Samuel Klein

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes
    Bettina Mittendorfer
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 60:1474-7. 2011
  2. ncbi request reprint Waist circumference and cardiometabolic risk: a consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Associat
    Samuel Klein
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes Care 30:1647-52. 2007
  3. ncbi request reprint Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Associat
    Samuel Klein
    Center for Human Nutrition and the Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 85:1197-202. 2007
  4. ncbi request reprint Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Associat
    Samuel Klein
    Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, Saint Louis, Missouri 63110, USA
    Obesity (Silver Spring) 15:1061-7. 2007
  5. pmc Gastric bypass and banding equally improve insulin sensitivity and β cell function
    David Bradley
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 122:4667-74. 2012
  6. pmc Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 95:2727-35. 2010
  7. pmc Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Am J Clin Nutr 84:1033-42. 2006
  8. pmc Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents
    Bernadette E Vitola
    Department of Medicine, Division of Geriatrics and Nutritional Science and Center for Human Nutrition, Washington University, School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 17:1744-8. 2009
  9. ncbi request reprint Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease
    Samuel Klein
    Center for Human Nutrition, Washington University School of Medicine, St Louis 63110, USA
    N Engl J Med 350:2549-57. 2004
  10. ncbi request reprint Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults
    Dennis T Villareal
    Geriatrics and Nutritional Science and the Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63108, USA
    Am J Clin Nutr 84:1317-23. 2006

Research Grants

  1. OBESITY AND NONALCOHOLIC FATTY LIVER DISEASE
    Samuel Klein; Fiscal Year: 2006
  2. OBESITY AND NONALCOHOLIC FATTY LIVER DISEASE
    Samuel Klein; Fiscal Year: 2006
  3. OBESITY AND NONALCOHOLIC FATTY LIVER DISEASE
    Samuel Klein; Fiscal Year: 2005
  4. METABOLICALLY NORMAL AND ABNORMAL OBESITY
    Samuel Klein; Fiscal Year: 2010
  5. ADIPOSE TISSUE METABOLISM IN HAART
    Samuel Klein; Fiscal Year: 2002
  6. ADIPOSE TISSUE METABOLISM IN HAART
    Samuel Klein; Fiscal Year: 2003
  7. ADIPOSE TISSUE METABOLISM IN HAART
    Samuel Klein; Fiscal Year: 2002
  8. THERMOGENESIS AND EXERCISE IN LEAN AND OBESE MAN
    Samuel Klein; Fiscal Year: 2001
  9. ADIPOSE TISSUE METABOLISM IN HAART
    Samuel Klein; Fiscal Year: 2001
  10. THERMOGENESIS AND EXERCISE IN LEAN AND OBESE MAN
    Samuel Klein; Fiscal Year: 2000

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. pmc Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes
    Bettina Mittendorfer
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 60:1474-7. 2011
    ..The purpose of the current study was to determine whether leptin treatment has weight loss-independent effects on insulin action in obese subjects with type 2 diabetes...
  2. ncbi request reprint Waist circumference and cardiometabolic risk: a consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Associat
    Samuel Klein
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes Care 30:1647-52. 2007
  3. ncbi request reprint Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Associat
    Samuel Klein
    Center for Human Nutrition and the Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 85:1197-202. 2007
  4. ncbi request reprint Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Associat
    Samuel Klein
    Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, Saint Louis, Missouri 63110, USA
    Obesity (Silver Spring) 15:1061-7. 2007
  5. pmc Gastric bypass and banding equally improve insulin sensitivity and β cell function
    David Bradley
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 122:4667-74. 2012
    ..We conclude that marked weight loss itself is primarily responsible for the therapeutic effects of RYGB and LAGB on insulin sensitivity, β cell function, and oral glucose tolerance in nondiabetic obese adults...
  6. pmc Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 95:2727-35. 2010
    ....
  7. pmc Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Am J Clin Nutr 84:1033-42. 2006
    ..However, exercise-induced energy expenditure may further improve glucoregulation through mechanisms independent of weight loss...
  8. pmc Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents
    Bernadette E Vitola
    Department of Medicine, Division of Geriatrics and Nutritional Science and Center for Human Nutrition, Washington University, School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 17:1744-8. 2009
    ..These results support the benefits of weight loss therapy in obese adolescents who do not have evidence of obesity-related metabolic complications during a standard medical evaluation...
