M J Holtzman

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Interleukin 12 p40 production by barrier epithelial cells during airway inflammation
    M J Walter
    Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Exp Med 193:339-51. 2001
  2. ncbi request reprint Drug development for asthma
    Michael J Holtzman
    Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 29:163-71. 2003
  3. ncbi request reprint Developing the epithelial, viral, and allergic paradigm for asthma: Giles F. Filley lecture
    Michael J Holtzman
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 123:377S-84S. 2003
  4. ncbi request reprint Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm
    Michael J Holtzman
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Physiol Rev 82:19-46. 2002
  5. ncbi request reprint Regulation of T cell apoptosis
    M J Holtzman
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Apoptosis 5:459-71. 2000
  6. ncbi request reprint Heterogeneity of cellular expression of arachidonate 15-lipoxygenase: implications for biological activity
    M J Holtzman
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110
    Biochim Biophys Acta 1003:204-8. 1989
  7. ncbi request reprint Arachidonate 12-lipoxygenase and cyclooxygenase: PGE isomerase are predominant pathways for oxygenation in bovine tracheal epithelial cells
    J R Hansbrough
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110
    Am J Respir Cell Mol Biol 1:237-44. 1989
  8. ncbi request reprint Selective differences in vascular endothelial- vs. airway epithelial-T cell adhesion mechanisms
    S Nakajima
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Physiol 267:L422-32. 1994
  9. ncbi request reprint Identification of a novel arachidonate 12-lipoxygenase in bovine tracheal epithelial cells distinct from leukocyte and platelet forms of the enzyme
    J R Hansbrough
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 265:1771-6. 1990
  10. pmc Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma
    D Sampath
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 103:1353-61. 1999

