Pilar Herrero

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Quantification of myocardial glucose utilization by PET and 1-carbon-11-glucose
    Pilar Herrero
    Cardiovascular Imaging Laboratory, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    J Nucl Cardiol 9:5-14. 2002
  2. ncbi request reprint PET measurements of myocardial glucose metabolism with 1-11C-glucose and kinetic modeling
    Pilar Herrero
    Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    J Nucl Med 48:955-64. 2007
  3. ncbi request reprint Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and 18F-fluorodeoxyglucose using the Patlak method
    Pilar Herrero
    Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 31:883-92. 2004
  4. ncbi request reprint L-3-11C-lactate as a PET tracer of myocardial lactate metabolism: a feasibility study
    Pilar Herrero
    Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 48:2046-55. 2007
  5. ncbi request reprint Assessment of myocardial blood flow using 15O-water and 1-11C-acetate in rats with small-animal PET
    Pilar Herrero
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:477-85. 2006
  6. ncbi request reprint Comparison of 1-(11)C-glucose and (18)F-FDG for quantifying myocardial glucose use with PET
    Pilar Herrero
    Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 43:1530-41. 2002
  7. pmc Exercise training impacts the myocardial metabolism of older individuals in a gender-specific manner
    Pablo F Soto
    Cardiovascular Div, Washington Univ School of Medicine, Campus Box 8225, 660 S Euclid Ave, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 295:H842-50. 2008
  8. pmc Sex and type 2 diabetes: obesity-independent effects on left ventricular substrate metabolism and relaxation in humans
    Linda R Peterson
    Division of Cardiovascular Diseases, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 20:802-10. 2012
  9. ncbi request reprint Assessment of myocardial metabolism in diabetic rats using small-animal PET: a feasibility study
    Michael J Welch
    The Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:689-97. 2006
  10. ncbi request reprint Fatty acids and insulin modulate myocardial substrate metabolism in humans with type 1 diabetes
    Linda R Peterson
    Cardiovascular Division, Department of Internal Medicine, Mallinckrodt Institute, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 57:32-40. 2008

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Quantification of myocardial glucose utilization by PET and 1-carbon-11-glucose
    Pilar Herrero
    Cardiovascular Imaging Laboratory, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    J Nucl Cardiol 9:5-14. 2002
    ..In this study we determined whether rMGU could be quantified by positron emission tomography (PET) and 1-carbon-11-glucose...
  2. ncbi request reprint PET measurements of myocardial glucose metabolism with 1-11C-glucose and kinetic modeling
    Pilar Herrero
    Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    J Nucl Med 48:955-64. 2007
    ..The aim of this study was to investigate whether compartmental modeling of 1-(11)C-glucose PET kinetics can be used for noninvasive measurements of myocardial glucose metabolism beyond its initial extraction...
  3. ncbi request reprint Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and 18F-fluorodeoxyglucose using the Patlak method
    Pilar Herrero
    Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 31:883-92. 2004
    ..Although further studies will be required to elucidate the reason for the egress of tracer from myocardium, not accounting for it will result in erroneous estimates of MGU...
  4. ncbi request reprint L-3-11C-lactate as a PET tracer of myocardial lactate metabolism: a feasibility study
    Pilar Herrero
    Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 48:2046-55. 2007
    ..In this study we tested L-3-(11)C-lactate ((11)C-lactate) as such a tracer...
  5. ncbi request reprint Assessment of myocardial blood flow using 15O-water and 1-11C-acetate in rats with small-animal PET
    Pilar Herrero
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:477-85. 2006
    ..This feasibility study was undertaken to determine whether myocardial blood flow (MBF, mL/g/min) could be quantified noninvasively in small rodents using microPET and 15O-water or 1-11C-acetate...
  6. ncbi request reprint Comparison of 1-(11)C-glucose and (18)F-FDG for quantifying myocardial glucose use with PET
    Pilar Herrero
    Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 43:1530-41. 2002
    ..In this study, we compared the accuracy of the rate of myocardial glucose use (rMGU) measured using PET and 1-(11)C-glucose with the rate measured using PET and the more conventional tracer (18)F-FDG...
