M H Kollef

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi An institutional perspective on the impact of recent antibiotic exposure on length of stay and hospital costs for patients with gram-negative sepsis
    Scott Micek
    Pharmacy Department, Barnes Jewish Hospital, St Louis, Missouri, USA
    BMC Infect Dis 12:56. 2012
  2. ncbi Non-invasive stroke volume measurement and passive leg raising predict volume responsiveness in medical ICU patients: an observational cohort study
    Steven W Thiel
    Pulmonary and Critical Care Division, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St, Louis, MO 63110, USA
    Crit Care 13:R111. 2009
  3. ncbi Morbidity and cost burden of methicillin-resistant Staphylococcus aureus in early onset ventilator-associated pneumonia
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Washington Hospital Center, Washington, District of Columbia, USA
    Crit Care 10:R97. 2006
  4. ncbi What is ventilator-associated pneumonia and why is it important?
    Marin H Kollef
    Pulmonary and Critical Care Division, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Respir Care 50:714-21; discussion 721-4. 2005
  5. ncbi The intensive care unit as a research laboratory: developing strategies to prevent antimicrobial resistance
    Marin H Kollef
    Pulmonary and Critical Care Division, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Surg Infect (Larchmt) 7:85-99. 2006
  6. ncbi Is antibiotic cycling the answer to preventing the emergence of bacterial resistance in the intensive care unit?
    Marin H Kollef
    Department of Internal Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri, USA
    Clin Infect Dis 43:S82-8. 2006
  7. ncbi Methicillin-resistant Staphylococcus aureus: a new community-acquired pathogen?
    Marin H Kollef
    Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Opin Infect Dis 19:161-8. 2006
  8. ncbi Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia
    Marin H Kollef
    Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Chest 128:3854-62. 2005
  9. ncbi Antibiotic management of ventilator-associated pneumonia due to antibiotic-resistant gram-positive bacterial infection
    M H Kollef
    Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Eur J Clin Microbiol Infect Dis 24:794-803. 2005
  10. ncbi Bench-to-bedside review: antimicrobial utilization strategies aimed at preventing the emergence of bacterial resistance in the intensive care unit
    Marin H Kollef
    Department of Internal Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine, St Louis, Missouri, USA
    Crit Care 9:459-64. 2005

Detail Information

Publications101 found, 100 shown here

  1. ncbi An institutional perspective on the impact of recent antibiotic exposure on length of stay and hospital costs for patients with gram-negative sepsis
    Scott Micek
    Pharmacy Department, Barnes Jewish Hospital, St Louis, Missouri, USA
    BMC Infect Dis 12:56. 2012
    ..The influence of prior antibiotic exposure on hospital length of stay (LOS) and costs in patients with severe sepsis or septic shock attributed to Gram-negative bacteremia has not been previously examined...
  2. ncbi Non-invasive stroke volume measurement and passive leg raising predict volume responsiveness in medical ICU patients: an observational cohort study
    Steven W Thiel
    Pulmonary and Critical Care Division, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St, Louis, MO 63110, USA
    Crit Care 13:R111. 2009
    ..Passive leg raising (PLR) represents an endogenous volume challenge that can be used to predict fluid responsiveness...
  3. ncbi Morbidity and cost burden of methicillin-resistant Staphylococcus aureus in early onset ventilator-associated pneumonia
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Washington Hospital Center, Washington, District of Columbia, USA
    Crit Care 10:R97. 2006
    ....
  4. ncbi What is ventilator-associated pneumonia and why is it important?
    Marin H Kollef
    Pulmonary and Critical Care Division, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Respir Care 50:714-21; discussion 721-4. 2005
    ..Additionally, clinical strategies aimed at the prevention of HAP and VAP should be employed in all hospital settings caring for patients at risk for these infections...
  5. ncbi The intensive care unit as a research laboratory: developing strategies to prevent antimicrobial resistance
    Marin H Kollef
    Pulmonary and Critical Care Division, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Surg Infect (Larchmt) 7:85-99. 2006
    ..To assemble the available clinical data on the prevention of antimicrobial resistance in the intensive care unit (ICU) setting...
  6. ncbi Is antibiotic cycling the answer to preventing the emergence of bacterial resistance in the intensive care unit?
    Marin H Kollef
    Department of Internal Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri, USA
    Clin Infect Dis 43:S82-8. 2006
    ..e., antibiotic heterogeneity) can be part of a broader effort aimed at curtailing antibiotic resistance within ICUs. Such efforts should be routine, given the limited availability of new antibiotic drug classes for the foreseeable future...