  9. ncbi request reprint Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease
    Samuel Klein
    Center for Human Nutrition, Washington University School of Medicine, St Louis 63110, USA
    N Engl J Med 350:2549-57. 2004
    ..We evaluated the effect of large-volume abdominal liposuction on metabolic risk factors for coronary heart disease in women with abdominal obesity...
  10. ncbi request reprint Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults
    Dennis T Villareal
    Geriatrics and Nutritional Science and the Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63108, USA
    Am J Clin Nutr 84:1317-23. 2006
    ..Coronary heart disease (CHD) risk factors increase with age and body mass index (BMI; in kg/m2). However, whether lifestyle intervention ameliorates metabolic CHD risk factors in obese older adults is unknown...
  11. ncbi request reprint Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Appl Physiol (1985) 102:634-40. 2007
    ..These findings suggest that, during EX, the body adapts to maintain or even enhance physical performance capacity...
  12. pmc Nonalcoholic fatty liver disease is associated with hepatic and skeletal muscle insulin resistance in overweight adolescents
    Sheela Deivanayagam
    Division of Geriatrics and Nutritional Science and Center for Human Nutrition and the Division of Pediatric Surgery, Washington University, School of Medicine, St Louis, MO, USA
    Am J Clin Nutr 88:257-62. 2008
    ..Nonalcoholic fatty liver disease (NAFLD) and insulin resistance are common in overweight adolescents...
  13. pmc Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults
    Krupa Shah
    Department of Medicine, Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 17:2162-8. 2009
    ..The addition of exercise to diet therapy improves physical function and other obesity- and aging-related metabolic abnormalities...
  14. pmc Multiorgan insulin sensitivity in lean and obese subjects
    Caterina Conte
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes Care 35:1316-21. 2012
    ..To provide a comprehensive assessment of multiorgan insulin sensitivity in lean and obese subjects with normal glucose tolerance...
  15. pmc Blunted lipolysis and fatty acid oxidation during moderate exercise in HIV-infected subjects taking HAART
    W Todd Cade
    Department of Medicine, Washington University School of Medicine, 4444 Forest Park Blvd, St Louis, MO 63108 2212, USA
    Am J Physiol Endocrinol Metab 292:E812-9. 2007
    ..Regional differences in adipose tissue lipolysis during rest and moderate exercise may be important in HIV and warrant further study...
  16. ncbi request reprint What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean?
    Bettina Mittendorfer
    Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 52:1641-8. 2003
    ....
  17. pmc Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:15430-5. 2009
    ..Furthermore, alterations in tissue fatty acid transport could be involved in the pathogenesis of ectopic triglyceride accumulation by redirecting plasma fatty acid uptake from adipose tissue toward other tissues...
  18. pmc Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 17:25-9. 2009
    ..The purpose of this study was to evaluate whether adipose tissue lipolytic activity and the rate of fatty acid release into plasma are increased in obese adolescents with NAFLD...
  19. pmc Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction
    Erik Kirk
    Center for Human Nutrition and Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 136:1552-60. 2009
    ..We determined the effects of acute and chronic calorie restriction with either a low-fat, high-carbohydrate (HC) diet or a low-carbohydrate (LC) diet on hepatic and skeletal muscle insulin sensitivity...
  20. pmc Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Gastroenterology 139:448-55. 2010
    ..Therefore, a reduction in VAT is considered an important target of obesity therapy. We evaluated whether reducing VAT mass by surgical removal of the omentum improves insulin sensitivity and metabolic function in obese patients...
  21. pmc Effect of moderate diet-induced weight loss and weight regain on cardiovascular structure and function
    Lisa De Las Fuentes
    Cardiovascular Imaging and Clinical Research Core Laboratory, Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri, USA
    J Am Coll Cardiol 54:2376-81. 2009
    ..The objective of this prospective, single-site, 2-year dietary intervention study was to evaluate the effects of moderate weight reduction and subsequent partial weight regain on cardiovascular structure and function...
  22. pmc Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production
    Luigi Fontana
    Washington University School of Medicine, St Louis, MO 63110, USA
    Age (Dordr) 32:97-108. 2010
    ..This impaired glucose tolerance is associated with lower circulating levels of IGF-1, total testosterone, and triiodothyronine, which are typical adaptations to life-extending CR in rodents...
  23. pmc Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Gastroenterology 134:424-31. 2008
    ..The purpose of this study was to evaluate TG metabolism in adipose tissue and liver in NAFLD...
