Research Topics
| Richard LaforestSummaryAffiliation: Washington University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Measurement of input functions in rodents: challenges and solutionsRichard Laforest
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 32:679-85. 2005..To be able to implement these approaches in rodent models of disease using small-animal PET (microPET), it is imperative that the input function is measured accurately...- Adaptive brachytherapy treatment planning for cervical cancer using FDG-PETLilie L Lin
Radiation Oncology Department, Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 67:91-6. 2007..A dosimetric study was conducted to compare intracavitary brachytherapy using both a conventional and a custom loading intended to cover a positron emission tomography (PET)-defined tumor volume in patients with cervix cancer... - Minimally invasive method of determining blood input function from PET images in rodentsJoonyoung Kim
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Nucl Med 47:330-6. 2006.... 
Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone)Farrokh Dehdashti
Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
J Nucl Med 49:201-5. 2008..9). Pretherapy (60)Cu-ATSM PET provides clinically relevant information about tumor oxygenation that is predictive of outcome in patients with cervical cancer...- An imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervixJason S Lewis
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, St Louis, Missouri, USA
J Nucl Med 49:1177-82. 2008.... - Radiochemical synthesis, rodent biodistribution and tumor uptake, and dosimetry calculations of [¹¹C] methylated LY2181308Carmen S Dence
Department of Radiology, Division of Radiological Sciences, Washington University School of Medicine, 510 S Kingshighway Blvd, Saint Louis, MO 63110, USA
Mol Imaging Biol 12:608-15. 2010.... - Feasibility and dosimetry studies for 18F-NOS as a potential PET radiopharmaceutical for inducible nitric oxide synthase in humansPilar Herrero
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 53:994-1001. 2012.... - Sequential FDG-PET brachytherapy treatment planning in carcinoma of the cervixLilie L Lin
Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 63:1494-501. 2005..CONCLUSIONS: Sequential FDG-PET brachytherapy imaging identifies the tumor response in individual patients, potentially making patient-specific brachytherapy treatment planning possible... - Three-dimensional maximum a posteriori (MAP) imaging with radiopharmaceuticals labeled with three Cu radionuclidesAnanya Ruangma
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 33:217-26. 2006.... 
Assessment of progesterone receptors in breast carcinoma by PET with 21-18F-fluoro-16α,17α-[(R)-(1'-α-furylmethylidene)dioxy]-19-norpregn-4-ene-3,20-dioneFarrokh Dehdashti
Divisions of Nuclear Medicine and Radiological Sciences, Edward Mallinckrodt Institute of Radiology, St Louis, MO, USA
J Nucl Med 53:363-70. 2012....- In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSMFarrokh Dehdashti
Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
Eur J Nucl Med Mol Imaging 30:844-50. 2003..04; P=0.9). (60)Cu-ATSM-PET can be readily performed in patients with NSCLC and the tumor uptake of (60)Cu-ATSM reveals clinically unique information about tumor oxygenation that is predictive of tumor response to therapy... - Physiologic FDG-PET three-dimensional brachytherapy treatment planning for cervical cancerRobert S Malyapa
Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4939 Children's Place, St. Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 54:1140-6. 2002..This technique has the potential for improving isodose tumor coverage for patients with cervical cancer while sparing critical structures... - Dosimetry of 60/61/62/64Cu-ATSM: a hypoxia imaging agent for PETRichard Laforest
Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 510 S Kingshighway, St Louis, MO 63110, USA
Eur J Nucl Med Mol Imaging 32:764-70. 2005..Dosimetry calculations by the established Medical Internal Radionuclide Dose (MIRD) approach were performed with both animal and patient data... - 18F-fluoroacetate: a potential acetate analog for prostate tumor imaging--in vivo evaluation of 18F-fluoroacetate versus 11C-acetateDatta E Ponde
Mallinckrodt Institute of Radiology and 2Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
J Nucl Med 48:420-8. 2007..18)F-Fluoroacetate ((18)F-FAC) is an analog of acetate with a longer radioactive half-life ((18)F = 110 min). This study was undertaken to assess the potential usefulness of (18)F-FAC as a prostate tumor imaging agent... - Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone)Jason S Lewis
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Nucl Med 43:1557-69. 2002..CONCLUSION: *Cu-ATSM PET has shown quantitative selective uptake in hypoxic myocardium within 20 min of tracer administration in 3 canine models of hypoxia... - Radiation dosimetry of N-([11C]methyl)benperidol as determined by whole-body PET imaging of primatesJo Ann V Antenor-Dorsey
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
Eur J Nucl Med Mol Imaging 35:771-8. 2008..We report the absorbed radiation dosimetry of i.v.-administered (11)C-NMB, a critical step before applying this radioligand to imaging studies in humans... - A novel PET tumor delineation method based on adaptive region-growing and dual-front active contoursHua Li
Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Med Phys 35:3711-21. 2008..Third, the final result is reproducible and is independent of the manual rough ROIs. Fourth, this method is an adaptive algorithm that can process different images automatically... - Production, processing and small animal PET imaging of titanium-45Amy L Vavere
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 32:117-22. 2005..Titanium-45 was prepared as a tool for elucidation of the mechanism of action of titanium anticancer drugs in vivo using microPET imaging... - Quantitative accuracy of MAP reconstruction for dynamic PET imaging in small animalsJu Chieh Kevin Cheng
Washington University School of Medicine, St Louis, MO 63110, USA
Med Phys 39:1029-41. 2012.... - Cascade removal and microPET imaging with 76BrRichard Laforest
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
Phys Med Biol 54:1503-31. 2009..These evaluations are crucial for accurate correction for partial volume effects and to provide accurate measurement of the activity concentrations in small animal PET imaging... - Nuclear uptake and dosimetry of 64Cu-labeled chelator somatostatin conjugates in an SSTr2-transfected human tumor cell lineMartin Eiblmaier
Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63130, USA
J Nucl Med 48:1390-6. 2007..6.2]hexadecane) was highly stable... - Preparation of high specific activity (86)Y using a small biomedical cyclotronJeongsoo Yoo
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Nucl Med Biol 32:891-7. 2005..We have established techniques for the routine, economical production of high purity, high specific activity 86Y on a small biomedical cyclotron that are translatable to other institutions... - Registration of [18F]FDG microPET and small-animal MRIDouglas J Rowland
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 32:567-72. 2005..Our technique requires no manual identification of image features and makes no use of surgically implanted or external fiducial markers or stereotactic apparatus... - Instrumentation aspects of animal PETYuan Chuan Tai
Department of Radiology, Washington University, Saint Louis, MO 63110, USA
Annu Rev Biomed Eng 7:255-85. 2005..This article reviews the fundamental and technical challenges of small-animal PET imaging, with a particular focus on the latest developments and future directions of detector technologies and system design... - Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclideW Barry Edwards
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Mol Imaging 8:101-10. 2009..Thus, the multimodal imaging approach could provide important complementary diagnostic information for monitoring the efficacy of new antiangiogenic drugs... - Quantitative small animal PET imaging with nonconventional nuclidesXiaodong Liu
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 36:551-9. 2009..We show that, with the knowledge of the measured point spread functions, the accurate activity concentration in small lesions can be recovered when imaging with long-range positron emitters... - A scatter and randoms weighted (SRW) iterative PET reconstructionJu Chieh Cheng
Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Med Phys 38:3186-92. 2011.... - PET-guided three-dimensional treatment planning of intracavitary gynecologic implantsSasa Mutic
Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 52:1104-10. 2002..This study evaluates the feasibility of using PET as the sole source of target, normal structure, and applicator delineation for intracavitary GYN implant treatment planning... - Production and purification of gallium-66 for preparation of tumor-targeting radiopharmaceuticalsMichael R Lewis
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Nucl Med Biol 29:701-6. 2002..Therefore, work is in progress to automate the diisopropyl ether extraction method for routine processing of (66)Ga... - Performance evaluation of the microPET focus: a third-generation microPET scanner dedicated to animal imagingYuan-Chuan Tai
Department of Radiology, Washington University School of Medicine, St. Louis, Missouri
J Nucl Med 46:455-63. 2005..This system represents the state-of-the-art scintillator-based animal PET scanner currently available and is expected to advance the potential of small animal PET... - Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticalsCarla J Mathias
Department of Industrial and Physical Pharmacy, Purdue University, West, Lafayette, IN, USA
Nucl Med Biol 30:725-31. 2003..The autoradiographic images of 1 mm tumor sections demonstrate the gross heterogeneity of the KB cell tumor xenograft, as well as subtle disparity in the regional accumulation of the two radiotracers... - Advances in the production, processing and microPET image quality of technetium-94mHeather M Bigott
Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211, USA
Nucl Med Biol 33:923-33. 2006..Preliminary studies demonstrate that useful images can be obtained with modern image reconstruction algorithms when using a correction for the cascade gamma ray contamination...
Research Grants
- Acquisition of a Small Animal CT ScannerRichard Laforest; Fiscal Year: 2003..This instrument will be made available to researchers of many disciplines at Washington University. ..
- Core-Instrumentation/Data Manipulation CoreRichard Laforest; Fiscal Year: 2007..A Data Management and Archival System (DMAS) will be deployed to provide database functionalities, data display and analysis, and a centralized on-line storage and archival for all studies performed under this program. ..