  7. ncbi Methicillin-resistant Staphylococcus aureus: a new community-acquired pathogen?
    Marin H Kollef
    Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Opin Infect Dis 19:161-8. 2006
    ..The main goal of this review is to describe the emergence of methicillin-resistant Staphylococcus aureus (MRSA) as a community pathogen...
  8. ncbi Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia
    Marin H Kollef
    Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Chest 128:3854-62. 2005
    ..Accumulating evidence suggests that health-care-associated infections are distinct from those that are truly community acquired...
  9. ncbi Antibiotic management of ventilator-associated pneumonia due to antibiotic-resistant gram-positive bacterial infection
    M H Kollef
    Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Eur J Clin Microbiol Infect Dis 24:794-803. 2005
    ..Studies are needed to define the optimal choice of antibiotic for pneumonias caused by this organism, and these choices will need to be balanced with the need to minimize the emergence of resistance...
  10. ncbi Bench-to-bedside review: antimicrobial utilization strategies aimed at preventing the emergence of bacterial resistance in the intensive care unit
    Marin H Kollef
    Department of Internal Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine, St Louis, Missouri, USA
    Crit Care 9:459-64. 2005
    ..The importance of preventing antimicrobial resistance is magnified by the limited availability of new antimicrobial drug classes for the foreseeable future...
  11. ncbi Antibiotic utilization and outcomes for patients with clinically suspected ventilator-associated pneumonia and negative quantitative BAL culture results
    Marin H Kollef
    Pulmonary and Critical Care Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid, St Louis, MO 63110, USA
    Chest 128:2706-13. 2005
    ..To evaluate antibiotic utilization and clinical outcomes among patients with clinically suspected ventilator-associated pneumonia (VAP) and culture-negative BAL (CNBAL)...
  12. ncbi Bugging the bugs: novel approaches in the strategic management of resistant Staphylococcus aureus infections
    Marin H Kollef
    Medical Intensive Care Unit and Respiratory Care Services, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine and Barnes-Jewish Hospital, St. Louis, MO 63110, USA
    Clin Infect Dis 45:S163-4. 2007
  13. ncbi Limitations of vancomycin in the management of resistant staphylococcal infections
    Marin H Kollef
    Medical Intensive Care Unit and Respiratory Care Services, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, MO 63110, USA
    Clin Infect Dis 45:S191-5. 2007
    ..Because of these problems, when using vancomycin, it is probably prudent to carefully establish the diagnosis, test for antimicrobial susceptibility, and monitor serum trough concentrations to ensure adequate dosing...
  14. ncbi Clinical characteristics and treatment patterns among patients with ventilator-associated pneumonia
    Marin H Kollef
    Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Chest 129:1210-8. 2006
    ..To evaluate clinical characteristics and treatment patterns among patients with ventilator-associated pneumonia (VAP), including the implementation of and outcomes associated with deescalation therapy...
  15. ncbi Appropriate empiric antimicrobial therapy of nosocomial pneumonia: the role of the carbapenems
    Marin H Kollef
    Department of Internal Medicine, Pulmonary Critical Care Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis MO 63110, USA
    Respir Care 49:1530-41. 2004
    ..The carbapenems are active against both Gram-positive and Gram-negative pathogens, including anaerobes; resistance to carbapenems remains rare...
  16. ncbi Review of recent clinical trials of hospital-acquired pneumonia and ventilator-associated pneumonia: a perspective from academia
    Marin H Kollef
    Virginia E and Sam J Golman Chair in Respiratory Intensive Care, Pulmonary and Critical Care Division, Washington University School of Medicine, and Medical Critical Care and Respiratory Care Services, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Clin Infect Dis 51:S29-35. 2010
    ....
  17. ncbi Gram-negative bacterial resistance: evolving patterns and treatment paradigms
    Marin H Kollef
    Pulmonary and Critical Care Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Infect Dis 40:S85-8. 2005
    ....
  18. ncbi New antimicrobial agents for methicillin-resistant Staphylococcus aureus
    Marin H Kollef
    Washington University School of Medicine, St Louis, MI, USA
    Crit Care Resusc 11:282-6. 2009
    ..These include the fifth-generation cephalosporins, ceftaroline and ceftobiprole; the glycopeptides, dalbavancin, oritavancin, and telavancin; and iclaprim...
  19. ncbi Health care-associated infection (HAI): a critical appraisal of the emerging threat-proceedings of the HAI Summit
    Marin H Kollef
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Infect Dis 47:S55-99; quiz S100-1. 2008
    ....
