J William Harbour

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A
    Amy E Loercher
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 168:35-40. 2005
  2. pmc p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis
    R B Delston
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Oncogene 30:588-99. 2011
  3. doi request reprint The genetics of uveal melanoma: an emerging framework for targeted therapy
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Pigment Cell Melanoma Res 25:171-81. 2012
  4. pmc Eye cancer: unique insights into oncogenesis: the Cogan Lecture
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Invest Ophthalmol Vis Sci 47:1736-45. 2006
  5. pmc Prognostic testing in uveal melanoma by transcriptomic profiling of fine needle biopsy specimens
    Michael D Onken
    Box 8096, 660 South Euclid Ave, St Louis, MO 63124, USA
    J Mol Diagn 8:567-73. 2006
  6. doi request reprint Molecular prognostic testing and individualized patient care in uveal melanoma
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Ophthalmol 148:823-9.e1. 2009
  7. pmc BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma
    Katie A Matatall
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St, Louis, Missouri, USA
    BMC Cancer 13:371. 2013
  8. doi request reprint Loss of Id2 potentiates the tumorigenic effect of Rb inactivation in a mouse model of retinoblastoma
    Solange Landreville
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Eye Res 35:435-9. 2010
  9. ncbi request reprint A metastasis modifier locus on human chromosome 8p in uveal melanoma identified by integrative genomic analysis
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Clin Cancer Res 14:3737-45. 2008
  10. pmc Frequent mutation of BAP1 in metastasizing uveal melanomas
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 330:1410-3. 2010

Collaborators

Detail Information

Publications61

  1. pmc MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A
    Amy E Loercher
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 168:35-40. 2005
    ....
  2. pmc p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis
    R B Delston
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Oncogene 30:588-99. 2011
    ..These findings provide a mechanistic explanation as to how Rb regulates cell division and apoptosis through different kinases, and reveal how Hdm2 may functionally link the tumor suppressors Rb and p53...
  3. doi request reprint The genetics of uveal melanoma: an emerging framework for targeted therapy
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Pigment Cell Melanoma Res 25:171-81. 2012
    ..These mutations appear to be key events that provide the potential for targeted therapy. This article will review the genetic findings in uveal melanoma over the past two decades and suggest important areas for future work...
  4. pmc Eye cancer: unique insights into oncogenesis: the Cogan Lecture
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Invest Ophthalmol Vis Sci 47:1736-45. 2006
  5. pmc Prognostic testing in uveal melanoma by transcriptomic profiling of fine needle biopsy specimens
    Michael D Onken
    Box 8096, 660 South Euclid Ave, St Louis, MO 63124, USA
    J Mol Diagn 8:567-73. 2006
    ..This method can be applied to specimens obtained from distant geographic locations and can stratify uveal melanoma patients based on metastatic risk...
  6. doi request reprint Molecular prognostic testing and individualized patient care in uveal melanoma
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Ophthalmol 148:823-9.e1. 2009
    ..To critically assess the status of molecular prognostic testing and its use for individualized patient care in uveal melanoma...
  7. pmc BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma
    Katie A Matatall
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St, Louis, Missouri, USA
    BMC Cancer 13:371. 2013
    ..The aim of this study was to investigate the role of BAP1 in uveal melanoma progression...
  8. doi request reprint Loss of Id2 potentiates the tumorigenic effect of Rb inactivation in a mouse model of retinoblastoma
    Solange Landreville
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Eye Res 35:435-9. 2010
    ..The role of Id2 has not yet been investigated in the prototype cancer Rb-defective cancer, retinoblastoma itself. This study investigated whether loss of Id2 modified the effects of Rb inactivation in a mouse model of retinoblastoma...
  9. ncbi request reprint A metastasis modifier locus on human chromosome 8p in uveal melanoma identified by integrative genomic analysis
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Clin Cancer Res 14:3737-45. 2008
    ....
  10. pmc Frequent mutation of BAP1 in metastasizing uveal melanomas
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 330:1410-3. 2010
    ..These findings implicate loss of BAP1 in uveal melanoma metastasis and suggest that the BAP1 pathway may be a valuable therapeutic target...
