Timothy E Holy

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint A public confession: the retina trumpets its failed predictions
    Timothy E Holy
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 55:831-2. 2007
  2. pmc Ultrasonic songs of male mice
    Timothy E Holy
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 3:e386. 2005
  3. pmc Structural characterization of sulfated steroids that activate mouse pheromone-sensing neurons
    Fong Fu Hsu
    Department of Internal Medicine, Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 47:14009-19. 2008
  4. pmc An ex vivo preparation of the intact mouse vomeronasal organ and accessory olfactory bulb
    Julian P Meeks
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8108, 660 S Euclid Ave, Saint Louis, MO 63110, United States
    J Neurosci Methods 177:440-7. 2009
  5. pmc Reliable sex and strain discrimination in the mouse vomeronasal organ and accessory olfactory bulb
    Illya I Tolokh
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA
    J Neurosci 33:13903-13. 2013
  6. doi request reprint Inhibition shapes sex selectivity in the mouse accessory olfactory bulb
    REBECCA C HENDRICKSON
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63130, USA
    J Neurosci 28:12523-34. 2008
  7. pmc Representation and transformation of sensory information in the mouse accessory olfactory system
    Julian P Meeks
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Neurosci 13:723-30. 2010
  8. doi request reprint Image-based calibration of a deformable mirror in wide-field microscopy
    Diwakar Turaga
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Appl Opt 49:2030-40. 2010
  9. doi request reprint Whole-mount imaging of responses in mouse vomeronasal neurons
    Pei Sabrina Xu
    Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, MO, USA
    Methods Mol Biol 1068:201-10. 2013
  10. pmc Robust encoding of stimulus identity and concentration in the accessory olfactory system
    Hannah A Arnson
    Department of Anatomy and Neurobiology, Washington University, St Louis, Missouri 63110, USA
    J Neurosci 33:13388-97. 2013

