JAMES MARTIN KRUEGER

Summary

Affiliation: Washington State University
Country: USA

Publications

  1. ncbi request reprint Sleep in host defense
    James M Krueger
    Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, P O Box 646520, Pullman 99164 6520, USA
    Brain Behav Immun 17:S41-7. 2003
  2. pmc Local use-dependent sleep; synthesis of the new paradigm
    James M Krueger
    WWAMI Medical Education Program and the Sleep and Performance Research Center, Washington State University, Spokane, WA 99210 1495, USA
    Curr Top Med Chem 11:2490-2. 2011
  3. pmc Sleep: a synchrony of cell activity-driven small network states
    James M Krueger
    Sleep and Performance Research Center, Washington State University, Pullman, WA, USA
    Eur J Neurosci 38:2199-209. 2013
  4. pmc Involvement of cytokines in slow wave sleep
    James M Krueger
    Sleep and Performance Research Center, Washington State University, Spokane, WA, USA
    Prog Brain Res 193:39-47. 2011
  5. pmc ATP and the purine type 2 X7 receptor affect sleep
    James M Krueger
    Sleep and Performance Research Center, Programs in Neuroscience, Dept of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
    J Appl Physiol (1985) 109:1318-27. 2010
  6. pmc Sleep as a fundamental property of neuronal assemblies
    James M Krueger
    Department of VCAPP, College of Veterinary Medicine, Washington State University, PO Box 646520, Pullman, Washington 99164 6520, USA
    Nat Rev Neurosci 9:910-9. 2008
  7. pmc The role of cytokines in sleep regulation
    James M Krueger
    Sleep and Performance Research Center, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
    Curr Pharm Des 14:3408-16. 2008
  8. ncbi request reprint Humoral links between sleep and the immune system: research issues
    James M Krueger
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164 6520, USA
    Ann N Y Acad Sci 992:9-20. 2003
  9. ncbi request reprint Sleep function
    James M Krueger
    Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164 6520, USA
    Front Biosci 8:d511-9. 2003
  10. ncbi request reprint Humoral regulation of physiological sleep: cytokines and GHRH
    J M Krueger
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, Pullman 99164, USA
    J Sleep Res 8:53-9. 1999

Research Grants

  1. SLEEP REGULATION AND TUMOR NECROSIS FACTOR
    JAMES MARTIN KRUEGER; Fiscal Year: 2010
  2. Interleukin-1: A Promoter of Slow Wave Sleep
    James Krueger; Fiscal Year: 2007
  3. SLEEP REGULATION AND TUMOR NECROSIS FACTOR
    James Krueger; Fiscal Year: 2005
  4. MECHANISMS OF SLEEP RESPONSES TO VIRAL INFECTIONS
    James Krueger; Fiscal Year: 2005
  5. Sleep Regulation-The Involvement of GHRH
    James Krueger; Fiscal Year: 2005
  6. SLEEP REGULATION AND TUMOR NECROSIS FACTOR
    James Krueger; Fiscal Year: 2004
  7. INTERLEUKIN 1--A PROMOTER OF SLOW WAVE SLEEP
    James Krueger; Fiscal Year: 2003
  8. Sleep Regulation - The Involvement of GHRH
    James Krueger; Fiscal Year: 2007
  9. Molecular Mechanisms of Sleep Responses to Viral Infection
    James Krueger; Fiscal Year: 2007
  10. Interleukin-1: A Promoter of Slow Wave Sleep
    JAMES MARTIN KRUEGER; Fiscal Year: 2010

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Sleep in host defense
    James M Krueger
    Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, P O Box 646520, Pullman 99164 6520, USA
    Brain Behav Immun 17:S41-7. 2003
    ..Fatigue and sleep disturbances are common in cancer patients and in those receiving cytokine therapy. Regardless, the role of sleep in cancer is relatively uninvestigated...
  2. pmc Local use-dependent sleep; synthesis of the new paradigm
    James M Krueger
    WWAMI Medical Education Program and the Sleep and Performance Research Center, Washington State University, Spokane, WA 99210 1495, USA
    Curr Top Med Chem 11:2490-2. 2011
    ..The views presented herein emphasize the inseparability of sleep mechanisms from a connectivity sleep function...
