Gregory Lanza

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Spectral properties of a bifunctional PARACEST europium chelate: an intermediate for targeted imaging applications
    Christopher Adair
    Macrocyclics, 2110 Research Row, STE 425, Dallas, TX 75235, USA
    Contrast Media Mol Imaging 2:55-8. 2007
  2. pmc Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics
    Trung D Tran
    Division of Cardiology, Washington University Medical School, 660 South Euclid Blvd, St Louis, Missouri 63110, USA
    Int J Nanomedicine 2:515-26. 2007
  3. ncbi request reprint Nanomedicine opportunities for cardiovascular disease with perfluorocarbon nanoparticles
    Gregory M Lanza
    Division of Cardiology, Washington University Medical School, Cortex Building, St Louis, MO 63108, USA
    Nanomedicine (Lond) 1:321-9. 2006
  4. doi request reprint Angiogenesis imaging with vascular-constrained particles: the why and how
    Gregory M Lanza
    Washington University Medical School, St Louis, MO 63146, USA
    Eur J Nucl Med Mol Imaging 37:S114-26. 2010
  5. ncbi request reprint Nanomedicine opportunities in cardiology
    Gregory Lanza
    Med and Biomed Engineering, School of Medicine, Washington University St Louis, 4003 Kingshighway Bldg, St Louis, MO 63130, USA
    Ann N Y Acad Sci 1080:451-65. 2006
  6. pmc Theragnostics for tumor and plaque angiogenesis with perfluorocarbon nanoemulsions
    G M Lanza
    Division of Cardiology, Department of Medicine, Washington University Medical School, 4320 Forest Park Ave, Suite 101, St Louis, MO 63108, USA
    Angiogenesis 13:189-202. 2010
  7. ncbi request reprint Novel paramagnetic contrast agents for molecular imaging and targeted drug delivery
    Gregory M Lanza
    Division of Cardiology, Campus Box 8086, Washington University Medical School, 600 S Euclid Ave, Saint Louis, MO 63110, USA
    Curr Pharm Biotechnol 5:495-507. 2004
  8. ncbi request reprint Molecular imaging and targeted drug delivery with a novel, ligand-directed paramagnetic nanoparticle technology
    Gregory M Lanza
    Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
    Acad Radiol 9:S330-1. 2002
  9. pmc Three-dimensional MR mapping of angiogenesis with alpha5beta1(alpha nu beta3)-targeted theranostic nanoparticles in the MDA-MB-435 xenograft mouse model
    Anne H Schmieder
    Washington University Medical School, Campus Box 8215, 4320 Forest Park Ave, St Louis, MO 63108, USA
    FASEB J 22:4179-89. 2008
  10. ncbi request reprint Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis
    Patrick M Winter
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arterioscler Thromb Vasc Biol 26:2103-9. 2006

Collaborators

Detail Information

Publications81

  1. ncbi request reprint Spectral properties of a bifunctional PARACEST europium chelate: an intermediate for targeted imaging applications
    Christopher Adair
    Macrocyclics, 2110 Research Row, STE 425, Dallas, TX 75235, USA
    Contrast Media Mol Imaging 2:55-8. 2007
    ....
  2. pmc Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics
    Trung D Tran
    Division of Cardiology, Washington University Medical School, 660 South Euclid Blvd, St Louis, Missouri 63110, USA
    Int J Nanomedicine 2:515-26. 2007
    ..One multimodality platform, targeted perfluorocarbon (PFC) nanoparticles, is useful for noninvasive detection with US and MR, targeted drug delivery, and quantification...
  3. ncbi request reprint Nanomedicine opportunities for cardiovascular disease with perfluorocarbon nanoparticles
    Gregory M Lanza
    Division of Cardiology, Washington University Medical School, Cortex Building, St Louis, MO 63108, USA
    Nanomedicine (Lond) 1:321-9. 2006
    ..As illustrated in this article, perfluorocarbon nanoparticles offer new tools to recognize and characterize pathology, to identify and segment high-risk patients and to treat chronic and acute disease...
  4. doi request reprint Angiogenesis imaging with vascular-constrained particles: the why and how
    Gregory M Lanza
    Washington University Medical School, St Louis, MO 63146, USA
    Eur J Nucl Med Mol Imaging 37:S114-26. 2010
    ..This review will explore biomedical imaging options being pursued to better segment and treat patients with angiogenesis-influenced disease using vascular-constrained contrast platform technologies...
