Michael J Holtzman

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery
    Dhara A Patel
    Drug Discovery Program, Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS ONE 7:e36594. 2012
  2. pmc Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens
    Michael J Holtzman
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, USA
    J Clin Invest 122:2741-8. 2012
  3. pmc Host epithelial-viral interactions as cause and cure for asthma
    Michael J Holtzman
    Drug Discovery Program, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Curr Opin Immunol 23:487-94. 2011
  4. pmc Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
    Edy Y Kim
    Department of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 14:633-40. 2008
  5. pmc Immune pathways for translating viral infection into chronic airway disease
    Michael J Holtzman
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Adv Immunol 102:245-76. 2009
  6. pmc Macrophage chitinase 1 stratifies chronic obstructive lung disease
    Eugene Agapov
    Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 41:379-84. 2009
  7. ncbi request reprint Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection
    Laurie P Shornick
    Department of Biology and Department of Molecular Microbiology and Immunology, Saint Louis University, St Louis, MO 63103, USA
    J Immunol 180:3319-28. 2008
  8. pmc Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells
    Brian T Edelson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 207:823-36. 2010
  9. pmc Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia
    Mitchell H Grayson
    Division of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Exp Med 204:2759-69. 2007
  10. ncbi request reprint Controls for lung dendritic cell maturation and migration during respiratory viral infection
    Mitchell H Grayson
    Division of Allergy and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 179:1438-48. 2007

