Ted H Hansen

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Recognition of open conformers of classical MHC by chaperones and monoclonal antibodies
    Ted H Hansen
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Rev 207:100-11. 2005
  2. pmc Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3
    Xiaoli Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 177:613-24. 2007
  3. pmc Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates
    Xiaoli Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 187:655-68. 2009
  4. pmc Basic and translational applications of engineered MHC class I proteins
    Ted H Hansen
    Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Trends Immunol 31:363-9. 2010
  5. pmc Endogenous MHC-related protein 1 is transiently expressed on the plasma membrane in a conformation that activates mucosal-associated invariant T cells
    Wei Jen Chua
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 186:4744-50. 2011
  6. ncbi request reprint Evidence for MR1 antigen presentation to mucosal-associated invariant T cells
    Shouxiong Huang
    Department of Pathology and Immunology, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 280:21183-93. 2005
  7. pmc Engineering superior DNA vaccines: MHC class I single chain trimers bypass antigen processing and enhance the immune response to low affinity antigens
    Lijin Li
    Department of Surgery, Washington University School of Medicine, Saint Louis, MO 63110, United States
    Vaccine 28:1911-8. 2010
  8. ncbi request reprint Enhanced immune presentation of a single-chain major histocompatibility complex class I molecule engineered to optimize linkage of a C-terminally extended peptide
    Lonnie Lybarger
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:27105-11. 2003
  9. pmc Requirements for the selective degradation of endoplasmic reticulum-resident major histocompatibility complex class I proteins by the viral immune evasion molecule mK3
    Xiaoli Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Virol 79:4099-108. 2005
  10. pmc A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire
    Baomei Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 326:871-4. 2009

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Recognition of open conformers of classical MHC by chaperones and monoclonal antibodies
    Ted H Hansen
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Rev 207:100-11. 2005
    ..Indeed, we propose these regions serve as peptide-binding hinges that are uniquely accessible in open MHC...
  2. pmc Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3
    Xiaoli Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 177:613-24. 2007
    ..Given that mK3 has numerous cellular and viral homologues, it will be of considerable interest to determine the pervasiveness of this novel mechanism of ubiquitination...
  3. pmc Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates
    Xiaoli Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 187:655-68. 2009
    ....
  4. pmc Basic and translational applications of engineered MHC class I proteins
    Ted H Hansen
    Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Trends Immunol 31:363-9. 2010
    ..Future applications of SCTs will be driven by their further engineering and the ever-expanding identification of disease-related peptides using chemical, genetic and computational approaches...
  5. pmc Endogenous MHC-related protein 1 is transiently expressed on the plasma membrane in a conformation that activates mucosal-associated invariant T cells
    Wei Jen Chua
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 186:4744-50. 2011
    ..Based on this pattern of MR1 expression, it is intriguing to speculate that constitutive expression of MR1 may be detrimental for maintenance of immune homeostasis in the gut and/or detection of pathogenic bacteria in mucosal tissues...
  6. ncbi request reprint Evidence for MR1 antigen presentation to mucosal-associated invariant T cells
    Shouxiong Huang
    Department of Pathology and Immunology, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 280:21183-93. 2005
    ..These combined data strongly support the conclusion that MR1 has an antigen presentation function...
  7. pmc Engineering superior DNA vaccines: MHC class I single chain trimers bypass antigen processing and enhance the immune response to low affinity antigens
    Lijin Li
    Department of Surgery, Washington University School of Medicine, Saint Louis, MO 63110, United States
    Vaccine 28:1911-8. 2010
    ..Taken together, our data demonstrate that dtSCT DNA vaccines coexpressing a universal CD4 epitope are highly effective in generating immune responses to poorly processed and presented cancer antigens...
  8. ncbi request reprint Enhanced immune presentation of a single-chain major histocompatibility complex class I molecule engineered to optimize linkage of a C-terminally extended peptide
    Lonnie Lybarger
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:27105-11. 2003
    ..SCT-based tetramers could have applications for the enumeration of T and natural killer cells that recognize peptide.class I complexes prone to dissociation...
  9. pmc Requirements for the selective degradation of endoplasmic reticulum-resident major histocompatibility complex class I proteins by the viral immune evasion molecule mK3
    Xiaoli Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Virol 79:4099-108. 2005
    ..These findings are consistent with a "partial dislocation" model for turnover of ER proteins and define some common features of ER degradation pathways initiated by structurally distinct herpesvirus proteins...
  10. pmc A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire
    Baomei Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 326:871-4. 2009
    ..Although selection on a single complex is peptide promiscuous, mature T cells are highly peptide specific. Thus, positive selection imparts MHC and peptide specificity on the peripheral CD8 T cell repertoire...