  5. ncbi request reprint Nanomedicine opportunities in cardiology
    Gregory Lanza
    Med and Biomed Engineering, School of Medicine, Washington University St Louis, 4003 Kingshighway Bldg, St Louis, MO 63130, USA
    Ann N Y Acad Sci 1080:451-65. 2006
    ..Moreover, displacement of antiproliferative agents from the intimal surface into the vascular wall is likely to improve rehealing of the endothelium, improving postprocedural management of these patients...
  6. pmc Theragnostics for tumor and plaque angiogenesis with perfluorocarbon nanoemulsions
    G M Lanza
    Division of Cardiology, Department of Medicine, Washington University Medical School, 4320 Forest Park Ave, Suite 101, St Louis, MO 63108, USA
    Angiogenesis 13:189-202. 2010
    ..As perfluorocarbon nanoparticles have recently entered Phase I clinical study, this review provides a timely focus on the development of this platform technology and its application for angiogenesis-related pathologies...
  7. ncbi request reprint Novel paramagnetic contrast agents for molecular imaging and targeted drug delivery
    Gregory M Lanza
    Division of Cardiology, Campus Box 8086, Washington University Medical School, 600 S Euclid Ave, Saint Louis, MO 63110, USA
    Curr Pharm Biotechnol 5:495-507. 2004
    ..The fundamental issues surrounding magnetic contrast agent development, rational drug delivery, MR molecular imaging, and their interdependence are elucidated...
  8. ncbi request reprint Molecular imaging and targeted drug delivery with a novel, ligand-directed paramagnetic nanoparticle technology
    Gregory M Lanza
    Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
    Acad Radiol 9:S330-1. 2002
  9. pmc Three-dimensional MR mapping of angiogenesis with alpha5beta1(alpha nu beta3)-targeted theranostic nanoparticles in the MDA-MB-435 xenograft mouse model
    Anne H Schmieder
    Washington University Medical School, Campus Box 8215, 4320 Forest Park Ave, St Louis, MO 63108, USA
    FASEB J 22:4179-89. 2008
    ..MR molecular imaging may be useful for characterizing tumors with sparse neovasculature that are unlikely to have a reduced growth response to targeted antiangiogenic therapy...
  10. ncbi request reprint Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis
    Patrick M Winter
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arterioscler Thromb Vasc Biol 26:2103-9. 2006
    ..Alpha(v)beta3 integrin-targeted paramagnetic nanoparticles were prepared for noninvasive assessment of angiogenesis in early atherosclerosis, for site-specific delivery of antiangiogenic drug, and for quantitative follow-up of response...
  11. pmc Antiangiogenic synergism of integrin-targeted fumagillin nanoparticles and atorvastatin in atherosclerosis
    Patrick M Winter
    Washington University, St Louis, Missouri 63108, USA
    JACC Cardiovasc Imaging 1:624-34. 2008
    ..Studies were performed to develop a prolonged antiangiogenesis therapy regimen based on theranostic alpha(nu)beta(3)-targeted nanoparticles...
  12. ncbi request reprint Fluorine cardiovascular magnetic resonance angiography in vivo at 1.5 T with perfluorocarbon nanoparticle contrast agents
    Anne M Neubauer
    Washington University, St Louis, MO 63108, USA
    J Cardiovasc Magn Reson 9:565-73. 2007
    ..The surprisingly high signal generated with very short scan times and low doses of perfluorocarbon indicates that this technique may be useful in clinical settings when coupled with advanced imaging strategies...
  13. pmc Targeting of alpha(nu)beta(3)-integrins expressed on tumor tissue and neovasculature using fluorescent small molecules and nanoparticles
    Walter J Akers
    Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Nanomedicine (Lond) 5:715-26. 2010
    ....
  14. pmc Paracrine induction of endothelium by tumor exosomes
    Joshua L Hood
    Division of Cardiology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    Lab Invest 89:1317-28. 2009
    ..These data suggest that, tumor exosomes can promote endothelial angiogenic responses, which could contribute to tumor metastatic potential...
  15. pmc Perfluorocarbon nanoemulsions for quantitative molecular imaging and targeted therapeutics
    Megan M Kaneda
    Department of Biomedical Engineering, Washington University, St Louis, MO, USA
    Ann Biomed Eng 37:1922-33. 2009
    ..This review will focus on liquid perfluorocarbon nanoparticles as (19)F molecular imaging agents and for targeted drug delivery in cancer and cardiovascular disease...