Research Grants

  1. BASIS OF CHRONIC MUCOUS CELL METAPLASIA
    Michael J Holtzman; Fiscal Year: 2010

Collaborators

Detail Information

Publications55

  1. pmc High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery
    Dhara A Patel
    Drug Discovery Program, Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS ONE 7:e36594. 2012
    ....
  2. pmc Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens
    Michael J Holtzman
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, USA
    J Clin Invest 122:2741-8. 2012
    ..A particular challenge will be to understand and balance the innate as well as the adaptive immune responses to defend the host against acute infection as well as chronic inflammatory disease...
  3. pmc Host epithelial-viral interactions as cause and cure for asthma
    Michael J Holtzman
    Drug Discovery Program, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Curr Opin Immunol 23:487-94. 2011
    ..We also introduce a rationale for how antiviral performance at the epithelial cell level might be improved to prevent acute infectious illness and chronic inflammatory disease caused by respiratory viruses...
  4. pmc Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
    Edy Y Kim
    Department of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 14:633-40. 2008
    ....
  5. pmc Immune pathways for translating viral infection into chronic airway disease
    Michael J Holtzman
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Adv Immunol 102:245-76. 2009
    ..Together, the findings identify an adaptive immune response that mediates acute disease and an innate immune response that drives chronic inflammatory lung disease in experimental and clinical settings...
  6. pmc Macrophage chitinase 1 stratifies chronic obstructive lung disease
    Eugene Agapov
    Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 41:379-84. 2009
    ..The findings provide a means to noninvasively track alternatively activated macrophages in chronic lung disease and thereby better differentiate molecular phenotypes in heterogeneous patient populations...
  7. ncbi request reprint Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection
    Laurie P Shornick
    Department of Biology and Department of Molecular Microbiology and Immunology, Saint Louis University, St Louis, MO 63103, USA
    J Immunol 180:3319-28. 2008
    ..These findings provide some of the most definitive evidence to date for the critical role of barrier epithelial cells in innate immunity to common pathogens, particularly in controlling viral replication...
  8. pmc Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells
    Brian T Edelson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 207:823-36. 2010
    ..These data provide evidence for a developmental relationship between lymphoid organ-resident CD8alpha+ cDCs and nonlymphoid CD103+ DCs...
  9. pmc Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia
    Mitchell H Grayson
    Division of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Exp Med 204:2759-69. 2007
    ..Therefore, lung DC expression of FcepsilonRIalpha is part of the antiviral response that recruits CD4(+) T cells and drives mucous cell metaplasia, thus linking antiviral responses to allergic/asthmatic Th2 responses...
  10. ncbi request reprint Controls for lung dendritic cell maturation and migration during respiratory viral infection
    Mitchell H Grayson
    Division of Allergy and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 179:1438-48. 2007
    ..Our results indicate that pDCs and cDCs respond distinctly to respiratory paramyxoviral infection with patterns of movement that should serve to coordinate the innate and adaptive immune responses, respectively...
  11. ncbi request reprint CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection
    Jeffrey W Tyner
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 11:1180-7. 2005
    ..The antiapoptotic action of chemokine signaling may therefore allow scavengers to finally stop the host cell-to-cell infectious process...
  12. pmc Cigarette smoke induces nucleic-acid oxidation in lung fibroblasts
    Gaetan Deslee
    Division of Pulmonary and Critical Care Medicine, School of Medicine, Washington University, St Louis, Missouri 63110, USA
    Am J Respir Cell Mol Biol 43:576-84. 2010
    ..Together, our results demonstrate ROS-dependent, cigarette smoke-induced nucleic-acid oxidation in alveolar fibroblasts, which may play a role in the pathogenesis of emphysema...
  13. ncbi request reprint Defining and adjusting divergent host responses to viral infection
    Michael J Holtzman
    Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:123-41. 2005
    ....
  14. pmc IL-13-induced airway mucus production is attenuated by MAPK13 inhibition
    Yael G Alevy
    Drug Discovery Program, Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 122:4555-68. 2012
    ..These results uncover and validate a new pathway for regulating mucus production as well as a corresponding therapeutic approach to mucus overproduction in inflammatory airway diseases...
  15. ncbi request reprint "Hit-and-run" effects of paramyxoviruses as a basis for chronic respiratory disease
    Michael J Holtzman
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Pediatr Infect Dis J 23:S235-45. 2004
    ..Here we question whether the innate immune system, including airway epithelial cells, and the adaptive one may manifest an aberrant antiviral response as an additional basis for chronic inflammatory diseases, including asthma...
  16. pmc Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection
    Antonina M Akk
    Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 180:3535-42. 2008
    ..These results indicate that DPPI and neutrophils play a critical role in Sendai virus-induced asthma phenotype as a result of a DPPI-dependent neutrophil recruitment and cytokine response...
  17. pmc Detection of respiratory viruses and the associated chemokine responses in serious acute respiratory illness
    Kaharu C Sumino
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Thorax 65:639-44. 2010
    ..A specific diagnosis of a lower respiratory viral infection is often difficult despite frequent clinical suspicion. This low diagnostic yield may be improved by use of sensitive detection methods and biomarkers...