Collaborators

Detail Information

Publications24

  1. ncbi request reprint A public confession: the retina trumpets its failed predictions
    Timothy E Holy
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 55:831-2. 2007
    ....
  2. pmc Ultrasonic songs of male mice
    Timothy E Holy
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 3:e386. 2005
    ..This study provides a quantitative initial description of male mouse songs, and opens the possibility of studying song production and perception in an established genetic model organism...
  3. pmc Structural characterization of sulfated steroids that activate mouse pheromone-sensing neurons
    Fong Fu Hsu
    Department of Internal Medicine, Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 47:14009-19. 2008
    ..The identification of this novel class of mammalian social signaling compounds suggests that steroid hormones, upon conjugation, assume a new biological role, conveying information about the organism's identity and physiological state...
  4. pmc An ex vivo preparation of the intact mouse vomeronasal organ and accessory olfactory bulb
    Julian P Meeks
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8108, 660 S Euclid Ave, Saint Louis, MO 63110, United States
    J Neurosci Methods 177:440-7. 2009
    ..These results demonstrate the utility of whole mount ex vivo preparations for studying sensory processing in the AOS, and suggest that similar strategies may improve experimental access to other difficult-to-study neural circuits...
  5. pmc Reliable sex and strain discrimination in the mouse vomeronasal organ and accessory olfactory bulb
    Illya I Tolokh
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA
    J Neurosci 33:13903-13. 2013
    ....
  6. doi request reprint Inhibition shapes sex selectivity in the mouse accessory olfactory bulb
    REBECCA C HENDRICKSON
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63130, USA
    J Neurosci 28:12523-34. 2008
    ..Together, these results indicate that laterally connected inhibitory circuitry in the accessory olfactory bulb plays an important role in shaping neural selectivity for natural stimuli...
  7. pmc Representation and transformation of sensory information in the mouse accessory olfactory system
    Julian P Meeks
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Neurosci 13:723-30. 2010
    ..Most VSN excitation patterns were also observed in the AOB, but excitation by estradiol sulfate processing streams was rare, suggesting AOB circuit organization is specific to the biological relevance of sensed cues...
  8. doi request reprint Image-based calibration of a deformable mirror in wide-field microscopy
    Diwakar Turaga
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Appl Opt 49:2030-40. 2010
    ..We thus show that image-based wavefront sensing, which requires no additional optical equipment, allows a simple but powerful method to calibrate a deformable optical element in a microscope setting...
  9. doi request reprint Whole-mount imaging of responses in mouse vomeronasal neurons
    Pei Sabrina Xu
    Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, MO, USA
    Methods Mol Biol 1068:201-10. 2013
    ..Here we document the preparation of the whole-mounted vomeronasal epithelium, multichannel stimulus delivery, and three-dimensional calcium imaging by OCPI microscopy. ..
  10. pmc Robust encoding of stimulus identity and concentration in the accessory olfactory system
    Hannah A Arnson
    Department of Anatomy and Neurobiology, Washington University, St Louis, Missouri 63110, USA
    J Neurosci 33:13388-97. 2013
    ..Thus, we show that a biophysically plausible circuit model can reconstruct concentration ratios from observed neuronal firing, representing a powerful mechanism to separate stimulus identity from absolute concentration...
  11. ncbi request reprint Miniaturization and defocus correction for objective-coupled planar illumination microscopy
    Diwakar Turaga
    Department of Anatomy and Neurobiology, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    Opt Lett 33:2302-4. 2008
    ..By introducing the ability to tune the angle of the light sheet, we show that defocus correction in a miniaturized OCPI microscope leads to a significant improvement in image sharpness deeper into tissue...
  12. ncbi request reprint Wake up and smell the conspecific!
    Timothy E Holy
    Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8108, St Louis, Missouri 63110, USA
    Trends Neurosci 26:463-5. 2003
    ..New electrophysiological recordings in behaving mice by Luo, Fee and Katz reveal aspects of pheromone biology and how these stimuli are represented by single neurons...
  13. pmc Sulfated steroids as natural ligands of mouse pheromone-sensing neurons
    Francesco Nodari
    Department of Anatomy and Neurobiology, School of Medicine, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Neurosci 28:6407-18. 2008
    ..These results provide an unprecedented characterization of the signals available for chemical communication among mice...
  14. pmc Chemosensory burst coding by mouse vomeronasal sensory neurons
    Hannah A Arnson
    Department of Anatomy and Neurobiology, Washington University, St Louis, Missouri, USA
    J Neurophysiol 106:409-20. 2011
    ..These findings indicate that as-yet unexplored characteristics of the sensory transduction cascade significantly constrain the representation of sensory information by vomeronasal neurons...
  15. ncbi request reprint Functional organization of glomerular maps in the mouse accessory olfactory bulb
    Gary F Hammen
    1 Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri, USA 2 MD PhD Program, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Neurosci 17:953-61. 2014
    ..Maps to a panel of sulfated steroid odorants identified tightly juxtaposed groups that were disparately tuned and dispersed groups that were similarly tuned. These results reveal a modular, nonchemotopic spatial organization in the AOB. ..
  16. pmc Organization of vomeronasal sensory coding revealed by fast volumetric calcium imaging
    Diwakar Turaga
    Department of Anatomy and Neurobiology, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 32:1612-21. 2012
    ..Recording from a whole sensory system thus revealed new organizational principles...
  17. doi request reprint Pavlov's moth: olfactory learning and spike timing-dependent plasticity
    Julian P Meeks
    Department of Anatomy and Neurobiology, Washington University in St Louis School of Medicine, 660 S Euclid, St Louis, Missouri 63110, USA
    Nat Neurosci 11:1126-7. 2008
  18. ncbi request reprint Sex selectivity of mouse ultrasonic songs
    Zhongsheng Guo
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Chem Senses 32:463-73. 2007
    ..However, modeling demonstrates that lateral inhibition could be one possible mechanism to account for the switch from synergy to independence...
  19. ncbi request reprint Physiologic diversity and development of intrinsically photosensitive retinal ganglion cells
    Daniel C Tu
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, Missouri 63110, USA
    Neuron 48:987-99. 2005
    ..These results demonstrate that ipRGCs are the first light-sensitive cells in the retina and suggest previously unappreciated diversity in this cell population...
  20. doi request reprint Fast three-dimensional fluorescence imaging of activity in neural populations by objective-coupled planar illumination microscopy
    Terrence F Holekamp
    Department of Anatomy and Neurobiology, Washington University in St Louis School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Neuron 57:661-72. 2008
    ....
  21. ncbi request reprint Loss of sex discrimination and male-male aggression in mice deficient for TRP2
    Lisa Stowers
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 295:1493-500. 2002
    ..Our study suggests that, in the mouse, sensory activation of the VNO is essential for sex discrimination of conspecifics and thus ensures gender-specific behavior...
  22. pmc Singing mice, songbirds, and more: models for FOXP2 function and dysfunction in human speech and language
    Stephanie A White
    Department of Physiological Science, University of California, Los Angeles, California 90095, USA
    J Neurosci 26:10376-9. 2006
    ..Below, we describe genetic through behavioral techniques used currently to investigate FoxP2 in birds, rodents, and humans for discovery of the neural bases of vocal learning and language...
  23. ncbi request reprint Olfactory coding: sniffing out signals
    Francesco Nodari
    Nat Neurosci 8:406-7. 2005