Research Topics
| Pilar HerreroSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
Quantification of myocardial glucose utilization by PET and 1-carbon-11-glucosePilar Herrero
Cardiovascular Imaging Laboratory, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
J Nucl Cardiol 9:5-14. 2002..In this study we determined whether rMGU could be quantified by positron emission tomography (PET) and 1-carbon-11-glucose...- L-3-11C-lactate as a PET tracer of myocardial lactate metabolism: a feasibility studyPilar Herrero
Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 48:2046-55. 2007..In this study we tested L-3-(11)C-lactate ((11)C-lactate) as such a tracer... - Assessment of myocardial blood flow using 15O-water and 1-11C-acetate in rats with small-animal PETPilar Herrero
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 47:477-85. 2006..This feasibility study was undertaken to determine whether myocardial blood flow (MBF, mL/g/min) could be quantified noninvasively in small rodents using microPET and 15O-water or 1-11C-acetate... - Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and 18F-fluorodeoxyglucose using the Patlak methodPilar Herrero
Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 31:883-92. 2004..Although further studies will be required to elucidate the reason for the egress of tracer from myocardium, not accounting for it will result in erroneous estimates of MGU... - Comparison of 1-(11)C-glucose and (18)F-FDG for quantifying myocardial glucose use with PETPilar Herrero
Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 43:1530-41. 2002..In this study, we compared the accuracy of the rate of myocardial glucose use (rMGU) measured using PET and 1-(11)C-glucose with the rate measured using PET and the more conventional tracer (18)F-FDG... - PET measurements of myocardial glucose metabolism with 1-11C-glucose and kinetic modelingPilar Herrero
Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
J Nucl Med 48:955-64. 2007..The aim of this study was to investigate whether compartmental modeling of 1-(11)C-glucose PET kinetics can be used for noninvasive measurements of myocardial glucose metabolism beyond its initial extraction... 
Exercise training impacts the myocardial metabolism of older individuals in a gender-specific mannerPablo F Soto
Cardiovascular Div, Washington Univ School of Medicine, Campus Box 8225, 660 S Euclid Ave, St Louis, MO 63110, USA
Am J Physiol Heart Circ Physiol 295:H842-50. 2008..These findings suggest a role for altered myocardial substrate metabolism in modulating the cardiovascular benefits of EET in older individuals...- Sex and type 2 diabetes: obesity-independent effects on left ventricular substrate metabolism and relaxation in humansLinda R Peterson
Division of Cardiovascular Diseases, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Obesity (Silver Spring) 20:802-10. 2012..Sexually dimorphic myocardial metabolic and relaxation responses to diabetes may play a role in the known cardiovascular differences between men and women with diabetes... - Impact of gender on the myocardial metabolic response to obesityLinda R Peterson
Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
JACC Cardiovasc Imaging 1:424-33. 2008..We sought to determine the gender-specific effects of obesity on myocardial metabolism, work, and efficiency... - Assessment of myocardial metabolism in diabetic rats using small-animal PET: a feasibility studyMichael J Welch
The Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Nucl Med 47:689-97. 2006..Thus, small-animal PET demonstrates significant promise in providing a means to link the myocardial metabolic abnormalities that occur in rat of disease with the human condition... - Fatty acids and insulin modulate myocardial substrate metabolism in humans with type 1 diabetesLinda R Peterson
Cardiovascular Division, Department of Internal Medicine, Mallinckrodt Institute, Washington University School of Medicine, St Louis, Missouri, USA
Diabetes 57:32-40. 2008..Whether conditions that affect myocardial glucose use and fatty acid utilization, oxidation, and storage in nondiabetic subjects alter them in type 1 diabetes is not well known... - Quantification of regional myocardial oxygenation by magnetic resonance imaging: validation with positron emission tomographyKyle S McCommis
Mallinckrodt Institute of Radiology and Center for Cardiovascular Research, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
Circ Cardiovasc Imaging 3:41-6. 2010..A cardiac MRI method was developed for assessing myocardial oxygenation. The purpose of this study was to evaluate and validate this technique compared with PET during pharmacological stress in a canine model of coronary artery stenosis... - Measurement of myocardial fatty acid esterification using [1-11C]palmitate and PET: comparison with direct measurements of myocardial triglyceride synthesisAndrew R Coggan
Division of Radiological Sciences, Cardiovascular Imaging Laboratory, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
J Nucl Cardiol 16:562-70. 2009..The purpose of the present study was to assess the accuracy of rates of myocardial fatty acid esterification (MFAE) obtained using positron emission tomography (PET)... - In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapyKooresh I Shoghi
Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Circ Cardiovasc Imaging 2:373-81. 2009..We aimed to assess noninvasively the efficacy of metformin and rosiglitazone monotherapy in normalizing myocardial substrate metabolism in an animal model of type 2 diabetes mellitus... - Sex differences in myocardial oxygen and glucose metabolismLinda R Peterson