  20. ncbi Silver-coated endotracheal tubes and incidence of ventilator-associated pneumonia: the NASCENT randomized trial
    Marin H Kollef
    Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    JAMA 300:805-13. 2008
    ..Ventilator-associated pneumonia (VAP) causes substantial morbidity. A silver-coated endotracheal tube has been designed to reduce VAP incidence by preventing bacterial colonization and biofilm formation...
  21. ncbi Broad-spectrum antimicrobials and the treatment of serious bacterial infections: getting it right up front
    Marin H Kollef
    Washington University School of Medicine and Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Clin Infect Dis 47:S3-13. 2008
    ..Improved clinical and economic outcomes after such an approach have been demonstrated...
  22. ncbi SMART approaches for reducing nosocomial infections in the ICU
    Marin Kollef
    Washington University School of Medicine, MO 63110, USA
    Chest 134:447-56. 2008
    ..Make objectives time bound; set dates for collecting baseline and periodic data, and a completion date for evaluating the success of the intervention...
  23. ncbi A randomized double-blind trial of iseganan in prevention of ventilator-associated pneumonia
    Marin Kollef
    Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8052, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 173:91-7. 2006
    ..The drug has shown little resistance in vitro and to be safe and well tolerated in 800 patients with cancer treated for up to 6 wk...
  24. ncbi The impact of nosocomial infections on patient outcomes following cardiac surgery
    M H Kollef
    Department of Internal Medicine, Pulmonary and Critical Care, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 112:666-75. 1997
    ..To evaluate the relationship between nosocomial infections and clinical outcomes following cardiac surgery, and to identify risk factors for the development of nosocomial infections in this patient population...
  25. ncbi The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumonia
    M H Kollef
    Department of Internal Medicine, Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 113:412-20. 1998
    ..To determine the influence of mini-BAL culture results on subsequent changes in antibiotic therapy and patient outcomes...
  26. ncbi Hospital mortality for patients with bacteremia due to Staphylococcus aureus or Pseudomonas aeruginosa
    Stephen Osmon
    Pulmonary and Critical Care Division, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
    Chest 125:607-16. 2004
    ..CONCLUSIONS: These data suggest that bloodstream infections due to P aeruginosa have a greater risk of hospital mortality compared to bloodstream infections due to S aureus despite adequate antibiotic treatment...
  27. ncbi Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients
    M H Kollef
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Chest 115:462-74. 1999
    ..To evaluate the relationship between inadequate antimicrobial treatment of infections (both community-acquired and nosocomial infections) and hospital mortality for patients requiring ICU admission...
  28. ncbi Empiric combination antibiotic therapy is associated with improved outcome against sepsis due to Gram-negative bacteria: a retrospective analysis
    Scott T Micek
    Pharmacy Department, Barnes Jewish Hospital, St Louis, Missouri, USA
    Antimicrob Agents Chemother 54:1742-8. 2010
    ..Our experience suggests that aminoglycosides offer broader coverage than fluoroquinolones as combination agents for patients with this serious infection...
  29. ncbi Experience with a clinical guideline for the treatment of ventilator-associated pneumonia
    E H Ibrahim
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA
    Crit Care Med 29:1109-15. 2001
    ..These findings suggest that similar types of guidelines employing local microbiological data can be used to improve overall antibiotic utilization for the treatment of ventilator-associated pneumonia...
  30. ncbi Antibiotic resistance in the intensive care unit
    M H Kollef
    Campus Box 8052, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Ann Intern Med 134:298-314. 2001
    ..Careful, focused attention to this problem at the local ICU level, using a multidisciplinary approach, will have the greatest likelihood of limiting the development and dissemination of antibiotic-resistant infections...
  31. ncbi Predictors of mortality for methicillin-resistant Staphylococcus aureus health-care-associated pneumonia: specific evaluation of vancomycin pharmacokinetic indices
    Meghan N Jeffres
    Department of Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, USA
    Chest 130:947-55. 2006
    ..Based on these results, aggressive dosing strategies for vancomycin (eg, trough concentrations of > 15 microg/mL) may not offer any advantage over traditional dose targets (range, 5 to 15 microg/mL)...
  32. ncbi Analysis of 30-day mortality for clostridium difficile-associated disease in the ICU setting
    Claire Kenneally
    Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8052, St Louis, MO 63110, USA
    Chest 132:418-24. 2007
    ..To examine the 30-day mortality rate among patients with Clostridium difficile-associated disease (CDAD) requiring intensive care...
  33. ncbi Endotracheal tube intraluminal volume loss among mechanically ventilated patients
    Chirag Shah
    Pulmonary and Critical Care Division, Washington University School of Medicine, St. Louis, MO 63110, USA
    Crit Care Med 32:120-5. 2004
    ..5 +/- 0.4 vs. 6.7 +/- 1.2 mm, p <.001). CONCLUSIONS: Endotracheal tube intraluminal volume loss is common among patients with acute respiratory failure requiring mechanical ventilation and increases with prolonged tracheal intubation...
