Anthony L Hinrichs

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc A genome-wide association study of alcohol dependence
    Laura J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:5082-7. 2010
  2. pmc Linkage analysis merging replicate phenotypes: an application to three quantitative phenotypes in two African samples
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8134, St, Louis, MO 63110, USA
    BMC Proc 5:S81. 2011
  3. pmc In search of causal variants: refining disease association signals using cross-population contrasts
    Nancy L Saccone
    Department of Genetics, Washington University, Campus Box 8232, 4566 Scott Avenue, Saint Louis, Missouri, USA
    BMC Genet 9:58. 2008
  4. pmc Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, St Louis, Misouri, USA
    Biol Psychiatry 67:581-3. 2010
  5. doi request reprint Incorporating linkage information into a common disease/rare variant framework
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Genet Epidemiol 35:S74-9. 2011
  6. pmc Population stratification and patterns of linkage disequilibrium
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 33:S88-92. 2009
  7. pmc Common polymorphisms in FMO1 are associated with nicotine dependence
    Anthony L Hinrichs
    Departments of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63119, USA
    Pharmacogenet Genomics 21:397-402. 2011
  8. pmc Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:453-66. 2009
  9. pmc A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
    Biol Psychiatry 64:922-9. 2008
  10. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009

Research Grants

  1. Statistical Methods for the Genetics of Alcoholism
    Anthony Hinrichs; Fiscal Year: 2007

Detail Information

Publications45

  1. pmc A genome-wide association study of alcohol dependence
    Laura J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:5082-7. 2010
    ..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence...
  2. pmc Linkage analysis merging replicate phenotypes: an application to three quantitative phenotypes in two African samples
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8134, St, Louis, MO 63110, USA
    BMC Proc 5:S81. 2011
    ..Using both methods, we found numerous significant linkage signals for Q1, although population colocalization was absent for most of these signals. The linkage analysis of Q2 and Q4 failed to reveal any strong linkage signals...
  3. pmc In search of causal variants: refining disease association signals using cross-population contrasts
    Nancy L Saccone
    Department of Genetics, Washington University, Campus Box 8232, 4566 Scott Avenue, Saint Louis, Missouri, USA
    BMC Genet 9:58. 2008
    ..The challenge we address is to distinguish among these correlated loci to highlight potential functional variants and prioritize them for follow-up...
  4. pmc Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, St Louis, Misouri, USA
    Biol Psychiatry 67:581-3. 2010
    ..Imaging of Abeta deposition in the human brain using Pittsburgh Compound B (PIB) offers the possibility of using cortical PIB binding as a quantitative endophenotype for genetic studies of late-onset Alzheimer's disease (LOAD)...
  5. doi request reprint Incorporating linkage information into a common disease/rare variant framework
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Genet Epidemiol 35:S74-9. 2011
    ..Clearly, when pedigrees are available, they can provide great assistance in the search for rare variants that influence common disorders...
  6. pmc Population stratification and patterns of linkage disequilibrium
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 33:S88-92. 2009
    ..g., in chromosomal inversions). Our group also reported a method for performing an association test controlling for substructure, when genome-wide markers are not available, to explicitly compute stratification...
  7. pmc Common polymorphisms in FMO1 are associated with nicotine dependence
    Anthony L Hinrichs
    Departments of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63119, USA
    Pharmacogenet Genomics 21:397-402. 2011
    ..A better understanding of the etiology of nicotine addiction may help to increase the success rate of cessation and to decrease the massive morbidity and mortality associated with smoking...
  8. pmc Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:453-66. 2009
    ....
  9. pmc A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
    Biol Psychiatry 64:922-9. 2008
    ..The goal of this study was to examine the association of this variant with cocaine dependence...
  10. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009
    ..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...
  11. ncbi request reprint Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin
    Jen C Wang
    Washington University in St Louis, MO 63110, USA
    Alcohol Clin Exp Res 31:209-15. 2007
    ..The perceived bitterness of PROP has also been associated with oral sensation and drinking behaviors...
  12. pmc Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
    ....
  13. pmc Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 104:471-7. 2009
    ..In the present report, we extend the previous study by expanding our genotyping efforts significantly for these two genes...
  14. pmc Novel genes identified in a high-density genome wide association study for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
    Hum Mol Genet 16:24-35. 2007