  11. pmc Single-chain HLA-A2 MHC trimers that incorporate an immundominant peptide elicit protective T cell immunity against lethal West Nile virus infection
    Sojung Kim
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 184:4423-30. 2010
    ....
  12. ncbi request reprint Applications of major histocompatibility complex class I molecules expressed as single chains
    Tina Primeau
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:109-21. 2005
    ..Thus, SCTs possess therapeutic potential both for prophylactic treatment and for the treatment of ongoing infection...
  13. pmc Model for the interaction of gammaherpesvirus 68 RING-CH finger protein mK3 with major histocompatibility complex class I and the peptide-loading complex
    Xiaoli Wang
    Department of Pathology and Immunology, Box 8118, Washington University School of Medicine, 4566 Scott Ave, St Louis, MO 63110, USA
    J Virol 78:8673-86. 2004
    ....
  14. pmc Structural mechanism of ER retrieval of MHC class I by cowpox
    William H McCoy
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Biol 10:e1001432. 2012
    ..These studies clarify mechanistically how CPXV203 coordinates with other cowpox proteins to thwart antigen presentation...
  15. pmc Human major histocompatibility complex (MHC) class I molecules with disulfide traps secure disease-related antigenic peptides and exclude competitor peptides
    Steven M Truscott
    Department of Pathology and Immunology, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:7480-90. 2008
    ..The mechanistic and practical applications of these findings for vaccine development and T cell isolation/enumeration are discussed...
  16. ncbi request reprint Biochemical features of the MHC-related protein 1 consistent with an immunological function
    Michael J Miley
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 170:6090-8. 2003
    ..Cumulatively, these findings demonstrate that surface expression of MR1 is possible but may be limited by a specific ligand or associated molecule...
  17. doi request reprint Role of the RING-CH domain of viral ligase mK3 in ubiquitination of non-lysine and lysine MHC I residues
    Roger A Herr
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Traffic 10:1301-17. 2009
    ..Our findings support the model that viral ligases have evolved a highly effective strategy to optimally orient their RING domain with substrate allowing them to ubiquitinate non-K residues...
  18. pmc Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells
    Minji Byun
    Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Host Microbe 6:422-32. 2009
    ..These data demonstrate that CPXV12 and CPXV203 proteins combine to ablate MHC class I expression and abrogate antiviral CD8 T cell responses...
  19. pmc MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells
    Shouxiong Huang
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    J Exp Med 205:1201-11. 2008
    ..These findings demonstrate that MR1 traffics through endocytic compartments, thereby allowing MAIT cells to sample both endocytosed and endogenous antigens...
  20. pmc MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution
    Shouxiong Huang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:8290-5. 2009
    ..Our findings demonstrate that the presentation pathway of MR1 to MAIT cells is highly evolutionarily conserved...
  21. pmc Cowpox virus employs a two-pronged strategy to outflank MHCI antigen presentation
    William H McCoy
    Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, United States
    Mol Immunol 55:156-8. 2013
    ..The strategy used by cowpox to both limit peptide supply and disrupt trafficking of fully assembled MHCI acts as a dual-edged sword that effectively disables adaptive immune surveillance of infected cells...
  22. pmc Cross-dressed CD8α+/CD103+ dendritic cells prime CD8+ T cells following vaccination
    Lijin Li
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 109:12716-21. 2012
    ..Thus, cross-dressing is an important pathway of antigen presentation, with important implications for the study of CD8(+) T-cell responses to viral infection, tumors, and vaccines...
  23. ncbi request reprint Disulfide bond engineering to trap peptides in the MHC class I binding groove
    Steven M Truscott
    Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 178:6280-9. 2007
    ....
  24. ncbi request reprint Virus subversion of the MHC class I peptide-loading complex
    Lonnie Lybarger
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 18:121-30. 2003
    ..Thus, mK3 subverts TAP/tapasin to specifically target class I molecules for destruction...
  25. pmc Newly discovered viral E3 ligase pK3 induces endoplasmic reticulum-associated degradation of class I major histocompatibility proteins and their membrane-bound chaperones
    Roger A Herr
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:14467-79. 2012
    ....
  26. doi request reprint MHC class I antigen presentation: learning from viral evasion strategies
    Ted H Hansen
    Washington University School of Medicine, Department of Pathology and Immunology, St Louis, Missouri 63110, USA
    Nat Rev Immunol 9:503-13. 2009
    ....
  27. pmc Structural engineering of pMHC reagents for T cell vaccines and diagnostics
    Vesselin Mitaksov
    Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Chem Biol 14:909-22. 2007
    ....
  28. ncbi request reprint The viral E3 ubiquitin ligase mK3 uses the Derlin/p97 endoplasmic reticulum-associated degradation pathway to mediate down-regulation of major histocompatibility complex class I proteins
    Xiaoli Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:8636-44. 2006
    ..The mechanistic implications of these findings are discussed...