  3. pmc Sleep: a synchrony of cell activity-driven small network states
    James M Krueger
    Sleep and Performance Research Center, Washington State University, Pullman, WA, USA
    Eur J Neurosci 38:2199-209. 2013
    ..Finally, we provide an example of how such local metabolic and state changes provide mechanistic explanations for clinical conditions, such as insomnia...
  4. pmc Involvement of cytokines in slow wave sleep
    James M Krueger
    Sleep and Performance Research Center, Washington State University, Spokane, WA, USA
    Prog Brain Res 193:39-47. 2011
    ..Whole-organism sleep is a bottom-up, self-organizing, and emergent property of the collective states of networks throughout the brain...
  5. pmc ATP and the purine type 2 X7 receptor affect sleep
    James M Krueger
    Sleep and Performance Research Center, Programs in Neuroscience, Dept of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
    J Appl Physiol (1985) 109:1318-27. 2010
    ....
  6. pmc Sleep as a fundamental property of neuronal assemblies
    James M Krueger
    Department of VCAPP, College of Veterinary Medicine, Washington State University, PO Box 646520, Pullman, Washington 99164 6520, USA
    Nat Rev Neurosci 9:910-9. 2008
    ....
  7. pmc The role of cytokines in sleep regulation
    James M Krueger
    Sleep and Performance Research Center, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
    Curr Pharm Des 14:3408-16. 2008
    ..We conclude that sleep is a local use-dependent process influenced by cytokines and their effector molecules such as nitric oxide, prostaglandins and adenosine...
  8. ncbi request reprint Humoral links between sleep and the immune system: research issues
    James M Krueger
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164 6520, USA
    Ann N Y Acad Sci 992:9-20. 2003
    ..It also seems likely that TNF-alpha and CRH also influence these neurons. In addition, we discuss an array of research issues raised by these studies that remain to be resolved...
  9. ncbi request reprint Sleep function
    James M Krueger
    Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164 6520, USA
    Front Biosci 8:d511-9. 2003
    ..Thus, not only is unconsciousness needed because output activity would be out of phase with environmental events, but it is the consequence of the process itself...
  10. ncbi request reprint Humoral regulation of physiological sleep: cytokines and GHRH
    J M Krueger
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, Pullman 99164, USA
    J Sleep Res 8:53-9. 1999
    ..These substances elicit non-rapid-eye-movement sleep via a biochemical cascade that includes other known sleep regulatory substances...
  11. ncbi request reprint Sleep. A physiologic role for IL-1 beta and TNF-alpha
    J M Krueger
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164 6520, USA
    Ann N Y Acad Sci 856:148-59. 1998
    ..Several additional substances are involved in inhibitory feedback mechanisms, some of which inhibit IL-1 and TNF. A major challenge to sleep research is to define how and where these molecular steps produce sleep...
  12. ncbi request reprint The role of cytokines in physiological sleep regulation
    J M Krueger
    Department of VCAPP, Washington State University, Pullman 99164 6520, USA
    Ann N Y Acad Sci 933:211-21. 2001
    ..As our knowledge of the biochemical regulation of sleep progresses, our understanding of sleep function and of many clinical conditions will improve...
  13. ncbi request reprint Influenza virus-induced sleep responses in mice with targeted disruptions in neuronal or inducible nitric oxide synthases
    Lichao Chen
    Department of Veterinary and Comparative Anatomy, Pharmacology, Physiology, Washington State University, Pullman, WA 99164 6520, USA
    J Appl Physiol (1985) 97:17-28. 2004
    ..Our results suggest that NO synthesized by both nNOS and iNOS plays a role in virus-induced sleep changes and that nNOS may modulate cytokine expression in the brain...
  14. pmc The olfactory nerve has a role in the body temperature and brain cytokine responses to influenza virus
    Victor H Leyva-Grado
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164 6520, USA
    Brain Behav Immun 24:281-8. 2010
    ..These results suggest that the olfactory nerve pathway is important for the initial pathogenesis of the influenza-induced APR...