    ..This work anticipates the future directions of large-scale genome wide association studies with state-of-the-art methodological approaches and sharing of data with the scientific community...
  15. pmc Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
    Arpana Agrawal
    Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 93:12-20. 2008
    ..0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence...
  16. ncbi request reprint Association studies testing for risk for late-onset Alzheimer's disease with common variants in the beta-amyloid precursor protein (APP)
    Petra Nowotny
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 144:469-74. 2007
    ..However, we cannot rule out the possibility that multiple rare variants that increase APP expression or Abeta production might influence the risk for LOAD...
  17. doi request reprint Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 103:1027-38. 2008
    ....
  18. pmc Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence
    Anthony L Hinrichs
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hum Genet 78:103-11. 2006
    ..6%), whereas 45% of African Americans carry the allele (MAF 26%), which makes it a much more significant risk factor in the African American population...
  19. pmc The efficacy of short tandem repeat polymorphisms versus single-nucleotide polymorphisms for resolving population structure
    John S K Kauwe
    Department of Psychiatry, Washington University of Medicine, St Louis, MO, USA
    BMC Genet 6:S84. 2005
    ..If SNPs with lower MAFs are used, then more than 250 SNPs may be required to obtain reliable results...
  20. ncbi request reprint Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample
    Arpana Agrawal
    Department of Psychiatry, Washington University in St Louis, St Louis, MO, USA
    Behav Genet 36:640-50. 2006
    ..There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence...
  21. pmc A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks
    Manav Kapoor
    Department of Psychiatry, B8134, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO, 63110, USA
    Hum Genet 132:1141-51. 2013
    ....
  22. pmc Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels
    Carlos Cruchaga
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Arch Neurol 68:581-6. 2011
    ..Rs1990622 (TMEM106B) was identified as a risk factor for frontotemporal lobar degeneration with TAR DNA-binding protein inclusions (FTLD-TDP) in a recent genome-wide association...
  23. pmc An analysis of identical single-nucleotide polymorphisms genotyped by two different platforms
    Brian K Suarez
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    BMC Genet 6:S152. 2005
    ..Some of this clustering may be due to the presence of a second segregating SNP that obliterates a XbaI site (the restriction enzyme used in the Affymetrix platform), resulting in a fragment too long (>1,000 bp) to be amplified...
  24. pmc Microsatellites versus single-nucleotide polymorphisms in linkage analysis for quantitative and qualitative measures
    Gerald Dunn
    Department of Psychiatry, Genetics, Washington University School of Medicine, St Louis, Missouri, USA
    BMC Genet 6:S122. 2005
    ..We also considered the effect of high linkage disequilibrium (LD) in regions near the linkage peaks by analysing a "sparse" SNP map obtained by dropping some markers in high LD with other markers in those regions...
  25. pmc Multipoint identity-by-descent computations for single-point polymorphism and microsatellite maps
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    BMC Genet 6:S34. 2005
    ..However, increased information has a computational cost: SNP maps require 100 times as many iterations as microsatellites to produce stable estimates...
  26. pmc Association studies between common variants in prolyl isomerase Pin1 and the risk for late-onset Alzheimer's disease
    Petra Nowotny
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurosci Lett 419:15-7. 2007
    ..A meta-analysis of two promoter SNPs, which combined the data from this study with two previous ones, did not show any association either suggesting that common SNPs in Pin1 do not increase the risk for LOAD...
  27. pmc The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans
    Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
    Pharmacogenet Genomics 21:403-16. 2011
    ..To study the association between cytochrome P450 2A6 (CYP2A6) genotype and metabolism of nicotine to cotinine, identify functional polymorphisms, and develop a predictive genetic model of nicotine metabolism...
  28. ncbi request reprint Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease
    Scott Smemo
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Street, St Louis, MO 63110, USA
    Ann Neurol 59:21-6. 2006
    ..We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in UBQLN1, increases risk for LOAD...
  29. pmc Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    Scott F Saccone
    Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hum Mol Genet 16:36-49. 2007
    ..Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies...
  30. ncbi request reprint Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome
    Jen C Wang
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 13:1903-11. 2004
    ..These findings provide strong evidence that variants within or close to the CHRM2 locus influence risk for two common psychiatric disorders...
  31. ncbi request reprint Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme
    Petra Nowotny
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 136:62-8. 2005