  16. ncbi request reprint Acoustic characterization in whole blood and plasma of site-targeted nanoparticle ultrasound contrast agent for molecular imaging
    Michael S Hughes
    Washington University School of Medicine, Cardiovascular Division, St Louis, Missouri 63110, USA
    J Acoust Soc Am 117:964-72. 2005
    ..The resulting data provide upper bounds on blood pool attenuation coefficient and backscatter and will be needed to more precisely define levels of molecular contrast enhancement that may be obtained in vivo...
  17. pmc High sensitivity: high-resolution SPECT-CT/MR molecular imaging of angiogenesis in the Vx2 model
    Michal Lijowski
    Washington University Medical School, St Louis, MO 63108, USA
    Invest Radiol 44:15-22. 2009
    ....
  18. ncbi request reprint Molecular MR imaging of melanoma angiogenesis with alphanubeta3-targeted paramagnetic nanoparticles
    Anne H Schmieder
    Department of Biomedical Engineering, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Magn Reson Med 53:621-7. 2005
    ..This technique may be employed to noninvasively detect very small regions of angiogenesis associated with nascent melanoma tumors, and to phenotype and stage early melanoma in a clinical setting...
  19. pmc Improved signal processing to detect cancer by ultrasonic molecular imaging of targeted nanoparticles
    Michael Hughes
    Cardiovascular Division, Washington University School of Medicine, Campus Box 8215, 4320 Forest Park Avenue, St Louis, Missouri 63108, USA
    J Acoust Soc Am 129:3756-67. 2011
    ..Results are presented showing the impact of different smoothing parameters. In addition, if smoothing is preceded by low-pass filtering of the waveforms, further improvements may be obtained...
  20. ncbi request reprint Quantitative "magnetic resonance immunohistochemistry" with ligand-targeted (19)F nanoparticles
    Anne M Morawski
    Department of Medicine, Washington University, Saint Louis, Missouri 63110, USA
    Magn Reson Med 52:1255-62. 2004
    ....
  21. ncbi request reprint Blood contrast enhancement with a novel, non-gaseous nanoparticle contrast agent
    Samuel A Wickline
    Barnes Jewish Hospital, Washington University School of Medicine, St Louis, MO 63146, USA
    Acad Radiol 9:S290-3. 2002
  22. pmc Alphavbeta3-targeted nanotherapy suppresses inflammatory arthritis in mice
    Hui Fang Zhou
    Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri, USA
    FASEB J 23:2978-85. 2009
    ..Ligand-targeted nanotherapy to deliver antiangiogenic agents may represent an effective way to treat inflammatory arthritis...
  23. ncbi request reprint Applications of nanotechnology to atherosclerosis, thrombosis, and vascular biology
    Samuel A Wickline
    Department of Medicine, Washington University, St Louis, MO, USA
    Arterioscler Thromb Vasc Biol 26:435-41. 2006
    ..The future of cardiovascular diagnosis already is being impacted by nanosystems that can both diagnose pathology and treat it with targeted delivery systems...
  24. pmc Lipid membrane editing with peptide cargo linkers in cells and synthetic nanostructures
    Hua Pan
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    FASEB J 24:2928-37. 2010
    ....
  25. pmc Nanoparticle pharmacokinetic profiling in vivo using magnetic resonance imaging
    Anne M Neubauer
    Consortium for Translational Research in Advanced Imaging and Nanomedicine, Washington University, St Louis, Missouri 63108, USA
    Magn Reson Med 60:1353-61. 2008
    ..A doubling of tissue exposure (or area under the curve) is obtained with targeted as compared to control nanoparticles, and key parameter differences are discovered that may aid in development of models for targeted drug delivery...
  26. pmc Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth
    Neelesh R Soman
    Department of Biomedical Engineering, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 119:2830-42. 2009
    ....
  27. pmc MR angiogenesis imaging with Robo4- vs. alphaVbeta3-targeted nanoparticles in a B16/F10 mouse melanoma model
    Kent S Boles
    Washington University Medical School, St Louis, MO 63108, USA
    FASEB J 24:4262-70. 2010
    ..0 T than Robo4. Noninvasive, neovascular assessments of the MR signal of Robo4, particularly combined with α(V)β(3)-integrin expression, may help define tumor character prior to and following cancer therapy...