  18. ncbi request reprint Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members
    Anand C Patel
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Physiol Genomics 25:502-13. 2006
    ....
  19. pmc Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals
    Jeffrey W Tyner
    Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:309-21. 2006
    ....
  20. pmc Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary disease
    Michael J Holtzman
    Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Am Thorac Soc 2:132-40. 2005
    ..Identifying specific components of the mucosal immune system that manifest an aberrant antiviral response may thereby allow for adjusting this response to improve acute and chronic outcomes after viral infection...
  21. pmc A transgenic FOXJ1-Cre system for gene inactivation in ciliated epithelial cells
    Yong Zhang
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Respir Cell Mol Biol 36:515-9. 2007
    ..It should prove extremely useful for defining ciliated cell function in airway mucosal immunity as well as development and reproduction...
  22. pmc High-throughput screening normalized to biological response: application to antiviral drug discovery
    Dhara A Patel
    1Drug Discovery Program, Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Biomol Screen 19:119-30. 2014
    ..Together, the results establish an HTS method that can be extended to screening for any class of compounds that influence a quantifiable biological response for which a standard is available. ..
  23. pmc Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease
    Derek E Byers
    Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Clin Invest 123:3967-82. 2013
    ..Together, these findings provide a paradigm for the role of the innate immune system in chronic disease based on the influence of long-term epithelial progenitor cells programmed for excess IL-33 production. ..
  24. ncbi request reprint Emerging role of dendritic cells in respiratory viral infection
    Mitchell H Grayson
    Department of Internal Medicine, Washington University School of Medicine, Campus Box 8122, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    J Mol Med (Berl) 85:1057-68. 2007
    ..Finally, we identify potential targets for future therapeutic strategies to ameliorate disease caused by respiratory virus infection...
  25. pmc New immune pathways from chronic post-viral lung disease
    Loralyn A Benoit
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann N Y Acad Sci 1183:195-210. 2010
    ..These findings extend our understanding of the complex mechanisms that underlie chronic obstructive lung disease and provide useful targets for diagnosis and therapy of this common disorder...
  26. pmc Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo
    Leonid Gitlin
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 6:e1000734. 2010
    ....
  27. ncbi request reprint Apoptosis in the airways: another balancing act in the epithelial program
    Mary P O'Sullivan
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 29:3-7. 2003
  28. pmc Viral induction of a chronic asthma phenotype and genetic segregation from the acute response
    Michael J Walter
    Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 110:165-75. 2002
    ..These two phenotypes can be segregated by their dependence on the ICAM-1 gene and so depend on distinct controls that appear critical for the development of lifelong airway diseases such as asthma...
  29. pmc Monitoring in vivo changes in lung microstructure with ³He MRI in Sendai virus-infected mice
    Wei Wang
    Department of Physics, Washington Univ Box 8131, Dept of Radiology, 510 S Kingshighway, St Louis, MO 63110, USA
    J Appl Physiol (1985) 112:1593-9. 2012
    ..Our results indicate that (3)He lung morphometry has good sensitivity in quantifying small microstructural changes in the mouse lung and that the Sendai mouse model has the potential to be a valid murine model of COPD...
  30. pmc Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells
    Aida Ibricevic
    Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Virol 80:7469-80. 2006
    ....
  31. ncbi request reprint Genetic variability of human metapneumovirus infection: evidence of a shift in viral genotype without a change in illness
    Eugene Agapov
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Infect Dis 193:396-403. 2006
    ..These findings suggest that hMPV may vary in genetic structure, to allow for a seasonal shift in predominant genotype and the maintenance of infection rates...
  32. pmc Alternatively activated macrophages and airway disease
    Derek E Byers
    Department of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 140:768-74. 2011
    ..Here, we review basic and clinical research studies that highlight the importance of AAMs in the pathogenesis of asthma, COPD, and other chronic airway diseases...
  33. pmc The role of CLCA proteins in inflammatory airway disease
    Anand C Patel
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Physiol 71:425-49. 2009
    ....
  34. pmc Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation
    Zeynep Yurtsever
    Biochemistry Program, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:42138-49. 2012
    ..These data provide both a mechanistic basis for CLCA1 self-cleavage and a novel mechanism for regulation of chloride channel activity specific to the mucosal interface...
  35. ncbi request reprint Developing the epithelial, viral, and allergic paradigm for asthma: Giles F. Filley lecture
    Michael J Holtzman
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 123:377S-84S. 2003
  36. pmc Epithelial cell proliferation contributes to airway remodeling in severe asthma
    Lance Cohen
    Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Am J Respir Crit Care Med 176:138-45. 2007
    ..Despite long-term therapy with corticosteroids, patients with severe asthma develop irreversible airway obstruction...
  37. pmc Oxidative damage to nucleic acids in severe emphysema
    Gaetan Deslee
    Washington University School of Medicine, Division of Pulmonary and Critical Care Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Chest 135:965-74. 2009
    ..Oxidative stress is a key element in the pathogenesis of emphysema, but oxidation of nucleic acids has been largely overlooked. The aim of this study was to investigate oxidative damage to nucleic acids in severe emphysematous lungs...
