J O Holloszy

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi request reprint Regulation of mitochondrial biogenesis and GLUT4 expression by exercise
    John O Holloszy
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Compr Physiol 1:921-40. 2011
  2. pmc β-Adrenergic stimulation does not activate p38 MAP kinase or induce PGC-1α in skeletal muscle
    Sang Hyun Kim
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 304:E844-52. 2013
  3. pmc "Deficiency" of mitochondria in muscle does not cause insulin resistance
    John O Holloszy
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 62:1036-40. 2013
  4. ncbi request reprint Regulation by exercise of skeletal muscle content of mitochondria and GLUT4
    J O Holloszy
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Physiol Pharmacol 59:5-18. 2008
  5. doi request reprint Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance
    John O Holloszy
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 89:463S-6S. 2009
  6. ncbi request reprint A high fat diet impairs stimulation of glucose transport in muscle. Functional evaluation of potential mechanisms
    P A Hansen
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 273:26157-63. 1998
  7. ncbi request reprint Activation of glucose transport in skeletal muscle by phospholipase C and phorbol ester. Evaluation of the regulatory roles of protein kinase C and calcium
    E J Henriksen
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 264:21536-43. 1989
  8. ncbi request reprint Muscle glucose transport: interactions of in vitro contractions, insulin, and exercise
    S H Constable
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Appl Physiol 64:2329-32. 1988
  9. ncbi request reprint Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
    B Li
    Departments of Medicine and Cell Biology and Physiology, Division of Atherosclerosis, Nutrition, and Lipid Research, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Med 6:1115-20. 2000
  10. ncbi request reprint Exercise increases susceptibility of muscle glucose transport to activation by various stimuli
    G D Cartee
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Physiol 258:E390-3. 1990

