Research Topics
Species | J E HuettnerSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
Antagonism of neuronal kainate receptors by lanthanum and gadoliniumJ E Huettner
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
Neuropharmacology 37:1239-47. 1998..In contrast to neuronal AMPA receptors, which require more than 100 microM lanthanides for half-maximal blockade, the inhibition of neuronal and recombinant kainate receptors by these ions displays significantly higher potency...- Spine-tingling excitement from glutamate receptorsJames E Huettner
Department of Cell Biology and Physiology, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
Sci STKE 2003:pe53. 2003..It is suggested that proteins in contact with specific glutamate receptor subunits may directly sense the conformational changes produced by agonist binding... - Kainate receptors: knocking out plasticityJ E Huettner
Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA corrected
Trends Neurosci 24:365-6. 2001.... - Kainate receptors and synaptic transmissionJames E Huettner
Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Prog Neurobiol 70:387-407. 2003..This review briefly addresses the properties of kainate receptors and considers in greater detail the physiological analysis of their contributions to synaptic transmission... - Glutamate and the presynaptic control of spinal sensory transmissionJames E Huettner
Department of Cell Biology and Physiology, Washington University Pain Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
Neuroscientist 8:89-92. 2002..Although the roles that these receptors play in normal physiology are not completely understood, recent work has provided strong evidence for their ability to modulate transmitter release from primary afferent terminals... - Gap junctions and connexon hemichannels in human embryonic stem cellsJames E Huettner
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Stem Cells 24:1654-67. 2006..Human ES cells provide a unique system for the study of human connexin proteins and their potential functions in cellular differentiation and the maintenance of pluripotency... - Presynaptic kainate receptors regulate spinal sensory transmissionG A Kerchner
Washington University Pain Center, Department of Anesthesiology, St. Louis, Missouri 63110, USA
J Neurosci 21:59-66. 2001..Together, these data suggest that kainate receptor agonists, acting at a presynaptic locus, can reduce glutamate release from primary afferent sensory synapses... 
Functional diversity and developmental changes in rat neuronal kainate receptorsT J Wilding
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
J Physiol 532:411-21. 2001..5. Collectively, these results highlight functional differences between neuronal kainate receptors that may reflect their distinct subunit composition and their diverse roles in synaptic transmission...- Embryonic stem cells express neuronal properties in vitroG Bain
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Dev Biol 168:342-57. 1995..We conclude that a complex system of neuronal gene expression can be activated in cultured ES cells. This system should be favorable for investigating some of the mechanisms that regulate neuronal differentiation... - KRIP6: a novel BTB/kelch protein regulating function of kainate receptorsFernanda Laezza
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
Mol Cell Neurosci 34:539-50. 2007..Taken together, these results suggest that KRIP6 can directly regulate native kainate receptors and provide the first evidence for a BTB/kelch protein in direct functional regulation of a mammalian glutamate receptor... - The BTB/kelch protein, KRIP6, modulates the interaction of PICK1 with GluR6 kainate receptorsFernanda Laezza
Department of Cell Biology and Physiology, Washington University, St Louis, MO 63110, USA
Neuropharmacology 55:1131-9. 2008.... - Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cellsW Matthew Leevy
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
Org Biomol Chem 3:3544-50. 2005..Whole cell patch clamping with mammalian cells confirms a channel mechanism in living cells suggesting that this family may comprise novel and flexible pharmacological agents... - Synthetic ion channel activity documented by electrophysiological methods in living cellsW Matthew Leevy
Department of Chemistry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, St. Louis, Missouri 63110, USA
J Am Chem Soc 126:15747-53. 2004..These studies show that the combination of structural features that have been designed into the hydraphiles afford true, albeit simple, channel function in live cells... - Fatty acid modulation and polyamine block of GluK2 kainate receptors analyzed by scanning mutagenesisTimothy J Wilding
Department of Cell Biology and Physiology, Washington University Medical School, St Louis, MO 63110, USA
J Gen Physiol 136:339-52. 2010.... - An in vitro pathway from embryonic stem cells to neurons and gliaD I Gottlieb
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
Cells Tissues Organs 165:165-72. 1999..It is thus suitable for a wide variety of mechanistic studies in the areas of neural development and cell biology... - Amino acid substitutions in the pore helix of GluR6 control inhibition by membrane fatty acidsTimothy J Wilding
Department of Cell Biology and Physiology, Washington University Medical School, St Louis, MO 63110, USA
J Gen Physiol 132:85-99. 2008..Based on homology with the pore loop of potassium channels, locations at which R substitution induces susceptibility to fatty acid inhibition face away from the cytoplasm toward the M1 and M3 helices and surrounding lipids... - Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal hornGeoffrey A Kerchner
Washington University Pain Center and Departments of Anesthesiology, Anatomy and Neurobiology, and Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 22:8010-7. 2002..These results highlight fundamental differences in KA receptor physiology between the two cell types and suggest possible strategies for the pharmacological modulation of nociception... - Regulation of mouse embryonic stem cell neural differentiation by retinoic acidMijeong Kim
Department of Cell Biology and Physiology, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
Dev Biol 328:456-71. 2009..Transcriptional profiling indicates a substantial representation of transit amplifying neuroblasts in SFD cultures not exposed to RA... - Q/R site editing controls kainate receptor inhibition by membrane fatty acidsTimothy J Wilding
Department of Cell Biology and Physiology, Washington University Medical School, St Louis, Missouri 63110, USA
J Neurosci 25:9470-8. 2005..Inhibition of fully edited channels is equivalent at voltages from -70 to +40 mV and is noncompetitive, consistent with allosteric regulation of channel function... - Intrinsic, nondeterministic circadian rhythm generation in identified mammalian neuronsAlexis B Webb
Department of Biology, Washington University, St Louis, MO 63130, USA
Proc Natl Acad Sci U S A 106:16493-8. 2009..Instead, these results indicate that AVP, VIP, and other SCN neurons are intrinsic but unstable circadian oscillators that rely on network interactions to stabilize their otherwise noisy cycling... - Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cellsIsaac H Solomon
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 285:26719-26. 2010..Drugs that block PrP-associated channels or pores may therefore represent novel therapeutic agents for treatment of patients with prion diseases... - Direct presynaptic regulation of GABA/glycine release by kainate receptors in the dorsal horn: an ionotropic mechanismG A Kerchner
Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Neuron 32:477-88. 2001..Thus, we show how presynaptic KA receptors are linked to changes in GABA/glycine release and highlight a novel role for these receptors in regulating sensory transmission... - R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanismRyan M Drenan
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 281:28222-31. 2006..Therefore, R7BP augments the function of the complex by a palmitoylation-regulated plasma membrane-targeting mechanism...