J E Huettner

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Kainate receptors: knocking out plasticity
    J E Huettner
    Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA corrected
    Trends Neurosci 24:365-6. 2001
  2. ncbi request reprint Antagonism of neuronal kainate receptors by lanthanum and gadolinium
    J E Huettner
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuropharmacology 37:1239-47. 1998
  3. ncbi request reprint Spine-tingling excitement from glutamate receptors
    James E Huettner
    Department of Cell Biology and Physiology, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Sci STKE 2003:pe53. 2003
  4. ncbi request reprint Kainate receptors and synaptic transmission
    James E Huettner
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Prog Neurobiol 70:387-407. 2003
  5. ncbi request reprint Glutamate and the presynaptic control of spinal sensory transmission
    James E Huettner
    Department of Cell Biology and Physiology, Washington University Pain Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuroscientist 8:89-92. 2002
  6. ncbi request reprint Gap junctions and connexon hemichannels in human embryonic stem cells
    James E Huettner
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Stem Cells 24:1654-67. 2006
  7. ncbi request reprint Presynaptic kainate receptors regulate spinal sensory transmission
    G A Kerchner
    Washington University Pain Center, Department of Anesthesiology, St. Louis, Missouri 63110, USA
    J Neurosci 21:59-66. 2001
  8. pmc Functional diversity and developmental changes in rat neuronal kainate receptors
    T J Wilding
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Physiol 532:411-21. 2001
  9. ncbi request reprint Embryonic stem cells express neuronal properties in vitro
    G Bain
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Biol 168:342-57. 1995
  10. pmc KRIP6: a novel BTB/kelch protein regulating function of kainate receptors
    Fernanda Laezza
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Neurosci 34:539-50. 2007

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Kainate receptors: knocking out plasticity
    J E Huettner
    Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA corrected
    Trends Neurosci 24:365-6. 2001
    ....
  2. ncbi request reprint Antagonism of neuronal kainate receptors by lanthanum and gadolinium
    J E Huettner
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuropharmacology 37:1239-47. 1998
    ..In contrast to neuronal AMPA receptors, which require more than 100 microM lanthanides for half-maximal blockade, the inhibition of neuronal and recombinant kainate receptors by these ions displays significantly higher potency...
  3. ncbi request reprint Spine-tingling excitement from glutamate receptors
    James E Huettner
    Department of Cell Biology and Physiology, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Sci STKE 2003:pe53. 2003
    ..It is suggested that proteins in contact with specific glutamate receptor subunits may directly sense the conformational changes produced by agonist binding...
  4. ncbi request reprint Kainate receptors and synaptic transmission
    James E Huettner
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Prog Neurobiol 70:387-407. 2003
    ..This review briefly addresses the properties of kainate receptors and considers in greater detail the physiological analysis of their contributions to synaptic transmission...
  5. ncbi request reprint Glutamate and the presynaptic control of spinal sensory transmission
    James E Huettner
    Department of Cell Biology and Physiology, Washington University Pain Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuroscientist 8:89-92. 2002
    ..Although the roles that these receptors play in normal physiology are not completely understood, recent work has provided strong evidence for their ability to modulate transmitter release from primary afferent terminals...
  6. ncbi request reprint Gap junctions and connexon hemichannels in human embryonic stem cells
    James E Huettner
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Stem Cells 24:1654-67. 2006
    ..Human ES cells provide a unique system for the study of human connexin proteins and their potential functions in cellular differentiation and the maintenance of pluripotency...
  7. ncbi request reprint Presynaptic kainate receptors regulate spinal sensory transmission
    G A Kerchner
    Washington University Pain Center, Department of Anesthesiology, St. Louis, Missouri 63110, USA
    J Neurosci 21:59-66. 2001
    ..Together, these data suggest that kainate receptor agonists, acting at a presynaptic locus, can reduce glutamate release from primary afferent sensory synapses...
  8. pmc Functional diversity and developmental changes in rat neuronal kainate receptors
    T J Wilding
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Physiol 532:411-21. 2001
    ..5. Collectively, these results highlight functional differences between neuronal kainate receptors that may reflect their distinct subunit composition and their diverse roles in synaptic transmission...
  9. ncbi request reprint Embryonic stem cells express neuronal properties in vitro
    G Bain
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Biol 168:342-57. 1995
    ..We conclude that a complex system of neuronal gene expression can be activated in cultured ES cells. This system should be favorable for investigating some of the mechanisms that regulate neuronal differentiation...
