Jin Moo Lee

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage
    Jin Moo Lee
    Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurol Sci 229:249-54. 2005
  2. ncbi request reprint Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy
    Jin Moo Lee
    Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8111, St Louis, MO, USA
    Ann Neurol 54:379-82. 2003
  3. ncbi request reprint Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes
    Shawei Chen
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University, School of Medicine, St Louis, MO 63110, USA
    J Neurochem 97:631-40. 2006
  4. pmc Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia
    Qingli Xiao
    Hope Center for Neurological Disorders and Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 32:13587-96. 2012
  5. ncbi request reprint Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ
    Ping Yan
    Department of Neurology and the Hope Center for Neurological Disorders, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:24566-74. 2006
  6. ncbi request reprint Abeta25-35 alters Akt activity, resulting in Bad translocation and mitochondrial dysfunction in cerebrovascular endothelial cells
    Ke Jie Yin
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cereb Blood Flow Metab 25:1445-55. 2005
  7. ncbi request reprint ATM gene regulates oxygen-glucose deprivation-induced nuclear factor-kappaB DNA-binding activity and downstream apoptotic cascade in mouse cerebrovascular endothelial cells
    Ke Jie Yin
    Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 33:2471-7. 2002
  8. pmc Neuronal activity regulates the regional vulnerability to amyloid-β deposition
    Adam W Bero
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Neurosci 14:750-6. 2011
  9. pmc Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway
    Jiunn Tay Lee
    Center for the Study of Nervous System Injury, Dept of Neurology, Washington University School of Medicine, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
    J Cell Biol 164:123-31. 2004
  10. ncbi request reprint JNK activation contributes to DP5 induction and apoptosis following traumatic spinal cord injury
    Ke Jie Yin
    Department of Neurology and Center for the Study of Nervous System Injury CSNSI, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 20:881-9. 2005

Research Grants

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage
    Jin Moo Lee
    Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurol Sci 229:249-54. 2005
    ..These results suggest that increased vascular MMP-9 expression, stimulated by Abeta, may play a role in the pathogenesis of spontaneous intracerebral hemorrhage (ICH) in patients with CAA...
  2. ncbi request reprint Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy
    Jin Moo Lee
    Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8111, St Louis, MO, USA
    Ann Neurol 54:379-82. 2003
    ..These results suggest that increased vascular MMP-9 expression, stimulated by Abeta, may play a role in the pathogenesis of spontaneous intracerebral hemorrhage in patients with CAA...
  3. ncbi request reprint Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes
    Shawei Chen
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University, School of Medicine, St Louis, MO 63110, USA
    J Neurochem 97:631-40. 2006
    ..Collectively, these results suggest that Abeta-induced apoptosis involves the sequential activation of nSMase with ceramide generation, JNK activation, AP-1 DNA binding, and DP5 expression...
  4. pmc Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia
    Qingli Xiao
    Hope Center for Neurological Disorders and Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 32:13587-96. 2012
    ..These results suggest that alternative pre-mRNA splicing may be an important regulatory mechanism for cell death after acute neurological injury and may potentially provide novel targets for intervention...
  5. ncbi request reprint Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ
    Ping Yan
    Department of Neurology and the Hope Center for Neurological Disorders, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:24566-74. 2006
    ..These findings suggest that MMP-9 can degrade fAbeta and may contribute to ongoing clearance of plaques from amyloid-laden brains...
  6. ncbi request reprint Abeta25-35 alters Akt activity, resulting in Bad translocation and mitochondrial dysfunction in cerebrovascular endothelial cells
    Ke Jie Yin
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cereb Blood Flow Metab 25:1445-55. 2005
    ..Together, these results establish that the Akt-Bad cascade is altered by Abeta25-35, resulting in CEC apoptosis...