  7. pmc Exercise training impacts the myocardial metabolism of older individuals in a gender-specific manner
    Pablo F Soto
    Cardiovascular Div, Washington Univ School of Medicine, Campus Box 8225, 660 S Euclid Ave, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 295:H842-50. 2008
    ..These findings suggest a role for altered myocardial substrate metabolism in modulating the cardiovascular benefits of EET in older individuals...
  8. pmc Sex and type 2 diabetes: obesity-independent effects on left ventricular substrate metabolism and relaxation in humans
    Linda R Peterson
    Division of Cardiovascular Diseases, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 20:802-10. 2012
    ..Sexually dimorphic myocardial metabolic and relaxation responses to diabetes may play a role in the known cardiovascular differences between men and women with diabetes...
  9. ncbi request reprint Assessment of myocardial metabolism in diabetic rats using small-animal PET: a feasibility study
    Michael J Welch
    The Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:689-97. 2006
    ..This feasibility study was undertaken to determine whether kinetic modeling in conjunction with small-animal PET could noninvasively quantify alterations in myocardial perfusion and substrate metabolism in rats...
  10. ncbi request reprint Fatty acids and insulin modulate myocardial substrate metabolism in humans with type 1 diabetes
    Linda R Peterson
    Cardiovascular Division, Department of Internal Medicine, Mallinckrodt Institute, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 57:32-40. 2008
    ..Whether conditions that affect myocardial glucose use and fatty acid utilization, oxidation, and storage in nondiabetic subjects alter them in type 1 diabetes is not well known...
  11. pmc Impact of gender on the myocardial metabolic response to obesity
    Linda R Peterson
    Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    JACC Cardiovasc Imaging 1:424-33. 2008
    ..We sought to determine the gender-specific effects of obesity on myocardial metabolism, work, and efficiency...
  12. pmc Impact of sex on the heart's metabolic and functional responses to diabetic therapies
    Matthew R Lyons
    Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri
    Am J Physiol Heart Circ Physiol 305:H1584-91. 2013
    ..Thus, in T2DM, different therapeutic regimens impact myocardial metabolism and diastolic function in a sex-specific manner. This suggests that sex should be taken into account when designing a patient's diabetes treatment. ..
  13. pmc Measurement of myocardial fatty acid esterification using [1-11C]palmitate and PET: comparison with direct measurements of myocardial triglyceride synthesis
    Andrew R Coggan
    Division of Radiological Sciences, Cardiovascular Imaging Laboratory, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
    J Nucl Cardiol 16:562-70. 2009
    ..The purpose of the present study was to assess the accuracy of rates of myocardial fatty acid esterification (MFAE) obtained using positron emission tomography (PET)...
  14. pmc In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy
    Kooresh I Shoghi
    Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Cardiovasc Imaging 2:373-81. 2009
    ..We aimed to assess noninvasively the efficacy of metformin and rosiglitazone monotherapy in normalizing myocardial substrate metabolism in an animal model of type 2 diabetes mellitus...
  15. pmc Quantification of regional myocardial oxygenation by magnetic resonance imaging: validation with positron emission tomography
    Kyle S McCommis
    Mallinckrodt Institute of Radiology and Center for Cardiovascular Research, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Circ Cardiovasc Imaging 3:41-6. 2010
    ..A cardiac MRI method was developed for assessing myocardial oxygenation. The purpose of this study was to evaluate and validate this technique compared with PET during pharmacological stress in a canine model of coronary artery stenosis...
  16. ncbi request reprint Increased myocardial fatty acid metabolism in patients with type 1 diabetes mellitus
    Pilar Herrero
    Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Coll Cardiol 47:598-604. 2006
    ..The purpose of this study was to determine if myocardial fatty acid utilization (MFAU) and myocardial fatty acid oxidation (MFAO) are increased in diabetic patients...