  15. ncbi request reprint Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice
    Eva Szentirmai
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 293:R510-7. 2007
    ..It is possible that redundancy in the arousal systems of the brain or activation of compensatory mechanisms during development allow for normal sleep-wake regulation in ghrelin KO mice...
  16. ncbi request reprint The role of nitric oxide synthases in the sleep responses to tumor necrosis factor-alpha
    Lichao Chen
    Department of VCAPP, Washington State University, Pullman, WA 99164 6520, USA
    Brain Behav Immun 18:390-8. 2004
    ..Rapid eye movement sleep (REMS) was suppressed by TNFalpha in nNOS controls but not in the other strains examined. The results suggest that TNFalpha affects sleep, in part, through nNOS...
  17. pmc Attenuation of the influenza virus sickness behavior in mice deficient in Toll-like receptor 3
    Jeannine A Majde
    Department of VCAPP, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
    Brain Behav Immun 24:306-15. 2010
    ..Locomotor activity suppression was similar in both strains. Therefore virus-associated dsRNA detected by TLR3 appears to play a substantial role in mediating several aspects of the influenza syndrome in mice...
  18. ncbi request reprint Interleukin-1beta has a role in cerebral cortical state-dependent electroencephalographic slow-wave activity
    Tadanobu Yasuda
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164 6520, USA
    Sleep 28:177-84. 2005
    ..To investigate the hypothesis that interleukin (IL)-1beta is involved in mediating localized electroencephalogram synchronization...
  19. ncbi request reprint State-specific asymmetries in EEG slow wave activity induced by local application of TNFalpha
    Hitoshi Yoshida
    Department of VCAPP, College of Veterinary Medicine, Washington State University, P O Box 646520, Pullman, WA 99164 6520, USA
    Brain Res 1009:129-36. 2004
    ..Results are consistent with the notion that sleep begins with state changes occurring within small groups of highly interconnected neurons and is driven in part by the local production of sleep regulating substances...
  20. pmc Cytokine mRNA induction by interleukin-1beta or tumor necrosis factor alpha in vitro and in vivo
    Ping Taishi
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Programs in Neuroscience, Washington State University, Pullman, WA 99164 6520, USA
    Brain Res 1226:89-98. 2008
    ..Results support the hypothesis that centrally active doses of IL1beta and TNFalpha enhance their own mRNA levels as well as affect mRNA levels for other neuronal growth factors...
  21. pmc Restricted feeding-induced sleep, activity, and body temperature changes in normal and preproghrelin-deficient mice
    Eva Szentirmai
    WWAMI Medical Education Program, Washington State Univ, Spokane, P O Box 1495, Spokane, WA 99210 1495, USA
    Am J Physiol Regul Integr Comp Physiol 298:R467-77. 2010
    ..Results indicate that the preproghrelin gene is not required for the manifestation of FAA but suggest a role for ghrelinergic mechanisms in food deprivation-induced arousal in mice...
  22. ncbi request reprint Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats
    Eva Szentirmai
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Neuroscience Program, Washington State University, Pullman, Washington, WA 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 292:R575-85. 2007
    ....
  23. pmc Physiological markers of local sleep
    David M Rector
    Sleep and Performance Research Center and Program in Neuroscience, Washington State University, Spokane, WA 99210 1495, USA
    Eur J Neurosci 29:1771-8. 2009
    ....
  24. ncbi request reprint REM sleep deprivation attenuates actin-binding protein cortactin: a link between sleep and hippocampal plasticity
    Christopher J Davis
    Department of Psychology, Washington State University, Pullman, WA 99164 6520, USA
    Neurosci Lett 400:191-6. 2006
    ..Thus, these data support a functional link between REMS and cytoskeletal reorganization in the hippocampus, a process that is essential for synaptic plasticity...
  25. pmc The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice
    Eva Szentirmai
    Sleep and Performance Research Center, Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 106:14069-74. 2009
    ..Results suggest that obestatin is a component in the coordinated regulation of metabolism and sleep during torpor...
  26. pmc The anterolateral projections of the medial basal hypothalamus affect sleep
    Zoltan Peterfi
    Department of Veterinary and Comparative Anatomy, Washington State Univesity, Pullman, WA 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1228-38. 2009
    ..Further, the MBH projections involved in sleep regulation are distinct from those involved in EEG delta activity, water intake, and brain temperature...