  7. ncbi request reprint ATM gene regulates oxygen-glucose deprivation-induced nuclear factor-kappaB DNA-binding activity and downstream apoptotic cascade in mouse cerebrovascular endothelial cells
    Ke Jie Yin
    Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 33:2471-7. 2002
    ..We investigated the potential interaction of ATM and NF-kappaB after oxygen-glucose deprivation (OGD) in cerebral endothelial cells (CECs)...
  8. pmc Neuronal activity regulates the regional vulnerability to amyloid-β deposition
    Adam W Bero
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Neurosci 14:750-6. 2011
    ..Long-term unilateral vibrissal deprivation decreased amyloid plaque formation and growth. Our results suggest a mechanism to account for the vulnerability of specific brain regions to Aβ deposition in Alzheimer's disease...
  9. pmc Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway
    Jiunn Tay Lee
    Center for the Study of Nervous System Injury, Dept of Neurology, Washington University School of Medicine, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
    J Cell Biol 164:123-31. 2004
    ..These results suggest that Abeta induces OLG death by activating the nSMase-ceramide cascade via an oxidative mechanism...
  10. ncbi request reprint JNK activation contributes to DP5 induction and apoptosis following traumatic spinal cord injury
    Ke Jie Yin
    Department of Neurology and Center for the Study of Nervous System Injury CSNSI, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 20:881-9. 2005
    ..These results suggest that JNK activation contributes to trauma-induced DP5 expression and subsequent apoptosis in SCI...
  11. ncbi request reprint MR imaging enhancement patterns as predictors of hemorrhagic transformation in acute ischemic stroke
    Katie D Vo
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    AJNR Am J Neuroradiol 24:674-9. 2003
    ..We sought to investigate gadolinium enhancement in acute ischemic stroke patients to determine their association with subsequent HT...
  12. ncbi request reprint Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism
    Ke Jie Yin
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:10939-48. 2006
    ..These results suggest that MMP-2 and -9 may contribute to extracellular brain Abeta clearance by promoting Abeta catabolism...
  13. pmc Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis
    Qingli Xiao
    Hope Center for Neurological Disorders and Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:21279-89. 2012
    ..PICALM contributes to amyloid plaque load in brain likely via its effect on Aβ metabolism...
  14. pmc Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury
    Jin Moo Lee
    The Hope Center for Neurological Disorders and Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 28:3141-9. 2008
    ..These results suggest that MP selectively inhibits oligodendrocyte but not neuronal cell death via a receptor-mediated action and may be a mechanism for its limited protective effect after SCI...
  15. ncbi request reprint Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death
    Ke Jie Yin
    Department of Neurology, The Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:2290-9. 2006
    ..These results implicate PP2A as an early regulator of Abeta-induced bim expression and CEC apoptosis via the Akt/FKHRL1 signaling pathway. We raise the possibility that this pathway may play a role in cerebrovascular degeneration in CAA...
  16. ncbi request reprint Combination therapy for ischemic stroke: potential of neuroprotectants plus thrombolytics
    Shang Der Chen
    Center for the Study of Nervous System Injury and Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Cardiovasc Drugs 2:303-13. 2002
    ....
  17. pmc Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking
    Rodrigo A Fuentealba
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e11884. 2010
    ..However, direct evidence of neuronal endocytosis of Abeta42 through LRP1 is lacking...
  18. pmc Characterization of cis-regulatory elements of the vascular endothelial growth inhibitor gene promoter
    Qingli Xiao
    The Hope Center for Neurological Disorders, Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St Louis, MO 63110, USA
    Biochem J 388:913-20. 2005
    ..These findings suggest that the transcription factor NF-kappaB plays an important role in the regulation of VEGI expression...
  19. pmc Accuracy of emergency medical services-reported last known normal times in patients suspected with acute stroke
    David Curfman
    From the Department of Neurology D C, P P, J M L, A L F, Program in Occupational Therapy L T C, Department of Radiology L T C, J M L, and Department of Emergency Medicine H P, L H, P P, D K T, Washington University School of Medicine, MO
    Stroke 45:1275-9. 2014
    ..We determined the congruence between neurologist-determined and EMS-reported LKN times and identified predictors of incongruent LKN times...