  17. pmc Sex differences in myocardial oxygen and glucose metabolism
    Linda R Peterson
    Cardiovascular Division, Mallinckrodt Institute of Radiology, St Louis, MO, USA
    J Nucl Cardiol 14:573-81. 2007
    ..The effect of sex on myocardial oxygen, glucose, and fatty acid metabolism in humans is unknown...
  18. pmc Effects of human immunodeficiency virus and metabolic complications on myocardial nutrient metabolism, blood flow, and oxygen consumption: a cross-sectional analysis
    W Todd Cade
    Program in Physical Therapy, Washington University School of Medicine, 4444 Forest Park Boulevard, St, Louis, Missouri 63108, USA
    Cardiovasc Diabetol 10:111. 2011
    ..We examined whether myocardial nutrient metabolism and left ventricular dysfunction are related to one another and worse in HIV infected men treated with cART vs. HIV-negative men with or without MC...
  19. pmc Assessment of myocardial triglyceride oxidation with PET and 11C-palmitate
    Zulfia Kisrieva-Ware
    Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
    J Nucl Cardiol 16:411-21. 2009
    ..The goal of this study was to test whether myocardial triglyceride (TG) turnover including oxidation of TG-derived fatty acids (FA) could be assessed with PET and (11)C-palmitate...
  20. ncbi request reprint Minimally invasive method of determining blood input function from PET images in rodents
    Joonyoung Kim
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:330-6. 2006
    ..A factor analysis (FA) technique for extracting the blood input function and myocardial time-activity curve from dynamic small-animal PET images of the rodent heart has been implemented to overcome these limitations...
  21. pmc Pilot study of pioglitazone and exercise training effects on basal myocardial substrate metabolism and left ventricular function in HIV-positive individuals with metabolic complications
    W Todd Cade
    Program in Physical Therapy, Washington University School of Medicine, St Louis, Missouri
    HIV Clin Trials 14:303-12. 2013
    ..It is unknown whether interventions shown to be effective in improving peripheral insulin sensitivity can improve basal myocardial insulin sensitivity and diastolic function in people with HIV and peripheral metabolic complications...
  22. ncbi request reprint Impact of aging on myocardial metabolic response to dobutamine
    Pablo F Soto
    Cardiovascular Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 285:H2158-64. 2003
    ..Although the clinical significance of these findings awaits further study, these results may partially explain the impaired contractile reserve and the increased incidence of cardiovascular disease in older individuals...
  23. ncbi request reprint Impact of hormone replacement on myocardial fatty acid metabolism: potential role of estrogen
    Pilar Herrero
    Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, 510 S Kingshighway Boulevard, St Louis, MO 63110, USA
    J Nucl Cardiol 12:574-81. 2005
    ..Whether these ovarian hormones exhibit similar effects on myocardial metabolism is unknown...
  24. pmc PET detection of the impact of dobutamine on myocardial glucose metabolism in women with type 1 diabetes mellitus
    Pilar Herrero
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    J Nucl Cardiol 15:791-9. 2008
    ..In experimental models of T1DM, myocardial glycolysis and glucose oxidation are reduced with the impairment becoming more pronounced with dobutamine. Whether similar changes occur in humans with T1DM is unclear...
  25. ncbi request reprint Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women
    Linda R Peterson
    Department of Medicine, Division of Cardiology, Washington University School of Medicine, Campus Box 8086, 660 S Euclid Ave, St Louis, MO 63110, USA
    Circulation 109:2191-6. 2004
    ..In the present study, we tested the hypothesis that myocardial fatty acid metabolism and efficiency are abnormal in obese women...
