Richard Laforest

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Measurement of input functions in rodents: challenges and solutions
    Richard Laforest
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 32:679-85. 2005
  2. ncbi request reprint Minimally invasive method of determining blood input function from PET images in rodents
    Joonyoung Kim
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:330-6. 2006
  3. ncbi request reprint Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET
    Lilie L Lin
    Radiation Oncology Department, Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 67:91-6. 2007
  4. doi request reprint Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone)
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    J Nucl Med 49:201-5. 2008
  5. ncbi request reprint Three-dimensional maximum a posteriori (MAP) imaging with radiopharmaceuticals labeled with three Cu radionuclides
    Ananya Ruangma
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 33:217-26. 2006
  6. doi request reprint An imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervix
    Jason S Lewis
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, St Louis, Missouri, USA
    J Nucl Med 49:1177-82. 2008
  7. doi request reprint Radiochemical synthesis, rodent biodistribution and tumor uptake, and dosimetry calculations of [¹¹C] methylated LY2181308
    Carmen S Dence
    Department of Radiology, Division of Radiological Sciences, Washington University School of Medicine, 510 S Kingshighway Blvd, Saint Louis, MO 63110, USA
    Mol Imaging Biol 12:608-15. 2010
  8. doi request reprint Feasibility and dosimetry studies for 18F-NOS as a potential PET radiopharmaceutical for inducible nitric oxide synthase in humans
    Pilar Herrero
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 53:994-1001. 2012
  9. ncbi request reprint Sequential FDG-PET brachytherapy treatment planning in carcinoma of the cervix
    Lilie L Lin
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 63:1494-501. 2005
  10. pmc Assessment of cellular proliferation in tumors by PET using 18F-ISO-1
    Farrokh Dehdashti
    Division of Nuclear Medicine and Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 54:350-7. 2013

Research Grants

  1. Acquisition of a Small Animal CT Scanner
    Richard Laforest; Fiscal Year: 2003
  2. Core-Instrumentation/Data Manipulation Core
    Richard Laforest; Fiscal Year: 2007