  28. ncbi request reprint Molecular imaging by MRI
    Patrick M Winter
    Cardiovascular Magnetic Resonance Laboratories, Washington University, St Louis, MO 63110, USA
    Curr Cardiol Rep 8:65-9. 2006
    ..If ultimately successful, these emerging molecular imaging agents and techniques will allow early disease recognition and quantification prompting therapeutic intervention before serious sequelae ensue...
  29. ncbi request reprint Improved molecular imaging contrast agent for detection of human thrombus
    Patrick M Winter
    Cardiovascular MR Laboratories, Department of Medicine, Cardiovascular Division, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 50:411-6. 2003
    ..45 +/- 0.02 1/s). These studies demonstrate marked improvement in a fibrin-specific molecular imaging agent that might allow sensitive, early detection of vascular microthrombi, the antecedent to stroke and heart attack...
  30. ncbi request reprint Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticles
    Patrick M Winter
    Cardiovascular Magnetic Resonance Laboratories, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 108:2270-4. 2003
    ..The precursory molecular or cellular events that initiate plaque growth and that ultimately contribute to plaque instability, however, cannot be detected directly with any current diagnostic modality...
  31. pmc Quantifying the evolution of vascular barrier disruption in advanced atherosclerosis with semipermeant nanoparticle contrast agents
    Huiying Zhang
    Department of Medicine, Washington University, St Louis, Missouri, United States of America
    PLoS ONE 6:e26385. 2011
    ....
  32. pmc Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions
    Megan M Kaneda
    Biomedical Engineering, Washington University School of Medicine, St Louis, MO 63108, USA
    Biomaterials 31:3079-86. 2010
    ..We further demonstrate markedly enhanced efficacy over conventional transfection agents for suppressing endothelial cell expression of upregulated vascular adhesion molecules...
  33. pmc Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle
    Dipanjan Pan
    C TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, Missouri 63108, USA
    J Am Chem Soc 131:15522-7. 2009
    ..This agent offers several-fold CT signal enhancement in vitro and in vivo demonstrating detection sensitivity reaching to the low nanomolar particulate concentration range...
  34. ncbi request reprint Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging
    Patrick M Winter
    Cardiovascular Magnetic Resonance Laboratories, Department of Medicine, Cardiovascular Division, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 63:5838-43. 2003
    ....
  35. pmc Molecular photoacoustic tomography with colloidal nanobeacons
    Dipanjan Pan
    C TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108, USA
    Angew Chem Int Ed Engl 48:4170-3. 2009
    ..Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging...
  36. doi request reprint Nanomedicine: perspective and promises with ligand-directed molecular imaging
    Dipanjan Pan
    Department of Medicine, Washington University Medical School, St Louis, MO, USA
    Eur J Radiol 70:274-85. 2009
    ..In this article, we have discussed the opportunities and potential of targeted molecular imaging with various modalities putting a particular emphasis on perfluorocarbon nanoemulsion-based platform technology...
  37. pmc Detection of targeted perfluorocarbon nanoparticle binding using 19F diffusion weighted MR spectroscopy
    Emily A Waters
    Department of Medicine, Division of Cardiology, Washington University Medical School, St Louis, Missouri, USA
    Magn Reson Med 60:1232-6. 2008
    ..01). In vivo (19)F DWS can be used for specific detection of bound perfluorocarbon nanoparticles by selectively suppressing background (19)F signal from nanoparticles flowing in blood...
  38. ncbi request reprint Temperature dependence of acoustic impedance for specific fluorocarbon liquids
    Jon N Marsh
    Washington University School of Medicine, Cardiovascular Division, 216 South Kingshighway, St Louis, Missouri 63110, USA
    J Acoust Soc Am 112:2858-62. 2002
    ..Computations from a simple transmission-line model used to predict reflectivity enhancement from surface-bound nanoparticles are discussed in light of these results...
  39. pmc Detection and quantification of angiogenesis in experimental valve disease with integrin-targeted nanoparticles and 19-fluorine MRI/MRS
    Emily A Waters
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Cardiovasc Magn Reson 10:43. 2008
    ..We also showed that fluorine MRI could be used to detect and quantify the development of neovasculature in the excised aortic valve leaflets...
  40. pmc Conquering the dark side: colloidal iron oxide nanoparticles
    Angana Senpan
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63108, USA
    ACS Nano 3:3917-26. 2009
    ....