Collaborators

Detail Information

Publications26

  1. doi request reprint Regulation of mitochondrial biogenesis and GLUT4 expression by exercise
    John O Holloszy
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Compr Physiol 1:921-40. 2011
    ..A major component of this review deals with the physiological and metabolic consequences of the exercise-induced increase in mitochondria and GLUT4...
  2. pmc β-Adrenergic stimulation does not activate p38 MAP kinase or induce PGC-1α in skeletal muscle
    Sang Hyun Kim
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 304:E844-52. 2013
    ..Our results show that the reason for the lack of effect of β-adrenergic stimulation on PGC-1α expression in muscle is that catecholamines do not activate p38 or increase ATF2 phosphorylation in muscle...
  3. pmc "Deficiency" of mitochondria in muscle does not cause insulin resistance
    John O Holloszy
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 62:1036-40. 2013
    ..In conclusion, it seems clear, based on this evidence, that the 30% reduction in muscle content of mitochondria in patients with T2DM is not responsible for insulin resistance...
  4. ncbi request reprint Regulation by exercise of skeletal muscle content of mitochondria and GLUT4
    J O Holloszy
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Physiol Pharmacol 59:5-18. 2008
    ..The purpose of this article is to present an overview of what is known regarding these phenomena...
  5. doi request reprint Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance
    John O Holloszy
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 89:463S-6S. 2009
    ..In light of this evidence, it seems highly unlikely that "mitochondrial deficiency" causes muscle insulin resistance...
  6. ncbi request reprint A high fat diet impairs stimulation of glucose transport in muscle. Functional evaluation of potential mechanisms
    P A Hansen
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 273:26157-63. 1998
    ....
  7. ncbi request reprint Activation of glucose transport in skeletal muscle by phospholipase C and phorbol ester. Evaluation of the regulatory roles of protein kinase C and calcium
    E J Henriksen
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 264:21536-43. 1989
    ..These findings provide evidence that an increase in cytoplasmic Ca2+ concentration is involved in the activation of glucose transport in skeletal muscle by PLC-Cp...
  8. ncbi request reprint Muscle glucose transport: interactions of in vitro contractions, insulin, and exercise
    S H Constable
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Appl Physiol 64:2329-32. 1988
    ....
  9. ncbi request reprint Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
    B Li
    Departments of Medicine and Cell Biology and Physiology, Division of Atherosclerosis, Nutrition, and Lipid Research, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Med 6:1115-20. 2000
    ..These data suggest that manipulating respiratory uncoupling in muscle is a viable treatment for obesity and its metabolic sequelae...
  10. ncbi request reprint Exercise increases susceptibility of muscle glucose transport to activation by various stimuli
    G D Cartee
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Physiol 258:E390-3. 1990
    ..In contrast to exercise (i.e., swimming), in vitro muscle contractions did not result in an increase in sensitivity of muscle glucose transport to insulin, raising the possibility that a humoral factor is necessary for this effect...
  11. ncbi request reprint Glucose transport into rat skeletal muscle: interaction between exercise and insulin
    H Wallberg-henriksson
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Appl Physiol 65:909-13. 1988
    ..These findings appear compatible with the hypothesis that the actions of exercise and insulin result in activation and/or translocation into the plasma membrane of two separate pools of glucose transporters in mammalian skeletal muscle...
  12. ncbi request reprint Increased GLUT-4 translocation mediates enhanced insulin sensitivity of muscle glucose transport after exercise
    P A Hansen
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Appl Physiol 85:1218-22. 1998
    ....
  13. ncbi request reprint Prolonged increase in insulin-stimulated glucose transport in muscle after exercise
    G D Cartee
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Physiol 256:E494-9. 1989
    ..5 mumol/g in the rats fed fat for 48 h, after exercise. The persistent increase in insulin sensitivity after exercise in carbohydrate-deprived rats was unrelated to caloric intake, as muscles of fasted and fat-fed rats behaved similarly...
  14. ncbi request reprint Response of serum leptin concentrations to 7 d of energy restriction in centrally obese African Americans with impaired or diabetic glucose tolerance
    S B Racette
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 66:33-7. 1997
    ..In summary, short-term energy restriction effectively reduced serum leptin concentrations and improved glucose tolerance and insulin action in obese individuals with impaired or diabetic glucose tolerance...
  15. ncbi request reprint Hypoxia causes glycogenolysis without an increase in percent phosphorylase a in rat skeletal muscle
    J M Ren
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Physiol 263:E1086-91. 1992
    ..The rate of glycogenolysis during 60 min of hypoxia was reduced by only approximately 14% in 2-deoxyglucose 6-phosphate-loaded muscles.(ABSTRACT TRUNCATED AT 250 WORDS)..
  16. ncbi request reprint The HIV protease inhibitor indinavir decreases insulin- and contraction-stimulated glucose transport in skeletal muscle
    L A Nolte
    Department of Internal Medicine, Washington University School of Medicine, 4566 Scott Ave, St Louis, MO 63110, USA
    Diabetes 50:1397-401. 2001
    ..These results provide evidence that indinavir inhibits the translocation or intrinsic activity of GLUT4 rather than insulin signaling...
  17. ncbi request reprint Effects of phenylarsine oxide on stimulation of glucose transport in rat skeletal muscle
    E J Henriksen
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Physiol 258:C648-53. 1990
    ....
  18. ncbi request reprint Skeletal muscle glucose transport and metabolism are enhanced in transgenic mice overexpressing the Glut4 glucose transporter
    P A Hansen
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 270:1679-84. 1995
    ..These findings are consistent with the role of Glut4 as the primary mediator of transport stimulated by insulin or contractions...
  19. ncbi request reprint Exercise training, glucose transporters, and glucose transport in rat skeletal muscles
    K J Rodnick
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Physiol 262:C9-14. 1992
    ....
  20. ncbi request reprint Development of glucose-induced insulin resistance in muscle requires protein synthesis
    K Kawanaka
    Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Biol Chem 276:20101-7. 2001
    ..They also suggest that dephosphorylation of a transcription factor may be involved in the induction of GIIR...
  21. ncbi request reprint Effects of Ca2+ ionophore ionomycin on insulin-stimulated and basal glucose transport in muscle
    A D Lee
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol 268:R997-1002. 1995
    ..They further show that stimulation of glucose transport by Ca2+ is also inhibited. A recovery period that allows this inhibition to wear off unmasks the stimulation of glucose transport by an increase in sarcoplasmic Ca2+...
  22. ncbi request reprint Differences in cardiovascular adaptations to endurance exercise training between older men and women
    R J Spina
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Appl Physiol 75:849-55. 1993
    ..There were no changes in these variables in the control subjects. The mechanisms responsible for the training-induced increase in VO2max in the older men were similar to those found in young people.(ABSTRACT TRUNCATED AT 250 WORDS)..
  23. ncbi request reprint Modest lifestyle intervention and glucose tolerance in obese African Americans
    S B Racette
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Obes Res 9:348-55. 2001
    ....
  24. ncbi request reprint Respiratory uncoupling induces delta-aminolevulinate synthase expression through a nuclear respiratory factor-1-dependent mechanism in HeLa cells
    B Li
    Departments of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 274:17534-40. 1999
    ..These data suggest that the transcription factor NRF-1 plays a key role in cellular adaptation to energy demands by translating physiological signals into an increased capacity for generating energy...
  25. ncbi request reprint Longevity of exercising male rats: effect of an antioxidant supplemented diet
    J O Holloszy
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Mech Ageing Dev 100:211-9. 1998
    ....
  26. pmc Does calorie restriction induce mitochondrial biogenesis? A reevaluation
    Chad R Hancock
    Washington University School of Medicine, Division of Geriatrics and Nutritional Sciences, 4566 Scott Ave, Campus Box 8113, St Louis, MO 63110, USA
    FASEB J 25:785-91. 2011
    ....