Collaborators

Detail Information

Publications46

  1. pmc Interleukin 12 p40 production by barrier epithelial cells during airway inflammation
    M J Walter
    Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Exp Med 193:339-51. 2001
    ..Taken together, these results suggest a novel role for epithelial-derived IL-12 p40 in modifying the level of airway inflammation during mucosal defense and disease...
  2. ncbi request reprint Drug development for asthma
    Michael J Holtzman
    Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 29:163-71. 2003
    ..Each of these considerations may provide an alternative strategy for further drug development for asthma and other complex diseases...
  3. ncbi request reprint Developing the epithelial, viral, and allergic paradigm for asthma: Giles F. Filley lecture
    Michael J Holtzman
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 123:377S-84S. 2003
  4. ncbi request reprint Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm
    Michael J Holtzman
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Physiol Rev 82:19-46. 2002
    ....
  5. ncbi request reprint Regulation of T cell apoptosis
    M J Holtzman
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Apoptosis 5:459-71. 2000
    ..In addition, we introduce the possibility that these same pathways may be abnormally programmed and so lead to immune cell accumulation during inflammatory diseases such as asthma...
  6. ncbi request reprint Heterogeneity of cellular expression of arachidonate 15-lipoxygenase: implications for biological activity
    M J Holtzman
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110
    Biochim Biophys Acta 1003:204-8. 1989
    ..Theories of functional significance for this enzymatic pathway will need to account for the selective expression of high levels of activity in a highly limited number of cell types...
  7. ncbi request reprint Arachidonate 12-lipoxygenase and cyclooxygenase: PGE isomerase are predominant pathways for oxygenation in bovine tracheal epithelial cells
    J R Hansbrough
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110
    Am J Respir Cell Mol Biol 1:237-44. 1989
    ..The findings demonstrate that bovine tracheal epithelial cells express both a cyclooxygenase:PGE isomerase and a 12-lipoxygenase pathway and therefore implicate this pathway as a new source of epithelial cell mediators...
  8. ncbi request reprint Selective differences in vascular endothelial- vs. airway epithelial-T cell adhesion mechanisms
    S Nakajima
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Physiol 267:L422-32. 1994
    ..g., dependence on a mixed- vs. a single-ligand system and distinct cytokine-responsiveness of ligand levels) may help to coordinate T cell traffic to epithelial barriers...
  9. ncbi request reprint Identification of a novel arachidonate 12-lipoxygenase in bovine tracheal epithelial cells distinct from leukocyte and platelet forms of the enzyme
    J R Hansbrough
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 265:1771-6. 1990
    ..We further suggest that lipoxygenase heterogeneity may provide a basis for different functional roles for the enzyme in different cell types...
  10. pmc Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma
    D Sampath
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 103:1353-61. 1999
    ....
  11. ncbi request reprint Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease
    V R Shannon
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Physiol 264:G104-11. 1993
    ....
  12. ncbi request reprint A hierarchy for integrin expression and adhesiveness among T cell subsets that is linked to TCR gene usage and emphasizes V delta 1+ gamma delta T cell adherence and tissue retention
    S Nakajima
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 155:1117-31. 1995
    ....
  13. pmc Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary disease
    Michael J Holtzman
    Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Am Thorac Soc 2:132-40. 2005
    ..Identifying specific components of the mucosal immune system that manifest an aberrant antiviral response may thereby allow for adjusting this response to improve acute and chronic outcomes after viral infection...
  14. pmc Immunogenetic programs for viral induction of mucous cell metaplasia
    Michael J Holtzman
    Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 35:29-39. 2006
  15. ncbi request reprint Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members
    Anand C Patel
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Physiol Genomics 25:502-13. 2006
    ....
  16. ncbi request reprint Emerging role of dendritic cells in respiratory viral infection
    Mitchell H Grayson
    Department of Internal Medicine, Washington University School of Medicine, Campus Box 8122, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    J Mol Med (Berl) 85:1057-68. 2007
    ..Finally, we identify potential targets for future therapeutic strategies to ameliorate disease caused by respiratory virus infection...
  17. pmc Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
    Edy Y Kim
    Department of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 14:633-40. 2008
    ....
  18. pmc Epithelial cell proliferation contributes to airway remodeling in severe asthma
    Lance Cohen
    Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Am J Respir Crit Care Med 176:138-45. 2007
    ..Despite long-term therapy with corticosteroids, patients with severe asthma develop irreversible airway obstruction...
  19. ncbi request reprint Controls for lung dendritic cell maturation and migration during respiratory viral infection
    Mitchell H Grayson
    Division of Allergy and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 179:1438-48. 2007
    ..Our results indicate that pDCs and cDCs respond distinctly to respiratory paramyxoviral infection with patterns of movement that should serve to coordinate the innate and adaptive immune responses, respectively...
  20. pmc Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia
    Mitchell H Grayson
    Division of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Exp Med 204:2759-69. 2007
    ..Therefore, lung DC expression of FcepsilonRIalpha is part of the antiviral response that recruits CD4(+) T cells and drives mucous cell metaplasia, thus linking antiviral responses to allergic/asthmatic Th2 responses...
  21. pmc Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection
    Antonina M Akk
    Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 180:3535-42. 2008
    ..These results indicate that DPPI and neutrophils play a critical role in Sendai virus-induced asthma phenotype as a result of a DPPI-dependent neutrophil recruitment and cytokine response...
  22. ncbi request reprint Defining and adjusting divergent host responses to viral infection
    Michael J Holtzman
    Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:123-41. 2005
    ....
  23. pmc Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness
    Mindy S Lo
    Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Virol 79:9315-9. 2005