  38. pmc Immunogenetic programs for viral induction of mucous cell metaplasia
    Michael J Holtzman
    Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 35:29-39. 2006
  39. ncbi request reprint Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma
    Robin Stephens
    Center for Immunology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 169:5458-67. 2002
    ..This implies that circulating Th2 cells in allergic individuals could enter the lungs in response to infection or inflammation and become activated to trigger allergy...
  40. ncbi request reprint Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airway
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Respir Crit Care Med 169:842-9. 2004
    ....
  41. ncbi request reprint Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation
    Christine Deppong
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 176:3909-13. 2006
    ..Thus, these receptors are critical determinants of the duration of allergic airway inflammation...
  42. ncbi request reprint Chemokine signaling regulates apoptosis as well as immune cell traffic in host defense
    Mitchell H Grayson
    Department of Medicine and Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri, USA
    Cell Cycle 5:380-3. 2006
    ..In addition, we introduce new work to support the more traditional role of CCL5 in mediating adaptive immune cell traffic and activation in this same setting...
  43. pmc Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life
    Kaharu Sumino
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Allergy Clin Immunol 129:1267-1273.e1. 2012
    ..However, the determinants of susceptibility to acute respiratory tract infections still need to be defined...
  44. ncbi request reprint Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node
    Mitchell H Grayson
    Division of Allergy and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Heart Circ Physiol 284:H2213-26. 2003
    ....
  45. ncbi request reprint Modification of the Stat1 SH2 domain broadly improves interferon efficacy in proportion to p300/CREB-binding protein coactivator recruitment
    Yong Zhang
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:34306-15. 2005
    ..Thus, SH2 domain determinants may be modified to direct better Stat1 phosphorylation, DNA binding, and coactivator recruitment to fully improve IFN efficacy...
  46. ncbi request reprint Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment
    Kaharu C Sumino
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Infect Dis 192:1052-60. 2005
    ..Infections with common respiratory tract viruses can cause high mortality, especially in immunocompromised hosts, but the impact of human metapneumovirus (hMPV) in this setting was previously unknown...
  47. pmc Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain
    Wenyu Lin
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Virol 80:9226-35. 2006
    ....
  48. pmc Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma
    Shadmehr Demehri
    Department of Developmental Biology and Division of Dermatology, Washington University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS Biol 7:e1000067. 2009
    ..Based on these findings, we propose that in addition to early treatment of the primary skin-barrier defects, selective inhibition of systemic TSLP may be the key to blocking the development of asthma in AD patients...
  49. ncbi request reprint Drug development for asthma
    Michael J Holtzman
    Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 29:163-71. 2003
    ..Each of these considerations may provide an alternative strategy for further drug development for asthma and other complex diseases...
  50. pmc Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease
    Quentin Philippot
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Washington University, St Louis, Missouri, United States of America Institut National de la Santé Et de la Recherche Medicale Unit 903, University Hospital, Reims, France
    PLoS ONE 9:e96285. 2014
    ..These results support activation of an iron sequestration mechanism by alveolar macrophages in COPD, which we postulate is a protective mechanism against iron induced oxidative stress...
  51. pmc Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases
    Daniel L Kober
    Molecular Microbiology and Microbial Pathogenesis Program, Washington University School of Medicine, St Louis, MO 63110, United States Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, United States
    Protein Expr Purif 96:32-8. 2014
    ..Such studies are crucial to understand the functional consequences of TREM-2 point mutations linked to the development of neurodegenerative diseases and, ultimately, to develop patient-specific molecular therapies to treat them. ..
  52. pmc A centennial history of research on asthma pathogenesis
    Michael J Walter
    Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 32:483-9. 2005
  53. pmc Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness
    Mindy S Lo
    Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Virol 79:9315-9. 2005
    ..RSV infection decreased human but not mouse Stat2 levels, so this mechanism of IFN antagonism may contribute to viral host range, as well as immune subversion...
  54. ncbi request reprint Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm
    Michael J Holtzman
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Physiol Rev 82:19-46. 2002
    ....
  55. pmc Molecular heterogeneity in the choroid plexus epithelium: the 22-member γ-protocadherin family is differentially expressed, apically localized, and implicated in CSF regulation
    Mark A Lobas
    Department of Biology, The University of Iowa, Iowa City, Iowa, USA
    J Neurochem 120:913-27. 2012
    ..Together, these results suggest an unsuspected role for the γ-Pcdhs in CSF production and demonstrate a surprising molecular heterogeneity in the CP epithelium...

Research Grants1

  1. BASIS OF CHRONIC MUCOUS CELL METAPLASIA
    Michael J Holtzman; Fiscal Year: 2010
    ..Our work will thereby provide new therapeutic strategies to restore normal lung architecture and correct mucus production to a level that is helpful rather than harmful for lung function. ..