  27. pmc Sleep loss changes microRNA levels in the brain: a possible mechanism for state-dependent translational regulation
    Christopher J Davis
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology and Program in Neuroscience, Washington State University, Pullman, WA 99164 6520, United States
    Neurosci Lett 422:68-73. 2007
    ..Current results are, to our knowledge, the first demonstration of the homeostatic process, sleep, altering brain miRNA levels...
  28. ncbi request reprint Unilateral cortical application of tumor necrosis factor alpha induces asymmetry in Fos- and interleukin-1beta-immunoreactive cells within the corticothalamic projection
    Lynn Churchill
    Department of VCAPP, College of Veterinary Medicine, Washington State University, PO Box 646520, Pullman, WA 99164 6520, USA
    Brain Res 1055:15-24. 2005
    ..Current results indicated that Fos- and IL1beta-IR may be utilized to study the functional neuroanatomy involved in the TNFalpha-mediated state-dependent enhancement of EEG slow wave activity...
  29. pmc A network model for activity-dependent sleep regulation
    Sandip Roy
    Department of Electrical Engineering, Washington State University, P O Box 642752, Pullman, WA 99164, USA
    J Theor Biol 253:462-8. 2008
    ..In analogy with other models for networked oscillators, our model also predicts the possibility for such phenomena as mode-locking...
  30. ncbi request reprint Differences in spatial learning comparing transgenic p75 knockout, New Zealand Black, C57BL/6, and Swiss Webster mice
    John W Wright
    Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
    Behav Brain Res 153:453-8. 2004
    ..On the other hand, these results do not support the use of the NZB mouse as an animal model of human learning disability and dementia...
  31. ncbi request reprint Alterations in EEG activity and sleep after influenza viral infection in GHRH receptor-deficient mice
    Jeremy A Alt
    Department of Veterinary and Comparative Anatomy and Pphysiology, Washington State University, College of Veterinary Medicine, Pullman, WA 99164 6520, USA
    J Appl Physiol 95:460-8. 2003
    ..Lung virus levels were similar in the two mouse strains. Lit/lit mice had a higher death rate after influenza challenge than the heterozygotes. In conclusion, GHRH signaling is involved in the NREMS response to influenza infection...
  32. ncbi request reprint Intratracheal double-stranded RNA plus interferon-gamma: a model for analysis of the acute phase response to respiratory viral infections
    Tim R Traynor
    Department of VCAPP, College of Veterinary Medicine, Washington State University, PO Box 646520, Pullman, WA 99164 6520, USA
    Life Sci 74:2563-76. 2004
    ..rC] and IFNgamma closely simulates the APR to an acute respiratory virus, and may serve as a suitable model for analyzing the molecular basis of the viral APR in gene knockout mice...
  33. ncbi request reprint Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes
    Lichao Chen
    Department of VCAPP, Washington State University, Pullman, WA 99164 6520, USA
    Brain Res 973:214-22. 2003
    ..In contrast, the iNOS KO mice had significantly more REMS than their controls. Inducible NOS KO mice also had less non-REMS (NREMS) during the dark period. Results suggest that nNOS and iNOS play opposite roles in REMS regulation...
  34. ncbi request reprint Interleukin-1beta induces CREB-binding protein (CBP) mRNA in brain and the sequencing of rat CBP
    Chad Tang
    Department of VCAPP, Program in Neuroscience, Washington State University, PO Box 646520, Pullman, WA 99164 6520, USA
    Brain Res Mol Brain Res 137:213-22. 2005
    ..We conclude that rat CBP shares many of the functional domains as human and murine CBP and that IL-1 upregulates genes previously associated with learning and sleep...
  35. ncbi request reprint Influenza virus-induced glucocorticoid and hypothalamic and lung cytokine mRNA responses in dwarf lit/lit mice
    Jeremiah A Alt
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164 6520, USA
    Brain Behav Immun 21:60-7. 2007
    ....