    ..RSV infection decreased human but not mouse Stat2 levels, so this mechanism of IFN antagonism may contribute to viral host range, as well as immune subversion...
  24. ncbi request reprint Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airway
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Respir Crit Care Med 169:842-9. 2004
    ....
  25. pmc Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals
    Jeffrey W Tyner
    Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:309-21. 2006
    ....
  26. ncbi request reprint Apoptosis in the airways: another balancing act in the epithelial program
    Mary P O'Sullivan
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 29:3-7. 2003
  27. ncbi request reprint Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma
    Robin Stephens
    Center for Immunology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 169:5458-67. 2002
    ..This implies that circulating Th2 cells in allergic individuals could enter the lungs in response to infection or inflammation and become activated to trigger allergy...
  28. ncbi request reprint "Hit-and-run" effects of paramyxoviruses as a basis for chronic respiratory disease
    Michael J Holtzman
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Pediatr Infect Dis J 23:S235-45. 2004
    ..Here we question whether the innate immune system, including airway epithelial cells, and the adaptive one may manifest an aberrant antiviral response as an additional basis for chronic inflammatory diseases, including asthma...
  29. ncbi request reprint Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection
    Laurie P Shornick
    Department of Biology and Department of Molecular Microbiology and Immunology, Saint Louis University, St Louis, MO 63103, USA
    J Immunol 180:3319-28. 2008
    ..These findings provide some of the most definitive evidence to date for the critical role of barrier epithelial cells in innate immunity to common pathogens, particularly in controlling viral replication...
  30. ncbi request reprint Modification of the Stat1 SH2 domain broadly improves interferon efficacy in proportion to p300/CREB-binding protein coactivator recruitment
    Yong Zhang
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:34306-15. 2005
    ..Thus, SH2 domain determinants may be modified to direct better Stat1 phosphorylation, DNA binding, and coactivator recruitment to fully improve IFN efficacy...
  31. pmc Viral induction of a chronic asthma phenotype and genetic segregation from the acute response
    Michael J Walter
    Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 110:165-75. 2002
    ..These two phenotypes can be segregated by their dependence on the ICAM-1 gene and so depend on distinct controls that appear critical for the development of lifelong airway diseases such as asthma...
  32. ncbi request reprint STAT1 activation causes translocation of Bax to the endoplasmic reticulum during the resolution of airway mucous cell hyperplasia by IFN-gamma
    Barbara A Stout
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87185, USA
    J Immunol 178:8107-16. 2007
    ..Collectively, these observations suggest that STAT1-dependent translocation of Bax to the ER is crucial for IFN-gamma-induced cell death of AECs and the resolution of allergen-induced mucous cell hyperplasia...
  33. doi request reprint Involvement of the p38 MAPK pathway in IL-13-induced mucous cell metaplasia in mouse tracheal epithelial cells
    Tomoyuki Fujisawa
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Respirology 13:191-202. 2008
    ..This study investigated the signalling mechanism of IL-13-induced mucous cell metaplasia in primary cultures of mouse tracheal epithelial cells (mTEC)...
  34. ncbi request reprint Where are the gaps in asthma research? A counter-perspective
    Michael J Holtzman
    J Allergy Clin Immunol 111:244-7. 2003
  35. pmc A transgenic FOXJ1-Cre system for gene inactivation in ciliated epithelial cells
    Yong Zhang
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Respir Cell Mol Biol 36:515-9. 2007
    ..It should prove extremely useful for defining ciliated cell function in airway mucosal immunity as well as development and reproduction...
  36. ncbi request reprint Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node
    Mitchell H Grayson
    Division of Allergy and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Heart Circ Physiol 284:H2213-26. 2003
    ....
  37. pmc Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells
    Aida Ibricevic
    Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Virol 80:7469-80. 2006
    ....
  38. pmc A centennial history of research on asthma pathogenesis
    Michael J Walter
    Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 32:483-9. 2005
  39. ncbi request reprint Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment
    Kaharu C Sumino
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Infect Dis 192:1052-60. 2005
    ..Infections with common respiratory tract viruses can cause high mortality, especially in immunocompromised hosts, but the impact of human metapneumovirus (hMPV) in this setting was previously unknown...
  40. ncbi request reprint CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection
    Jeffrey W Tyner
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 11:1180-7. 2005
    ..The antiapoptotic action of chemokine signaling may therefore allow scavengers to finally stop the host cell-to-cell infectious process...
  41. ncbi request reprint Genetic variability of human metapneumovirus infection: evidence of a shift in viral genotype without a change in illness
    Eugene Agapov
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Infect Dis 193:396-403. 2006
    ..These findings suggest that hMPV may vary in genetic structure, to allow for a seasonal shift in predominant genotype and the maintenance of infection rates...
  42. ncbi request reprint Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1
    Ya Jen Chang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 65:589-98. 2004
    ..One is the JAK1/2-dependent PLC-gamma pathway inducing the activations of PKCalpha, c-Src, and STAT1, and the other is the direct activation of STAT1 by JAK1/2...
  43. ncbi request reprint Chemokine signaling regulates apoptosis as well as immune cell traffic in host defense
    Mitchell H Grayson
    Department of Medicine and Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri, USA
    Cell Cycle 5:380-3. 2006
    ..In addition, we introduce new work to support the more traditional role of CCL5 in mediating adaptive immune cell traffic and activation in this same setting...
  44. ncbi request reprint Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation
    Christine Deppong
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 176:3909-13. 2006
    ..Thus, these receptors are critical determinants of the duration of allergic airway inflammation...
  45. ncbi request reprint Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum
    Kenneth B Adler
    Am J Respir Cell Mol Biol 34:523-6. 2006
  46. pmc Chemokine complexity: the case for CCL5
    Mitchell H Grayson
    Am J Respir Cell Mol Biol 35:143-6. 2006