  24. pmc Estrogen deficiency after menopause does not result in male very-low-density lipoprotein metabolism phenotype
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Endocrinol Metab 95:3377-84. 2010
    ..The mechanisms responsible for this are unclear but are thought to be related to differences in the sex hormone milieu in men and women...
  25. pmc Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects
    Kevin M Korenblat
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Gastroenterology 134:1369-75. 2008
    ....
  26. pmc Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women
    Marleen Kars
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 59:1899-905. 2010
    ..The purpose of this study was to determine the effect of TUDCA therapy on multiorgan insulin action and metabolic factors associated with insulin resistance in obese men and women...
  27. pmc Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 145:366-74.e1-3. 2013
    ..Insulin sensitivity was determined by using the hyperinsulinemic euglycemic clamp procedure...
  28. ncbi request reprint Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 293:E197-202. 2007
    ..Data from the present study provide evidence that CR- and EX-induced negative energy balance result in substantial and similar improvements in the major risk factors for CHD in normal-weight and overweight middle-aged adults...
  29. pmc Myocardial oxygen consumption change predicts left ventricular relaxation improvement in obese humans after weight loss
    C Huie Lin
    Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 19:1804-12. 2011
    ..Decreased total MVO2 independently predicted improved LV relaxation, suggesting that myocardial oxygen metabolism may be mechanistically important in determining cardiac relaxation...
  30. pmc Relationship between adipose tissue lipolytic activity and skeletal muscle insulin resistance in nondiabetic women
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 97:E1219-23. 2012
    ..Increased adipose tissue lipolytic activity is considered an important factor in the pathogenesis of skeletal muscle insulin resistance associated with obesity...
  31. ncbi request reprint Effect of sex and obesity on basal VLDL-triacylglycerol kinetics
    Bettina Mittendorfer
    Center for Human Nutrition and the Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 77:573-9. 2003
    ..Plasma fatty acid availability is a major regulator of VLDL-triacylglycerol production. Basal whole-body lipolysis is higher in women than in men and is higher in persons with abdominal obesity than in lean individuals...
  32. pmc Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism
    Faidon Magkos
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 62:2757-61. 2013
    ..Plasma BCAA concentration is negatively associated with skeletal muscle insulin sensitivity, but the mechanism(s) responsible for this relationship is not known...
  33. pmc Weight loss therapy improves pancreatic endocrine function in obese older adults
    Dennis T Villareal
    Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 16:1349-54. 2008
    ..Obesity and aging increase the risk of type 2 diabetes (T2D). We evaluated whether weight loss therapy improves pancreatic endocrine function and insulin sensitivity in obese older adults...
  34. pmc Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: a randomized controlled trial
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Rejuvenation Res 11:605-9. 2008
    ..This effect does not appear to be attributable to changes in body fat mass because a comparable decrease in T(3) concentration was not observed in response to an exercise-induced fat mass reduction...
  35. pmc Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance
    Jun Yoshino
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Metab 16:658-64. 2012
    ..These findings demonstrate that resveratrol supplementation does not have beneficial metabolic effects in nonobese, postmenopausal women with normal glucose tolerance...
  36. ncbi request reprint Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk
    Luigi Fontana
    Division of Geriatrics and Nutritional Science and the Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 84:1456-62. 2006
    ..Western diets, obesity, and sedentary lifestyles are associated with increased cancer risk. The mechanisms responsible for this increased risk, however, are not clear...
  37. pmc Relationship between body fat mass and free fatty acid kinetics in men and women
    Bettina Mittendorfer
    Division of Geriatrics and Nutritional Science and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 17:1872-7. 2009
    ....
  38. pmc Long-term effects of large-volume liposuction on metabolic risk factors for coronary heart disease
    B Selma Mohammed
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 16:2648-51. 2008
    ..These data demonstrate that removal of a large amount of abdominal SAT by using liposuction does not improve CHD metabolic risk factors associated with abdominal obesity, despite a long-term reduction in body fat...
  39. ncbi request reprint One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue
    Susan B Racette
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63108 2212, USA
    J Gerontol A Biol Sci Med Sci 61:943-50. 2006
    ..The objectives of this study were to determine the feasibility of prolonged CR in nonobese adults and to compare the effects of CR- and exercise-induced weight loss on body composition and abdominal adiposity...
  40. ncbi request reprint Effect of weight loss on VLDL-triglyceride and apoB-100 kinetics in women with abdominal obesity
    Bettina Mittendorfer
    Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 284:E549-56. 2003
    ..There is a dissociation in the effect of weight loss on VLDL-TG and apoB-100 metabolic pathways that may affect VLDL particle size...