  11. pmc Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma
    Solange Landreville
    Departments of Ophthalmology and Visual Sciences, Otolaryngology, and Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Cancer Res 18:408-16. 2012
    ..The purpose of this study was to identify therapeutic agents that reverse the phenotypic effects of BAP1 loss in UM...
  12. ncbi request reprint Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase
    Jonathan H Lieman
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Ave, St Louis, Missouri 63110, USA
    J Biol Chem 280:10484-90. 2005
    ..These findings reveal a new mechanistic link between Rb-E2F and the extrinsic (caspase 8-mediated) apoptotic pathway...
  13. ncbi request reprint Transcriptomic versus chromosomal prognostic markers and clinical outcome in uveal melanoma
    Lori A Worley
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Missouri 63110, USA
    Clin Cancer Res 13:1466-71. 2007
    ..To compare a gene expression-based classifier versus the standard genetic prognostic marker, monosomy 3, for predicting metastasis in uveal melanoma...
  14. doi request reprint Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling
    Lori A Worley
    Department of Ophthalmology and Visual Sciences and Siteman Comprehensive Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
    Melanoma Res 18:184-90. 2008
    ..miRNA expression may represent a highly accurate biomarker for metastatic risk in uveal melanoma. In addition, these results may provide new insights into the role of miRNAs in tumor progression and the metastatic phenotype...
  15. doi request reprint Hepatic metastasis from uveal melanoma: angiographic pattern predictive of survival after hepatic arterial chemoembolization
    Pouya N Dayani
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 127:628-32. 2009
    ..To identify clinical features associated with survival after hepatic arterial chemoembolization (HACE) for uveal melanoma metastasis...
  16. ncbi request reprint Functional analysis of the p53 pathway in response to ionizing radiation in uveal melanoma
    Young Sun
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Invest Ophthalmol Vis Sci 46:1561-4. 2005
    ..The current study was conducted to analyze the functional integrity of the p53 pathway in primary uveal melanoma cells...
  17. pmc An accurate, clinically feasible multi-gene expression assay for predicting metastasis in uveal melanoma
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Mol Diagn 12:461-8. 2010
    ..This prognostic assay provides an important addition to the armamentarium for managing patients with uveal melanoma, and it provides a proof of principle for the development of similar assays for other cancers...
  18. ncbi request reprint DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma
    Justis P Ehlers
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Clin Cancer Res 11:3609-13. 2005
    ..In this profile, a cluster of genes at chromosome 8q was overexpressed in high-grade tumors, providing an opportunity to search for potential oncogenes in this region...
  19. pmc Oncogenic mutations in GNAQ occur early in uveal melanoma
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Invest Ophthalmol Vis Sci 49:5230-4. 2008
    ..An extensive search for such mutations was undertaken, focusing on the RAF/MEK/ERK pathway, which is often the target of initiating mutations in other types of cancer...
  20. ncbi request reprint Loss of heterozygosity of chromosome 3 detected with single nucleotide polymorphisms is superior to monosomy 3 for predicting metastasis in uveal melanoma
    Michael D Onken
    Department of Ophthalmology, Washington University, St Louis, Missouri, USA
    Clin Cancer Res 13:2923-7. 2007
    ..It is not known whether techniques that identify loss of heterozygosity for chromosome 3 predict metastasis more accurately than those that detect only numerical loss of chromosome 3 (monosomy 3)...
  21. pmc Association between gene expression profile, proliferation and metastasis in uveal melanoma
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Eye Res 35:857-63. 2010
    ..Towards such an explanation, this study was conducted to determine whether class 2 tumors have a higher proliferative rate than class 1 tumors...
  22. ncbi request reprint Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Res 64:7205-9. 2004
    ..These studies offer new insights into melanoma pathogenesis, and they provide a practical foundation for effective clinical predictive testing...
  23. ncbi request reprint Functional gene expression analysis uncovers phenotypic switch in aggressive uveal melanomas
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 66:4602-9. 2006
    ..These findings reveal new roles for Id2 and E-cadherin in uveal melanoma progression, and they identify potential targets for therapeutic intervention...
