Research Topics
| M J HoltzmanSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
Interleukin 12 p40 production by barrier epithelial cells during airway inflammationM J Walter
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Exp Med 193:339-51. 2001..Taken together, these results suggest a novel role for epithelial-derived IL-12 p40 in modifying the level of airway inflammation during mucosal defense and disease...
Drug development for asthmaMichael J Holtzman
Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
Am J Respir Cell Mol Biol 29:163-71. 2003..Each of these considerations may provide an alternative strategy for further drug development for asthma and other complex diseases...- Developing the epithelial, viral, and allergic paradigm for asthma: Giles F. Filley lectureMichael J Holtzman
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Chest 123:377S-84S. 2003 - Regulation of T cell apoptosisM J Holtzman
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Apoptosis 5:459-71. 2000..In addition, we introduce the possibility that these same pathways may be abnormally programmed and so lead to immune cell accumulation during inflammatory diseases such as asthma... - Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigmMichael J Holtzman
Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Physiol Rev 82:19-46. 2002.... - Persistent activation of an innate immune response translates respiratory viral infection into chronic lung diseaseEdy Y Kim
Department of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
Nat Med 14:633-40. 2008.... - Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signalsJeffrey W Tyner
Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 116:309-21. 2006.... - Immunogenetic programs for viral induction of mucous cell metaplasiaMichael J Holtzman
Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Am J Respir Cell Mol Biol 35:29-39. 2006 - Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family membersAnand C Patel
Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Physiol Genomics 25:502-13. 2006.... - Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infectionAntonina M Akk
Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 180:3535-42. 2008..These results indicate that DPPI and neutrophils play a critical role in Sendai virus-induced asthma phenotype as a result of a DPPI-dependent neutrophil recruitment and cytokine response... - Epithelial cell proliferation contributes to airway remodeling in severe asthmaLance Cohen
Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
Am J Respir Crit Care Med 176:138-45. 2007..Despite long-term therapy with corticosteroids, patients with severe asthma develop irreversible airway obstruction... - Controls for lung dendritic cell maturation and migration during respiratory viral infectionMitchell H Grayson
Division of Allergy and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 179:1438-48. 2007..Our results indicate that pDCs and cDCs respond distinctly to respiratory paramyxoviral infection with patterns of movement that should serve to coordinate the innate and adaptive immune responses, respectively... - Emerging role of dendritic cells in respiratory viral infectionMitchell H Grayson
Department of Internal Medicine, Washington University School of Medicine, Campus Box 8122, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
J Mol Med (Berl) 85:1057-68. 2007..Finally, we identify potential targets for future therapeutic strategies to ameliorate disease caused by respiratory virus infection... - Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasiaMitchell H Grayson
Division of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
J Exp Med 204:2759-69. 2007..Therefore, lung DC expression of FcepsilonRIalpha is part of the antiviral response that recruits CD4(+) T cells and drives mucous cell metaplasia, thus linking antiviral responses to allergic/asthmatic Th2 responses... - Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary diseaseMichael J Holtzman
Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
Proc Am Thorac Soc 2:132-40. 2005..Identifying specific components of the mucosal immune system that manifest an aberrant antiviral response may thereby allow for adjusting this response to improve acute and chronic outcomes after viral infection... - Defining and adjusting divergent host responses to viral infectionMichael J Holtzman
Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Immunol Res 32:123-41. 2005.... - Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthmaRobin Stephens
Center for Immunology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
J Immunol 169:5458-67. 2002..This implies that circulating Th2 cells in allergic individuals could enter the lungs in response to infection or inflammation and become activated to trigger allergy... - Apoptosis in the airways: another balancing act in the epithelial programJeffrey W Tyner
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Am J Respir Cell Mol Biol 29:3-7. 2003 - Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsivenessMindy S Lo
Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St. Louis, MO 63110, USA
J Virol 79:9315-9. 2005..RSV infection decreased human but not mouse Stat2 levels, so this mechanism of IFN antagonism may contribute to viral host range, as well as immune subversion... - Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airwayMario Castro
