John J Lehman

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis
    John J Lehman
    Center for Cardiovascular Research, Washington Univ School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 295:H185-96. 2008
  2. ncbi request reprint Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner
    Laurie K Russell
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 94:525-33. 2004
  3. ncbi request reprint Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma
    David J Mancuso
    Division of Bioorganic Chemistry and Molecular Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:9216-27. 2007
  4. pmc PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis
    Teresa C Leone
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 3:e101. 2005
  5. ncbi request reprint A role for the transcriptional coactivator PGC-1alpha in muscle refueling
    Adam R Wende
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:36642-51. 2007
  6. pmc The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
    Brian N Finck
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 109:121-30. 2002
  7. ncbi request reprint Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth
    John J Lehman
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Heart Fail Rev 7:175-85. 2002
  8. pmc Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1α-/- mouse cortex: a potential lipidomic role of PGC-1α in neurodegeneration
    Michael A Kiebish
    Division of Bioorganic Chemistry and Molecular Pharmacology and Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 53:273-81. 2012
  9. ncbi request reprint Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart
    John J Lehman
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Exp Pharmacol Physiol 29:339-45. 2002
  10. pmc PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart
    Smita Sihag
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8086, St Louis, Missouri 63110, USA
    J Mol Cell Cardiol 46:201-12. 2009

Collaborators

Detail Information

Publications10

  1. pmc The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis
    John J Lehman
    Center for Cardiovascular Research, Washington Univ School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 295:H185-96. 2008
    ..Overall, these results demonstrate that PGC-1alpha is essential for the maintenance of maximal, efficient cardiac mitochondrial fatty acid oxidation, ATP synthesis, and myocardial lipid homeostasis...
  2. ncbi request reprint Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner
    Laurie K Russell
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 94:525-33. 2004
    ....
  3. ncbi request reprint Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma
    David J Mancuso
    Division of Bioorganic Chemistry and Molecular Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:9216-27. 2007
    ....
  4. pmc PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis
    Teresa C Leone
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 3:e101. 2005
    ..Lastly, vacuolar lesions were detected in the central nervous system of PGC-1alpha(-/-) mice. These results demonstrate that PGC-1alpha is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life...
  5. ncbi request reprint A role for the transcriptional coactivator PGC-1alpha in muscle refueling
    Adam R Wende
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:36642-51. 2007
    ..These findings identify PGC-1alpha as a critical regulator of skeletal muscle fuel stores...
  6. pmc The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
    Brian N Finck
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 109:121-30. 2002
    ....
  7. ncbi request reprint Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth
    John J Lehman
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Heart Fail Rev 7:175-85. 2002
    ....
  8. pmc Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1α-/- mouse cortex: a potential lipidomic role of PGC-1α in neurodegeneration
    Michael A Kiebish
    Division of Bioorganic Chemistry and Molecular Pharmacology and Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 53:273-81. 2012
    ....
  9. ncbi request reprint Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart
    John J Lehman
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Exp Pharmacol Physiol 29:339-45. 2002
    ..Future studies aim at defining whether this transcriptional 'switch' and its effects on myocardial metabolism are adaptive or maladaptive in the hypertrophied heart...
  10. pmc PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart
    Smita Sihag
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8086, St Louis, Missouri 63110, USA
    J Mol Cell Cardiol 46:201-12. 2009
    ....