  41. pmc Metabolic and structural effects of phosphatidylcholine and deoxycholate injections on subcutaneous fat: a randomized, controlled trial
    Dominic N Reeds
    Washington University School of Medicine, St Louis, Missouri, USA
    Aesthet Surg J 33:400-8. 2013
    ..Phosphatidylcholine and deoxycholate (PC-DC) injections are a popular nonsurgical method to eliminate unwanted fat. The safety and efficacy of this approach is uncertain...
  42. pmc Validation of a novel index to assess insulin resistance of adipose tissue lipolytic activity in obese subjects
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Lipid Res 53:321-4. 2012
    ..854, P < 0.001). These results demonstrate that the ATIRI provides a reliable index of adipose tissue insulin resistance in obese subjects...
  43. pmc Metabolic response to high-carbohydrate and low-carbohydrate meals in a nonhuman primate model
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 304:E444-51. 2013
    ..These observations demonstrate that LCHF diets cause minimal perturbations in glucose homeostasis and pancreatic β-cell activity...
  44. pmc Alterations in ventricular structure and function in obese adolescents with nonalcoholic fatty liver disease
    Gautam K Singh
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Pediatr 162:1160-8, 1168.e1. 2013
    ..To determine the association among nonalcoholic fatty liver disease (NAFLD), metabolic function, and cardiac function in obese adolescents...
  45. ncbi request reprint Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA
    Rejuvenation Res 10:225-34. 2007
    ..We evaluated the long-term effects of consuming a low-calorie low-protein vegan diet or performing regular endurance exercise on cardiometabolic risk factors...
  46. ncbi request reprint Weight management through lifestyle modification for the prevention and management of type 2 diabetes: rationale and strategies: a statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American So
    Samuel Klein
    Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes Care 27:2067-73. 2004
  47. pmc Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease
    Shelby Sullivan
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Mo Division of Gastroenterology, Washington University School of Medicine, St Louis, MO
    Hepatology 55:1738-45. 2012
    ..7 ± 3.9 μmol/min before and 16.8 ± 5.4 μmol/min after training) or VLDL-apoB-100 secretion rate (1.5 ± 0.5 nmol/min before and 1.6 ± 0.6 nmol/min after training)...
  48. pmc Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction
    Faidon Magkos
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 18:1510-5. 2010
    ..608). We conclude that increased adiposity without a concomitant increase in IHTG content does not cause additional abnormalities in adipose tissue, skeletal muscle, and hepatic insulin sensitivity, or VLDL metabolism...
  49. ncbi request reprint Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial
    Dennis T Villareal
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 166:2502-10. 2006
    ..We tested the hypothesis that EX-induced weight loss is associated with less bone loss compared with CR-induced weight loss...
  50. ncbi request reprint VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of sex and obesity
    Bettina Mittendorfer
    Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 284:E708-15. 2003
    ..Glucose and insulin decrease VLDL-TG production in both lean men and lean women; obesity is associated with resistance to the glucose- and insulin-mediated suppression of VLDL-TG secretion in women, but not in men...
  51. ncbi request reprint Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society
    Dennis T Villareal
    Division of Geriatrics and Nutritional Sciences, Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Obes Res 13:1849-63. 2005
    ..Therefore, weight-loss therapy that minimizes muscle and bone losses is recommended for older persons who are obese and who have functional impairments or medical complications that can benefit from weight loss...
  52. ncbi request reprint Adipose tissue, hepatic, and skeletal muscle insulin sensitivity in extremely obese subjects with acanthosis nigricans
    Dominic N Reeds
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 55:1658-63. 2006
    ..However, marked insulin hypersecretion can compensate for impaired insulin action, resulting in normal glucose and fatty acid metabolism during basal conditions...
  53. pmc Insulin sensitivity is not associated with palmitoleate availability in obese humans
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Lipid Res 52:808-12. 2011
    ..16 ± 0.04 mmol/l and 5.0% ± 0.4%, respectively). These data demonstrate that decreased palmitoleate in plasma and in VLDL is not associated with insulin resistance in skeletal muscle, liver, or adipose tissue in obese people...
  54. ncbi request reprint Effect of weight loss and exercise on frailty in obese older adults
    Dennis T Villareal
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 166:860-6. 2006
    ..However, appropriate treatment for obese older persons is unknown. We evaluated the effects of weight loss and exercise therapy on physical function and body composition in obese older persons...