Cardiovascular Division, Mallinckrodt Institute of Radiology, St Louis, MO, USA
J Nucl Cardiol 14:573-81. 2007..The effect of sex on myocardial oxygen, glucose, and fatty acid metabolism in humans is unknown... - Increased myocardial fatty acid metabolism in patients with type 1 diabetes mellitusPilar Herrero
Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Am Coll Cardiol 47:598-604. 2006..403 +/- 191 nmol/g/min, p = 0.0008). CONCLUSIONS: Humans with diabetes mellitus exhibit increased MFAU and MFAO and reduced MGU consistent with observations obtained in experimental models of diabetes... - Effects of human immunodeficiency virus and metabolic complications on myocardial nutrient metabolism, blood flow, and oxygen consumption: a cross-sectional analysisW Todd Cade
Program in Physical Therapy, Washington University School of Medicine, 4444 Forest Park Boulevard, St, Louis, Missouri 63108, USA
Cardiovasc Diabetol 10:111. 2011..We examined whether myocardial nutrient metabolism and left ventricular dysfunction are related to one another and worse in HIV infected men treated with cART vs. HIV-negative men with or without MC... - Assessment of myocardial triglyceride oxidation with PET and 11C-palmitateZulfia Kisrieva-Ware
Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
J Nucl Cardiol 16:411-21. 2009..The goal of this study was to test whether myocardial triglyceride (TG) turnover including oxidation of TG-derived fatty acids (FA) could be assessed with PET and (11)C-palmitate... - Minimally invasive method of determining blood input function from PET images in rodentsJoonyoung Kim
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Nucl Med 47:330-6. 2006.... - Impact of hormone replacement on myocardial fatty acid metabolism: potential role of estrogenPilar Herrero
Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, 510 S. Kingshighway Boulevard, St Louis, MO 63110, USA
J Nucl Cardiol 12:574-81. 2005..Thus, when the cardiac effects of hormone replacement therapy are being assessed, alterations in myocardial substrate metabolism should be considered... - PET detection of the impact of dobutamine on myocardial glucose metabolism in women with type 1 diabetes mellitusPilar Herrero
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
J Nucl Cardiol 15:791-9. 2008..In experimental models of T1DM, myocardial glycolysis and glucose oxidation are reduced with the impairment becoming more pronounced with dobutamine. Whether similar changes occur in humans with T1DM is unclear... - Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young womenLinda R Peterson
Department of Medicine, Division of Cardiology, Washington University School of Medicine, Campus Box 8086, 660 S Euclid Ave, St Louis, MO 63110, USA
Circulation 109:2191-6. 2004..In the present study, we tested the hypothesis that myocardial fatty acid metabolism and efficiency are abnormal in obese women... - Impact of aging on myocardial metabolic response to dobutaminePablo F Soto
Cardiovascular Division, Washington University School of Medicine, St. Louis, MO 63110, USA
Am J Physiol Heart Circ Physiol 285:H2158-64. 2003..Although the clinical significance of these findings awaits further study, these results may partially explain the impaired contractile reserve and the increased incidence of cardiovascular disease in older individuals... - Hypertensive left ventricular hypertrophy is associated with abnormal myocardial fatty acid metabolism and myocardial efficiencyLisa De Las Fuentes
Cardiovascular Imaging and Clinical Research Core Laboratory, Department of Medicine, Cardiovascular Division, Washington University School of Medicine, St Louis, MO, USA
J Nucl Cardiol 13:369-77. 2006..Hypertension-induced left ventricular hypertrophy (LVH) is associated with an increased risk of cardiovascular morbidity and death by mechanisms not well characterized... 
Potentiation of abnormalities in myocardial metabolism with the development of diabetes in women with obesity and insulin resistanceJanet B McGill
Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
J Nucl Cardiol 18:421-9; quiz 432-3. 2011....- Myocardial fatty acid metabolism: independent predictor of left ventricular mass in hypertensive heart diseaseLisa De Las Fuentes
Cardiovascular Imaging and Clinical Research Core Laboratory, Washington University School of Medicine, St Louis, MO 63110, USA
Hypertension 41:83-7. 2003..The extent to which reduced myocardial fatty acid metabolism affects cardiovascular morbidity and mortality and whether pharmacologic modulation results in improved outcomes remains to be determined... - Time course of alterations in myocardial glucose utilization in the Zucker diabetic fatty rat with correlation to gene expression of glucose transporters: a small-animal PET investigationKooresh I Shoghi
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 49:1320-7. 2008.... - Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone)Jason S Lewis
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Nucl Med 43:1557-69. 2002..CONCLUSION: *Cu-ATSM PET has shown quantitative selective uptake in hypoxic myocardium within 20 min of tracer administration in 3 canine models of hypoxia... - Measurement of input functions in rodents: challenges and solutionsRichard Laforest
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 32:679-85. 2005..To be able to implement these approaches in rodent models of disease using small-animal PET (microPET), it is imperative that the input function is measured accurately... - Impact of aging on substrate metabolism by the human heartAndrew M Kates
Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA
J Am Coll Cardiol 41:293-9. 2003..The clinical significance of this metabolic switch awaits further study... - Myocardial oxygen consumption change predicts left ventricular relaxation improvement in obese humans after weight lossC Huie Lin
Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Obesity (Silver Spring) 19:1804-12. 2011..Decreased total MVO2 independently predicted improved LV relaxation, suggesting that myocardial oxygen metabolism may be mechanistically important in determining cardiac relaxation... - The effects of plasma insulin and glucose on myocardial blood flow in patients with type 1 diabetes mellitusMuthayyah Srinivasan
Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA
J Am Coll Cardiol 46:42-8. 2005..0001). CONCLUSIONS: In the short term, hyperglycemia has a deleterious effect on myocardial vasodilator function, which outweighs the beneficial effect of hyperinsulinemia... - Feasibility study of myocardial perfusion and oxygenation by noncontrast MRI: comparison with PET study in a canine modelKyle S McCommis
Mallinckrodt Institute of Radiology, Box 8225, Washington University School of Medicine, St Louis, MO 63110, USA
Magn Reson Imaging 26:11-9. 2008..The proposed noncontrast MRI technique is a promising method to quantitatively assess myocardial perfusion and oxygenation... - Techniques necessary for multiple tracer quantitative small-animal imaging studiesTerry L Sharp
Division of Radiological Sciences, The Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, St. Louis, MO 63110, USA
Nucl Med Biol 32:875-84. 2005..CONCLUSION: The intrastudy stability of the physiological measurements and substrate levels and interstudy reproducibility of the measurements are reported... - Synthesis and evaluation of 15-(4-(2-[¹⁸F]Fluoroethoxy)phenyl)pentadecanoic acid: a potential PET tracer for studying myocardial fatty acid metabolismZhude Tu
Division of Radiological Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
Bioconjug Chem 21:2313-9. 2010..0030 ± 0.0005 vs 0.0006 ± 0.00013, P < 0.01). These initial studies suggest that [¹⁸F]7 could be a potentially useful clinical PET tracer to assess abnormal myocardial fatty acid metabolism... - Imaging myocardium enzymatic pathways with carbon-11 radiotracersCarmen S Dence
Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Methods Enzymol 385:286-315. 2004 - Feasibility and dosimetry studies for 18F-NOS as a potential PET radiopharmaceutical for inducible nitric oxide synthase in humansPilar Herrero
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 53:994-1001. 2012.... - Imaging of myocardial metabolismPilar Herrero
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
J Nucl Cardiol 12:345-58. 2005..Both the current and future capabilities of metabolic imaging to furthering our understanding of cardiac disease are highlighted... - Dynamic coronary MR angiography and first-pass perfusion with intracoronary administration of contrast agentNikolaos V Tsekos
Cardiovascular Imaging Laboratory, Mallinckrodt Institute of Radiology, Washington University Medical Center, St Louis, Missouri 63110, USA
J Magn Reson Imaging 16:311-9. 2002.... - Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathyVictor G Davila-Roman
Cardiovascular Imaging and Clinical Research Core Laboratory, Cardiovascular Division, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
J Am Coll Cardiol 40:271-7. 2002..The purpose of this study was to determine whether patients with idiopathic dilated cardiomyopathy (IDCM) exhibit alterations in myocardial fatty acid and glucose metabolism... - The glucose-regulated nuclear localization of hexokinase 2 in Saccharomyces cerevisiae is Mig1-dependentDeifilia Ahuatzi
Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Campus del Cristo, 33006 Oviedo, Spain
J Biol Chem 279:14440-6. 2004..We conclude that Hxk2 operates by interacting with Mig1 to generate a repressor complex located in the nucleus of S. cerevisiae during growth in glucose medium... - Rgt1, a glucose sensing transcription factor, is required for transcriptional repression of the HXK2 gene in Saccharomyces cerevisiaeAaron Palomino
Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Campus del Cristo, Edificio Santiago Gascon, 33006 Oviedo, Spain
Biochem J 388:697-703. 2005..The physiological significance of the connection between two glucose-signalling pathways, the Snf3/Rgt2 that causes glucose induction and the Mig1/Hxk2 that causes glucose repression, was also analysed... - Hxk2 regulates the phosphorylation state of Mig1 and therefore its nucleocytoplasmic distributionDeifilia Ahuatzi
Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Campus del Cristo, Edificio Santiago Gascon, 33006 Oviedo, Spain
J Biol Chem 282:4485-93. 2007..These results allow postulating that the Hxk2 operates by interacting both with Mig1 and Snf1 to inhibit the Mig1 phosphorylation at serine 311 during high glucose grown... - The hexokinase 2-dependent glucose signal transduction pathway of Saccharomyces cerevisiaeFernando Moreno
Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Edificio Santiago Gascon, Campus del Cristo, 33006 Oviedo, Spain
FEMS Microbiol Rev 26:83-90. 2002.... - A glucose response element from the S. cerevisiae hexose transporter HXT1 gene is sensitive to glucose in human fibroblastsAndreu Ferrer-Martínez
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Marti i Franques, 1 E 08028 Barcelona, Spain
J Mol Biol 338:657-67. 2004..These data suggest that the instructions carried within gene regulatory elements controlling nutrient regulation of gene expression have been conserved throughout evolution...