  34. ncbi A comparison of culture-positive and culture-negative health-care-associated pneumonia
    Andrew J Labelle
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8052, St Louis, MO 63110, USA
    Chest 137:1130-7. 2010
    ..The aim of this study is to describe the initial antibiotic treatment regimens, severity of illness, and in-hospital mortality among culture-negative (CN) and culture-positive (CP) patients with health-care-associated pneumonia (HCAP)...
  35. ncbi Methicillin-resistant Staphylococcus aureus sterile-site infection: The importance of appropriate initial antimicrobial treatment
    Garrett E Schramm
    Critical Care Specialty Resident, Barnes-Jewish Hospital, St. Louis, MO, USA
    Crit Care Med 34:2069-74. 2006
    ....
  36. ncbi Opinion: the clinical use of selective digestive decontamination
    M H Kollef
    Pulmonary and Critical Care Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Crit Care 4:327-32. 2000
    ..Prolonged decontamination of the aerodigestive tract with topical antimicrobials does not appear to influence outcome, and should not be routinely employed...
  37. ncbi Acute respiratory failure: a gender-based outcomes analysis
    M H Kollef
    Pulmonary and Critical Care Division, Washington University School of Medicine, Campus Box 8052, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Gend Specif Med 1:24-30. 1998
    ..To determine the influence of gender on patient outcomes and the delivery of medical care during mechanical ventilation for acute respiratory failure...
  38. ncbi The influence of infection on hospital mortality for patients requiring > 48 h of intensive care
    Steven Osmon
    Pulmonary and Critical Care Division, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
    Chest 124:1021-9. 2003
    ....
  39. ncbi Occurrence of co-colonization or co-infection with vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus in a medical intensive care unit
    David K Warren
    Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Infect Control Hosp Epidemiol 25:99-104. 2004
    ..The recent emergence of vancomycin-resistant Staphylococcus aureus and the presence of a patient population co-colonized or co-infected with VRE and MRSA support the need for aggressive infection control measures in the ICU...
  40. ncbi Ventilator-associated pneumonia in a multi-hospital system: differences in microbiology by location
    Hilary M Babcock
    Division of Infectious Diseases, Washington University School of Medicine, USA
    Infect Control Hosp Epidemiol 24:853-8. 2003
    ..CONCLUSIONS: Microbiologic etiologies of ventilator-associated pneumonia vary between and within hospitals. Knowledge of these differences can improve selection of initial antimicrobial regimens, which may decrease mortality...
  41. ncbi Clinical utility of blood cultures drawn from central vein catheters and peripheral venipuncture in critically ill medical patients
    Michelle Beutz
    Pulmonary and Critical Care Division, Washington University School of Medicine, St. Louis 63110, USA
    Chest 123:854-61. 2003
    ..Clinicians should also be aware that additional blood samples may be necessary when interpreting positive blood culture results for common skin or central vein catheter contaminants...
  42. ncbi Health care-associated pneumonia and community-acquired pneumonia: a single-center experience
    Scott T Micek
    Department of Pharmacy, Barnes Jewish Hospital, St Louis, MO, USA
    Antimicrob Agents Chemother 51:3568-73. 2007
    ..Health care providers should differentiate patients with HCAP from those with CAP in order to provide more appropriate initial antimicrobial therapy...
  43. ncbi Before-after study of a standardized hospital order set for the management of septic shock
    Scott T Micek
    Department of Pharmacy, Barnes-Jewish Hospital, St Louis, MO, USA
    Crit Care Med 34:2707-13. 2006
    ..These data suggest that the use of standardized order sets for the management of septic shock should be routinely employed...
  44. ncbi A retrospective analysis of possible renal toxicity associated with vancomycin in patients with health care-associated methicillin-resistant Staphylococcus aureus pneumonia
    Meghan N Jeffres
    Department of Pharmacy, Barnes Jewish Hospital, St Louis, Missouri, USA
    Clin Ther 29:1107-15. 2007
    ....
  45. ncbi The modified APACHE II score outperforms Curb65 pneumonia severity score as a predictor of 30-day mortality in patients with methicillin-resistant Staphylococcus aureus pneumonia
    Katherine E Kollef
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Chest 133:363-9. 2008
    ....