  55. pmc Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation
    Mayurranjan S Mitra
    Department of Medicine, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 110:642-7. 2013
    ....
  56. ncbi request reprint Excess body fat in men decreases plasma fatty acid availability and oxidation during endurance exercise
    Bettina Mittendorfer
    Center for Human Nutrition and Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 286:E354-62. 2004
    ..However, the rate of total fat oxidation was similar in all groups because of a compensatory increase in the oxidation of nonsystemic fatty acids...
  57. pmc Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 142:1444-6.e2. 2012
    ..609; P = .012), but not with intrahepatic ceramide or acylcarnitine. These data indicate that intrahepatic diacylglycerol is an important mediator of hepatic insulin resistance in obese people with nonalcoholic fatty liver disease...
  58. ncbi request reprint Effect of marked weight loss on adiponectin gene expression and plasma concentrations
    Carrie C Coughlin
    Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Obesity (Silver Spring) 15:640-5. 2007
    ....
  59. ncbi request reprint Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women
    Linda R Peterson
    Department of Medicine, Division of Cardiology, Washington University School of Medicine, Campus Box 8086, 660 S Euclid Ave, St Louis, MO 63110, USA
    Circulation 109:2191-6. 2004
    ..In the present study, we tested the hypothesis that myocardial fatty acid metabolism and efficiency are abnormal in obese women...
  60. pmc Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Aging Cell 7:681-7. 2008
    ....
  61. pmc Ginseng and ginsenoside Re do not improve β-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes
    Dominic N Reeds
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes Care 34:1071-6. 2011
    ..The purpose of this study was to determine whether ginseng or ginsenoside Re improves β-cell function and insulin sensitivity (IS) in insulin-resistant subjects...
  62. pmc Pathogenesis and pathophysiology of the cardiometabolic syndrome
    Erik P Kirk
    Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    J Clin Hypertens (Greenwich) 11:761-5. 2009
    ..In addition, increased free fatty acid delivery to the liver can stimulate hepatic very low-density lipoprotein triglyceride production, leading to dyslipidemia...
  63. pmc Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial
    Dennis T Villareal
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, 4488 Forest Park Boulevard, St Louis, MO 63108, USA
    J Clin Endocrinol Metab 93:2181-7. 2008
    ..Although weight loss and exercise ameliorates frailty and improves cardiac risk factors in obese older adults, the long-term effect of lifestyle intervention on bone metabolism and mass is unknown...
  64. pmc Weight loss induced by Roux-en-Y gastric bypass but not laparoscopic adjustable gastric banding increases circulating bile acids
    Rohit Kohli
    Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Clin Endocrinol Metab 98:E708-12. 2013
    ....
  65. pmc Lack of a relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people
    Shelby Sullivan
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO, USA
    Transl Res 158:302-6. 2011
    ..083, P = 0.614) or clearance rate (r = 0.032, P = 0.845). These data suggest that PCSK9 is likely involved in LDL-cholesterol metabolism, but it is not a clinically important regulator of VLDL kinetics in obese individuals...
  66. ncbi request reprint Women produce fewer but triglyceride-richer very low-density lipoproteins than men
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 92:1311-8. 2007
    ..The concentrations of VLDL particles and VLDL-triglyceride (TG) in plasma are lower in women than men, but the mechanisms responsible for these differences are unclear...
  67. ncbi request reprint Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss
    Michelle A Croce
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetes 56:2395-9. 2007
    ..We sought to determine the expression of lipin 1 isoforms (lipin 1alpha and -beta) in liver and adipose tissue of obese subjects and to evaluate cellular mechanisms involved in the regulation of lipin 1 expression by physiologic stimuli...
  68. ncbi request reprint Effect of gender on lipid kinetics during endurance exercise of moderate intensity in untrained subjects
    Bettina Mittendorfer
    Center for Human Nutrition and Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 283:E58-65. 2002
    ..However, total fat oxidation is the same in both groups because of a reciprocal decrease in the oxidation rate of fatty acids derived from nonplasma sources, presumably intramuscular and possibly plasma triglycerides, in women...
  69. ncbi request reprint Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society
    Dennis T Villareal
    Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 82:923-34. 2005
    ..Therefore, weight-loss therapy that minimizes muscle and bone losses is recommended for older persons who are obese and who have functional impairments or medical complications that can benefit from weight loss...