    ..Although our results are not universally negative, we were unable to replicate the results of previous studies and conclude that common variants or haplotypes of these variants in IDE are not major risk factors for LOAD...
  32. pmc HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin
    Odity Mukherjee
    Washington University Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 60:314-22. 2006
    ....
  33. ncbi request reprint Genotyping errors, pedigree errors, and missing data
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 29:S120-4. 2005
    ..However, a fairly high rate of no-calls, especially for the Affymetrix platform, suggests that the inconsistency rate may be higher than observed...
  34. ncbi request reprint A family study of alcohol dependence: coaggregation of multiple disorders in relatives of alcohol-dependent probands
    John I Nurnberger
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Arch Gen Psychiatry 61:1246-56. 2004
    ..We also assessed the aggregation of other psychiatric disorders in the same sample to identify areas of possible shared genetic vulnerability...
  35. pmc Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample
    Brian K Suarez
    Department of Psychiatry and Genetics, Washington University, St Louis, MO, USA
    Am J Hum Genet 78:315-33. 2006
    ..3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Z(lr) scores was observed for 5p14.1-q12.1, where the maximum Z(lr) increased from 2.77 initially to 3.80 after fine mapping in the EA families...
  36. pmc Power and false-positive rates for the restricted partition method (RPM) in a large candidate gene data set
    Robert Culverhouse
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St, Louis, Missouri 63110, USA
    BMC Proc 3:S74. 2009
    ..Power and false-positive rates were evaluated using the first 100 replicate datasets. This included an exploration of the utility of using of all genotyped family members compared with selecting one member per family...
  37. ncbi request reprint A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence
    Laura Jean Bierut
    School of Medicine, Washington University School of Medicine, 4940 Children s Place, St Louis, MO 63110, USA
    Am J Med Genet A 124:19-27. 2004
    ..Finally, there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitual smoking and alcohol dependence...
  38. pmc Detecting population stratification using related individuals
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Campus Box 8134, St, Louis, Missouri 63110 USA
    BMC Proc 3:S106. 2009
    ..We examine a generalization of principal-component analyses to allow for the inclusion of related individuals by down-weighting the significance of individual comparisons...
  39. pmc Gene x gene and gene x environment interactions for complex disorders
    Robert Culverhouse
    Department of Medicine, Washington University, 660 South Euclid, GMS Box 8005, St, Louis, Missouri 63110, USA
    BMC Proc 1:S72. 2007
    ....
  40. pmc A search for non-chromosome 6 susceptibility loci contributing to rheumatoid arthritis
    Brian K Suarez
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Campus Box 8134, St, Louis, Missouri 63110, USA
    BMC Proc 3:S15. 2009
    ..0001. Eight of these SNPs (rs10498105, rs2398966, rs7664880, rs7447161, rs2793471, rs2611279, rs7967594, and rs742605) were common to both lists...
  41. pmc Linkage and association analyses of principal components in expression data
    Anthony L Hinrichs
    Department of Psychiatry, Washington University, 660 South Euclid, Box 8134, St, Louis, Missouri 63110, USA
    BMC Proc 1:S46. 2007
    ..Furthermore, we have identified two single-nucleotide polymorphisms that may influence the expression of multiple genes linked to chromosome 14...
  42. pmc Stratify or adjust? Dealing with multiple populations when evaluating rare variants
    ROBERT C CULVERHOUSE
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    BMC Proc 5:S101. 2011
    ..However, including population as a covariate was not an effective substitute for analyzing the subpopulations separately when only one subpopulation contained a rare variant linked to the phenotype...
  43. pmc Escitalopram reduces attentional performance in anxious older adults with high-expression genetic variants at serotonin 2A and 1B receptors
    Eric J Lenze
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Int J Neuropsychopharmacol 16:279-88. 2013
    ..These results, if confirmed, could lead to the personalization of SSRI use to reduce adverse neurocognitive effects...
  44. pmc Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family
    Yonghong Li
    Celera Diagnostics, Alameda, CA 94502, USA
    Proc Natl Acad Sci U S A 101:15688-93. 2004
    ..Our observations raise the possibility that GAPD genes are AD risk factors, a hypothesis that is consistent with the role of GAPD in neuronal apoptosis...
  45. pmc A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease
    Andrew Grupe
    Celera Diagnostics, Alameda, CA, USA
    Am J Hum Genet 78:78-88. 2006
    ..0165). These results indicate that variants in the RPS3A homologue are associated with LOAD and implicate this gene, adjacent genes, or other functional variants (e.g., noncoding RNAs) in the pathogenesis of this disorder...

Research Grants2

  1. Statistical Methods for the Genetics of Alcoholism
    Anthony Hinrichs; Fiscal Year: 2007
    ..Additionally, a publicly accessible online archive will be created to freely provide simulated data and software developed during this award. ..