  36. ncbi request reprint Detection of mouse-adapted human influenza virus in the olfactory bulbs of mice within hours after intranasal infection
    Jeannine A Majde
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164, USA
    J Neurovirol 13:399-409. 2007
    ..Therefore a mouse-adapted human influenza virus strain, not known to be neurotropic, was detected in the mouse OB within 4 h PI where it appeared to induce replication intermediates and cytokines...
  37. ncbi request reprint Intracerebroventricular injection of erythropoietin enhances sleep in the rat
    Fabio Garcia-Garcia
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, P O Box 99164 6520, Pullman, WA, USA
    Brain Res Bull 61:541-6. 2003
    ..In contrast, EPO injection during the light period failed to affect sleep. Brain temperature (Tbr) was not affected by any dose of EPO. These results suggest that EPO could be part of the cytokine network involved in sleep regulation...
  38. pmc TNFalpha siRNA reduces brain TNF and EEG delta wave activity in rats
    Ping Taishi
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Program in Neuroscience, Washington State University Pullman, WA 99164 6520, USA
    Brain Res 1156:125-32. 2007
    ..Results also are consistent with the notion that TNFalpha is involved in CNS physiology including sleep regulation...
  39. ncbi request reprint Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression
    Eva Szentirmai
    Washington State University, College of Veterinary Medicine, Program in Neuroscience, Pullman, WA 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 293:R922-30. 2007
    ..These results suggest that cortical GHRH and GHRHR have a role in the regulation of localized EEG delta power that is state dependent, as well as in their more classic hypothalamic role in NREMS regulation...
  40. ncbi request reprint Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells
    Judith A Brandt
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, P O Box 646520, Pullman, WA 99164 6520, USA
    Brain Res 1004:91-7. 2004
    ..These results suggest that NF-kappa B expressing cells within the lateral hypothalamus may be important in the maintenance of the sleep-wake cycle...
  41. ncbi request reprint Intrapreoptic microinjection of TNF-alpha enhances non-REM sleep in rats
    Takeshi Kubota
    Department of Veterinary Comparative Anatomy, College of Veterinary Medicine, P O Box 646520, Washington State University, Pullman, WA 99164 6520, USA
    Brain Res 932:37-44. 2002
    ..Combined with previous results showing diurnal variations of TNFalpha in the hypothalamus, the present data suggest that POA TNFalpha is involved, in part, in the regulation of physiological sleep...
  42. ncbi request reprint Homer1a and 1bc levels in the rat somatosensory cortex vary with the time of day and sleep loss
    Scott E Nelson
    Neuroscience Program, College of Veterinary Medicine, Washington State University, WA, USA
    Neurosci Lett 367:105-8. 2004
    ..Sleep loss upregulated Homer1a in the morning but not at night. Homer1bc was much less affected by manipulations of sleep. Thus, Homer1a may be a state- and activity-dependent synaptic scaling factor...
  43. pmc Time of day differences in the number of cytokine-, neurotrophin- and NeuN-immunoreactive cells in the rat somatosensory or visual cortex
    Krista Hight
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Sleep and Performance Research Center, Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
    Brain Res 1337:32-40. 2010
    ..These data demonstrate that expressions of the molecules examined are dependent on activity, the sleep-wake cycle and brain location. These factors interact to modulate time-of-day expression...
  44. ncbi request reprint State-dependent effects of light-dark cycle on somatosensory and visual cortex EEG in rats
    Tadanobu Yasuda
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, PO Box 646520, Pullman, WA 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1083-9. 2005
    ..We concluded that the SSctx and Vctx EEGs are differentially affected by light during subsequent sleep. Results provide support for the notion that regional sleep intensity is dependent on prior regional afferent input...
  45. ncbi request reprint Glutamate induces the expression and release of tumor necrosis factor-alpha in cultured hypothalamic cells
    Alok De
    Program in Neuroscience, Department of VCAPP, College of Veterinary Medicine, Washington State University, 205 Wegner Hall, Pullman, WA 99164 6520, USA
    Brain Res 1053:54-61. 2005
    ..These findings support the hypothesis that TNFalpha can participate in normal physiological regulation of sleep and feeding...
