Denise Head

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition
    Denise Head
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Arch Neurol 69:636-43. 2012
  2. pmc The moderating role of exercise on stress-related effects on the hippocampus and memory in later adulthood
    Denise Head
    Washington University, Department of Psychology, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Neuropsychology 26:133-43. 2012
  3. pmc Age differences in perseveration: cognitive and neuroanatomical mediators of performance on the Wisconsin Card Sorting Test
    Denise Head
    Department of Psychology, Washington University, St Louis, USA
    Neuropsychologia 47:1200-3. 2009
  4. pmc Neuroanatomical and cognitive mediators of age-related differences in episodic memory
    Denise Head
    Department of Psychology, Division of Biology and Biomedical Sciences, Washington University in St Louis, MO 63130, USA
    Neuropsychology 22:491-507. 2008
  5. doi Age effects on wayfinding and route learning skills
    Denise Head
    Department of Psychology, Washington University, St Louis, MO, USA
    Behav Brain Res 209:49-58. 2010
  6. pmc Role of family history for Alzheimer biomarker abnormalities in the adult children study
    Chengjie Xiong
    Charles F and Joanne Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri, USA
    Arch Neurol 68:1313-9. 2011
  7. pmc Toward a multifactorial model of Alzheimer disease
    Martha Storandt
    Department of Psychology, Washington University, St Louis, Missouri, USA
    Neurobiol Aging 33:2262-71. 2012
  8. pmc Exercise and Alzheimer's disease biomarkers in cognitively normal older adults
    Kelvin Y Liang
    From the Program in Neuroscience, Division of Biology and Biomedical Sciences, Washington University, St Louis, MO 63130, USA
    Ann Neurol 68:311-8. 2010
  9. pmc Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease
    John C Morris
    Alzheimer s Disease Research Center, St Louis, Missouri 63108, USA
    Arch Neurol 66:1469-75. 2009
  10. pmc Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Biol Psychiatry 67:584-7. 2010

Detail Information

Publications32

  1. pmc Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition
    Denise Head
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Arch Neurol 69:636-43. 2012
    ..The primary objective here was to examine whether physical exercise moderates the association between APOE genotype and amyloid deposition in cognitively normal adults...
  2. pmc The moderating role of exercise on stress-related effects on the hippocampus and memory in later adulthood
    Denise Head
    Washington University, Department of Psychology, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Neuropsychology 26:133-43. 2012
    ..The current investigation examined effects of lifetime stress on hippocampal volume and memory, the moderating role of stress on age effects, and the moderating role of exercise on stress-related effects...
  3. pmc Age differences in perseveration: cognitive and neuroanatomical mediators of performance on the Wisconsin Card Sorting Test
    Denise Head
    Department of Psychology, Washington University, St Louis, USA
    Neuropsychologia 47:1200-3. 2009
    ..We conclude that age-related increase in perseveration is indeed differentially dependent on the integrity of prefrontal cortex and on declines in selected cognitive processes dependent on this region...
  4. pmc Neuroanatomical and cognitive mediators of age-related differences in episodic memory
    Denise Head
    Department of Psychology, Division of Biology and Biomedical Sciences, Washington University in St Louis, MO 63130, USA
    Neuropsychology 22:491-507. 2008
    ..No direct effects of age on episodic memory remained once these factors were taken into account. These analyses highlight the value of a multivariate approach with the understanding of complex relationships in cognitive and brain aging...
  5. doi Age effects on wayfinding and route learning skills
    Denise Head
    Department of Psychology, Washington University, St Louis, MO, USA
    Behav Brain Res 209:49-58. 2010
    ..These results provide indications of specific aspects of navigational learning that may contribute to age-related declines and potential neural substrates...
  6. pmc Role of family history for Alzheimer biomarker abnormalities in the adult children study
    Chengjie Xiong
    Charles F and Joanne Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri, USA
    Arch Neurol 68:1313-9. 2011
    ..To assess whether family history (FH) of Alzheimer disease (AD) alone influences AD biomarker abnormalities...
