John J Lehman

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis
    John J Lehman
    Center for Cardiovascular Research, Washington Univ School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 295:H185-96. 2008
  2. ncbi request reprint Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner
    Laurie K Russell
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 94:525-33. 2004
  3. pmc PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis
    Teresa C Leone
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 3:e101. 2005
  4. ncbi request reprint Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma
    David J Mancuso
    Division of Bioorganic Chemistry and Molecular Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:9216-27. 2007
  5. ncbi request reprint A role for the transcriptional coactivator PGC-1alpha in muscle refueling
    Adam R Wende
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:36642-51. 2007
  6. pmc The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
    Brian N Finck
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 109:121-30. 2002
  7. pmc Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1α-/- mouse cortex: a potential lipidomic role of PGC-1α in neurodegeneration
    Michael A Kiebish
    Division of Bioorganic Chemistry and Molecular Pharmacology and Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 53:273-81. 2012
  8. ncbi request reprint Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth
    John J Lehman
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Heart Fail Rev 7:175-85. 2002
  9. ncbi request reprint Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart
    John J Lehman
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Exp Pharmacol Physiol 29:339-45. 2002
  10. pmc PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart
    Smita Sihag
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8086, St Louis, Missouri 63110, USA
    J Mol Cell Cardiol 46:201-12. 2009

Collaborators

Detail Information

Publications10

  1. pmc The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis
    John J Lehman
    Center for Cardiovascular Research, Washington Univ School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 295:H185-96. 2008
    ..Overall, these results demonstrate that PGC-1alpha is essential for the maintenance of maximal, efficient cardiac mitochondrial fatty acid oxidation, ATP synthesis, and myocardial lipid homeostasis...
  2. ncbi request reprint Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner
    Laurie K Russell
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 94:525-33. 2004
    ....
  3. pmc PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis
    Teresa C Leone
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 3:e101. 2005
    ..Lastly, vacuolar lesions were detected in the central nervous system of PGC-1alpha(-/-) mice. These results demonstrate that PGC-1alpha is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life...
  4. ncbi request reprint Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma
    David J Mancuso
    Division of Bioorganic Chemistry and Molecular Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:9216-27. 2007
    ....
  5. ncbi request reprint A role for the transcriptional coactivator PGC-1alpha in muscle refueling
    Adam R Wende
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:36642-51. 2007
    ..These findings identify PGC-1alpha as a critical regulator of skeletal muscle fuel stores...
  6. pmc The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
    Brian N Finck
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 109:121-30. 2002
    ....
  7. pmc Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1α-/- mouse cortex: a potential lipidomic role of PGC-1α in neurodegeneration
    Michael A Kiebish
    Division of Bioorganic Chemistry and Molecular Pharmacology and Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 53:273-81. 2012
    ....
  8. ncbi request reprint Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth
    John J Lehman
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Heart Fail Rev 7:175-85. 2002
    ....
  9. ncbi request reprint Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart
    John J Lehman
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Exp Pharmacol Physiol 29:339-45. 2002
    ..Future studies aim at defining whether this transcriptional 'switch' and its effects on myocardial metabolism are adaptive or maladaptive in the hypertrophied heart...
  10. pmc PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart
    Smita Sihag
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8086, St Louis, Missouri 63110, USA
    J Mol Cell Cardiol 46:201-12. 2009
    ....