Paul Hruz

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle
    Lauren Aerni-Flessner
    Department of Pediatrics, Washington University School of Medicine, St, Louis, MO, USA
    Cardiovasc Diabetol 11:63. 2012
  2. pmc Molecular mechanisms for insulin resistance in treated HIV-infection
    Paul W Hruz
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Best Pract Res Clin Endocrinol Metab 25:459-68. 2011
  3. pmc GS-8374, a novel HIV protease inhibitor, does not alter glucose homeostasis in cultured adipocytes or in a healthy-rodent model system
    Paul W Hruz
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8208, St Louis, MO 63110, USA
    Antimicrob Agents Chemother 55:1377-82. 2011
  4. doi request reprint HIV protease inhibitors that block GLUT4 precipitate acute, decompensated heart failure in a mouse model of dilated cardiomyopathy
    Paul W Hruz
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    FASEB J 22:2161-7. 2008
  5. ncbi request reprint Indinavir induces acute and reversible peripheral insulin resistance in rats
    Paul W Hruz
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 51:937-42. 2002
  6. pmc Direct comparison of the acute in vivo effects of HIV protease inhibitors on peripheral glucose disposal
    Qingyun Yan
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Acquir Immune Defic Syndr 40:398-403. 2005
  7. pmc A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity
    Johann Hertel
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 279:55147-52. 2004
  8. ncbi request reprint Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations
    Haruhiko Murata
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    AIDS 16:859-63. 2002
  9. pmc HIV protease inhibitors acutely impair glucose-stimulated insulin release
    Joseph C Koster
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 52:1695-700. 2003
  10. ncbi request reprint Tipranavir without ritonavir does not acutely induce peripheral insulin resistance in a rodent model
    Paul W Hruz
    J Acquir Immune Defic Syndr 43:624-5. 2006

Collaborators

Detail Information

Publications10

  1. pmc GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle
    Lauren Aerni-Flessner
    Department of Pediatrics, Washington University School of Medicine, St, Louis, MO, USA
    Cardiovasc Diabetol 11:63. 2012
    ....
  2. pmc Molecular mechanisms for insulin resistance in treated HIV-infection
    Paul W Hruz
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Best Pract Res Clin Endocrinol Metab 25:459-68. 2011
    ..Further elucidation of these mechanisms provides potential for the continued development of safer antiviral drugs and targeted treatment of insulin resistance in affected patients...
  3. pmc GS-8374, a novel HIV protease inhibitor, does not alter glucose homeostasis in cultured adipocytes or in a healthy-rodent model system
    Paul W Hruz
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8208, St Louis, MO 63110, USA
    Antimicrob Agents Chemother 55:1377-82. 2011
    ....
  4. doi request reprint HIV protease inhibitors that block GLUT4 precipitate acute, decompensated heart failure in a mouse model of dilated cardiomyopathy
    Paul W Hruz
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    FASEB J 22:2161-7. 2008
    ..The potential for HIV protease inhibitors to contribute to or exacerbate cardiomyopathy in human patients warrants further investigation...
  5. ncbi request reprint Indinavir induces acute and reversible peripheral insulin resistance in rats
    Paul W Hruz
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 51:937-42. 2002
    ..These data demonstrate that indinavir causes acute and reversible changes in whole-body glucose homeostasis in rats and support the contribution of GLUT4 inhibition to the development of insulin resistance in patients treated with PIs...
  6. pmc Direct comparison of the acute in vivo effects of HIV protease inhibitors on peripheral glucose disposal
    Qingyun Yan
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Acquir Immune Defic Syndr 40:398-403. 2005
    ..Preclinical testing of novel candidate PIs in a rodent model system may be useful in identifying the future risk of altering glucose homeostasis...
  7. pmc A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity
    Johann Hertel
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 279:55147-52. 2004
    ..These data establish a structural basis for PI effects on GLUT4 activity and support the direct binding of PIs to the transport protein as the mechanism for acute inhibition of insulin-stimulated glucose uptake...
  8. ncbi request reprint Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations
    Haruhiko Murata
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    AIDS 16:859-63. 2002
    ..To determine the relative sensitivities of glucose transporter isoforms to the protease inhibitor indinavir and to determine the kinetic mechanism of indinavir-mediated Glut4 isoform inhibition...
  9. pmc HIV protease inhibitors acutely impair glucose-stimulated insulin release
    Joseph C Koster
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 52:1695-700. 2003
    ..Thus, together with peripheral insulin resistance, beta-cell dysfunction likely contributes to altered glucose homeostasis associated with highly active antiretroviral therapy...
  10. ncbi request reprint Tipranavir without ritonavir does not acutely induce peripheral insulin resistance in a rodent model
    Paul W Hruz
    J Acquir Immune Defic Syndr 43:624-5. 2006

Research Grants12

  1. DIRECT EFFECTS OF ANTIRETROVIRAL THERAPY ON CARDIAC ENERGY HOMEOSTASIS
    Paul W Hruz; Fiscal Year: 2010
    ..This research also has significant potential to improve the prevention and treatment of heart disease in the wider context of type 2 diabetes. ..
  2. Mechanisms for Altered Glucose Homeostasis During HAART
    Paul Hruz; Fiscal Year: 2009
    ....
  3. Mechanisms for Altered Glucose Homeostasis During HAART
    Paul W Hruz; Fiscal Year: 2010
    ....
  4. Mechanisms for Altered Glucose Homeostasis During HAART
    Paul Hruz; Fiscal Year: 2006
    ..abstract_text> ..
  5. Mechanism of GLUT4 Inhibition by HIV Protease Inhibitor
    Paul Hruz; Fiscal Year: 2005
    ..The results of this research may also facilitate the development of newer HIV protease inhibitors that maintain their efficacy in HIV treatment while avoiding their adverse metabolic consequences. ..