  7. pmc Toward a multifactorial model of Alzheimer disease
    Martha Storandt
    Department of Psychology, Washington University, St Louis, Missouri, USA
    Neurobiol Aging 33:2262-71. 2012
    ..The lack of correlation between these 2 processes and brain volume in the regions most often affected in AD suggests the operation of a third process related to brain atrophy...
  8. pmc Exercise and Alzheimer's disease biomarkers in cognitively normal older adults
    Kelvin Y Liang
    From the Program in Neuroscience, Division of Biology and Biomedical Sciences, Washington University, St Louis, MO 63130, USA
    Ann Neurol 68:311-8. 2010
    ..The objective of this study was to elucidate the association between exercise and AD pathology in humans using Pittsburgh compound-B (PIB), amyloid-beta (Abeta)(42), tau, and phosphorylated tau (ptau)(181) biomarkers...
  9. pmc Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease
    John C Morris
    Alzheimer s Disease Research Center, St Louis, Missouri 63108, USA
    Arch Neurol 66:1469-75. 2009
    ..To determine whether preclinical Alzheimer disease (AD), as detected by the amyloid-imaging agent Pittsburgh Compound B (PiB) in cognitively normal older adults, is associated with risk of symptomatic AD...
  10. pmc Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Biol Psychiatry 67:584-7. 2010
    ....
  11. pmc Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition
    Martha Storandt
    Department of Psychology, School of Arts and Sciences, Washington University, St Louis, Missouri 63108, USA
    Arch Neurol 66:1476-81. 2009
    ..To examine the relation of amyloid-beta peptide (Abeta) levels in the cerebral cortex with structural brain integrity and cognitive performance in cognitively healthy older people...
  12. pmc Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 65:176-83. 2009
    ..The objective of this study was to determine whether cerebrospinal fluid (CSF) biomarkers for AD suggest the presence of brain damage in the preclinical stage of AD...
  13. pmc Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, St Louis, Misouri, USA
    Biol Psychiatry 67:581-3. 2010
    ..Imaging of Abeta deposition in the human brain using Pittsburgh Compound B (PIB) offers the possibility of using cortical PIB binding as a quantitative endophenotype for genetic studies of late-onset Alzheimer's disease (LOAD)...
  14. pmc Structural correlates of prospective memory
    Brian A Gordon
    Department of Psychology, Washington University, St Louis, MO 63130, United States
    Neuropsychologia 49:3795-800. 2011
    ..These novel results confirm a relationship between behavior and underlying brain structure proposed by the multiprocess theory of PM, and extend findings on cognitive correlates of medial temporal lobe integrity...
  15. pmc Disruption of large-scale brain systems in advanced aging
    Jessica R Andrews-Hanna
    Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Neuron 56:924-35. 2007
    ..These results suggest that cognitive decline in normal aging arises from functional disruption in the coordination of large-scale brain systems that support cognition...
  16. ncbi Frontal-hippocampal double dissociation between normal aging and Alzheimer's disease
    Denise Head
    Howard Hughes Medical Institute, One Brookings Drive, Department of Psychology, Washington University, St Louis, MO 63130, USA
    Cereb Cortex 15:732-9. 2005
    ..A separate process, ubiquitous in aging, affects brain white matter with an anterior-to-posterior gradient and may underlie the executive difficulties common in aging...
  17. ncbi A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume
    Randy L Buckner
    Department of Psychology, HHMI at Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Neuroimage 23:724-38. 2004
    ..Thus, atlas normalization provides a common framework for both morphometric and functional data analysis...
  18. pmc Exercise moderates age-related atrophy of the medial temporal lobe
    Julie M Bugg
    Washington University, Department of Psychology, Campus Box 1125, One Brookings Dr, St Louis, MO 63130, USA
    Neurobiol Aging 32:506-14. 2011
    ..This novel finding extends support for the efficacy of exercise to the potential maintenance of medial temporal lobe integrity in older adults...
  19. ncbi Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the Alzheimer type: evidence from diffusion tensor imaging
    Denise Head
    Howard Hughes Medical Institute, Washington University, St Louis, MO 63130, USA
    Cereb Cortex 14:410-23. 2004
    ..The dissociation between the regional effects of age and dementia status suggests that the mechanisms underlying age-associated cognitive decline are likely distinct from those underlying DAT...