  20. pmc Clinically relevant reperfusion in acute ischemic stroke: MTT performs better than Tmax and TTP
    Andria L Ford
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Transl Stroke Res 5:415-21. 2014
    ..0002) and tissue salvage (MTTp >3 s and 4 s, P < 0.0001). MTT-defined reperfusion was the best predictor of neurological improvement and tissue salvage in hyperacute ischemic stroke. ..
  21. pmc Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice
    Andrew W Kraft
    The Hope Center for Neurological Disorders, Knight Alzheimer s Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63124, USA
    FASEB J 27:187-98. 2013
    ..These results suggest that astrocyte activation limits plaque growth and attenuates plaque-related dystrophic neurites. These activities may require intimate contact between astrocyte and plaque...
  22. pmc Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide
    Xiaoyan Hu
    Hope Center for Neurological Disorders and Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:20324-9. 2009
    ..We speculate that extrusion of these aggregates may seed extracellular amyloid plaque formation during AD pathogenesis...
  23. pmc Intravital imaging of amyloid plaques in a transgenic mouse model using optical-resolution photoacoustic microscopy
    Song Hu
    Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri, USA
    Opt Lett 34:3899-901. 2009
    ..OR-PAM, capable of providing both exogenous molecular contrast and endogenous hemoglobin contrast, has the potential to serve as a new technology for in vivo microscopic observations of cerebral plaque deposits...
  24. doi request reprint Defining the ischemic penumbra using hyperacute neuroimaging: deriving quantitative ischemic thresholds
    Andria L Ford
    Department of Neurology, Washington University, School of Medicine, 600 South Euclid Avenue, Campus Box 8111, Saint Louis, MO, 63110, USA
    Transl Stroke Res 3:198-204. 2012
    ..In this review, we discuss one possible approach to define these thresholds by following tissue fate in the presence or absence of early reperfusion. ..
  25. pmc Symptomatic intracranial arterial disease: incidence, natural history, diagnosis, and management
    Ananth K Vellimana
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Neurosurg Focus 30:E14. 2011
    ..In rare cases, surgical intervention is considered. A thorough review of the available literature was performed, and treatment recommendations based on these data are provided...
  26. pmc Hippocampal seizures cause depolymerization of filamentous actin in neurons independent of acute morphological changes
    Yannan Ouyang
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Res 1143:238-46. 2007
    ..In addition to affecting non-structural functions of spines, the degree to which overt structural changes occur with actin depolymerization is dependent on the severity and type of the pathophysiological stimulus...
  27. pmc Reducing door-to-needle times using Toyota's lean manufacturing principles and value stream analysis
    Andria L Ford
    Washington University School of Medicine, Department of Neurology, and Emergency Department, Neurology and Neursurgery Center, Barnes Jewish Hospital, 600 South Euclid Avenue, Box 8111, St Louis, MO 63110, USA
    Stroke 43:3395-8. 2012
    ..We used lean process improvement methodology to develop a streamlined intravenous tPA protocol...
  28. ncbi request reprint Lentiviral transduction of murine oligodendrocytes in vivo
    Sally R McIver
    Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci Res 82:397-403. 2005
    ....
  29. pmc Cerebral amyloid angiopathy: progressive disruption of the neurovascular unit
    Gregory J Zipfel
    Department of Neurosurgery, Washington University School of Medicine, St Louis, MO, USA
    Stroke 40:S16-9. 2009
    ....
  30. doi request reprint Elements of a stroke center
    Matthew R Reynolds
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Tech Vasc Interv Radiol 15:5-9. 2012
    ..In this article, the authors briefly discuss the status of stroke center certification and the evolution of stroke systems of care...
  31. pmc Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease
    Rawan Tarawneh
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 70:274-85. 2011
    ..Visinin-like protein-1 (VILIP-1) has demonstrated potential utility as a marker of neuronal injury. Here we investigate CSF VILIP-1 and VILIP-1/amyloid-β42 (Aβ42) ratio as diagnostic and prognostic markers in early AD...