  24. ncbi request reprint Association between microarray gene expression signature and extravascular matrix patterns in primary uveal melanomas
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Ophthalmol 140:748-9. 2005
    ..To determine whether there is an association between gene expression profile and looping extravascular matrix patterns in primary uveal melanomas...
  25. ncbi request reprint NBS1 expression as a prognostic marker in uveal melanoma
    Justis P Ehlers
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Clin Cancer Res 11:1849-53. 2005
    ..Here, we use microarray gene expression data to identify a new prognostic marker...
  26. ncbi request reprint Transducible peptide therapy for uveal melanoma and retinoblastoma
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Campus Box 8069, 660 S Euclid Ave, St Louis, MO 63110, USA
    Arch Ophthalmol 120:1341-6. 2002
    ..To determine whether transducible peptides that inhibit the oncoproteins HDM2 and Bcl-2 may selectively kill uveal melanoma and retinoblastoma cells...
  27. doi request reprint Prognostic biomarkers in uveal melanoma: evidence for a stem cell-like phenotype associated with metastasis
    Shu Hong Chang
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Melanoma Res 18:191-200. 2008
    ....
  28. doi request reprint Diagnostic testing and treatment choices in primary vitreoretinal lymphoma
    Rithwick Rajagopal
    Ocular Oncology Service, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Retina 31:435-40. 2011
    ..Primary vitreoretinal lymphoma is a rare intraocular malignancy often seen in the context of central nervous system lymphoma. This review updates the current approaches to the management of primary vitreoretinal lymphoma...
  29. ncbi request reprint Distinct mechanisms for regulating the tumor suppressor and antiapoptotic functions of Rb
    Duanduan Ma
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:19358-66. 2003
    ..As a survival strategy, some cancer cells may exploit this dual role of Rb by phosphorylating sites that regulate tumor suppression but avoiding phosphorylation of Ser567 and consequent apoptotic stimulus...
  30. pmc Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Genet 45:133-5. 2013
    ..Thus, uveal melanoma is among a small group of cancers associated with SF3B1 mutations, and these mutations denote a distinct molecular subset of uveal melanomas...
  31. pmc Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma
    Michael D Onken
    Washington University and Siteman Cancer Center, St Louis, Missouri, USA
    Ophthalmology 119:1596-603. 2012
    ..This study evaluates the prognostic performance of a 15 gene expression profiling (GEP) assay that assigns primary posterior uveal melanomas to prognostic subgroups: class 1 (low metastatic risk) and class 2 (high metastatic risk)...
  32. ncbi request reprint Correlation study of benign cytomorphology and final clinical diagnosis
    Jing Zhai
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Acta Cytol 52:196-200. 2008
    ..To assess significance of cytologically benign vitreous samples and identify cellular patterns that may correspond to specific clinical entities...
  33. doi request reprint Id2 deficiency promotes metastasis in a mouse model of ocular cancer
    Olga A Agapova
    Department of Ophthalmology and Visual Sciences and Siteman Cancer Center, Washington University School of Medicine, Campus Box 8096, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Clin Exp Metastasis 27:91-6. 2010
    ..These findings provide new insights into the role of Id2 in metastasis...
  34. ncbi request reprint Fine needle aspiration biopsy with adjunct immunohistochemistry in intraocular tumor management
    Beverly E Faulkner-Jones
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Acta Cytol 49:297-308. 2005
    ..To assess the effectiveness of fine needle aspiration biopsy (FNAB), with and without immunohistochemistry (IHC), in the management of solid intraocular tumors...
  35. pmc ABCB1 identifies a subpopulation of uveal melanoma cells with high metastatic propensity
    Solange Landreville
    Departments of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA Département d Ophtalmologie, Universite Laval, Quebec, QC, Canada Department of Otolaryngology, Washington University School of Medicine, St Louis, MO, USA
    Pigment Cell Melanoma Res 24:430-7. 2011
    ..These findings suggest that some uveal melanoma cells have greater potential for metastasis than others and that a better understanding of such cells may be necessary for more successful therapies for metastatic melanoma...