  70. ncbi request reprint Weight management through lifestyle modification for the prevention and management of type 2 diabetes: rationale and strategies. A statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American So
    Samuel Klein
    Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St Louis, MO, USA
    Am J Clin Nutr 80:257-63. 2004
    ....
  71. ncbi request reprint Fundamentals of cardiometabolic risk factor reduction: achieving and maintaining weight loss with pharmacotherapy or bariatric surgery
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cornerstone 9:41-8; discussion 49-51. 2008
    ..9 kg/m(2) with > or =1 severe obesity-related medical complication)...
  72. ncbi request reprint Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
    Luigi Fontana
    Washington University School of Medicine, Campus Box 8031, 660 South Euclid Ave, St Louis, MO 63110, USA
    Diabetes 56:1010-3. 2007
    ..These data suggest that visceral fat is an important site for IL-6 secretion and provide a potential mechanistic link between visceral fat and systemic inflammation in people with abdominal obesity...
  73. ncbi request reprint Thiazolidinediones enhance insulin-mediated suppression of fatty acid flux in type 2 diabetes mellitus
    Susan B Racette
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Metabolism 51:169-74. 2002
    ..However, TZD therapy did not affect whole-body glycerol R(a), possibly because of upregulation of lipoprotein lipase action on plasma triglycerides...
  74. ncbi request reprint Regional muscle and adipose tissue amino acid metabolism in lean and obese women
    Bruce W Patterson
    Center for Human Nutrition and Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 282:E931-6. 2002
    ..In addition, adipose tissue is a quantitatively important site for proteolysis in both lean and obese subjects...
  75. pmc Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile
    Latisha Love-Gregory
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 20:193-201. 2011
    ..The SNPs in this study may have predictive potential on CD36 expression and disease susceptibility in African Americans. Further studies are warranted to validate and determine whether these findings are population specific...
  76. ncbi request reprint Clinical trial experience with fat-restricted vs. carbohydrate-restricted weight-loss diets
    Samuel Klein
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Obes Res 12:141S-4S. 2004
    ..Low-carbohydrate diets cause greater short-term (up to 6 months) weight loss than low-fat diets, but the long-term clinical safety and efficacy of these diets has not been studied...
  77. ncbi request reprint Clinical obesity issues from an internist's perspective
    Samuel Klein
    Center for Human Nutrition, Washington University School of Medicine, 660 S Euclid Avenue, Box 8031, St Louis, MO 63110 1093, USA
    Obes Res 10:87S-88S. 2002
  78. pmc Alterations in thigh subcutaneous adipose tissue gene expression in protease inhibitor-based highly active antiretroviral therapy
    Juan Chaparro
    Departments of Medicine and Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 54:561-7. 2005
    ..Prospective longitudinal studies of thigh fat adipose tissue gene expression could provide further insights on the pathogenesis of metabolic complications associated with PI-based HAART...
  79. ncbi request reprint Celiac disease unmasked after pancreaticoduodenectomy
    Christian D Stone
    Department of Medicine, Division of Gastroenterology, Washington University in Saint Louis, Saint Louis, Missouri 63110, USA
    JPEN J Parenter Enteral Nutr 29:270-1. 2005
  80. ncbi request reprint Advances in the long-term treatment of obesity
    Samuel Klein
    Division of Geriatrics and Nutritional Sciences, Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St Louis, MO 63110, USA
    Obes Res 12:149S-50S. 2004
  81. ncbi request reprint Aging, adiposity, and calorie restriction
    Luigi Fontana
    Division of Geriatrics and Nutritional Science and Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    JAMA 297:986-94. 2007
    ..In rodent models, calorie restriction with adequate nutrient intake decreases the risk of developing chronic disease and extends maximum life span...
  82. ncbi request reprint Physical frailty and body composition in obese elderly men and women
    Dennis T Villareal
    Washington University Older Adult Health Center, 4488 Forest Park Boulevard, St Louis, MO 63108, USA
    Obes Res 12:913-20. 2004
    ..To evaluate the prevalence of frailty and interrelationships among body composition, physical function, and quality of life in community-dwelling obese elderly (OE) persons...
  83. pmc The case of visceral fat: argument for the defense
    Samuel Klein
    Center for Human Nutrition and Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 113:1530-2. 2004
    ..A study reported in this issue of the JCI evaluates the relative contribution of fatty acids released during lipolysis of visceral adipose tissue triglycerides to portal and systemic fatty acid flux in human subjects...
  84. ncbi request reprint Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease
    Samuel Klein
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Gastroenterology 130:1564-72. 2006
    ....
