D A Leib

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo
    D A Leib
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 189:663-72. 1999
  2. ncbi request reprint Role of cis-acting sequences of the ICPO promoter of herpes simplex virus type 1 in viral pathogenesis, latency and reactivation
    D J Davido
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Gen Virol 77:1853-63. 1996
  3. pmc Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene
    D A Leib
    Department of Ophthalmology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 97:6097-101. 2000
  4. pmc Herpes simplex virus type 1 corneal infection results in periocular disease by zosteriform spread
    B C Summers
    Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Virol 75:5069-75. 2001
  5. ncbi request reprint Counteraction of interferon-induced antiviral responses by herpes simplex viruses
    D A Leib
    Departments of Ophthalmology and Visual Sciences and Molecular Microbiology, Washington University School of Medicine, Box 8096, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Top Microbiol Immunol 269:171-85. 2002

Collaborators

  • B C Summers
  • D J Davido
  • T P Margolis

Detail Information

Publications5

  1. pmc Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo
    D A Leib
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 189:663-72. 1999
    ..The phenotypes of mutant viruses therefore cannot be interpreted based solely upon studies in cell culture but must be considered carefully in the context of host factors that may define the in vivo phenotype...
  2. ncbi request reprint Role of cis-acting sequences of the ICPO promoter of herpes simplex virus type 1 in viral pathogenesis, latency and reactivation
    D J Davido
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Gen Virol 77:1853-63. 1996
    ..This indicates that elements which regulate ICPO expression and virulence during acute infection may be distinct from those involved in reactivation...
  3. pmc Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene
    D A Leib
    Department of Ophthalmology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 97:6097-101. 2000
    ..The use of recombinant viruses to infect animals with null mutations in host defense genes provides a formal genetic test for identifying in vivo mechanisms and targets of microbial virulence genes...
  4. pmc Herpes simplex virus type 1 corneal infection results in periocular disease by zosteriform spread
    B C Summers
    Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Virol 75:5069-75. 2001
    ..Furthermore, clinical evidence is discussed suggesting that a similar mode of spreading and disease occurs in humans following primary ocular infection...
  5. ncbi request reprint Counteraction of interferon-induced antiviral responses by herpes simplex viruses
    D A Leib
    Departments of Ophthalmology and Visual Sciences and Molecular Microbiology, Washington University School of Medicine, Box 8096, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Top Microbiol Immunol 269:171-85. 2002
    ..In particular, the roles of specific viral genes in resistance to the antiviral effects of PKR and RNaseL are described, along with other HSV genes and loci associated with resistance to IFN for which mechanisms have yet to be described...