  36. ncbi request reprint Lipid exudation following plaque radiotherapy for posterior uveal melanoma
    Michael D Mills
    Ocular Oncology Service, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Ophthalmol 141:594-595. 2006
    ..To investigate factors associated with lipid exudation after plaque radiotherapy for uveal melanoma...
  37. pmc Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration
    Abdoulaye Sene
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Cell Metab 17:549-61. 2013
    ..Monocytes from older humans with age-related macular degeneration showed similar changes. These findings provide an avenue for therapeutic modulation of macrophage function in common age-related diseases...
  38. ncbi request reprint Status of the NF1 tumor suppressor locus in uveal melanoma
    William J Foster
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 121:1311-5. 2003
    ..A clinical association has been observed between uveal melanoma and neurofibromatosis type 1 (NF1). This study aims to determine whether the NF1 tumor suppressor gene is mutated in uveal melanoma...
  39. ncbi request reprint Rate of resolution of exudative retinal detachment after plaque radiotherapy for uveal melanoma
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, PO Box 8069, 660 S Euclid Ave, St Louis, MO 63110, USA
    Arch Ophthalmol 120:1463-9. 2002
    ..To determine the clinical relevance of exudative retinal detachment (ERD) and the rate of ERD resolution after plaque radiotherapy of posterior uveal melanomas...
  40. ncbi request reprint Hepatic arterial chemoembolization for management of metastatic melanoma
    Karun V Sharma
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    AJR Am J Roentgenol 190:99-104. 2008
    ..However, the reports of outcomes are limited. We present our outcomes with hepatic arterial chemoembolization for metastasis of stage 4 melanoma...
  41. ncbi request reprint Pars plana vitrectomy in eyes containing a treated posterior uveal melanoma
    William J Foster
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, and Barnes Retina Institute, St Louis, Missouri 63110, USA
    Am J Ophthalmol 136:471-6. 2003
    ..To determine the safety of pars plana vitrectomy in eyes containing a treated posterior uveal melanoma...
  42. ncbi request reprint Transpupillary thermotherapy versus plaque radiotherapy for suspected choroidal melanomas
    J William Harbour
    Ocular Oncology Service, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Ophthalmology 110:2207-14; discussion 2215. 2003
    ..To examine the outcomes and complications of transpupillary thermotherapy for treatment of small choroidal melanomas...
  43. doi request reprint Tilting of radioactive plaques after initial accurate placement for treatment of uveal melanoma
    Arghavan Almony
    Ocular Oncology Service, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 126:65-70. 2008
    ..To evaluate plaque movement as a potential factor in local failure using intraoperative ultrasonography at plaque insertion and removal...
  44. ncbi request reprint Optical coherence tomography in the evaluation of retinal changes associated with suspicious choroidal melanocytic tumors
    Gabriella Espinoza
    Ocular Oncology Service, Department of Ophthalmology and Visual Sciences and Barnes Retina Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Ophthalmol 137:90-5. 2004
    ..This study investigates optical coherence tomography (OCT) in evaluating SRF in suspicious choroidal melanocytic tumors...
  45. ncbi request reprint Molecular genetics of uveal melanoma
    Amy E Loercher
    Department of Ophthalmology and Visual Sciences, Washington University, School of Medicine, St Louis, MO 63110, USA
    Curr Eye Res 27:69-74. 2003
    ..Herein, we review the findings to date, discuss the insights they provide, and suggest future directions for molecular research in uveal melanoma...
  46. ncbi request reprint Cytologic diagnosis of intraocular lymphoma in vitreous aspirates
    Tunde Farkas
    Department of Pathology and Immunology, Washington University Medical Center, St Louis, Missouri 63110, USA
    Acta Cytol 48:487-91. 2004
    ..To evaluate the cytologic findings of vitreous fluids with atypical, suspicious for malignancy or malignant lymphoid cells to assess cytologic parameters that may help in reaching the diagnosis of intraoclular lymphoma...
  47. ncbi request reprint Photodynamic therapy for choroidal metastasis from carcinoid tumor
    J William Harbour
    Ocular Oncology Service, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Ophthalmol 137:1143-5. 2004
    ..To determine the efficacy of photodynamic therapy for the treatment of a choroidal metastasis unresponsive to chemotherapy and radiation therapy...