  85. ncbi request reprint Medical management of obesity: present and future therapy
    Samuel Klein
    Center for Human Nutrition and Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Gastrointest Surg 7:464-7. 2003
  86. ncbi request reprint Impaired mononuclear cell immune function in extreme obesity is corrected by weight loss
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Rejuvenation Res 10:41-6. 2007
    ....
  87. ncbi request reprint Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes
    Teresa Soccio
    Research Division, Joslin Diabetes Center, Boston, MA, USA
    Diabetes 55:2763-70. 2006
    ..001-0.014). Our findings point to genetic variability at the ADIPOR1 locus as a strong determinant of CAD susceptibility in type 2 diabetes...
  88. ncbi request reprint Pre-operative nutritional status does not alter the metabolic response to major gastrointestinal surgery in patients with oesophageal cancer
    Peter H Bisschop
    Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands
    Br J Nutr 98:181-6. 2007
    ..However, this catabolic response does not seem to be influenced by pre-operative nutritional status...
  89. ncbi request reprint A multicompartmental model of in vivo adipose tissue glycerol kinetics and capillary permeability in lean and obese humans
    Simon W Coppack
    Diabetes and Metabolic Medicine, St Bartholomew s and The London School of Medicine, London, UK
    Diabetes 54:1934-41. 2005
    ..45, P < 0.05). Our results support previous estimates of interstitial glycerol concentration within adipose tissue and reveal capillary diffusion capacity is reduced in obesity...
  90. ncbi request reprint Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones
    Luigi Fontana
    Washington University School of Medicine, 4566 Scott Avenue, Campus Box 8113, St Louis, MO 63110, USA
    J Clin Endocrinol Metab 91:3232-5. 2006
    ..Caloric restriction (CR) retards aging in mammals. It has been hypothesized that a reduction in T(3) hormone may increase life span by conserving energy and reducing free-radical production...
  91. pmc Energy expenditure, sex, and endogenous fuel availability in humans
    Søren Nielsen
    Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 111:981-8. 2003
    ..We conclude that "normal" adipose tissue lipolysis is different in men and women and that the fuel export role of adipose tissue in obesity will need to be reassessed...
  92. ncbi request reprint Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes: A 1-year randomized controlled trial
    David E Kelley
    Montifiore Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Diabetes Care 25:1033-41. 2002
    ..The aim of this study was to assess the effect of orlistat, a gastrointestinal lipase inhibitor, on weight loss, glycemic control, and cardiovascular risk factors in overweight or obese insulin-treated type 2 diabetic patients...
  93. ncbi request reprint Long-term pharmacotherapy for obesity
    Samuel Klein
    Division of Geriatrics and Nutritional Sciences, Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St Louis, MO 63110, USA
    Obes Res 12:163S-6S. 2004
    ..Their use must be combined with behavior modification and a structured meal plan, however, for patients to reap the full benefits of such treatment...
  94. pmc Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol
    Latisha Love-Gregory
    Department of Medicine, Center for Human Nutrition, Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 17:1695-704. 2008
    ..0059). Fifteen additional SNPs associated with HDL-C (P = 0.0028-0.044). We conclude that CD36 variants may impact MetS pathophysiology and HDL metabolism, both predictors of the risk of heart disease and type 2 diabetes...
  95. ncbi request reprint Paradigm shifts in obesity research and treatment: roundtable discussion
    Jesse Roth
    North Shore Long Island Jewish Health System, Great Neck, New York, USA
    Obes Res 12:145S-8S. 2004
  96. ncbi request reprint Effect of orlistat in overweight and obese patients with type 2 diabetes treated with metformin
    John M Miles
    Lipid and Diabetes Research Center, St Lukes Hospital, Kansas City, Missouri, USA
    Diabetes Care 25:1123-8. 2002
    ..The purpose of this study was to assess the effect of orlistat, a gastrointestinal lipase inhibitor, on body weight, glycemic control, and cardiovascular risk factors in metformin-treated type 2 diabetic patients...
  97. ncbi request reprint A randomized trial of a low-carbohydrate diet for obesity
    Gary D Foster
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3309, USA
    N Engl J Med 348:2082-90. 2003
    ..Despite the popularity of the low-carbohydrate, high-protein, high-fat (Atkins) diet, no randomized, controlled trials have evaluated its efficacy...
  98. ncbi request reprint Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Found
    Samuel Klein
    Circulation 110:2952-67. 2004
    ..The data demonstrate that weight loss and physical activity can prevent and treat obesity-related coronary heart disease risk factors and should be considered a primary therapy for obese patients with cardiovascular disease...
