Timothy Graubert

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc A high-resolution map of segmental DNA copy number variation in the mouse genome
    Timothy A Graubert
    Department of Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, Missouri, United States of America
    PLoS Genet 3:e3. 2007
  2. doi request reprint Genetics of myelodysplastic syndromes: new insights
    Timothy Graubert
    Washington University, St Louis, MO 63110, USA
    Hematology Am Soc Hematol Educ Program 2011:543-9. 2011
  3. pmc A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes
    Timothy J Ley
    Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:14275-80. 2003
  4. pmc DNMT3A mutations in acute myeloid leukemia
    Timothy J Ley
    Department of Genetics, Genome Center, Washington University, St Louis, MO 63110, USA
    N Engl J Med 363:2424-33. 2010
  5. pmc Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia
    Daniel C Link
    Division of Oncology, Department of Medicine, Washington University, St Louis, MO 63110, USA
    Blood 110:1648-55. 2007
  6. pmc Therapy related acute myeloid leukemia in breast cancer survivors, a population-based study
    Mike G Martin
    Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8007, Saint Louis, MO 63110, USA
    Breast Cancer Res Treat 118:593-8. 2009
  7. pmc Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia
    Michael H Tomasson
    Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 111:4797-808. 2008
  8. pmc DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
    Timothy J Ley
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 456:66-72. 2008
  9. pmc Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice
    Ryan K Funk
    Department of Internal Medicine, Division of Oncology, Stem Cell Biology Section, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 112:1434-42. 2008
  10. pmc wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data
    Patrick Cahan
    Department of Internal Medicine and Department of Genetics, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, MO, USA
    Nucleic Acids Res 36:e41. 2008

Research Grants

  1. ACQUISTION OF A CYTOMATION MOFLO CELL SORTER
    Timothy Graubert; Fiscal Year: 2001
  2. GENETIC TARGETING OF HEMATOPOIETIC STEM CELLS
    Timothy Graubert; Fiscal Year: 2002
  3. Acquistion of an inFlux GMP cell sorter.
    Timothy Graubert; Fiscal Year: 2005
  4. Genomics of myelodysplastic syndromes
    Timothy Graubert; Fiscal Year: 2007