  46. pmc Whisker stimulation increases expression of nerve growth factor- and interleukin-1beta-immunoreactivity in the rat somatosensory cortex
    Heather Hallett
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Sleep and Performance Research Center, Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
    Brain Res 1333:48-56. 2010
    ..These whisker-stimulated increases in the Sctx did not occur in the auditory cortex. These data demonstrate that expression of NGF or IL1beta in Sctx neurons and IL1beta in Sctx astrocytes is, in part, afferent input-dependent...
  47. ncbi request reprint Obestatin alters sleep in rats
    Eva Szentirmai
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Neuroscience Program, Washington State University, College of Veterinary Medicine, Pullman, 99164 6520, USA
    Neurosci Lett 404:222-6. 2006
    ..Current results confirm the finding that two regulatory peptides derived from the same gene have opposite actions in the same species...
  48. ncbi request reprint Rapid eye movement sleep is reduced in prolactin-deficient mice
    Ferenc Obal
    Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164 6520, USA
    J Neurosci 25:10282-9. 2005
    ..Data support the notion that PRL is involved in REMS regulation...
  49. ncbi request reprint Links between the innate immune system and sleep
    Jeannine A Majde
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164 6520, USA
    J Allergy Clin Immunol 116:1188-98. 2005
    ..We also summarize our current understanding of the role of sleep in host defense and asthma exacerbation...
  50. pmc Influenza virus- and cytokine-immunoreactive cells in the murine olfactory and central autonomic nervous systems before and after illness onset
    Victor H Leyva-Grado
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164 6520, United States
    J Neuroimmunol 211:73-83. 2009
    ..These results suggest that the OB virus influences the brain cytokines and therefore the onset of illness...
  51. ncbi request reprint Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity
    Lichao Chen
    Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, 205 Wegner Hall, P O Box 646520, Pullman, WA 99164 6520, USA
    Brain Res Mol Brain Res 129:179-84. 2004
    ..The results suggest that NO inhibits PRL. No differences in the genes measured were observed in inducible NOS KO mice...
  52. ncbi request reprint Unilateral cortical application of interleukin-1beta (IL1beta) induces asymmetry in fos, IL1beta and nerve growth factor immunoreactivity: implications for sleep regulation
    Kyo Yasuda
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Program in Neuroscience, Center for Integrated Biotechnology, College of Veterinary Medicine, Washington State University, PO Box 646520, Pullman, WA 99164 6520, USA
    Brain Res 1131:44-59. 2007
    ..These results are consistent with the hypothesis that sleep is initiated within the cortex after the local activation of specific cytokines and that whole organism sleep is coordinated via cortical connections with the subcortical sites...
  53. ncbi request reprint Tumor necrosis factor alpha increases cytosolic calcium responses to AMPA and KCl in primary cultures of rat hippocampal neurons
    Alok De
    Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, 205 Wegner Hall, Pullman, WA 99164 6520, USA
    Brain Res 981:133-42. 2003
    ..These actions may be related to the behavioral effects produced by TNFalpha that occur within this time frame...
  54. ncbi request reprint Interleukin-8 promotes non-rapid eye movement sleep in rabbits and rats
    Fabio Garcia-Garcia
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164 6520, USA
    J Sleep Res 13:55-61. 2004
    ..IL-8 also induced fever in rabbits but not rats. Heat inactivated IL-8 did not alter any of the parameters measured. Current results support the notion that the brain cytokine network plays a role in sleep regulation...
  55. pmc Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus
    Tim R Traynor
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, P O Box 646520, Pullman, WA 99164 6520, USA
    Brain Behav Immun 21:311-22. 2007
    ..In conclusion, our results indicate that the presence of functional type I IFN slightly ameliorates disease symptoms early in the X-31 infection while exacerbating disease symptoms later in the infection...
  56. ncbi request reprint Time of day differences in IL1beta and TNFalpha mRNA levels in specific regions of the rat brain
    Cassia Cearley
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, College of Veterinary Medicine, PO Box 646520, Pullman, WA 99164 6520, USA
    Neurosci Lett 352:61-3. 2003
    ..Time-of-day differences in TNFalpha mRNA levels were observed in all these brain regions. These results support the hypothesis that TNFalpha and IL1beta have physiological roles within the brain...