  46. ncbi Optimizing therapy for MRSA pneumonia
    Lee P Skrupky
    Department of Pharmacy, Barnes Jewish Hospital, 216 S Kingshighway Boulevard, St Louis, MO 63110, USA
    Semin Respir Crit Care Med 28:615-23. 2007
    ..Other treatment options are limited, but new prospects are being investigated. This paper reviews the epidemiology and pharmacotherapy of MRSA pneumonia...
  47. ncbi The effect of an education program on the incidence of central venous catheter-associated bloodstream infection in a medical ICU
    David K Warren
    Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8052, St. Louis, MO 63110, USA
    Chest 126:1612-8. 2004
    ..Education programs may lead to a substantial decrease in medical-care costs and patient morbidity attributed to central venous catheterization when implemented as part of mandatory training...
  48. ncbi Pseudomonas aeruginosa bloodstream infection: importance of appropriate initial antimicrobial treatment
    Scott T Micek
    Department of Pharmacy, Barnes-Jewish Hospital, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8052, St. Louis, Missouri 63110, USA
    Antimicrob Agents Chemother 49:1306-11. 2005
    ..aeruginosa bloodstream infection. Inappropriate antimicrobial treatment of P. aeruginosa bloodstream infections may be minimized by increased use of combination antimicrobial treatment until susceptibility results become known...
  49. ncbi Effect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia
    Jeanne E Zack
    Department of Hospital Epidemiology, Barnes-Jewish Hospital, St. Louis, MO, USA
    Crit Care Med 30:2407-12. 2002
    ..Education programs should be more widely employed for infection control in the intensive care unit setting and can lead to substantial decreases in cost and patient morbidity attributed to hospital-acquired infections...
  50. ncbi Is there a role for antibiotic cycling in the intensive care unit?
    M H Kollef
    Department of Internal Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 29:N135-42. 2001
    ..The main goal of cycling is to allow resistance rates for specific antibiotics to decrease, or at least remain stable, when their use is periodically eliminated from the intensive care unit...
  51. ncbi Optimizing antibiotic therapy in the intensive care unit setting
    M H Kollef
    Department of Internal Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine, Barnes Jewish Hospital, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Crit Care 5:189-95. 2001
    ..Only in this way can the impact of interventions aimed at improving antibiotic use (e.g. antibiotic rotation, de-escalation therapy) be evaluated at the local level...
  52. ncbi Inadequate antimicrobial treatment: an important determinant of outcome for hospitalized patients
    M H Kollef
    Department of Internal Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Infect Dis 31:S131-8. 2000
    ..Further study evaluating the use of antibiotic practice guidelines and strategies to reduce inadequate treatment is necessary to determine their impact on patient outcomes...
  53. ncbi Epidemiology and risk factors for nosocomial pneumonia. Emphasis on prevention
    M H Kollef
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Clin Chest Med 20:653-70. 1999
    ..To be successful, such quality improvement programs must be embraced at the institutional level. Only in this way can hospitals hope to successfully reduce their rates of VAP and sustain or improve upon those efforts over time...
  54. ncbi Methicillin-resistant Staphylococcus aureus nasal colonization is a poor predictor of intensive care unit-acquired methicillin-resistant Staphylococcus aureus infections requiring antibiotic treatment
    Kiran V Sarikonda
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 38:1991-5. 2010
    ..To test whether intensive care unit (ICU) nasal screening for methicillin-resistant Staphylococcus aureus (MRSA) predicts the presence or absence of MRSA infections requiring antimicrobial treatment...
  55. ncbi Predictors of in-hospital mortality for bloodstream infections caused by Enterobacter species or Citrobacter freundii
    Eli N Deal
    Department of Pharmacy, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Pharmacotherapy 27:191-9. 2007
    ..To identify predictors of in-hospital mortality among patients with bacteremia caused by Enterobacter cloacae, Enterobacter aerogenes, or Citrobacter freundii...
  56. ncbi Increasing incidence of sterile-site infections due to non-multidrug-resistant, oxacillin-resistant Staphylococcus aureus among hospitalized patients
    Garrett E Schramm
    Department of Pharmacy, Barnes Jewish Hospital, St Louis, MO 63110, USA
    Infect Control Hosp Epidemiol 28:95-7. 2007
    ..The annual percentage of MRSA isolates from cases of healthcare-associated and hospital-acquired infection that were susceptible to 3 or more non- beta -lactam antibiotics increased significantly...
  57. ncbi Prevention of hospital infection
    David K Warren
    Division of Infectious Diseases, Washington University School of Medicine, Saint Louis, MO, USA
    Microbes Infect 7:268-74. 2005
    ..These infection-control policies also require the presence of a dedicated group of infection-control practitioners to provide education, collect surveillance data, and oversee the implementation of the local infection-control plan...