  26. ncbi request reprint Hypertensive left ventricular hypertrophy is associated with abnormal myocardial fatty acid metabolism and myocardial efficiency
    Lisa De Las Fuentes
    Cardiovascular Imaging and Clinical Research Core Laboratory, Department of Medicine, Cardiovascular Division, Washington University School of Medicine, St Louis, MO, USA
    J Nucl Cardiol 13:369-77. 2006
    ..Hypertension-induced left ventricular hypertrophy (LVH) is associated with an increased risk of cardiovascular morbidity and death by mechanisms not well characterized...
  27. ncbi request reprint Measurement of input functions in rodents: challenges and solutions
    Richard Laforest
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 32:679-85. 2005
    ..To be able to implement these approaches in rodent models of disease using small-animal PET (microPET), it is imperative that the input function is measured accurately...
  28. pmc Potentiation of abnormalities in myocardial metabolism with the development of diabetes in women with obesity and insulin resistance
    Janet B McGill
    Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Nucl Cardiol 18:421-9; quiz 432-3. 2011
    ....
  29. ncbi request reprint Myocardial fatty acid metabolism: independent predictor of left ventricular mass in hypertensive heart disease
    Lisa De Las Fuentes
    Cardiovascular Imaging and Clinical Research Core Laboratory, Washington University School of Medicine, St Louis, MO 63110, USA
    Hypertension 41:83-7. 2003
    ..The extent to which reduced myocardial fatty acid metabolism affects cardiovascular morbidity and mortality and whether pharmacologic modulation results in improved outcomes remains to be determined...
  30. ncbi request reprint Impact of aging on substrate metabolism by the human heart
    Andrew M Kates
    Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Am Coll Cardiol 41:293-9. 2003
    ..Results of studies in experimental animals have shown that, with age, myocardial fatty acid metabolism decreases, and glucose metabolism increases. Whether similar changes occur in humans is unknown...
  31. ncbi request reprint Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone)
    Jason S Lewis
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 43:1557-69. 2002
    ..Using canine models of hypoxic myocardium, we report our findings on *Cu-ATSM PET (*Cu is defined as either (60)Cu, (61)Cu, or (64)Cu) for the delineation of ischemic and hypoxic myocardium...
  32. pmc Time course of alterations in myocardial glucose utilization in the Zucker diabetic fatty rat with correlation to gene expression of glucose transporters: a small-animal PET investigation
    Kooresh I Shoghi
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 49:1320-7. 2008
    ....
  33. pmc Myocardial oxygen consumption change predicts left ventricular relaxation improvement in obese humans after weight loss
    C Huie Lin
    Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 19:1804-12. 2011
    ..Decreased total MVO2 independently predicted improved LV relaxation, suggesting that myocardial oxygen metabolism may be mechanistically important in determining cardiac relaxation...
  34. ncbi request reprint The effects of plasma insulin and glucose on myocardial blood flow in patients with type 1 diabetes mellitus
    Muthayyah Srinivasan
    Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Am Coll Cardiol 46:42-8. 2005
    ..The objective of this study was to determine the impact of insulin and glucose on myocardial vasodilator function in patients with type 1 diabetes mellitus (T1DM)...
  35. pmc Synthesis and evaluation of 15-(4-(2-[¹⁸F]Fluoroethoxy)phenyl)pentadecanoic acid: a potential PET tracer for studying myocardial fatty acid metabolism
    Zhude Tu
    Division of Radiological Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Bioconjug Chem 21:2313-9. 2010
    ..0030 ± 0.0005 vs 0.0006 ± 0.00013, P < 0.01). These initial studies suggest that [¹⁸F]7 could be a potentially useful clinical PET tracer to assess abnormal myocardial fatty acid metabolism...
  36. ncbi request reprint Techniques necessary for multiple tracer quantitative small-animal imaging studies
    Terry L Sharp
    Division of Radiological Sciences, The Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, St Louis, MO 63110, USA
    Nucl Med Biol 32:875-84. 2005
    ..These techniques need to be reproducible in the same animal while maintaining hemodynamic and physiological stability...