  57. ncbi request reprint Sleep and body temperature responses in an acute viral infection model are altered in interferon type I receptor-deficient mice
    Tim R Traynor
    Department of VCAPP, Washington State University, USA
    Brain Behav Immun 20:290-9. 2006
    ..rC]/IFNgamma challenge. Our results implicate type I IFNs as inhibitors of the hypothermic response and enhancers of the NREMS response to IT poly[rI.rC]/IFNgamma, a model of acute viral infection...
  58. ncbi request reprint GHRH and IL1beta increase cytoplasmic Ca(2+) levels in cultured hypothalamic GABAergic neurons
    Alok De
    Department of VCAPP, Program in Neuroscience, Washington State University, PO Box 646520, Pullman, WA 99164 6520, USA
    Brain Res 949:209-12. 2002
    ..6 and 4.0% of cultured hypothalamic neurons tested, respectively, and 1.2% of neurons responded to both. The neurons that responded were mostly GABAergic (96, 81, and 100% for GHRH, IL1beta, and dual-responsive neurons, respectively)...
  59. ncbi request reprint Brain distribution of cytokine mRNA induced by systemic administration of interleukin-1beta or tumor necrosis factor alpha
    Lynn Churchill
    Department of Veterinary and Comparative Anatomy, Program in Neuroscience, Washington State University, Pullman, WA 99164 6520, USA
    Brain Res 1120:64-73. 2006
    ..These results support the hypothesis that somnogenic doses of IL1beta and TNFalpha enhance their own mRNA levels as well as affect mRNA levels for other sleep-promoting substances...
  60. ncbi request reprint Diurnal effects of acute and chronic administration of ethanol on sleep in rats
    Takeshi Kubota
    Department of Veterinary, Comparative Anatomy, Pharmacology, and Physiology VCAPP, Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
    Alcohol Clin Exp Res 26:1153-61. 2002
    ..Disturbances in sleep patterns are a complicating factor in recovery from alcoholism. The effects of acute and chronic alcohol treatments on sleep in rats were determined...
  61. pmc Localized suppression of cortical growth hormone-releasing hormone receptors state-specifically attenuates electroencephalographic delta waves
    Fan Liao
    Sleep and Performance Research Center, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164 6520, USA
    J Neurosci 30:4151-9. 2010
    ..Our data suggest that endogenous cortical GHRH activates local cortical cells to affect EEG delta wave power state-specifically. Results are also consistent with the hypothesis that GHRH contributes to local network state regulation...
  62. ncbi request reprint A cyclooxygenase-2 inhibitor attenuates spontaneous and TNF-alpha-induced non-rapid eye movement sleep in rabbits
    Hitoshi Yoshida
    Dept of VCAPP, PO Box 646520, Washington State University, Pullman, WA 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 285:R99-109. 2003
    ..These data suggest that COX-2 is involved in the regulation of spontaneous and TNF-alpha-induced sleep...
  63. ncbi request reprint Sleep disturbances in the rotenone animal model of Parkinson disease
    Fabio Garcia-Garcia
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, 205 Wegner Hall, Pullman, WA 99164 6520, USA
    Brain Res 1042:160-8. 2005
    ..Such results question the validity of the RT-PD rat model...

Research Grants54

  1. SLEEP REGULATION AND TUMOR NECROSIS FACTOR
    JAMES MARTIN KRUEGER; Fiscal Year: 2010
    ..Preliminary data provide a rationale for each specific aim and demonstrate feasibility. Successful completion of the experiments will help integrate the biochemical, neuroanatomical and electrophysiological sleep regulatory literature. ..
  2. Interleukin-1: A Promoter of Slow Wave Sleep
    James Krueger; Fiscal Year: 2007
    ..Anticipated results will help establish a unique view of biochemical sleep mechanisms and will thereby significantly impact sleep medicine and sleep research. ..
  3. SLEEP REGULATION AND TUMOR NECROSIS FACTOR
    James Krueger; Fiscal Year: 2005
    ..Preliminary data provides a rationale for each specific aim and demonstrate feasibility. Successful completion of the experiments will help integrate the biochemical, neuroanatomical and electrophysiological sleep regulatory literature. ..