Detail Information

Publications36

  1. ncbi request reprint Measurement of input functions in rodents: challenges and solutions
    Richard Laforest
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 32:679-85. 2005
    ..To be able to implement these approaches in rodent models of disease using small-animal PET (microPET), it is imperative that the input function is measured accurately...
  2. ncbi request reprint Minimally invasive method of determining blood input function from PET images in rodents
    Joonyoung Kim
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:330-6. 2006
    ..A factor analysis (FA) technique for extracting the blood input function and myocardial time-activity curve from dynamic small-animal PET images of the rodent heart has been implemented to overcome these limitations...
  3. ncbi request reprint Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET
    Lilie L Lin
    Radiation Oncology Department, Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 67:91-6. 2007
    ..A dosimetric study was conducted to compare intracavitary brachytherapy using both a conventional and a custom loading intended to cover a positron emission tomography (PET)-defined tumor volume in patients with cervix cancer...
  4. doi request reprint Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone)
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    J Nucl Med 49:201-5. 2008
    ..9). Pretherapy (60)Cu-ATSM PET provides clinically relevant information about tumor oxygenation that is predictive of outcome in patients with cervical cancer...
  5. ncbi request reprint Three-dimensional maximum a posteriori (MAP) imaging with radiopharmaceuticals labeled with three Cu radionuclides
    Ananya Ruangma
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 33:217-26. 2006
    ....
  6. doi request reprint An imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervix
    Jason S Lewis
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, St Louis, Missouri, USA
    J Nucl Med 49:1177-82. 2008
    ....
  7. doi request reprint Radiochemical synthesis, rodent biodistribution and tumor uptake, and dosimetry calculations of [¹¹C] methylated LY2181308
    Carmen S Dence
    Department of Radiology, Division of Radiological Sciences, Washington University School of Medicine, 510 S Kingshighway Blvd, Saint Louis, MO 63110, USA
    Mol Imaging Biol 12:608-15. 2010
    ....
  8. doi request reprint Feasibility and dosimetry studies for 18F-NOS as a potential PET radiopharmaceutical for inducible nitric oxide synthase in humans
    Pilar Herrero
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 53:994-1001. 2012
    ....
  9. ncbi request reprint Sequential FDG-PET brachytherapy treatment planning in carcinoma of the cervix
    Lilie L Lin
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 63:1494-501. 2005
    ..To evaluate the utility of sequential (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging for brachytherapy treatment planning in patients with carcinoma of the cervix...
  10. pmc Assessment of cellular proliferation in tumors by PET using 18F-ISO-1
    Farrokh Dehdashti
    Division of Nuclear Medicine and Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 54:350-7. 2013
    ....
  11. pmc Assessment of progesterone receptors in breast carcinoma by PET with 21-18F-fluoro-16α,17α-[(R)-(1'-α-furylmethylidene)dioxy]-19-norpregn-4-ene-3,20-dione
    Farrokh Dehdashti
    Divisions of Nuclear Medicine and Radiological Sciences, Edward Mallinckrodt Institute of Radiology, St Louis, MO, USA
    J Nucl Med 53:363-70. 2012
    ....
  12. ncbi request reprint In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 30:844-50. 2003
    ..04; P=0.9). (60)Cu-ATSM-PET can be readily performed in patients with NSCLC and the tumor uptake of (60)Cu-ATSM reveals clinically unique information about tumor oxygenation that is predictive of tumor response to therapy...
  13. ncbi request reprint Physiologic FDG-PET three-dimensional brachytherapy treatment planning for cervical cancer
    Robert S Malyapa
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4939 Children s Place, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 54:1140-6. 2002
    ....
  14. ncbi request reprint Dosimetry of 60/61/62/64Cu-ATSM: a hypoxia imaging agent for PET
    Richard Laforest
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 510 S Kingshighway, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 32:764-70. 2005
    ..Dosimetry calculations by the established Medical Internal Radionuclide Dose (MIRD) approach were performed with both animal and patient data...
  15. ncbi request reprint Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone)
    Jason S Lewis
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 43:1557-69. 2002
    ..Using canine models of hypoxic myocardium, we report our findings on *Cu-ATSM PET (*Cu is defined as either (60)Cu, (61)Cu, or (64)Cu) for the delineation of ischemic and hypoxic myocardium...
  16. ncbi request reprint 18F-fluoroacetate: a potential acetate analog for prostate tumor imaging--in vivo evaluation of 18F-fluoroacetate versus 11C-acetate
    Datta E Ponde
    Mallinckrodt Institute of Radiology and 2Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Nucl Med 48:420-8. 2007
    ..18)F-Fluoroacetate ((18)F-FAC) is an analog of acetate with a longer radioactive half-life ((18)F = 110 min). This study was undertaken to assess the potential usefulness of (18)F-FAC as a prostate tumor imaging agent...
  17. pmc A novel PET tumor delineation method based on adaptive region-growing and dual-front active contours
    Hua Li
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Med Phys 35:3711-21. 2008
    ..Third, the final result is reproducible and is independent of the manual rough ROIs. Fourth, this method is an adaptive algorithm that can process different images automatically...
  18. pmc Radiation dosimetry of N-([11C]methyl)benperidol as determined by whole-body PET imaging of primates
    Jo Ann V Antenor-Dorsey
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 35:771-8. 2008
    ..We report the absorbed radiation dosimetry of i.v.-administered (11)C-NMB, a critical step before applying this radioligand to imaging studies in humans...
  19. ncbi request reprint Production, processing and small animal PET imaging of titanium-45
    Amy L Vavere
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 32:117-22. 2005
    ..Titanium-45 was prepared as a tool for elucidation of the mechanism of action of titanium anticancer drugs in vivo using microPET imaging...