  58. ncbi Predictors of 30-day mortality and hospital costs in patients with ventilator-associated pneumonia attributed to potentially antibiotic-resistant gram-negative bacteria
    Katherine E Kollef
    Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 134:281-7. 2008
    ....
  59. ncbi The occurrence of ventilator-associated pneumonia in a community hospital: risk factors and clinical outcomes
    E H Ibrahim
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Washington University School of Medicine, Barnes-Jewish Hospital, Saint Louis, MO 63110, USA
    Chest 120:555-61. 2001
    ..More importantly, they should cooperate in the development of local multidisciplinary strategies aimed at the prevention of VAP and other nosocomial infections...
  60. ncbi A randomized clinical trial of continuous aspiration of subglottic secretions in cardiac surgery patients
    M H Kollef
    Department of Internal Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine, St Louis, MO, USA
    Chest 116:1339-46. 1999
    ..To determine whether the application of continuous aspiration of subglottic secretions (CASS) is associated with a decreased incidence of ventilator-associated pneumonia (VAP)...
  61. ncbi Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia
    Manuel Iregui
    Pulmonary and Critical Care Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
    Chest 122:262-8. 2002
    ..Clinicians should avoid delaying the administration of appropriate antibiotic treatment to patients with VAP in order to minimize their risk of mortality...
  62. ncbi Selective digestive decontamination should not be routinely employed
    Marin H Kollef
    Pulmonary and Critical Care Division, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, MO 63110, USA
    Chest 123:464S-8S. 2003
    ..Unfortunately, the application of SDD has been associated with emergence of antibiotic-resistant bacterial strains, limiting its overall utility...
  63. ncbi The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections
    James A Driscoll
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA
    Drugs 67:351-68. 2007
    ..Multidrug-resistant P. aeruginosa may require treatment with less commonly used antibacterials (e.g. colistin), but newer anti-pseudomonal antibacterials are expected to be available in the near future...
  64. ncbi Methicillin-resistant Staphylococcus aureus prolongs intensive care unit stay in ventilator-associated pneumonia, despite initially appropriate antibiotic therapy
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Crit Care Med 34:700-6. 2006
    ..Confronting the adverse impact of MRSA will require efforts that address more than the initial antibiotic prescription...
  65. ncbi The importance of early treatment with doxycycline in human ehrlichiosis
    Brian J Hamburg
    Division of Pulmonary and Critical Care Medicine, Barnes Jewish Hospital, St Louis, Missouri, USA
    Medicine (Baltimore) 87:53-60. 2008
    ..7 d, respectively; p = 0.001). These data suggest that clinicians living in an area where Ehrlichia is endemic should have a high suspicion for ehrlichiosis, and a low threshold for instituting empiric antibiotic therapy with doxycycline...
  66. ncbi Optimizing antibiotic treatment for ventilator-associated pneumonia
    Scott T Micek
    Department of Pharmacy, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Pharmacotherapy 26:204-13. 2006
    ....
  67. ncbi The epidemiology of vancomycin-resistant Enterococcus colonization in a medical intensive care unit
    David K Warren
    Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Infect Control Hosp Epidemiol 24:257-63. 2003
    ..This was likely due in large part to prior VRE exposures in the rest of the hospital where these control measures were not being used...
  68. ncbi Association between a silver-coated endotracheal tube and reduced mortality in patients with ventilator-associated pneumonia
    Bekele Afessa
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55905 0001, USA
    Chest 137:1015-21. 2010
    ..A silver-coated endotracheal tube (ETT) reduced the incidence of ventilator-associated pneumonia (VAP) compared with an uncoated ETT in the North American Silver-Coated Endotracheal Tube (NASCENT) study...
  69. ncbi Determinants of outcome for patients admitted to a long-term ventilator unit
    Manuel Iregui
    Pulmonary and Critical Care Division, Washington University School of Medicine, St. Louis, MO 63110, USA
    South Med J 95:310-7. 2002
    ....
  70. ncbi Antimicrobial stewardship in the intensive care unit: advances and obstacles
    Kevin L Lawrence
    Department of Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    Am J Respir Crit Care Med 179:434-8. 2009
    ..Clinicians should realize that antimicrobials are important therapeutic agents and strive to use them wisely...
  71. ncbi Effects of an antibiotic cycling program on antibiotic prescribing practices in an intensive care unit
    Liana R Merz
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Antimicrob Agents Chemother 48:2861-5. 2004
    ..In conclusion, the successful implementation of this cycling protocol increased antibiotic heterogeneity over time in the study unit...
