Kerry Kornfeld

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi request reprint Valproic acid extends Caenorhabditis elegans lifespan
    Kimberley Evason
    Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8103, St Louis, MO 63110, USA
    Aging Cell 7:305-17. 2008
  2. ncbi request reprint Effects of anticonvulsant drugs on life span
    Kerry Kornfeld
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Arch Neurol 63:491-6. 2006
  3. ncbi request reprint Anticonvulsant medications extend worm life-span
    Kimberley Evason
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 307:258-62. 2005
  4. pmc ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis
    Hyun Cheol Roh
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO, USA
    PLoS Genet 9:e1003522. 2013
  5. pmc The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan
    James J Collins
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO, USA
    PLoS Genet 4:e1000230. 2008
  6. pmc Lysosome-related organelles in intestinal cells are a zinc storage site in C. elegans
    Hyun Cheol Roh
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Metab 15:88-99. 2012
  7. pmc Identification of mutations that delay somatic or reproductive aging of Caenorhabditis elegans
    Stacie E Hughes
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genetics 189:341-56. 2011
  8. pmc Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans
    John T Murphy
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 7:e1002013. 2011
  9. pmc Genetic and pharmacological factors that influence reproductive aging in nematodes
    Stacie E Hughes
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 3:e25. 2007
  10. ncbi request reprint Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans
    James J Collins
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Gerontol 41:1032-9. 2006

Collaborators

  • Chengjie Xiong
  • Xiaowei Lu
  • Takao Inoue
  • Elaine R Mardis
  • Paul W Sternberg
  • Sander van den Heuvel
  • Raphael Kopan
  • ANTHONY MUSLIN
  • Zhenyi Liu
  • Kimberley Evason
  • Hyun Cheol Roh
  • Janelle J Bruinsma
  • James J Collins
  • J David Robertson
  • James Guthrie
  • Cheng Huang
  • Daniel L Schneider
  • Stacie E Hughes
  • Sara Collier
  • Christopher L Pickett
  • Diana E Davis
  • Danielle Glossip
  • Ginger R Miley
  • John T Murphy
  • Krupa Deshmukh
  • Virginia Hsu
  • Javier A Wagmaister
  • Jessica L Goldstein
  • Elizabeth R Leight
  • Angus Harding
  • Asif Chinwalla
  • Stacie Hughes
  • Julie E Gleason
  • Sudhir Nayak
  • Corey A Morris
  • David M Eisenmann
  • Leilani M Miller
  • Douglas F Covey
  • Idella Yamben
  • Douglas Fantz
  • R Mako Saito
  • Robert E Palmer
  • John F Hancock
  • Tim Schedl
  • Tanawat Jirakulaporn
  • Cheri L Zobel
  • Eric J Lambie

