C F Hardy

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Cdc5 interacts with the Wee1 kinase in budding yeast
    C R Bartholomew
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 21:4949-59. 2001
  2. ncbi The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner
    Z Hilioti
    The Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Biol 11:1347-52. 2001
  3. pmc A novel role for Cdc5p in DNA replication
    C F Hardy
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 16:6775-82. 1996
  4. pmc mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p
    C F Hardy
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 94:3151-5. 1997
  5. ncbi Identification of Cdc45p, an essential factor required for DNA replication
    C F Hardy
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gene 187:239-46. 1997
  6. pmc Cell cycle regulation of DNA replication initiator factor Dbf4p
    L Cheng
    Department of Cell Biology and Physiology and Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 19:4270-8. 1999
  7. pmc Characterization of an essential Orc2p-associated factor that plays a role in DNA replication
    C F Hardy
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 16:1832-41. 1996
  8. pmc Cell cycle regulation of the Saccharomyces cerevisiae polo-like kinase cdc5p
    L Cheng
    Department of Cell Biology and Physiology and Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 18:7360-70. 1998
  9. ncbi A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation
    C F Hardy
    Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Genes Dev 6:801-14. 1992

Collaborators

Detail Information

Publications9

  1. pmc Cdc5 interacts with the Wee1 kinase in budding yeast
    C R Bartholomew
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 21:4949-59. 2001
    ..From these results, we conclude that multinucleate formation in response to Cdc5 overexpression is linked to titration of Swe1 function. These results also suggest that Cdc5 may be a negative regulator of Swe1...
  2. ncbi The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner
    Z Hilioti
    The Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Biol 11:1347-52. 2001
    ..We also find that Pds1 does not interact with Cdh1. Finally, the effect of spindle assembly checkpoint activation, known to inhibit APC/C function [8], on the Pds1-Cdc20 interaction is examined...
  3. pmc A novel role for Cdc5p in DNA replication
    C F Hardy
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 16:6775-82. 1996
    ..cdc5-1 orc2-1 double mutants are synthetically lethal. Levels of Cdc5p were found to be cell cycle regulated and peaked in G2/M. These results suggest a role for Cdc5p and possibly Polo-like kinases at origin complexes...
  4. pmc mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p
    C F Hardy
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 94:3151-5. 1997
    ..Moreover, Mcm5p/Cdc46p may have both positive and negative effects on the ability of cell to initiate replication...
  5. ncbi Identification of Cdc45p, an essential factor required for DNA replication
    C F Hardy
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gene 187:239-46. 1997
    ..The cdc45-1 mutant has a plasmid maintenance defect which is rescued by the addition of multiple potential origins to the plasmid...
  6. pmc Cell cycle regulation of DNA replication initiator factor Dbf4p
    L Cheng
    Department of Cell Biology and Physiology and Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 19:4270-8. 1999
    ..These results further link the actions of the initiator protein, Dbf4p, to the completion of mitosis and suggest possible roles for Dbf4p during progression through mitosis...
  7. pmc Characterization of an essential Orc2p-associated factor that plays a role in DNA replication
    C F Hardy
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 16:1832-41. 1996
    ..These results suggest a role for OAFI in the initiation of DNA replication. Mutant alleles of cdc7 and cdc14 were also isolated in the orc2-1 synthetic lethal screen. Cdc7p, like Oaf1p, also interacts with Orc2p in two-hybrid assays...
  8. pmc Cell cycle regulation of the Saccharomyces cerevisiae polo-like kinase cdc5p
    L Cheng
    Department of Cell Biology and Physiology and Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 18:7360-70. 1998
    ..These results further link the actions of the APC to the completion of mitosis and suggest possible roles for Cdc5p during progression through and completion of mitosis...
  9. ncbi A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation
    C F Hardy
    Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Genes Dev 6:801-14. 1992
    ..By use of the two-hybrid system, we have isolated a mutation in RIF1 that partially restores the interaction with rap1s mutant proteins...