Collaborators

Detail Information

Publications17

  1. pmc A high-resolution map of segmental DNA copy number variation in the mouse genome
    Timothy A Graubert
    Department of Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, Missouri, United States of America
    PLoS Genet 3:e3. 2007
    ..Annotation of CNVs in the mouse genome combined with sequence-based analysis provides an important resource that will help define the genetic basis of complex traits...
  2. doi request reprint Genetics of myelodysplastic syndromes: new insights
    Timothy Graubert
    Washington University, St Louis, MO 63110, USA
    Hematology Am Soc Hematol Educ Program 2011:543-9. 2011
    ..Additional studies will be required to understand the prognostic implications of these mutations for treatment response, progression to AML, and survival...
  3. pmc A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes
    Timothy J Ley
    Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:14275-80. 2003
    ..This strategy represents a viable approach for the detection of potentially relevant, nonrandom mutations in primary human cancer cell genomes...
  4. pmc DNMT3A mutations in acute myeloid leukemia
    Timothy J Ley
    Department of Genetics, Genome Center, Washington University, St Louis, MO 63110, USA
    N Engl J Med 363:2424-33. 2010
    ..The genetic alterations responsible for an adverse outcome in most patients with acute myeloid leukemia (AML) are unknown...
  5. pmc Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia
    Daniel C Link
    Division of Oncology, Department of Medicine, Washington University, St Louis, MO 63110, USA
    Blood 110:1648-55. 2007
    ..These data support the hypothesis that mutations of CSF3R may provide the "activated tyrosine kinase signal" that is thought to be important for leukemogenesis...
  6. pmc Therapy related acute myeloid leukemia in breast cancer survivors, a population-based study
    Mike G Martin
    Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8007, Saint Louis, MO 63110, USA
    Breast Cancer Res Treat 118:593-8. 2009
    ..This association maybe explained by either greater chemotherapy exposure or an interaction between therapy and genetic predisposition...
  7. pmc Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia
    Michael H Tomasson
    Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 111:4797-808. 2008
    ..Additional studies will be required to define the roles that these somatic and germline TK gene variants play in AML pathogenesis...
  8. pmc DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
    Timothy J Ley
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 456:66-72. 2008
    ..Our study establishes whole-genome sequencing as an unbiased method for discovering cancer-initiating mutations in previously unidentified genes that may respond to targeted therapies...
  9. pmc Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice
    Ryan K Funk
    Department of Internal Medicine, Division of Oncology, Stem Cell Biology Section, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 112:1434-42. 2008
    ..Improved understanding of genetic risk factors should lead to tailored treatment regimens that reduce risk for patients predisposed to t-AML...
  10. pmc wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data
    Patrick Cahan
    Department of Internal Medicine and Department of Genetics, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, MO, USA
    Nucleic Acids Res 36:e41. 2008
    ..At a FPR of <10%, the algorithm can detect CNVs with five probes on the 385K platform and three on the 2.1M and 3.1M platforms, resulting in effective resolutions of 24 kb, 2-5 kb and 1 kb, respectively...
  11. pmc The impact of copy number variation on local gene expression in mouse hematopoietic stem and progenitor cells
    Patrick Cahan
    Department of Internal Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, MO, USA
    Nat Genet 41:430-7. 2009
    ....
  12. pmc Identification of somatic JAK1 mutations in patients with acute myeloid leukemia
    Zhifu Xiang
    Department of Medicine, Washington University School of Medicine, St Louis, St Louis, MO 63110, USA
    Blood 111:4809-12. 2008
    ..This is the first report to demonstrate somatic JAK1 mutations in AML and suggests that JAK1 mutations may function as disease-modifying mutations in AML pathogenesis...
  13. pmc Acquired copy number alterations in adult acute myeloid leukemia genomes
    Matthew J Walter
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:12950-5. 2009
    ....
  14. pmc Recurring mutations found by sequencing an acute myeloid leukemia genome
    Elaine R Mardis
    Department of Genetics, Washington University, St Louis, MO 63110, USA
    N Engl J Med 361:1058-66. 2009
    ..The full complement of DNA mutations that are responsible for the pathogenesis of acute myeloid leukemia (AML) is not yet known...
  15. pmc Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis
    Timothy A Graubert
    Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 4:e4583. 2009
    ..2 genes are not common events in MDS, and implicate haploinsufficiency of multiple genes as the relevant genetic consequence of this common deletion...
  16. ncbi request reprint Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice
    Timothy S Fenske
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 66:5029-38. 2006
    ....
  17. ncbi request reprint A mouse-based strategy for cyclophosphamide pharmacogenomic discovery
    James W Watters
    Washington Univ School of Medicine, Dept of Medicine, Campus Box 8069, St Louis, MO 63110, USA
    J Appl Physiol 95:1352-60. 2003
    ..This phenotypic and genotypic variation among inbred strains provides a framework for cyclophosphamide pharmacogenomic discovery...

Research Grants8

  1. ACQUISTION OF A CYTOMATION MOFLO CELL SORTER
    Timothy Graubert; Fiscal Year: 2001
    ..An advisory committee will oversee management of the cell sorter and ensure its long-term stability as a resource for the medical school...
  2. GENETIC TARGETING OF HEMATOPOIETIC STEM CELLS
    Timothy Graubert; Fiscal Year: 2002
    ..The long-term goal of this investigator is to study the molecular bases of hematopoiesis and leukemogenesis as an active member of a clinical Hematology/Bone Marrow Transplant Division. ..
  3. Acquistion of an inFlux GMP cell sorter.
    Timothy Graubert; Fiscal Year: 2005
    ..This instrument will provide added value for many funded projects at Washington University that collectively accounted for over $328M in total awards from the NIH in 2002, placing it third among medical centers in the United States. ..
  4. Genomics of myelodysplastic syndromes
    Timothy Graubert; Fiscal Year: 2007
    ..These findings should improve our ability to predict the prognosis of patients with MDS and provide a rational basis for designing specific therapies that are more effective and less toxic. ..