Richard Grucza

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc In search of causal variants: refining disease association signals using cross-population contrasts
    Nancy L Saccone
    Department of Genetics, Washington University, Campus Box 8232, 4566 Scott Avenue, Saint Louis, Missouri, USA
    BMC Genet 9:58. 2008
  2. pmc Correspondence between secular changes in alcohol dependence and age of drinking onset among women in the United States
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, MO 63110, USA
    Alcohol Clin Exp Res 32:1493-501. 2008
  3. pmc A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
    Biol Psychiatry 64:922-9. 2008
  4. pmc Discrepancies in estimates of prevalence and correlates of substance use and disorders between two national surveys
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Addiction 102:623-9. 2007
  5. pmc Prevalence and correlates of binge eating disorder in a community sample
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Compr Psychiatry 48:124-31. 2007
  6. pmc Cigarette smoking and the risk for alcohol use disorders among adolescent drinkers
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 30:2046-54. 2006
  7. ncbi request reprint Novelty seeking as a moderator of familial risk for alcohol dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 30:1176-83. 2006
  8. ncbi request reprint Personality as a mediator of demographic risk factors for suicide attempts in a community sample
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Compr Psychiatry 46:214-22. 2005
  9. pmc Secular trends in the lifetime prevalence of alcohol dependence in the United States: a re-evaluation
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 32:763-70. 2008
  10. pmc Long-term effects of minimum drinking age laws on past-year alcohol and drug use disorders
    KAREN E NORBERG
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Alcohol Clin Exp Res 33:2180-90. 2009