  20. pmc The role of p53 in combination radioimmunotherapy with 64Cu-DOTA-cetuximab and cisplatin in a mouse model of colorectal cancer
    Yunjun Guo
    Mallinckrodt Institute of Radiology, Washington University, St Louis, Missouri, USA
    J Nucl Med 54:1621-9. 2013
    ..For example, the KRAS mutation is predictive of poor response to anti-epidermal growth factor receptor therapies in colorectal cancer, whereas p53 is frequently mutated in tumors, causing resistance to multiple therapeutic regimens...
  21. ncbi request reprint Performance evaluation of the microPET focus: a third-generation microPET scanner dedicated to animal imaging
    Yuan Chuan Tai
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri
    J Nucl Med 46:455-63. 2005
    ..This study evaluated the basic performance of the scanner and compared it with the Primate (P4) and Rodent (R4) models...
  22. doi request reprint Initial characterization of a dually radiolabeled peptide for simultaneous monitoring of protein targets and enzymatic activity
    Efrem Mebrahtu
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, Box 8225, St Louis, MO 63110, USA
    Nucl Med Biol 40:190-6. 2013
    ....
  23. doi request reprint Erratum to: Radiation dosimetry of N-([(11)C]methyl)benperidol as determined by whole-body PET imaging of primates
    Jo Ann V Antenor-Dorsey
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA
    Eur J Nucl Med Mol Imaging 40:795-6. 2013
    ..We report the absorbed radiation dosimetry of i.v.-administered [(11)C]NMB, a critical step prior to applying this radioligand to imaging studies in humans...
  24. pmc Quantitative accuracy of MAP reconstruction for dynamic PET imaging in small animals
    Ju Chieh Kevin Cheng
    Washington University School of Medicine, St Louis, MO 63110, USA
    Med Phys 39:1029-41. 2012
    ....
  25. ncbi request reprint Nuclear uptake and dosimetry of 64Cu-labeled chelator somatostatin conjugates in an SSTr2-transfected human tumor cell line
    Martin Eiblmaier
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63130, USA
    J Nucl Med 48:1390-6. 2007
    ..6.2]hexadecane) was highly stable...
  26. ncbi request reprint Preparation of high specific activity (86)Y using a small biomedical cyclotron
    Jeongsoo Yoo
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 32:891-7. 2005
    ..We have established techniques for the routine, economical production of high purity, high specific activity 86Y on a small biomedical cyclotron that are translatable to other institutions...
  27. ncbi request reprint Registration of [18F]FDG microPET and small-animal MRI
    Douglas J Rowland
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 32:567-72. 2005
    ..Our technique requires no manual identification of image features and makes no use of surgically implanted or external fiducial markers or stereotactic apparatus...
  28. ncbi request reprint Cascade removal and microPET imaging with 76Br
    Richard Laforest
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Phys Med Biol 54:1503-31. 2009
    ..These evaluations are crucial for accurate correction for partial volume effects and to provide accurate measurement of the activity concentrations in small animal PET imaging...
  29. ncbi request reprint Instrumentation aspects of animal PET
    Yuan Chuan Tai
    Department of Radiology, Washington University, Saint Louis, MO 63110, USA
    Annu Rev Biomed Eng 7:255-85. 2005
    ..This article reviews the fundamental and technical challenges of small-animal PET imaging, with a particular focus on the latest developments and future directions of detector technologies and system design...
  30. doi request reprint Quantitative small animal PET imaging with nonconventional nuclides
    Xiaodong Liu
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 36:551-9. 2009
    ..We show that, with the knowledge of the measured point spread functions, the accurate activity concentration in small lesions can be recovered when imaging with long-range positron emitters...
  31. pmc Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide
    W Barry Edwards
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Imaging 8:101-10. 2009
    ..Thus, the multimodal imaging approach could provide important complementary diagnostic information for monitoring the efficacy of new antiangiogenic drugs...
  32. ncbi request reprint Production and purification of gallium-66 for preparation of tumor-targeting radiopharmaceuticals
    Michael R Lewis
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 29:701-6. 2002
    ..Therefore, work is in progress to automate the diisopropyl ether extraction method for routine processing of (66)Ga...
  33. pmc A scatter and randoms weighted (SRW) iterative PET reconstruction
    Ju Chieh Cheng
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Med Phys 38:3186-92. 2011
    ....
  34. ncbi request reprint PET-guided three-dimensional treatment planning of intracavitary gynecologic implants
    Sasa Mutic
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 52:1104-10. 2002
    ..This study evaluates the feasibility of using PET as the sole source of target, normal structure, and applicator delineation for intracavitary GYN implant treatment planning...
  35. ncbi request reprint Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticals
    Carla J Mathias
    Department of Industrial and Physical Pharmacy, Purdue University, West, Lafayette, IN, USA
    Nucl Med Biol 30:725-31. 2003
    ..The autoradiographic images of 1 mm tumor sections demonstrate the gross heterogeneity of the KB cell tumor xenograft, as well as subtle disparity in the regional accumulation of the two radiotracers...
  36. ncbi request reprint Advances in the production, processing and microPET image quality of technetium-94m
    Heather M Bigott
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Nucl Med Biol 33:923-33. 2006
    ..Preliminary studies demonstrate that useful images can be obtained with modern image reconstruction algorithms when using a correction for the cascade gamma ray contamination...

Research Grants3

  1. Acquisition of a Small Animal CT Scanner
    Richard Laforest; Fiscal Year: 2003
    ..This instrument will be made available to researchers of many disciplines at Washington University. ..
  2. Core-Instrumentation/Data Manipulation Core
    Richard Laforest; Fiscal Year: 2007
    ..A Data Management and Archival System (DMAS) will be deployed to provide database functionalities, data display and analysis, and a centralized on-line storage and archival for all studies performed under this program. ..