  72. ncbi Cycling empirical antimicrobial agents to prevent emergence of antimicrobial-resistant Gram-negative bacteria among intensive care unit patients
    David K Warren
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 32:2450-6. 2004
    ..To determine the impact of the rotation of antimicrobial agents on the rates of infection, intestinal colonization, and acquisition with antimicrobial-resistant Gram-negative bacteria...
  73. ncbi Staphylococcus aureus nasal colonization and subsequent infection in intensive care unit patients: does methicillin resistance matter?
    Hitoshi Honda
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Control Hosp Epidemiol 31:584-91. 2010
    ..aureus infection. However, MRSA-colonized patients may have more comorbidities than methicillin-susceptible S. aureus (MSSA)-colonized or noncolonized patients and therefore may be more susceptible to infection on that basis...
  74. ncbi Bacteremia increases the risk of death among patients with soft-tissue infections
    Scott T Micek
    Department of Pharmacy, Barnes Jewish Hospital, St Louis, Missouri, USA
    Surg Infect (Larchmt) 11:169-76. 2010
    ..The influence of secondary bacteremia on the outcomes of patients with soft-tissue infections is not well described...
  75. ncbi Outcome and attributable cost of ventilator-associated pneumonia among intensive care unit patients in a suburban medical center
    David K Warren
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 31:1312-7. 2003
    ..To determine the attributable cost of ventilator-associated pneumonia from a hospital-based cost perspective, after adjusting for potential confounders...
  76. ncbi The management of severe sepsis and septic shock
    Matthew R Morrell
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Barnes Jewish Hospital, 660 South Euclid Avenue, Campus Box 8052, St Louis, MO 63110, USA
    Infect Dis Clin North Am 23:485-501. 2009
    ....
  77. ncbi Strategies to prevent antimicrobial resistance in the intensive care unit
    Marin H Kollef
    Department of Internal Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 33:1845-53. 2005
    ..To assemble the available clinical data for the prevention of antimicrobial resistance into practical recommendations for clinicians...
  78. ncbi Using protocols to improve patient outcomes in the intensive care unit: focus on mechanical ventilation and sepsis
    Marin H Kollef
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Semin Respir Crit Care Med 31:19-30. 2010
    ..This review focuses on the use of protocols in the ICU setting and how they can best be utilized to improve patient outcomes...
  79. ncbi Prevention of pneumonia in the hospital setting
    Stephen B Osmon
    Pulmonary and Critical Care Division, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St. Louis, MO 63110, USA
    Clin Chest Med 26:135-42. 2005
    ..Given the evidence supporting greater morbidity, hospital mortality, and medical care costs among patients who have VAP, the prevention of this nosocomial infection should be an important priority in the hospital setting...
  80. ncbi An educational intervention to reduce ventilator-associated pneumonia in an integrated health system: a comparison of effects
    Hilary M Babcock
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, MO, USA
    Chest 125:2224-31. 2004
    ..To determine whether an educational initiative could decrease rates of ventilator-associated pneumonia in a regional health-care system...
  81. ncbi Deep vein thrombosis during prolonged mechanical ventilation despite prophylaxis
    Emad H Ibrahim
    Pulmonary and Critical Care Division, Washington University School of Medicine, St. Louis, MO, USA
    Crit Care Med 30:771-4. 2002
    ..Additionally, early detection methods should be considered to reduce the potential morbidity associated with untreated DVT in this high-risk population...
  82. ncbi The effect of respiratory therapist-initiated treatment protocols on patient outcomes and resource utilization
    M H Kollef
    Department of Internal Medicine, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, MO 63110, USA
    Chest 117:467-75. 2000
    ..Physicians frequently prescribe respiratory treatments to hospitalized patients, but the influence of such treatments on clinical outcomes is difficult to assess...
  83. ncbi The impact of the introduction of a rapid D-dimer assay on the diagnostic evaluation of suspected pulmonary embolism
    N M Goldstein
    Campus Box 8052, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Arch Intern Med 161:567-71. 2001
    ..Although this hypothesis is anticipated to decrease the use of ventilation-perfusion (VQ) scans and other diagnostic tests for PE, it has not been tested in a "real-world" environment...
  84. ncbi Using protocols to improve the outcomes of mechanically ventilated patients. Focus on weaning and sedation
    E H Ibrahim
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, Barnes-Jewish Hospital, Saint Louis, Missouri, USA
    Crit Care Clin 17:989-1001. 2001
    ..Protocols are one method for potentially reducing those delays and ensuring that medical care is administered in a more standardized and efficient manner...