  48. ncbi request reprint Rb at the interface between cell cycle and apoptotic decisions
    Rachel B Delston
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Mol Med 6:713-8. 2006
    ..For many of these studies, we have chosen the melanocyte lineage as a model cell system because of the established role for Rb in melanocyte differentiation and survival, and the frequent deregulation of the Rb pathway in melanoma...
  49. ncbi request reprint Altered expression of Rb and p53 in uveal melanomas following plaque radiotherapy
    Milam A Brantley
    Center for Ocular Oncology, Department of Ophthalmology and Visual Sciences and Division of Molecular Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Ophthalmol 133:242-8. 2002
    ..To examine the expression of proteins in the Rb and p53 tumor suppressor pathways in uveal melanomas following plaque radiotherapy...
  50. doi request reprint Review of 676 second primary tumors in patients with retinoblastoma: association between age at onset and tumor type
    Kyung In Woo
    Ocular Oncology Service, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Arch Ophthalmol 128:865-70. 2010
    ..To obtain a more accurate understanding of second primary tumors (SPTs) by analyzing a large number of SPTs from the published literature...
  51. pmc Emerging insights into the molecular pathogenesis of uveal melanoma
    Solange Landreville
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Future Oncol 4:629-36. 2008
    ..Taken together, this pathogenetic scheme can be used to construct a molecularly based and prognostically relevant classification of uveal melanomas that can be used clinically for personalized patient management...
  52. ncbi request reprint Ocular melanoma: a review and the relationship to cutaneous melanoma
    Eva A Hurst
    Division of Dermatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Dermatol 139:1067-73. 2003
    ..We review the incidence and characteristics of OM, evaluate the existent data regarding its potential relationship to CM, and provide some guidance for the dermatologist regarding the evaluation and diagnosis of this ocular tumor...
  53. ncbi request reprint Photodynamic therapy for circumscribed choroidal hemangioma
    Tom G Sheidow
    Ivey Eye Institute, Department of Ophthalmology, University of Western Ontario, London
    Can J Ophthalmol 37:314-7. 2002
  54. doi request reprint Integrative genomic analysis of aneuploidy in uveal melanoma
    Justis P Ehlers
    Wills Eye Hospital, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 14:115-22. 2008
    ..Uveal melanoma is an attractive solid tumor for studying aneuploidy because it is a relatively homogeneous cancer that is highly metastatic and has low nonspecific chromosomal instability...
  55. ncbi request reprint Molecular prognostic testing in uveal melanoma: has it finally come of age?
    J William Harbour
    Arch Ophthalmol 125:1122-3. 2007
  56. ncbi request reprint Risk factors for metastasis in retinoblastoma
    Paul T Finger
    The New York Eye Cancer Center, New York, NY, USA
    Surv Ophthalmol 47:1-16. 2002
    ..This review has been performed to help those caring for patients with retinoblastoma and to aid informed consent...
  57. ncbi request reprint For whom the bell tolls: susceptibility to common adult cancers in retinoblastoma survivors
    Frederic J Kaye
    J Natl Cancer Inst 96:342-3. 2004
  58. ncbi request reprint What is the best treatment for retinoblastoma?
    J William Harbour
    Am J Ophthalmol 138:471-3. 2004
  59. ncbi request reprint Molecular pathobiology of uveal melanoma
    Justis P Ehlers
    Willis Eye Hospital, Philadelphia, PA 19107, USA
    Int Ophthalmol Clin 46:167-80. 2006
  60. ncbi request reprint Uveal melanoma: genetic aspects
    Arun D Singh
    Department of Ophthalmic Oncology, Cole Eye Institute i3 129, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Ophthalmol Clin North Am 18:85-97, viii. 2005
    ..This article reviews the clinical genetics, cytogenetics, and molecular genetic aspects of uveal melanoma...
  61. ncbi request reprint Inhibiting angiogenesis in retinoblastoma
    Rajendra S Apte
    Ophthalmic Res 39:188-90. 2007