  32. ncbi request reprint Expression profiling identifies a molecular signature of reactive astrocytes stimulated by cyclic AMP or proinflammatory cytokines
    Girish C Daginakatte
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Neurol 210:261-7. 2008
    ..Moreover, this pattern of differential gene expression is not observed in hyperproliferating or neoplastic glia...
  33. doi request reprint Distance from home to hospital and thrombolytic utilization for acute ischemic stroke
    Aninda B Acharya
    Department of Neurology and Psychiatry, St Louis University School of Medicine, St Louis, MO 63104, USA
    J Stroke Cerebrovasc Dis 20:295-301. 2011
    ..Our data indicate that patients living in close proximity to the hospital are more likely to receive thrombolytic therapy for stroke compared with those living farther away. This finding cannot be explained by earlier arrival time...
  34. pmc Resident-based acute stroke protocol is expeditious and safe
    Andria L Ford
    Department of Neurology, Cerebrovascular Disease Section, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 40:1512-4. 2009
    ..The decision to administer tPA to acute stroke patients is frequently made by stroke attendings or fellows, but placing residents in this position may make tPA delivery more efficient...
  35. pmc Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice
    Ping Yan
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:10706-14. 2009
    ..Together, these findings indicate that individual amyloid plaque growth in vivo occurs over a period of weeks and may be influenced by interstitial Abeta concentration as well as reactive gliosis...
  36. doi request reprint Noninvasive detection of brainstem and spinal cord axonal degeneration in an amyotrophic lateral sclerosis mouse model
    Joong Hee Kim
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    NMR Biomed 24:163-9. 2011
    ..The present study demonstrates that in vivo diffusion tensor imaging-derived axial diffusivity may be used to accurately evaluate axonal degeneration in an animal model of amyotrophic lateral sclerosis...
  37. ncbi request reprint Rapid perfusion abnormality estimation in acute stroke with temporal correlation analysis
    Yueh Z Lee
    Department of Biomedical Engineering, University of North Carolina, Chapel Hill 27599 7515, USA
    Stroke 34:1686-92. 2003
    ..We explored the utility of a simple technique to define perfusion abnormality in acute stroke patients...
  38. ncbi request reprint Intravenous tissue-type plasminogen activator therapy is an independent risk factor for symptomatic intracerebral hemorrhage after carotid endarterectomy
    Ananth K Vellimana
    Department of Neurological Surgery, Mallinckrodt Institute of Radiology, and Department of Neurology, Washington University School of Medicine, St Louis, Missouri Department of Neurosurgery, University of Florida, Gainesville, Florida
    Neurosurgery 74:254-61. 2014
    ....
  39. pmc The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients
    Jin Moo Lee
    Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Chem 54:1617-23. 2008
    ....
  40. pmc Preexisting statin use is associated with greater reperfusion in hyperacute ischemic stroke
    Andria L Ford
    Washington University, School of Medicine, Department of Neurology, 600 South Euclid Avenue, Campus Box 8111, St Louis, MO 63110, USA
    Stroke 42:1307-13. 2011
    ..Although several mechanisms have been examined in animal models, few have been examined in patients. We hypothesized that patients using statins before stroke onset may have greater reperfusion than patients not using statins...
  41. ncbi request reprint Evidence-based neuroimaging in acute ischemic stroke
    Katie D Vo
    Neuroradiology Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, Campus Box 8131, Saint Louis, MO 63110, USA
    Neuroimaging Clin N Am 13:167-83. 2003
    ..Clinical outcome data are lacking; therefore, the routine use of screening MR imaging before t-PA therapy is not supported. Rigorous validation and correlation to clinical outcomes will be required...
  42. ncbi request reprint Patent foramen ovale and stroke: Should PFOs be closed in otherwise cryptogenic stroke?