  99. ncbi request reprint A 6-month randomized, placebo-controlled, dose-ranging trial of topiramate for weight loss in obesity
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, Louisiana Baylor Hospital, Dallas, Texas, USA
    Obes Res 11:722-33. 2003
    ..To evaluate the efficacy and safety of topiramate (TPM) for weight loss in healthy obese subjects...
  100. ncbi request reprint Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of insulin sensitization therapy
    John M Miles
    Mid America Heart Institute of Saint Luke s Hospital, University of Missouri Kansas City, Kansas City, MO, USA
    Diabetes 52:675-81. 2003
    ..In summary, nocturnal and postprandial FFA R(a) is increased in type 2 diabetes. Postprandial lipolysis appears to be preferentially improved by thiazolidinediones compared with nocturnal lipolysis...
  101. ncbi request reprint Use of stable isotopically labeled tracers to measure very low density lipoprotein-triglyceride turnover
    Bruce W Patterson
    Center for Human Nutrition, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St Louis, MO 63110, USA
    J Lipid Res 43:223-33. 2002
    ....

Research Grants20

  1. OBESITY AND NONALCOHOLIC FATTY LIVER DISEASE
    Samuel Klein; Fiscal Year: 2006
    ..The results from these studies will lay the groundwork for the development of novel therapeutic interventions for NAFLD in obese patients. ..
  2. OBESITY AND NONALCOHOLIC FATTY LIVER DISEASE
    Samuel Klein; Fiscal Year: 2006
    ..The results from these studies will lay the groundwork for the development of novel therapeutic interventions for NAFLD in obese patients. ..
  3. OBESITY AND NONALCOHOLIC FATTY LIVER DISEASE
    Samuel Klein; Fiscal Year: 2005
    ..The results from these studies will lay the groundwork for the development of novel therapeutic interventions for NAFLD in obese patients. ..
  4. METABOLICALLY NORMAL AND ABNORMAL OBESITY
    Samuel Klein; Fiscal Year: 2010
    ....
  5. ADIPOSE TISSUE METABOLISM IN HAART
    Samuel Klein; Fiscal Year: 2002
    ....
  6. ADIPOSE TISSUE METABOLISM IN HAART
    Samuel Klein; Fiscal Year: 2003
    ....
  7. ADIPOSE TISSUE METABOLISM IN HAART
    Samuel Klein; Fiscal Year: 2002
    ....
  8. THERMOGENESIS AND EXERCISE IN LEAN AND OBESE MAN
    Samuel Klein; Fiscal Year: 2001
    ..The information derived from these studies may improve our understanding of the regulation fat metabolism and the underlying metabolic factors which lead to obesity-related comorbidities. ..
  9. ADIPOSE TISSUE METABOLISM IN HAART
    Samuel Klein; Fiscal Year: 2001
    ....
  10. THERMOGENESIS AND EXERCISE IN LEAN AND OBESE MAN
    Samuel Klein; Fiscal Year: 2000
    ..The information derived from these studies may improve our understanding of the regulation fat metabolism and the underlying metabolic factors which lead to obesity-related comorbidities. ..
  11. THERMOGENESIS AND EXERCISE IN LEAN AND OBESE MAN
    Samuel Klein; Fiscal Year: 2002
    ..The information derived from these studies may improve our understanding of the regulation fat metabolism and the underlying metabolic factors which lead to obesity-related comorbidities. ..
  12. THERMOGENESIS AND EXERCISE IN LEAN AND OBESE MAN
    Samuel Klein; Fiscal Year: 1999
    ..The information derived from these studies may improve our understanding of the regulation fat metabolism and the underlying metabolic factors which lead to obesity-related comorbidities. ..
  13. OBESITY AND NONALCOHOLIC FATTY LIVER DISEASE
    Samuel Klein; Fiscal Year: 2007
    ..The results from these studies will lay the groundwork for the development of novel therapeutic interventions for NAFLD in obese patients. ..
  14. OBESITY AND NONALCOHOLIC FATTY LIVER DISEASE
    Samuel Klein; Fiscal Year: 2004
    ..The results from these studies will lay the groundwork for the development of novel therapeutic interventions for NAFLD in obese patients. ..
  15. ADIPOSE TISSUE METABOLISM IN HAART
    Samuel Klein; Fiscal Year: 2004
    ....