  41. doi request reprint Anti-angiogenic perfluorocarbon nanoparticles for diagnosis and treatment of atherosclerosis
    Shelton D Caruthers
    Washington University School of Medicine and Philips Medical Systems, St Louis, MO, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:311-23. 2009
    ....
  42. ncbi request reprint Improvements in the ultrasonic contrast of targeted perfluorocarbon nanoparticles using an acoustic transmission line model
    Jon N Marsh
    Washington University School of Medicine, St Louis, MO 63110, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 49:29-38. 2002
    ..For future clinical applications, PFO nanoparticles may provide the best combination of acoustic enhancement, in vivo physical stability, and safety...
  43. pmc A facile synthesis of novel self-assembled gold nanorods designed for near-infrared imaging
    Dipanjan Pan
    C TRAIN and Division of Cardiology, Washington University School of Medicine, St Louis, MO 63108, USA
    J Nanosci Nanotechnol 10:8118-23. 2010
    ..In addition to the synthesis and characterization, sensitive near-infrared photoacoustic detection was impressively demonstrated in vitro...
  44. pmc Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons
    Dipanjan Pan
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    FASEB J 25:875-82. 2011
    ....
  45. pmc Molecular imaging of angiogenic therapy in peripheral vascular disease with alphanubeta3-integrin-targeted nanoparticles
    Patrick M Winter
    Washington University, St Louis, Missouri, USA
    Magn Reson Med 64:369-76. 2010
    ....
  46. ncbi request reprint Targeted antiproliferative drug delivery to vascular smooth muscle cells with a magnetic resonance imaging nanoparticle contrast agent: implications for rational therapy of restenosis
    Gregory M Lanza
    Department of Medicine, Division of Cardiology, Washington University Medical School, St Louis, MO 63110, USA
    Circulation 106:2842-7. 2002
    ..In the present study, the concept of VSMC-targeted nanoparticles as a drug-delivery platform for the prevention of restenosis after angioplasty is studied...
  47. ncbi request reprint Molecular imaging, targeted therapeutics, and nanoscience
    Samuel A Wickline
    Department of Medicine, Barnes Jewish Hospital and Washington University, St Louis, MO, USA
    J Cell Biochem Suppl 39:90-7. 2002
    ..In this perspective, examples of the progress and the prospects for the future of molecular imaging and linked targeted therapeutics are reviewed...
  48. doi request reprint Quantitative magnetic resonance fluorine imaging: today and tomorrow
    Junjie Chen
    Consortium for Translational Research in Advanced Imaging and Nanomedicine, St Louis, MO 63108, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 2:431-40. 2010
    ..This article reviews quantitative 19F MRI applications for mapping tumor oxygenation, assessing molecular expression in vascular diseases, and tracking labeled stem cells...
  49. ncbi request reprint Magnetic resonance nanoparticles for cardiovascular molecular imaging and therapy
    Tillmann Cyrus
    Washington University School of Medicine, Barnes Jewish Hospital, 660 South Euclid Ave, Box 8086, Saint Louis, MO 63110, USA
    Expert Rev Cardiovasc Ther 3:705-15. 2005
    ..This review focuses on recent developments of nanoparticle technologies with an emphasis on cardiovascular applications of magnetic resonance imaging...
  50. pmc Near infrared photoacoustic detection of sentinel lymph nodes with gold nanobeacons
    Dipanjan Pan
    C TRAIN and Division of Cardiology, Washington University School of Medicine, Saint Louis, MO 63108, USA
    Biomaterials 31:4088-93. 2010
    ....
  51. pmc Ligand-directed nanobialys as theranostic agent for drug delivery and manganese-based magnetic resonance imaging of vascular targets
    Dipanjan Pan
    C TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, Missouri 63108, USA
    J Am Chem Soc 130:9186-7. 2008
    ....
  52. pmc Exploiting lipid raft transport with membrane targeted nanoparticles: a strategy for cytosolic drug delivery
    Kathryn C Partlow
    Department of Medicine, Washington University in St Louis, School of Medicine, Campus Box 8215, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Biomaterials 29:3367-75. 2008
    ..We suggest that local drug delivery to selected cell types could be facilitated by employing targeted nanoparticles designed specifically to utilize alternative membrane transport mechanisms...