    David A Carpenter
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Atheroscler Rep 12:251-8. 2010
    ..Completion of the randomized clinical trials of PFO closure currently in progress is vital to determine if the benefits of PFO closure in cryptogenic stroke outweigh its risks...
  43. pmc Erythropoietin and its carbamylated derivative prevent the development of experimental diabetic autonomic neuropathy in STZ-induced diabetic NOD-SCID mice
    Robert E Schmidt
    Department of Pathology and Immunology, Division of Neuropathology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Exp Neurol 209:161-70. 2008
    ..These findings may represent a major clinical advance since EPO has been widely and safely used in anemic patients due to a variety of clinical conditions...
  44. ncbi request reprint Identification of novel brain biomarkers
    Omar F Laterza
    Department of Pathology and Immunology, Division of Laboratory Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Chem 52:1713-21. 2006
    ..In this study, we pursued the discovery of biomarkers that might be specific and sensitive to brain injury...
  45. ncbi request reprint Temporal relationship between apparent diffusion coefficient and absolute measurements of cerebral blood flow in acute stroke patients
    Weili Lin
    Department of Radiology and Biomedical Engineering, University of North Carolina at Chapel Hill, 27599, USA
    Stroke 34:64-70. 2003
    ....
  46. ncbi request reprint Magnetic resonance cerebral metabolic rate of oxygen utilization in hyperacute stroke patients
    Jin Moo Lee
    Department of Radiology and Biomedical Engineering, University of North Carolina at Chapel Hill, 27599, USA
    Ann Neurol 53:227-32. 2003
    ....
  47. ncbi request reprint Vascular permeability precedes spontaneous intracerebral hemorrhage in stroke-prone spontaneously hypertensive rats
    Jin Moo Lee
    Stroke 38:3289-91. 2007
    ..The precise spatial and temporal relationship between these events has not been well-delineated...
  48. ncbi request reprint Does the white matter matter in Alzheimer disease and cerebral amyloid angiopathy?
    Jin Moo Lee
    Neurology 66:6-7. 2006

Research Grants10

  1. AMYLOID INDUCED CEREBROENDOTHELIAL DEGENERATION
    Jin Moo Lee; Fiscal Year: 2003
    ..The ultimate goal of this project is to develop therapeutic strategies to delay amyloid induced cerebrovascular degeneration by blocking the AB-ceramide cascade and the downstream apoptotic processes originating from mitochondria. ..
  2. Untangling Amyloid Plaques With Proteases
    Jin Moo Lee; Fiscal Year: 2009
    ..If the hypothesis is true, potential targets for intervention to degrade plaques may be identified. ..
  3. Mechanisms of Amyloid Angiopathy-Related Hemorrhage
    Jin Moo Lee; Fiscal Year: 2009
    ....
  4. Mechanisms of Amyloid Angiopathy-Related Hemorrhage
    Jin Moo Lee; Fiscal Year: 2007
    ....
  5. Mechanisms of Amyloid Angiopathy-Related Hemorrhage
    Jin Moo Lee; Fiscal Year: 2006
    ....
  6. Mechanisms of Amyloid Angiopathy-Related Hemorrhage
    Jin Moo Lee; Fiscal Year: 2005
    ....
  7. THE ROLE OF ZINC IN FOCAL ISCHEMIC BRAIN INJURY
    Jin Moo Lee; Fiscal Year: 2004
    ..abstract_text> ..
  8. AMYLOID INDUCED CEREBROENDOTHELIAL DEGENERATION
    Jin Moo Lee; Fiscal Year: 2004
    ..The ultimate goal of this project is to develop therapeutic strategies to delay amyloid induced cerebrovascular degeneration by blocking the AB-ceramide cascade and the downstream apoptotic processes originating from mitochondria. ..
  9. Untangling Amyloid Plaques With Proteases
    Jin Moo Lee; Fiscal Year: 2010
    ..If the hypothesis is true, potential targets for intervention to degrade plaques may be identified. ..