Affiliation: Washington State University
Hotzel I, Suarez C, McElwain T, Palmer G. Genetic variation in the dimorphic regions of RAP-1 genes and rap-1 loci of Babesia bigemina. Mol Biochem Parasitol. 1997;90:479-89 pubmed
..Collectively, the data suggest that gene conversion and unequal recombination events contribute to overall rap-1 sequence conservation among gene variants and strains but may also generate new rap-1 variants. ..
Hotzel I, Cheevers W. Sequence similarity between the envelope surface unit (SU) glycoproteins of primate and small ruminant lentiviruses. Virus Res. 2000;69:47-54 pubmed
..The results indicate that SU glycoproteins from primate and small ruminant lentiviruses have structurally related domains. ..
Hötzel I, Cheevers W. A maedi-visna virus strain K1514 receptor gene is located in sheep chromosome 3p and the syntenic region of human chromosome 2. J Gen Virol. 2002;83:1759-64 pubmed
..These regions do not include any known lentivirus receptor or coreceptor gene, indicating that MVV-K1514 uses a new lentivirus receptor to infect human cells. ..
Hötzel I, Cheevers W. Differential receptor usage of small ruminant lentiviruses in ovine and caprine cells: host range but not cytopathic phenotype is determined by receptor usage. Virology. 2002;301:21-31 pubmed
..Therefore, our results indicate that the differential species tropism of SRLV is determined by receptor usage. However, receptor usage is unrelated to cytopathic phenotype. ..
Hötzel I, Cheevers W. Caprine arthritis-encephalitis virus envelope surface glycoprotein regions interacting with the transmembrane glycoprotein: structural and functional parallels with human immunodeficiency virus type 1 gp120. J Virol. 2003;77:11578-87 pubmed
..Our results indicate structural and functional parallels between CAEV gp135 and HIV-1 gp120 that may be more broadly applicable to the SU of other lentiviruses. ..
Hotzel I, Cheevers W. Conservation of human immunodeficiency virus type 1 gp120 inner-domain sequences in lentivirus and type A and B retrovirus envelope surface glycoproteins. J Virol. 2001;75:2014-8 pubmed
..Thus, the antiparallel beta-strands 5 and 25 of gp120 form an SU surface highly conserved among the lentiviruses and at least partially conserved in the type A and B retroviral envelope glycoproteins...
Hotzel I, Cheevers W. Host range of small-ruminant lentivirus cytopathic variants determined with a selectable caprine arthritis- encephalitis virus pseudotype system. J Virol. 2001;75:7384-91 pubmed
..The results indicate a differential receptor recognition by MVV strains which is unrelated to cytopathic phenotype...
Hötzel I. Conservation of the human immunodeficiency virus type 1 gp120 V1/V2 stem/loop structure in the equine infectious anemia virus (EIAV) gp90. AIDS Res Hum Retroviruses. 2003;19:923-4 pubmed