  29. ncbi request reprint Cowpox virus exploits the endoplasmic reticulum retention pathway to inhibit MHC class I transport to the cell surface
    Minji Byun
    Howard Hughes Medical Institute, Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Host Microbe 2:306-15. 2007
    ..This viral mechanism for MHC class I downregulation may explain virulence differences between clinical isolates of orthopoxviruses...
  30. pmc Single chain MHC I trimer-based DNA vaccines for protection against Listeria monocytogenes infection
    Sojung Kim
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, United States
    Vaccine 30:2178-86. 2012
    ..Our study further demonstrates that the SCT serves as a potent platform for DNA vaccines against various infectious diseases...
  31. doi request reprint Ubiquitination of substrates by esterification
    Xiaoli Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Traffic 13:19-24. 2012
    ..In this review we discuss recent evidence for the ubiquitination of protein substrates by esterification and speculate on its mechanism and its physiological importance...
  32. pmc IL-12 enhances CTL synapse formation and induces self-reactivity
    Mary A Markiewicz
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 182:1351-61. 2009
    ..These responses correlated with expression of functionally higher avidity LFA-1 on IL-12-treated CTLs. These findings have implications for the function of IL-12 in T cell-mediated autoimmunity...
  33. ncbi request reprint Patterns of nonclassical MHC antigen presentation
    Ted H Hansen
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Nat Immunol 8:563-8. 2007
    ..Here we propose that another MHC class Ib protein, MR1, which is required for the gut flora-dependent development of mucosa-associated invariant T cells, presents either a microbe-produced or a microbe-induced pattern...
  34. ncbi request reprint Licensing of natural killer cells by host major histocompatibility complex class I molecules
    Sungjin Kim
    Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 436:709-13. 2005
    ..This self-tolerance mechanism may be more broadly applicable within the vertebrate immune system because related germline-encoded inhibitory receptors are widely expressed on other immune cells...
  35. ncbi request reprint Cutting edge: single-chain trimers of MHC class I molecules form stable structures that potently stimulate antigen-specific T cells and B cells
    Yik Y L Yu
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 168:3145-9. 2002
    ..Our combined findings suggest that single-chain trimers may have applications as DNA vaccines against virus infection or tumors...
  36. pmc Decoupling the role of ubiquitination for the dislocation versus degradation of major histocompatibility complex (MHC) class I proteins during endoplasmic reticulum-associated degradation (ERAD)
    Xiaoli Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 288:23295-306. 2013
    ....
  37. pmc Amino-terminal extended peptide single-chain trimers are potent synthetic agonists for memory human CD8+ T cells
    Beatriz M Carreno
    Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 188:5839-49. 2012
    ..Our findings demonstrate that modified peptide-MHC structures, such as AT-SCT, can be engineered as T cell agonists to promote the growth and expansion of memory human CD8(+) T cells...
  38. ncbi request reprint Antigen-specific cytotoxic T lymphocytes protect against lethal West Nile virus encephalitis
    Whitney E Purtha
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Immunol 37:1845-54. 2007
    ..Based on this, we conclude that CTL responses against immundominant WNV epitopes confer protective immunity and thus should be targets for inclusion in new vaccines...
  39. ncbi request reprint Recognition of HLA-A2-restricted mammaglobin-A-derived epitopes by CD8+ cytotoxic T lymphocytes from breast cancer patients
    André Jaramillo
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Breast Cancer Res Treat 88:29-41. 2004
    ..1+ breast cancer cell line. In conclusion, these results demonstrate the immunotherapeutic potential of mammaglobin-A for the treatment and prevention of breast cancer...
  40. ncbi request reprint Homology between an alloantigen and a self MHC allele calibrates the avidity of the alloreactive T cell repertoire independent of TCR affinity
    Tara M C Hornell
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 170:4506-14. 2003
    ....
  41. pmc Specific mutation of a gammaherpesvirus-expressed antigen in response to CD8 T cell selection in vivo
    Joy Loh
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Virol 86:2887-93. 2012
    ..This finding may have relevance for the use of herpesvirus vectors for chronic antigen expression in vivo...
  42. pmc Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection
    Wei Jen Chua
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Infect Immun 80:3256-67. 2012
    ....
  43. pmc Physical association of the K3 protein of gamma-2 herpesvirus 68 with major histocompatibility complex class I molecules with impaired peptide and beta(2)-microglobulin assembly
    Y Y Lawrence Yu
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 76:2796-803. 2002
    ..The detection of K3 with class I assembly intermediates raises the possibility that molecular chaperones involved in class I assembly are involved in K3-mediated class I regulation...