  37. ncbi request reprint Imaging myocardium enzymatic pathways with carbon-11 radiotracers
    Carmen S Dence
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Methods Enzymol 385:286-315. 2004
  38. pmc Feasibility study of myocardial perfusion and oxygenation by noncontrast MRI: comparison with PET study in a canine model
    Kyle S McCommis
    Mallinckrodt Institute of Radiology, Box 8225, Washington University School of Medicine, St Louis, MO 63110, USA
    Magn Reson Imaging 26:11-9. 2008
    ..The proposed noncontrast MRI technique is a promising method to quantitatively assess myocardial perfusion and oxygenation...
  39. ncbi request reprint Feasibility and dosimetry studies for 18F-NOS as a potential PET radiopharmaceutical for inducible nitric oxide synthase in humans
    Pilar Herrero
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 53:994-1001. 2012
    ....
  40. ncbi request reprint Imaging of myocardial metabolism
    Pilar Herrero
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    J Nucl Cardiol 12:345-58. 2005
    ..Both the current and future capabilities of metabolic imaging to furthering our understanding of cardiac disease are highlighted...
  41. ncbi request reprint Dynamic coronary MR angiography and first-pass perfusion with intracoronary administration of contrast agent
    Nikolaos V Tsekos
    Cardiovascular Imaging Laboratory, Mallinckrodt Institute of Radiology, Washington University Medical Center, St Louis, Missouri 63110, USA
    J Magn Reson Imaging 16:311-9. 2002
    ....
  42. ncbi request reprint Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy
    Victor G Davila-Roman
    Cardiovascular Imaging and Clinical Research Core Laboratory, Cardiovascular Division, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Am Coll Cardiol 40:271-7. 2002
    ..The purpose of this study was to determine whether patients with idiopathic dilated cardiomyopathy (IDCM) exhibit alterations in myocardial fatty acid and glucose metabolism...
  43. ncbi request reprint The glucose-regulated nuclear localization of hexokinase 2 in Saccharomyces cerevisiae is Mig1-dependent
    Deifilia Ahuatzi
    Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Campus del Cristo, 33006 Oviedo, Spain
    J Biol Chem 279:14440-6. 2004
    ..We conclude that Hxk2 operates by interacting with Mig1 to generate a repressor complex located in the nucleus of S. cerevisiae during growth in glucose medium...
  44. ncbi request reprint The hexokinase 2-dependent glucose signal transduction pathway of Saccharomyces cerevisiae
    Fernando Moreno
    Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Edificio Santiago Gascon, Campus del Cristo, 33006 Oviedo, Spain
    FEMS Microbiol Rev 26:83-90. 2002
    ....
  45. ncbi request reprint Hxk2 regulates the phosphorylation state of Mig1 and therefore its nucleocytoplasmic distribution
    Deifilia Ahuatzi
    Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Campus del Cristo, Edificio Santiago Gascon, 33006 Oviedo, Spain
    J Biol Chem 282:4485-93. 2007
    ..These results allow postulating that the Hxk2 operates by interacting both with Mig1 and Snf1 to inhibit the Mig1 phosphorylation at serine 311 during high glucose grown...
  46. pmc Rgt1, a glucose sensing transcription factor, is required for transcriptional repression of the HXK2 gene in Saccharomyces cerevisiae
    Aaron Palomino
    Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Campus del Cristo, Edificio Santiago Gascon, 33006 Oviedo, Spain
    Biochem J 388:697-703. 2005
    ..The physiological significance of the connection between two glucose-signalling pathways, the Snf3/Rgt2 that causes glucose induction and the Mig1/Hxk2 that causes glucose repression, was also analysed...
  47. ncbi request reprint A glucose response element from the S. cerevisiae hexose transporter HXT1 gene is sensitive to glucose in human fibroblasts
    Andreu Ferrer-Martínez
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Marti i Franques, 1 E 08028 Barcelona, Spain
    J Mol Biol 338:657-67. 2004
    ..These data suggest that the instructions carried within gene regulatory elements controlling nutrient regulation of gene expression have been conserved throughout evolution...