  85. ncbi Providing appropriate antimicrobial therapy in the intensive care unit: surveillance vs. de-escalation
    Marin H Kollef
    Crit Care Med 34:903-5. 2006
  86. ncbi An empirical approach to the treatment of multidrug-resistant ventilator-associated pneumonia
    Marin H Kollef
    Clin Infect Dis 36:1119-21. 2003
  87. ncbi Treatment of ventilator-associated pneumonia: get it right from the start
    Marin H Kollef
    Crit Care Med 31:969-70. 2003
  88. ncbi Ventilator-associated pneumonia: insights from recent clinical trials
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC, USA
    Chest 128:583S-591S. 2005
    ..This review highlights selected areas of new clinical research on VAP treatment and prevention in order to place their significance in context...
  89. ncbi Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia
    Richard G Wunderink
    Methodist Healthcare Memphis and the University of Tennessee, Memphis, TN 38104 3499, USA
    Chest 124:1789-97. 2003
    ..To assess the effect of baseline variables, including treatment, on outcome in patients with nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA)...
  90. ncbi Levofloxacin for treatment of ventilator-associated pneumonia: a subgroup analysis from a randomized trial
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Clin Infect Dis 40:S123-9. 2005
    ..imipenem-cilastatin) was not predictive of outcomes, thus suggesting that the treatment regimens were equivalent. Both levofloxacin and imipenem-cilastatin regimens were well tolerated and had similar adverse event profiles...
  91. ncbi Linezolid for treatment of ventilator-associated pneumonia: a cost-effective alternative to vancomycin
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC, USA
    Crit Care Med 32:137-43. 2004
    ..CONCLUSIONS: Linezolid is a cost-effective alternative to vancomycin for the treatment of ventilator-associated pneumonia...
  92. ncbi Time to get serious about infection prevention in the ICU
    Marin H Kollef
    Chest 130:1293-6. 2006
  93. ncbi Antibiotic heterogeneity: should we use it?
    Marin H Kollef
    Crit Care Med 31:2074-6. 2003
  94. ncbi Pneumonia caused by methicillin-resistant Staphylococcus aureus
    Ethan Rubinstein
    University of Manitoba, Winnipeg, Canada
    Clin Infect Dis 46:S378-85. 2008
    ..This article reviews the clinical features of, diagnosis of, and therapies for MRSA pneumonia...
  95. ncbi Healthcare-associated bloodstream infection: A distinct entity? Insights from a large U.S. database
    Andrew F Shorr
    Washington Hospital Center, Washington, DC, USA
    Crit Care Med 34:2588-95. 2006
    ..To gain a better understanding of the epidemiology, microbiology, and outcomes of early-onset, culture-positive, community-acquired, healthcare-associated, and hospital-acquired bloodstream infections...
  96. ncbi Invasive approaches to the diagnosis of ventilator-associated pneumonia: a meta-analysis
    Andrew F Shorr
    Walter Reed Army Medical Center, Washington, DC, USA
    Crit Care Med 33:46-53. 2005
    ..Invasive strategies do not alter mortality. Invasive approaches to ventilator-associated pneumonia affect antibiotic use and prescribing...
  97. ncbi Risk factors for ventilator-associated pneumonia: from epidemiology to patient management
    Marc J M Bonten
    Department of Internal Medicine, Division of Acute Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Infect Dis 38:1141-9. 2004
    ..In settings with high levels of antibiotic resistance, combined approaches of non-antibiotic using strategies and education programs might be most beneficial...
  98. ncbi Red blood cell transfusion and ventilator-associated pneumonia: A potential link?
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC, USA
    Crit Care Med 32:666-74. 2004
    ..To determine the relationship between packed red blood cell transfusion practice and the development of ventilator-associated pneumonia (VAP)...
  99. ncbi Continuation of a randomized, double-blind, multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumonia
    Richard G Wunderink
    Methodist Healthcare Memphis and the University of Tennessee, Memphis, Tennessee 38104 3499, USA
    Clin Ther 25:980-92. 2003
    ....
  100. ncbi Epidemiology and outcomes of ventilator-associated pneumonia in a large US database
    Jordi Rello
    University Hospital Joan XXIII, University Rovira and Virgili, Tarragona, Spain
    Chest 122:2115-21. 2002
    ..While strategies to prevent the occurrence of VAP may not reduce mortality, they may yield other important benefits to patients, their families, and hospital systems...
  101. ncbi Health care-associated pneumonia: identification and initial management in the ED
    Fredrick M Abrahamian
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Emerg Med 26:1-11. 2008
    ..The aim of this article is to create awareness of the entity known as HCAP and to provide knowledge of its identification and initial management in the emergency department...