  53. pmc Minute dosages of alpha(nu)beta3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbits
    Patrick M Winter
    Washington University Medical School, Campus Box 8215, 4320 Forest Park Ave, St Louis, MO 63108, USA
    FASEB J 22:2758-67. 2008
    ..These results suggest that alpha(nu)beta(3)-targeted fumagillin nanoparticles could provide a safe and effective means to deliver MetAP2 inhibitors alone or in combination with cytotoxic or immunotherapy...
  54. ncbi request reprint Emerging nanomedicine opportunities with perfluorocarbon nanoparticles
    Patrick M Winter
    Medicine and Biomedical Engineering, C TRAIN Group, St Louis, MO 63108, USA
    Expert Rev Med Devices 4:137-45. 2007
    ..By combining targeted molecular imaging and localized drug delivery, PFC nanoparticles provide diagnosis and therapy with a single agent...
  55. ncbi request reprint Molecular imaging and therapy of atherosclerosis with targeted nanoparticles
    Samuel A Wickline
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    J Magn Reson Imaging 25:667-80. 2007
    ..We review a variety of nanotechnologies that are capable of detecting early cardiovascular pathology, as well as associated imaging approaches and conjunctive strategies for site-targeted treatment with nanoparticle delivery systems...
  56. ncbi request reprint Nanotechnological applications in medicine
    Shelton D Caruthers
    Consortium for Translational Research in Advanced Imaging and Nanomedicine, Washington University School of Medicine, 4444 Forest Park Avenue, Campus Box 8215, St Louis, MO 63108 2212, USA
    Curr Opin Biotechnol 18:26-30. 2007
    ..Highlighting clinically available and preclinical applications, this review explores the opportunities and issues surrounding nanomedicine...
  57. ncbi request reprint Sonic activation of molecularly-targeted nanoparticles accelerates transmembrane lipid delivery to cancer cells through contact-mediated mechanisms: implications for enhanced local drug delivery
    Kathryn C Crowder
    Department of Medicine, Washington University in St Louis, School of Medicine, St Louis, MO 63110, USA
    Ultrasound Med Biol 31:1693-700. 2005
    ..g., drugs) from targeted nanoparticles directly into cell cytoplasm can be augmented rapidly and safely with conventional ultrasound imaging devices through nondestructive mechanisms...
  58. pmc Targeted PARACEST nanoparticle contrast agent for the detection of fibrin
    Patrick M Winter
    Department of Medicine, Cardiovascular Division, Washington University, St Louis, Missouri 63108, USA
    Magn Reson Med 56:1384-8. 2006
    ..PARACEST nanoparticles were targeted to clots via antifibrin antibodies and produced a contrast-to-noise ratio (CNR) of 10 at the clot surface...
  59. ncbi request reprint Characterization of digital waveforms using thermodynamic analogs: detection of contrast-targeted tissue in vivo
    Michael S Hughes
    Washington University School of Medicine, St Louis, MO, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 53:1609-16. 2006
    ..The study shows that the thermodynamic analog is capable of detecting differences in backscattered signals that are not apparent with the B-mode approach...
  60. ncbi request reprint In vitro demonstration using 19F magnetic resonance to augment molecular imaging with paramagnetic perfluorocarbon nanoparticles at 1.5 Tesla
    Shelton D Caruthers
    Division of Cardiology, Washington University Medical School, St Louis, Missouri 63110, USA
    Invest Radiol 41:305-12. 2006
    ..This study explored the use of F spectroscopy and imaging with targeted perfluorocarbon nanoparticles for the simultaneous identification of multiple bio-signatures at 1.5 T...
  61. ncbi request reprint Acoustic activation of targeted liquid perfluorocarbon nanoparticles does not compromise endothelial integrity
    Neelesh R Soman
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    IEEE Trans Nanobioscience 5:69-75. 2006
    ....
  62. ncbi request reprint MR three-dimensional molecular imaging of intramural biomarkers with targeted nanoparticles
    Tillmann Cyrus
    Division of Cardiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Cardiovasc Magn Reson 8:535-41. 2006
    ..In conclusion, MR molecular imaging with alphavbeta3-integrin or collagen Ill-targeted nanoparticles enables the non-invasive, three-dimensional characterization of arterial pathology unanticipated from routine angiography...
  63. pmc Molecular imaging with targeted perfluorocarbon nanoparticles: quantification of the concentration dependence of contrast enhancement for binding to sparse cellular epitopes
    Jon N Marsh
    Center for Applied Nanomedicine, Department of Internal Medicine, Washington University, St Louis, MO 63108, USA
    Ultrasound Med Biol 33:950-8. 2007
    ..Furthermore, it may be possible to assess the quantity of bound cellular epitopes through acoustic means...
