Audrey O T Lau
Affiliation: Washington State University
Hines S, Ramsay J, Kappmeyer L, Lau A, Ojo K, Van Voorhis W, et al
. Theileria equi isolates vary in susceptibility to imidocarb dipropionate but demonstrate uniform in vitro susceptibility to a bumped kinase inhibitor. Parasit Vectors. 2015;8:33 pubmed publisher
..equi infection in vivo, raises concern for the emergence of drug resistance in clinical cases undergoing treatment. Bumped kinase inhibitors may be effective as alternative drugs for the treatment of resistant T. equi parasites. ..
Pedroni M, Vidadala R, Choi R, Keyloun K, Reid M, Murphy R, et al
. Bumped kinase inhibitor prohibits egression in Babesia bovis. Vet Parasitol. 2016;215:22-8 pubmed publisher
..The distinct, abnormal phenotype induced by RM-1-152 suggests that this BKI can be used to investigate less studied cellular processes such as egression in piroplasm. ..
Lau A. An overview of the Babesia, Plasmodium and Theileria genomes: a comparative perspective. Mol Biochem Parasitol. 2009;164:1-8 pubmed publisher
..This review, therefore, summarizes comparisons of genome structure, protein families, metabolic pathways and organelle biology in these three apicomplexans and how such knowledge has and will continue to enhance the field. ..
Pedroni M, Sondgeroth K, Gallego Lopez G, Echaide I, Lau A. Comparative transcriptome analysis of geographically distinct virulent and attenuated Babesia bovis strains reveals similar gene expression changes through attenuation. BMC Genomics. 2013;14:763 pubmed publisher
..Furthermore, upregulation of the spherical body protein 2 gene family may play a role in the attenuated phenotype. Exactly how these two gene families may contribute to the loss or gain of virulence is discussed. ..
Kappmeyer L, Thiagarajan M, Herndon D, Ramsay J, Caler E, Djikeng A, et al
. Comparative genomic analysis and phylogenetic position of Theileria equi. BMC Genomics. 2012;13:603 pubmed publisher
..equi relative to sequenced apicomplexan parasites...
Lau A, McElwain T, Brayton K, Knowles D, Roalson E. Babesia bovis: a comprehensive phylogenetic analysis of plastid-encoded genes supports green algal origin of apicoplasts. Exp Parasitol. 2009;123:236-43 pubmed publisher
..The results also substantiate earlier findings that plastids found in Heterokonts such as Odontella and Thalassiosira were derived from a separate secondary endosymbiotic event likely originating from a red algal lineage...
Lau A, Cereceres K, Palmer G, Fretwell D, Pedroni M, Mosqueda J, et al
. Genotypic diversity of merozoite surface antigen 1 of Babesia bovis within an endemic population. Mol Biochem Parasitol. 2010;172:107-12 pubmed publisher
..bovis within an individual animal in an endemic region. Co-infection with multiple diverse MSA-1 genotypes provides a basis for more extensive genotypic shifts that characterizes outbreak strains...
Lau A, Kalyanaraman A, Echaide I, Palmer G, Bock R, Pedroni M, et al
. Attenuation of virulence in an apicomplexan hemoparasite results in reduced genome diversity at the population level. BMC Genomics. 2011;12:410 pubmed publisher
..We expected virulence loss to be accompanied by consistent changes at the gene level, and that such changes would be shared among attenuated parasites of diverse geographic and genetic background...