  20. pmc White matter integrity and reaction time intraindividual variability in healthy aging and early-stage Alzheimer disease
    Jonathan D Jackson
    Department of Psychology, Washington University in St Louis, St Louis, MO 63130, USA
    Neuropsychologia 50:357-66. 2012
    ....
  21. pmc Cognitive and neural correlates of aerobic fitness in obese older adults
    Julie M Bugg
    Department of Psychology, Washington University in St Louis, St Louis, Missouri 63130, USA
    Exp Aging Res 38:131-45. 2012
    ....
  22. doi Changes in events alter how people remember recent information
    Khena M Swallow
    Washington University in St Louis, WA, USA
    J Cogn Neurosci 23:1052-64. 2011
    ..These data strongly suggest that the segmentation of ongoing activity into events is a control process that regulates when memory for events is updated...
  23. pmc Exploring the relationship between personality and regional brain volume in healthy aging
    Jonathan Jackson
    Department of Psychology, Washington University in St Louis, St Louis, MO 63130, USA
    Neurobiol Aging 32:2162-71. 2011
    ..These results suggest that personality may not only relate to, but may also moderate age-related cross-sectional decline in prefrontal and medial temporal regions...
  24. pmc Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease
    Rawan Tarawneh
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 70:274-85. 2011
    ..Visinin-like protein-1 (VILIP-1) has demonstrated potential utility as a marker of neuronal injury. Here we investigate CSF VILIP-1 and VILIP-1/amyloid-β42 (Aβ42) ratio as diagnostic and prognostic markers in early AD...
  25. ncbi Age-related differences in the course of cognitive skill acquisition: the role of regional cortical shrinkage and cognitive resources
    Denise Head
    Department of Psychology, University of Memphis, Tennessee, USA
    Psychol Aging 17:72-84. 2002
    ..When hypertensive participants were excluded, the effect of prefrontal shrinkage on executive aspects of performance was no longer significant, but the effect of working memory remained...
  26. pmc Evidence for a detrimental relationship between hypertension history, prospective memory, and prefrontal cortex white matter in cognitively normal older adults
    Michael K Scullin
    Washington University in St Louis, St Louis, MO, USA
    Cogn Affect Behav Neurosci 13:405-16. 2013
    ....
  27. doi Medial temporal lobe volume predicts elders' everyday memory
    Heather R Bailey
    Washington University in St Louis, MO 63130, USA
    Psychol Sci 24:1113-22. 2013
    ..Thus, the current findings suggest that during perception, the medial temporal lobes support the construction of event representations that determine subsequent memory. ..
  28. doi Effects of aging and Alzheimer's disease along the longitudinal axis of the hippocampus
    Brian A Gordon
    Department of Psychology, Washington University in St Louis, St Louis, MO, USA
    J Alzheimers Dis 37:41-50. 2013
    ..These results indicate that there is an anterior-to-posterior gradient of loss within the hippocampus with both advancing age and AD. ..
  29. ncbi Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume
    Naftali Raz
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Neurobiol Aging 25:377-96. 2004
    ....
  30. ncbi Differential age-related changes in the regional metencephalic volumes in humans: a 5-year follow-up
    Naftali Raz
    Institute of Gerontology, Wayne State University, Detroit, Detroit, MI 48202, USA
    Neurosci Lett 349:163-6. 2003
    ..Neither sex differences, nor sex-specific aging trends were found. We conclude that differential age-related shrinkage of the metencephalic structures occurs in healthy adults, but its magnitude differs from cross-sectional estimates...
  31. ncbi Regional brain changes in aging healthy adults: general trends, individual differences and modifiers
    Naftali Raz
    Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry St, 226 Knapp Building, Detroit, MI 48202, USA
    Cereb Cortex 15:1676-89. 2005
    ..No sex differences in age trends except for the caudate were observed. We found no evidence of neuroprotective effects of larger brain size or educational attainment...
  32. ncbi Differential aging of the human striatum: longitudinal evidence
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit MI, USA
    AJNR Am J Neuroradiol 24:1849-56. 2003
    ....