  10. pmc KRIP6: a novel BTB/kelch protein regulating function of kainate receptors
    Fernanda Laezza
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Neurosci 34:539-50. 2007
    ..Taken together, these results suggest that KRIP6 can directly regulate native kainate receptors and provide the first evidence for a BTB/kelch protein in direct functional regulation of a mammalian glutamate receptor...
  11. pmc The BTB/kelch protein, KRIP6, modulates the interaction of PICK1 with GluR6 kainate receptors
    Fernanda Laezza
    Department of Cell Biology and Physiology, Washington University, St Louis, MO 63110, USA
    Neuropharmacology 55:1131-9. 2008
    ....
  12. pmc Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells
    W Matthew Leevy
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Org Biomol Chem 3:3544-50. 2005
    ..Whole cell patch clamping with mammalian cells confirms a channel mechanism in living cells suggesting that this family may comprise novel and flexible pharmacological agents...
  13. ncbi request reprint Synthetic ion channel activity documented by electrophysiological methods in living cells
    W Matthew Leevy
    Department of Chemistry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, St Louis, Missouri 63110, USA
    J Am Chem Soc 126:15747-53. 2004
    ..These studies show that the combination of structural features that have been designed into the hydraphiles afford true, albeit simple, channel function in live cells...
  14. pmc Fatty acid modulation and polyamine block of GluK2 kainate receptors analyzed by scanning mutagenesis
    Timothy J Wilding
    Department of Cell Biology and Physiology, Washington University Medical School, St Louis, MO 63110, USA
    J Gen Physiol 136:339-52. 2010
    ....
  15. ncbi request reprint An in vitro pathway from embryonic stem cells to neurons and glia
    D I Gottlieb
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cells Tissues Organs 165:165-72. 1999
    ..It is thus suitable for a wide variety of mechanistic studies in the areas of neural development and cell biology...
  16. pmc Amino acid substitutions in the pore helix of GluR6 control inhibition by membrane fatty acids
    Timothy J Wilding
    Department of Cell Biology and Physiology, Washington University Medical School, St Louis, MO 63110, USA
    J Gen Physiol 132:85-99. 2008
    ..Based on homology with the pore loop of potassium channels, locations at which R substitution induces susceptibility to fatty acid inhibition face away from the cytoplasm toward the M1 and M3 helices and surrounding lipids...
  17. ncbi request reprint Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn
    Geoffrey A Kerchner
    Washington University Pain Center and Departments of Anesthesiology, Anatomy and Neurobiology, and Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 22:8010-7. 2002
    ..These results highlight fundamental differences in KA receptor physiology between the two cell types and suggest possible strategies for the pharmacological modulation of nociception...
  18. pmc Regulation of mouse embryonic stem cell neural differentiation by retinoic acid
    Mijeong Kim
    Department of Cell Biology and Physiology, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 328:456-71. 2009
    ..Transcriptional profiling indicates a substantial representation of transit amplifying neuroblasts in SFD cultures not exposed to RA...
  19. ncbi request reprint Q/R site editing controls kainate receptor inhibition by membrane fatty acids
    Timothy J Wilding
    Department of Cell Biology and Physiology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Neurosci 25:9470-8. 2005
    ..Inhibition of fully edited channels is equivalent at voltages from -70 to +40 mV and is noncompetitive, consistent with allosteric regulation of channel function...
  20. pmc Intrinsic, nondeterministic circadian rhythm generation in identified mammalian neurons
    Alexis B Webb
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 106:16493-8. 2009
    ..Instead, these results indicate that AVP, VIP, and other SCN neurons are intrinsic but unstable circadian oscillators that rely on network interactions to stabilize their otherwise noisy cycling...
  21. pmc Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells
    Isaac H Solomon
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 285:26719-26. 2010
    ..Drugs that block PrP-associated channels or pores may therefore represent novel therapeutic agents for treatment of patients with prion diseases...
  22. ncbi request reprint Direct presynaptic regulation of GABA/glycine release by kainate receptors in the dorsal horn: an ionotropic mechanism
    G A Kerchner
    Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA
    Neuron 32:477-88. 2001
    ..Thus, we show how presynaptic KA receptors are linked to changes in GABA/glycine release and highlight a novel role for these receptors in regulating sensory transmission...
  23. ncbi request reprint R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism
    Ryan M Drenan
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:28222-31. 2006
    ..Therefore, R7BP augments the function of the complex by a palmitoylation-regulated plasma membrane-targeting mechanism...