F F Hsu

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. Hsu F. Mass spectrometry-based shotgun lipidomics - a critical review from the technical point of view. Anal Bioanal Chem. 2018;: pubmed publisher
    ..Graphical abstract ?. ..
  2. Frankfater C, Jiang X, Hsu F. Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry. J Am Soc Mass Spectrom. 2018;29:1688-1699 pubmed publisher
    ..Graphical Abstract ?. ..
  3. Hsu F, Nodari F, Kao L, Fu X, Holekamp T, Turk J, et al. Structural characterization of sulfated steroids that activate mouse pheromone-sensing neurons. Biochemistry. 2008;47:14009-19 pubmed publisher
    ..The identification of this novel class of mammalian social signaling compounds suggests that steroid hormones, upon conjugation, assume a new biological role, conveying information about the organism's identity and physiological state. ..
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    Hsu F, Turk J. Structural determination of glycosphingolipids as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisional-activated dissociation on a triple stage quadrupole instrument. J Am Soc Mass Spectrom. 2001;12:61-79 pubmed
    ..Constant neutral loss and precursor ion scannings to identify galactosylceramides with sphingosine or sphinganine LCB subclasses, and with specific N-2-hydroxyl fatty acid subclass in mixtures are also demonstrated. ..
  5. Hsu F, Turk J, Williams T, Welti R. Electrospray ionization multiple stage quadrupole ion-trap and tandem quadrupole mass spectrometric studies on phosphatidylglycerol from Arabidopsis leaves. J Am Soc Mass Spectrom. 2007;18:783-90 pubmed
    ..This low-energy tandem mass spectrometric approach also permits the structures of the Arabidopsis PGs that consist of two isomeric structures to be unveiled. ..
  6. Hsu F, Turk J. Characterization of cardiolipin as the sodiated ions by positive-ion electrospray ionization with multiple stage quadrupole ion-trap mass spectrometry. J Am Soc Mass Spectrom. 2006;17:1146-57 pubmed
    ..However, their uses for structural characterization are less desirable because formation of the [M + Na]+ and the [M - H + 2Na]+ ions for CL is not predictable. ..
  7. Hsu F, Turk J. Characterization of cardiolipin from Escherichia coli by electrospray ionization with multiple stage quadrupole ion-trap mass spectrometric analysis of [M - 2H + Na]- ions. J Am Soc Mass Spectrom. 2006;17:420-9 pubmed
    ..This method permits the structures of CL in a mixture isolated from Escherichia coli, including species that consist of various isomers, to be unveiled in detail. ..
  8. Hsu F, Turk J, Zhang K, Beverley S. Characterization of inositol phosphorylceramides from Leishmania major by tandem mass spectrometry with electrospray ionization. J Am Soc Mass Spectrom. 2007;18:1591-604 pubmed
  9. Hsu F, Turk J. Differentiation of 1-O-alk-1'-enyl-2-acyl and 1-O-alkyl-2-acyl glycerophospholipids by multiple-stage linear ion-trap mass spectrometry with electrospray ionization. J Am Soc Mass Spectrom. 2007;18:2065-73 pubmed
    ..Because the [M - H](-) ions are readily formed by various GPL classes (except glycerophosphocholine) in the negative-ion mode, these mass spectrometric approaches should have broad application in the structural identification of GPLs. ..

More Information

Publications20

  1. Hsu F, Turk J. Structural characterization of unsaturated glycerophospholipids by multiple-stage linear ion-trap mass spectrometry with electrospray ionization. J Am Soc Mass Spectrom. 2008;19:1681-91 pubmed publisher
  2. Hsu F, Turk J. Electrospray ionization with low-energy collisionally activated dissociation tandem mass spectrometry of glycerophospholipids: mechanisms of fragmentation and structural characterization. J Chromatogr B Analyt Technol Biomed Life Sci. 2009;877:2673-95 pubmed publisher
    ..The tandem mass spectrometric approaches afford the identification of the polar head group, the fatty acid substituents and the location of the radyl groups on the glycerol backbone of all the GPLs. ..
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    Hsu F, Turk J, Shi Y, Groisman E. Characterization of acylphosphatidylglycerols from Salmonella typhimurium by tandem mass spectrometry with electrospray ionization. J Am Soc Mass Spectrom. 2004;15:1-11 pubmed
    ..The identities of the minor isomeric species in the molecules can be revealed by the aforementioned structural information arising from the various ion series combined. ..
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    Hsu F, Turk J, Thukkani A, Messner M, Wildsmith K, Ford D. Characterization of alkylacyl, alk-1-enylacyl and lyso subclasses of glycerophosphocholine by tandem quadrupole mass spectrometry with electrospray ionization. J Mass Spectrom. 2003;38:752-63 pubmed
    ..Examples for identification of various subclasses of PC in biological extracts by tandem mass spectrometry applying various constant neutral loss scannings are also shown. ..
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    Hsu F, Turk J. Studies on sulfatides by quadrupole ion-trap mass spectrometry with electrospray ionization: structural characterization and the fragmentation processes that include an unusual internal galactose residue loss and the classical charge-remote fragmenta. J Am Soc Mass Spectrom. 2004;15:536-46 pubmed
    ..The fragmentation pathways of sulfatides under low-energy CAD are proposed. The pathways are supported by the MS(2)- and MS(3)-spectra of various compounds, and of their H-D exchanged analogs. ..
  6. Hsu F, Lakshmi V, Zenser T. Characterization of new metabolites from in vivo biotransformation of 2-amino-3-methylimidazo[4,5-f]quinoline in mouse by mass spectrometry. J Mass Spectrom. 2009;44:1359-68 pubmed publisher
    ..The observation of these more polar metabolites relative to IQ suggests that they may arise from a previously undescribed detoxification pathway. ..
  7. Hsu F. Characterization of Hydroxyphthioceranoic and Phthioceranoic Acids by Charge-Switch Derivatization and CID Tandem Mass Spectrometry. J Am Soc Mass Spectrom. 2016;27:622-32 pubmed publisher
    ..tuberculosis. Graphical Abstract á…Ÿ. ..
  8. Hsu F. Complete structural characterization of ceramides as [M-H]- ions by multiple-stage linear ion trap mass spectrometry. Biochimie. 2016;130:63-75 pubmed publisher
  9. Lin M, Miner J, Turk J, Hsu F. Linear ion-trap MSn with high-resolution MS reveals structural diversity of 1-O-acylceramide family in mouse epidermis. J Lipid Res. 2017;58:772-782 pubmed publisher
    ..An estimation of more than 700 1-O-acylceramide species, largely isobaric isomers, are present, underscoring the complexity of this Cer family. ..
  10. Hsu F, Soehl K, Turk J, Haas A. Characterization of mycolic acids from the pathogen Rhodococcus equi by tandem mass spectrometry with electrospray ionization. Anal Biochem. 2011;409:112-22 pubmed publisher
  11. Hsu F, Wohlmann J, Turk J, Haas A. Structural definition of trehalose 6-monomycolates and trehalose 6,6'-dimycolates from the pathogen Rhodococcus equi by multiple-stage linear ion-trap mass spectrometry with electrospray ionization. J Am Soc Mass Spectrom. 2011;22:2160-70 pubmed publisher