  64. ncbi request reprint Sensitive ultrasonic delineation of steroid treatment in living dystrophic mice with energy-based and entropy-based radio frequency signal processing
    Kirk D Wallace
    Washington University School of Medicine, Washington University, St Louis, MO, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:2291-9. 2007
    ..Successful differentiation among dystrophic, steroid-treated, and normal tissues suggests the potential for local noninvasive monitoring of disease severity and therapeutic effects...
  65. pmc Intramural delivery of rapamycin with alphavbeta3-targeted paramagnetic nanoparticles inhibits stenosis after balloon injury
    Tillmann Cyrus
    Division of Cardiology, Washington University School of Medicine, Saint Louis, MO 63108, USA
    Arterioscler Thromb Vasc Biol 28:820-6. 2008
    ....
  66. ncbi request reprint Imaging of Vx-2 rabbit tumors with alpha(nu)beta3-integrin-targeted 111In nanoparticles
    Grace Hu
    Department of Medicine, Division of Cardiology, Washington University Medical School, St Louis, MO, USA
    Int J Cancer 120:1951-7. 2007
    ....
  67. pmc Gadolinium-modulated 19F signals from perfluorocarbon nanoparticles as a new strategy for molecular imaging
    Anne M Neubauer
    C TRAIN Group, Washington University, St Louis, Missouri 63108, USA
    Magn Reson Med 60:1066-72. 2008
    ..This novel strategy dramatically improves the sensitivity and range of (19)F MRI/MRS and forms the basis for designing contrast agents capable of sensing their surface chemistry...
  68. ncbi request reprint 19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons
    Kathryn C Partlow
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    FASEB J 21:1647-54. 2007
    ..This method should facilitate longitudinal investigation of cellular events in vivo for multiple cell types simultaneously...
  69. ncbi request reprint Magnetic resonance molecular imaging with nanoparticles
    Gregory M Lanza
    Division of Cardiology, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Nucl Cardiol 11:733-43. 2004
    ..Combining high-resolution MR molecular imaging with drug delivery will facilitate verification and quantification of treatment (ie, rational targeted therapy) and will offer new clinical approaches to many diseases...
  70. ncbi request reprint Molecular imaging of human thrombus with computed tomography
    Patrick M Winter
    Cardiovascular Magnetic Resonance Laboratory, Washington University, St Louis, MO, USA
    Acad Radiol 12:S9-13. 2005
  71. ncbi request reprint Targeted nanoparticles for quantitative imaging of sparse molecular epitopes with MRI
    Anne M Morawski
    Cardiovascular MR Laboratories, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 51:480-6. 2004
    ..Thus, for targeted paramagnetic agents carrying high payloads of gadolinium, it is possible to quantify molecular epitopes present in picomolar concentrations in single cells with routine MRI...
  72. ncbi request reprint Targeted ultrasonic contrast agents for molecular imaging and therapy
    Gregory M Lanza
    Curr Probl Cardiol 28:625-53. 2003
    ....
  73. pmc Synthesis and characterization of stable fluorocarbon nanostructures as drug delivery vehicles for cytolytic peptides
    Neelesh R Soman
    Department of Biomedical Engineering, Washington University School of Medicine, St Louis, MI 63110, USA
    Nano Lett 8:1131-6. 2008
    ..27 nM) and retains its pore-forming activity after contact-mediated delivery to model bilayer membrane (liposomes) thereby demonstrating the effectiveness of perfluorocarbon nanoparticles as unique nanocarriers for cytolytic peptides...
  74. ncbi request reprint Ultrasonic delineation of aortic microstructure: the relative contribution of elastin and collagen to aortic elasticity
    Jon N Marsh
    Washington University School of Medicine, Cardiovascular Division, St Louis, Missouri 63110, USA
    J Acoust Soc Am 115:2032-40. 2004
    ..The results suggest that elastin is the primary contributor to aortic medial stiffness in the unloaded state, and that there is relatively little anisotropy in the speed of sound or stiffness in the aortic wall...
  75. ncbi request reprint Clinical utility of rapid prescreening magnetic resonance angiography of peripheral vascular disease prior to cardiac catheterization
    Jason H Rogers
    Division of Cardiovascular Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Cardiovasc Magn Reson 6:25-31. 2004
    ....
