cancer is further validated...
- Toxicity and dosimetry of (177)Lu-DOTA-Y3-octreotate in a rat modelJ S Lewis
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Int J Cancer 94:873-7. 2001..The absorbed dose to the rat CA20948 tumor was estimated to be 336 rad/mCi (91 mGy/MBq). These data demonstrate that (177)Lu-DOTA-Y3-TATE is an effective targeted radiotherapy agent at levels that show minimal toxicity in this rat model...
- Retention mechanism of hypoxia selective nuclear imaging/radiotherapeutic agent cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) in tumor cellsA Obata
Biomedical Imaging Research Center, Fukui Medical University, Matsuoka, Japan
Ann Nucl Med 15:499-504. 2001..This enzymatic reduction was enhanced by the induction of hypoxia. Radiocopper labeled Cu-ATSM provides useful information for the detection of hypoxia as well as the microsomal bioreductive enzyme expression in tumor...