Celeste M Karch
Affiliation: Washington University School of Medicine
Tavana J, Rosene M, Jensen N, Ridge P, Kauwe J, Karch C. RAB10: an Alzheimer's disease resilience locus and potential drug target. Clin Interv Aging. 2019;14:73-79 pubmed publisher
..Here, we review the possible genetic, molecular, and functional role of RAB10 in AD and potential therapeutic approaches to target RAB10. ..
Jiang S, Wen N, Li Z, Dube U, Del Aguila J, Budde J, et al
. Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP. Transl Psychiatry. 2018;8:265 pubmed publisher
..Here, we demonstrate that MAPT p.R406W is sufficient to induce changes in GABA-mediated signaling and synaptic function, which may contribute to the pathogenesis of FTLD-tau and other primary tauopathies. ..
Broce I, Tan C, Fan C, Jansen I, Savage J, Witoelar A, et al
. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathol. 2019;137:209-226 pubmed publisher
..Our collective findings support a disease model in which cardiovascular biology is integral to the development of clinical AD in a subset of individuals. ..
Sato C, Barthélemy N, Mawuenyega K, Patterson B, Gordon B, Jockel Balsarotti J, et al
. Tau Kinetics in Neurons and the Human Central Nervous System. Neuron. 2018;97:1284-1298.e7 pubmed publisher
..4 days. In cognitively normal and Alzheimer's disease participants, the production rate of tau positively correlates with the amount of amyloid plaques, indicating a biological link between amyloid plaques and tau physiology. ..
Hsu S, Gordon B, Hornbeck R, Norton J, Levitch D, Louden A, et al
. Discovery and validation of autosomal dominant Alzheimer's disease mutations. Alzheimers Res Ther. 2018;10:67 pubmed publisher
..This study outlines a critical approach for translating genetic data into meaningful clinical outcomes. ..
Karch C, Hernández D, Wang J, Marsh J, Hewitt A, Hsu S, et al
. Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network. Alzheimers Res Ther. 2018;10:69 pubmed publisher
..These cells were thoroughly characterized for pluripotency markers. This library represents a comprehensive resource that can be used for disease modeling and the development of novel therapeutics. ..