  4. MECHANISMS OF SLEEP RESPONSES TO VIRAL INFECTIONS
    James Krueger; Fiscal Year: 2005
    ..The anticipated results will greatly aid our understanding of the molecular mechanisms involved in viral-induced sleep responses and other facets of the acute phase response. ..
  5. Sleep Regulation-The Involvement of GHRH
    James Krueger; Fiscal Year: 2005
    ..Anticipated results are expected to support the hypothesis that GHRH is a key regulatory component of NREMS and provide cellular mechanistic explanations for the involvement of GHRH in sleep regulation. ..
  6. SLEEP REGULATION AND TUMOR NECROSIS FACTOR
    James Krueger; Fiscal Year: 2004
    ..We anticipate that results will be directly relevant to therapeutics, e.g., a TNF soluble receptor has already been shown to reduce fatigue associated with rheumatoid arthritis. ..
  7. INTERLEUKIN 1--A PROMOTER OF SLOW WAVE SLEEP
    James Krueger; Fiscal Year: 2003
    ..They will also help our understanding of the cellular and molecular mechanisms of sleep regulation. Knowledge of such mechanisms is likely to be a necessary step toward our understanding of sleep function. ..
  8. Sleep Regulation - The Involvement of GHRH
    James Krueger; Fiscal Year: 2007
    ..Anticipated results are expected to support the hypothesis that GHRH is a key regulatory component of NREMS and provide cellular mechanistic explanations for the involvement of GHRH in sleep regulation. ..
  9. Molecular Mechanisms of Sleep Responses to Viral Infection
    James Krueger; Fiscal Year: 2007
    ..The proposed work will provide insights into how viruses induce disease symptoms as well as such complications as SIDS and viral encephalitis/encephalopathy. ..
  10. Interleukin-1: A Promoter of Slow Wave Sleep
    JAMES MARTIN KRUEGER; Fiscal Year: 2010
    ..Results will have practical application to IL1-associated brain pathologies including inflammation-associated sleep disturbances occurring in sleep apnea and metabolic syndrome. ..
  11. Sleep Regulation - The Involvement of GHRH
    James Krueger; Fiscal Year: 2009
    ..Anticipated results are expected to support the hypothesis that GHRH is a key regulatory component of NREMS and provide cellular mechanistic explanations for the involvement of GHRH in sleep regulation. ..
  12. Molecular Mechanisms of Sleep Responses to Viral Infection
    JAMES MARTIN KRUEGER; Fiscal Year: 2010
    ..The proposed work will provide insights into how viruses induce disease symptoms as well as such complications as SIDS and viral encephalitis/encephalopathy. ..
  13. SLEEP REGULATION AND TUMOR NECROSIS FACTOR
    JAMES MARTIN KRUEGER; Fiscal Year: 2010
    ..Successful completion of the experiments will help integrate the biochemical, neuroanatomical and electrophysiological sleep regulatory literature. ..
  14. Molecular Mechanisms of Sleep Responses to Viral Infection
    James Krueger; Fiscal Year: 2009
    ..The proposed work will provide insights into how viruses induce disease symptoms as well as such complications as SIDS and viral encephalitis/encephalopathy. ..
  15. MECHANISMS OF SLEEP RESPONSES TO VIRAL INFECTIONS
    James Krueger; Fiscal Year: 2000
    ..The anticipated results will greatly aid our understanding of the molecular mechanisms involved in viral-induced sleep responses as well as physiological sleep mechanisms. ..
  16. SLEEP REGULATION AND TUMOR NECROSIS FACTOR
    James Krueger; Fiscal Year: 2000
    ..Anticipated results aim to provide molecular-mechanistic advances to understanding sleep regulation as well as aid our general understanding of cytokine regulation in the brain. ..
  17. SLEEP REGULATION--THE INVOLVEMENT OF GHRH
    James Krueger; Fiscal Year: 2001
    ..Anticipated results are expected to support the hypothesis that GHRH is a key regulatory component of sleep and provide explanation as to the mechanisms by which GHRH promotes sleep. ..