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Am J Respir Crit Care Med 169:842-9. 2004.... - "Hit-and-run" effects of paramyxoviruses as a basis for chronic respiratory diseaseMichael J Holtzman
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
Pediatr Infect Dis J 23:S235-45. 2004..Here we question whether the innate immune system, including airway epithelial cells, and the adaptive one may manifest an aberrant antiviral response as an additional basis for chronic inflammatory diseases, including asthma... - STAT1 activation causes translocation of Bax to the endoplasmic reticulum during the resolution of airway mucous cell hyperplasia by IFN-gammaBarbara A Stout
Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87185, USA
J Immunol 178:8107-16. 2007..Collectively, these observations suggest that STAT1-dependent translocation of Bax to the ER is crucial for IFN-gamma-induced cell death of AECs and the resolution of allergen-induced mucous cell hyperplasia... - Where are the gaps in asthma research? A counter-perspectiveMichael J Holtzman
J Allergy Clin Immunol 111:244-7. 2003 - Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph nodeMitchell H Grayson
Division of Allergy and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Physiol Heart Circ Physiol 284:H2213-26. 2003.... - Modification of the Stat1 SH2 domain broadly improves interferon efficacy in proportion to p300/CREB-binding protein coactivator recruitmentYong Zhang
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Biol Chem 280:34306-15. 2005..Thus, SH2 domain determinants may be modified to direct better Stat1 phosphorylation, DNA binding, and coactivator recruitment to fully improve IFN efficacy... - Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infectionLaurie P Shornick
Department of Biology and Department of Molecular Microbiology and Immunology, Saint Louis University, St Louis, MO 63103, USA
J Immunol 180:3319-28. 2008..These findings provide some of the most definitive evidence to date for the critical role of barrier epithelial cells in innate immunity to common pathogens, particularly in controlling viral replication... - Viral induction of a chronic asthma phenotype and genetic segregation from the acute responseMichael J Walter
Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 110:165-75. 2002..These two phenotypes can be segregated by their dependence on the ICAM-1 gene and so depend on distinct controls that appear critical for the development of lifelong airway diseases such as asthma... 
Involvement of the p38 MAPK pathway in IL-13-induced mucous cell metaplasia in mouse tracheal epithelial cellsTomoyuki Fujisawa
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
Respirology 13:191-202. 2008..This study investigated the signalling mechanism of IL-13-induced mucous cell metaplasia in primary cultures of mouse tracheal epithelial cells (mTEC)...- A transgenic FOXJ1-Cre system for gene inactivation in ciliated epithelial cellsYong Zhang
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Am J Respir Cell Mol Biol 36:515-9. 2007..It should prove extremely useful for defining ciliated cell function in airway mucosal immunity as well as development and reproduction... - Chemokine complexity: the case for CCL5Mitchell H Grayson
Am J Respir Cell Mol Biol 35:143-6. 2006 - Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessmentKaharu C Sumino
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Infect Dis 192:1052-60. 2005.... - A centennial history of research on asthma pathogenesisMichael J Walter
Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Am J Respir Cell Mol Biol 32:483-9. 2005 - Genetic variability of human metapneumovirus infection: evidence of a shift in viral genotype without a change in illnessEugene Agapov
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
J Infect Dis 193:396-403. 2006..These findings suggest that hMPV may vary in genetic structure, to allow for a seasonal shift in predominant genotype and the maintenance of infection rates... - Chemokine signaling regulates apoptosis as well as immune cell traffic in host defenseMitchell H Grayson
Department of Medicine and Department of Cell Biology, Washington University School of Medicine, St. Louis, Missouri, USA
Cell Cycle 5:380-3. 2006..In addition, we introduce new work to support the more traditional role of CCL5 in mediating adaptive immune cell traffic and activation in this same setting... - Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1Ya Jen Chang
Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
Mol Pharmacol 65:589-98. 2004..One is the JAK1/2-dependent PLC-gamma pathway inducing the activations of PKCalpha, c-Src, and STAT1, and the other is the direct activation of STAT1 by JAK1/2... - Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammationChristine Deppong
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 176:3909-13. 2006..Thus, these receptors are critical determinants of the duration of allergic airway inflammation... - Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. BasbaumKenneth B Adler
Am J Respir Cell Mol Biol 34:523-6. 2006 - Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cellsAida Ibricevic
Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
J Virol 80:7469-80. 2006.... - CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infectionJeffrey W Tyner
Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
Nat Med 11:1180-7. 2005..The antiapoptotic action of chemokine signaling may therefore allow scavengers to finally stop the host cell-to-cell infectious process...