  76. ncbi request reprint Nanotechnology for molecular imaging and targeted therapy
    Samuel A Wickline
    Circulation 107:1092-5. 2003
  77. pmc Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with duchenne muscular dystrophy using an entropy-based signal receiver
    Michael S Hughes
    Washington University, School of Medicine, St Louis, MO 63108, USA
    Ultrasound Med Biol 33:1236-43. 2007
    ..005, student two-tailed paired t-test). Consequently, these imaging techniques may prove useful for longitudinal monitoring of disease progression and therapy...
  78. ncbi request reprint Targeted magnetic resonance imaging contrast agents
    Shelton D Caruthers
    Cardiovascular MR Labs, Division of Cardiology, Washington University, St Louis, Missouri, USA
    Methods Mol Med 124:387-400. 2006
    ..As exemplified by perfluorocarbon nanoparticles, these new agents, in combination with the rapid innovations in imaging hardware and software, will allow the emergence of new medical diagnostic and therapeutic paradigms...
  79. ncbi request reprint Molecular imaging by cardiovascular MR
    Tillmann Cyrus
    Division of Cardiology, Washington University School of Medicine, St Louis, MO 63108, USA
    J Cardiovasc Magn Reson 9:827-43. 2007
    ....
  80. ncbi request reprint Quantification of stenotic mitral valve area with magnetic resonance imaging and comparison with Doppler ultrasound
    Shiow Jiuan Lin
    Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Coll Cardiol 44:133-7. 2004
    ....
  81. ncbi request reprint 1H/19F magnetic resonance molecular imaging with perfluorocarbon nanoparticles
    Gregory M Lanza
    Division of Cardiology, Washington University Medical School, St Louis, MO 63110, USA
    Curr Top Dev Biol 70:57-76. 2005
    ..In conjunction with rapid improvements in MR imaging, the prospects for personalized medicine and early recognition and treatment of disease have never been better...

Research Grants9

  1. Combined Therapeutic-Imaging Agent for Atherosclerosis
    Gregory Lanza; Fiscal Year: 2005
    ..This novel application of molecular imaging and targeted drug delivery could serve as part of a primary prevention strategy to diagnose, treat, and monitor early atherosclerosis. ..
  2. Combined Therapeutic-Imaging Agent for Atherosclerosis
    Gregory Lanza; Fiscal Year: 2006
    ..This novel application of molecular imaging and targeted drug delivery could serve as part of a primary prevention strategy to diagnose, treat, and monitor early atherosclerosis. ..
  3. Combined Therapeutic-Imaging Agent for Atherosclerosis
    Gregory Lanza; Fiscal Year: 2007
    ..This novel application of molecular imaging and targeted drug delivery could serve as part of a primary prevention strategy to diagnose, treat, and monitor early atherosclerosis. ..
  4. Fibrin-Specific Thrombolytic Nanoparticles for Acute Stroke
    Gregory Lanza; Fiscal Year: 2007
    ..To evaluate the dose dependent safety of Fibrin-Lytic-NP with particular regard to hemorrhagic complications in vivo rodent surgical wound models. ..
  5. Fibrin-Specific Thrombolytic Nanoparticles for Acute Stroke
    Gregory Lanza; Fiscal Year: 2009
    ..To evaluate the dose dependent safety of Fibrin-Lytic-NP with particular regard to hemorrhagic complications in vivo rodent surgical wound models. ..
  6. COLLOIDAL IRON-OXIDE NANOBEACONS FOR THERANOSTIC USE IN ATHEROSCLEROSIS
    Gregory Lanza; Fiscal Year: 2009
    ..Demonstrate image-guided drug delivery of antiangiogenic therapy potential with ligand-targeted non-gadolinium nanoplatform in vivo. ..
  7. Fibrin-Specific Thrombolytic Nanoparticles for Acute Stroke
    Gregory M Lanza; Fiscal Year: 2010
    ..To evaluate the dose dependent safety of Fibrin-Lytic-NP with particular regard to hemorrhagic complications in vivo rodent surgical wound models. ..
  8. COLLOIDAL IRON-OXIDE NANOBEACONS FOR THERANOSTIC USE IN ATHEROSCLEROSIS
    Gregory M Lanza; Fiscal Year: 2010
    ..Demonstrate image-guided drug delivery of antiangiogenic therapy potential with ligand-targeted non-gadolinium nanoplatform in vivo. ..