Detail Information

Publications22

  1. doi request reprint Valproic acid extends Caenorhabditis elegans lifespan
    Kimberley Evason
    Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8103, St Louis, MO 63110, USA
    Aging Cell 7:305-17. 2008
    ..These data suggest that the mechanism of action of VA is distinct from that of trimethadione, and demonstrate that lifespan-extending drugs can be combined to produce additive effects...
  2. ncbi request reprint Effects of anticonvulsant drugs on life span
    Kerry Kornfeld
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Arch Neurol 63:491-6. 2006
    ..We also discuss models that explain how the nervous system influences lifespan...
  3. ncbi request reprint Anticonvulsant medications extend worm life-span
    Kimberley Evason
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 307:258-62. 2005
    ..These findings suggest that the life-span-extending activity of these compounds is related to the anticonvulsant activity and implicate neural activity in the regulation of aging...
  4. pmc ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis
    Hyun Cheol Roh
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO, USA
    PLoS Genet 9:e1003522. 2013
    ..These findings define a parallel negative feedback circuit that promotes zinc homeostasis and advance the understanding of the physiological roles of the gastrointestinal tract in zinc metabolism in animals...
  5. pmc The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan
    James J Collins
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO, USA
    PLoS Genet 4:e1000230. 2008
    ..These studies highlight the potential of ethosuximide and related drugs that modulate sensory perception to extend lifespan in diverse animals...
  6. pmc Lysosome-related organelles in intestinal cells are a zinc storage site in C. elegans
    Hyun Cheol Roh
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Metab 15:88-99. 2012
    ..We defined a genetic pathway that mediates the formation of bilobed morphology. These findings elucidate mechanisms of zinc storage, detoxification, and mobilization in C. elegans and may be relevant to other animals...
  7. pmc Identification of mutations that delay somatic or reproductive aging of Caenorhabditis elegans
    Stacie E Hughes
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genetics 189:341-56. 2011
    ..These studies provide new insights into the genetic regulation of age-related degenerative changes in somatic and reproductive tissues...
  8. pmc Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans
    John T Murphy
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 7:e1002013. 2011
    ..These studies identify a novel role for haly-1 and histidine in zinc metabolism and may be relevant for other animals...
  9. pmc Genetic and pharmacological factors that influence reproductive aging in nematodes
    Stacie E Hughes
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 3:e25. 2007
    ..The implications of these findings for evolutionary theories of aging are discussed...
  10. ncbi request reprint Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans
    James J Collins
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Gerontol 41:1032-9. 2006
    ..elegans aging, and important challenges and opportunities remain in determining the mechanisms of action of these compounds and the relevance of these observations to aging of other animals...
  11. ncbi request reprint Sumoylation of LIN-1 promotes transcriptional repression and inhibition of vulval cell fates
    Elizabeth R Leight
    Department of Molecular Biology and Pharmacology Washington University School of Medicine, St Louis, MO 63110, USA
    Development 132:1047-56. 2005
    ..These studies identify a molecular mechanism for SUMO-mediated transcriptional repression...
  12. pmc Age-related degeneration of the egg-laying system promotes matricidal hatching in Caenorhabditis elegans
    Christopher L Pickett
    Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8103, St Louis, MO 63110, USA
    Aging Cell 12:544-53. 2013
    ....
  13. pmc The cation diffusion facilitator gene cdf-2 mediates zinc metabolism in Caenorhabditis elegans
    Diana E Davis
    Department of Developmental Biology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Genetics 182:1015-33. 2009
    ..These studies advance C. elegans as a model of zinc metabolism and identify cdf-2 as a new gene that has a critical role in zinc storage...
  14. pmc The CRAL/TRIO and GOLD domain protein CGR-1 promotes induction of vulval cell fates in Caenorhabditis elegans and interacts genetically with the Ras signaling pathway
    Jessica L Goldstein
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genetics 172:929-42. 2006
    ..The analysis of cgr-1 identifies a novel in vivo function for a member of this family and a potential new regulator of Ras-mediated signaling...
  15. pmc Identification of mutations in Caenorhabditis elegans that cause resistance to high levels of dietary zinc and analysis using a genomewide map of single nucleotide polymorphisms scored by pyrosequencing
    Janelle J Bruinsma
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genetics 179:811-28. 2008
    ..These genes are likely to be involved in zinc metabolism, and the analysis of these genes will provide insights into mechanisms of excess zinc toxicity...
  16. pmc Identification of residues of the Caenorhabditis elegans LIN-1 ETS domain that are necessary for DNA binding and regulation of vulval cell fates
    Ginger R Miley
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genetics 167:1697-709. 2004
    ..The identification of multiple mutations that reduce the function of lin-1 as an inhibitor of the primary vulval cell fate and also reduce DNA binding suggest that DNA binding is essential for LIN-1 function in an animal...
  17. pmc Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans
    Cheng Huang
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:8084-9. 2004
    ..These measurements were used to generate a system of four stages that describes the aging process and is useful for the analysis of genetic and environmental effects on aging...
  18. doi request reprint Simple copy number determination with reference query pyrosequencing (RQPS)
    Zhenyi Liu
    Department of Developmental Biology, School of Medicine, Washington University, St Louis, Missouri 63110, USA
    Cold Spring Harb Protoc 2010:pdb.prot5491. 2010
    ....
  19. ncbi request reprint Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling
    Janelle J Bruinsma
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Cell 2:567-78. 2002
    ..These findings suggest that Zn(2+) negatively regulates a conserved element of the signaling pathway and that Zn(2+) regulation is important for maintaining the inactive state of the Ras pathway...
  20. pmc Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates
    Virginia Hsu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genetics 160:481-92. 2002
    ..elegans development...
  21. ncbi request reprint Identification of residues and domains of Raf important for function in vivo and in vitro
    Angus Harding
    Institute for Molecular Bioscience and Department of Molecular and Cellular Pathology, University of Queensland, Brisbane 4072, Australia
    J Biol Chem 278:45519-27. 2003
    ..elegans phenotype...
  22. ncbi request reprint Identification of cis-regulatory elements from the C. elegans Hox gene lin-39 required for embryonic expression and for regulation by the transcription factors LIN-1, LIN-31 and LIN-39
    Javier A Wagmaister
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Dev Biol 297:550-65. 2006
    ..p. Therefore, we have begun to unravel the cis-acting sites regulating lin-39 Hox gene expression and have shown that lin-39 is a direct target of the Ras pathway acting via LIN-1 and LIN-31...