Detail Information

Publications31

  1. pmc In search of causal variants: refining disease association signals using cross-population contrasts
    Nancy L Saccone
    Department of Genetics, Washington University, Campus Box 8232, 4566 Scott Avenue, Saint Louis, Missouri, USA
    BMC Genet 9:58. 2008
    ..The challenge we address is to distinguish among these correlated loci to highlight potential functional variants and prioritize them for follow-up...
  2. pmc Correspondence between secular changes in alcohol dependence and age of drinking onset among women in the United States
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, MO 63110, USA
    Alcohol Clin Exp Res 32:1493-501. 2008
    ..The present report sought to confirm the trends in AOD and to determine the extent to which they might account for secular trends in alcohol dependence...
  3. pmc A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
    Biol Psychiatry 64:922-9. 2008
    ..The goal of this study was to examine the association of this variant with cocaine dependence...
  4. pmc Discrepancies in estimates of prevalence and correlates of substance use and disorders between two national surveys
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Addiction 102:623-9. 2007
    ....
  5. pmc Prevalence and correlates of binge eating disorder in a community sample
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Compr Psychiatry 48:124-31. 2007
    ..Few epidemiological studies of BED have been conducted. Our aim was to describe the prevalence and correlates of BED, as assessed by the Patient Health Questionnaire (PHQ) in a community sample...
  6. pmc Cigarette smoking and the risk for alcohol use disorders among adolescent drinkers
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 30:2046-54. 2006
    ..We sought to address this issue using data from a nationally representative U.S. sample of adolescents and young adults. Specifically, we analyzed the relationship between cigarette smoking, drinking, and AUDs...
  7. ncbi request reprint Novelty seeking as a moderator of familial risk for alcohol dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 30:1176-83. 2006
    ..We examined this possibility by analyzing the association between NS and alcohol dependence in individuals at intermediate and high levels of familial risk for alcohol dependence...
  8. ncbi request reprint Personality as a mediator of demographic risk factors for suicide attempts in a community sample
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Compr Psychiatry 46:214-22. 2005
    ..We conclude that risk associated with certain nonmodifiable demographic factors is often mediated by potentially modifiable intrapersonal factors, such as SD...
  9. pmc Secular trends in the lifetime prevalence of alcohol dependence in the United States: a re-evaluation
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 32:763-70. 2008
    ..However, it remains unclear whether such patterns truly reflect secular trends or are confounded by age-dependent factors such as differential recall, differential mortality, and other effects...
  10. pmc Long-term effects of minimum drinking age laws on past-year alcohol and drug use disorders
    KAREN E NORBERG
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Alcohol Clin Exp Res 33:2180-90. 2009
    ..Many studies have found that earlier drinking initiation predicts higher risk of later alcohol and substance use problems, but the causal relationship between age of initiation and later risk of substance use disorder remains unknown...
  11. pmc Dissection of the phenotypic and genotypic associations with nicotinic dependence
    Li Shiun Chen
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660S Euclid Ave, St Louis, MO 63110, USA
    Nicotine Tob Res 14:425-33. 2012
    ..We examined how these identified genetic variants relate to nicotine dependence defined by different categorical and dimensional measures...
  12. pmc A genome-wide association study of DSM-IV cannabis dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Saint Louis, MO 63110, USA
    Addict Biol 16:514-8. 2011
    ..While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence...
  13. pmc Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers
    Sarah M Hartz
    Washington University School of Medicine, St Louis, Missouri, USA
    Arch Gen Psychiatry 69:854-60. 2012
    ..Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968...
  14. ncbi request reprint Using dimensional models of externalizing psychopathology to aid in gene identification
    Danielle M Dick
    Washington University, St Louis, Missouri, USA
    Arch Gen Psychiatry 65:310-8. 2008
    ..However, this information has not been widely used in gene identification efforts, which have focused on specific disorders diagnosed using traditional psychiatric classification systems...
  15. ncbi request reprint Co-occurring risk factors for alcohol dependence and habitual smoking: update on findings from the Collaborative Study on the Genetics of Alcoholism
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Alcohol Res Health 29:172-8. 2006
    ..The results to date suggest that both common and drug-specific genetic influences play a role in the development of alcohol and nicotine dependence...
  16. pmc Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5
    Jen C Wang
    Department of Psychiatry, Washington University, 660 South Euclid, PO BOX 8134, St Louis, MO 63110, USA
    Hum Mol Genet 18:3125-35. 2009
    ....
  17. pmc Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptoms
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Alcohol Clin Exp Res 33:2047-56. 2009
    ..In this study, we examine whether age at first drink moderates genetic and environmental influences, via gene x environment interactions, on DSM-IV alcohol dependence symptoms...
  18. pmc Alcohol criteria endorsement and psychiatric and drug use disorders among DUI offenders: greater severity among women and multiple offenders
    Vivia V McCutcheon
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8134, St Louis, MO 63110 1010, United States
    Addict Behav 34:432-9. 2009
    ....
  19. pmc Prevalence and predictors of pathological gambling: results from the St. Louis personality, health and lifestyle (SLPHL) study
    Renee M Cunningham-Williams
    Department of Psychiatry, Washington University School of Medicine, 40 N Kingshighway, St Louis, MO 63108, USA
    J Psychiatr Res 39:377-90. 2005
    ..We report the prevalence of and risk and protective factors for DSM-IV sub-threshold gambling (1-4 criteria) and pathological gambling disorder (PGD; 5-10 criteria) in a non-clinical household sample of St. Louis area gamblers...
  20. pmc Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
    ....
  21. pmc The emerging link between alcoholism risk and obesity in the United States
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 67:1301-8. 2010
    ..The prevalence of obesity has risen sharply in the United States in the past few decades. Etiologic links between obesity and substance use disorders have been hypothesized...
  22. pmc Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence
    ROBERT C CULVERHOUSE
    Division of General Medical Sciences, Department of Medicine, Washington University, Saint Louis, MO 63110, USA
    Hum Genet 129:177-88. 2011
    ..Methodologies that limit analyses of joint effects to variants that demonstrate association in single SNP analyses, or require a significant interaction term, will likely miss important joint effects...
  23. pmc Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Addict Biol 15:346-57. 2010
    ..Incorporation of logically chosen interaction parameters, such as AOS, into genetic models of substance use disorders may increase the degree of explained phenotypic variation and constitutes a promising avenue for gene discovery...
  24. pmc A genome-wide association study of alcohol dependence
    Laura J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:5082-7. 2010
    ..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence...
  25. pmc Screening for alcohol problems: an epidemiological perspective and implications for primary care
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, USA
    Mo Med 105:67-71. 2008
    ....
  26. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009
    ..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...
  27. pmc Binge drinking among youths and young adults in the United States: 1979-2006
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Acad Child Adolesc Psychiatry 48:692-702. 2009
    ....
  28. pmc Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
    Arpana Agrawal
    Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 93:12-20. 2008
    ..0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence...
  29. pmc Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:453-66. 2009
    ....
  30. ncbi request reprint Personality and depressive symptoms: a multi-dimensional analysis
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Affect Disord 74:123-30. 2003
    ..The relationship of temperamental aspects of personality to symptoms of depression in a community-based sample of 804 individuals was examined using a multi-dimensional approach to account for heterogeneity in symptom patterns...
  31. ncbi request reprint The comparative validity of 11 modern personality inventories: predictions of behavioral acts, informant reports, and clinical indicators
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, USA
    J Pers Assess 89:167-87. 2007
    ..On the other hand, there were important differences between inventories in their predictive capabilities for particular criteria. We discuss the factors that lead to differential validity across predictors and criteria...

Research Grants3