Research Topics
Genomes and GenesSpecies | Julia D GrantSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
A comparison of the latent class structure of cannabis problems among adult men and women who have used cannabis repeatedlyJulia D Grant
Department of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 101:1133-42. 2006..Current evidence is not conclusive regarding gender differences for cannabis use, abuse and dependence. It is not known if symptom profiles differ by gender...- Spousal concordance for alcohol dependence: evidence for assortative mating or spousal interaction effects?Julia D Grant
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Alcohol Clin Exp Res 31:717-28. 2007..The primary goal of the present analyses is to test hypotheses about the source(s) and magnitude of spousal associations for AD using a twin-spouse design... - Subjective reactions to cocaine and marijuana are associated with abuse and dependenceJulia D Grant
Department of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, 40 N Kingshighway, Suite 3, St Louis, MO 63108, United States
Addict Behav 30:1574-86. 2005..7; 95% CI: 5.6-62.6) classes. We found evidence for both qualitative and quantitative subjective effect profiles. Subjective effects, both positive and adverse are associated with lifetime risk for marijuana and cocaine dependence... - Adolescent alcohol use is a risk factor for adult alcohol and drug dependence: evidence from a twin designJulia D Grant
Department of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
Psychol Med 36:109-18. 2006..Early alcohol use is associated with abuse and dependence of licit and illicit substances later in life. The role of genetic and environmental factors in this association is not conclusive... 
Parent, sibling and peer influences on smoking initiation, regular smoking and nicotine dependence. Results from a genetically informative designJeffrey F Scherrer
St Louis Veterans Affairs Medical Center, Research Service 151 JC, 915 North Grand Blvd, St Louis, MO 63106, USA
Addict Behav 37:240-7. 2012..Smoking interventions may have greatest impact by targeting smoking prevention among peer groups in adolescent and young adult populations...- Common genetic contributions to alcohol and cannabis use and dependence symptomatologyCarolyn E Sartor
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Alcohol Clin Exp Res 34:545-54. 2010.... - Associations of alcohol, nicotine, cannabis, and drug use/dependence with educational attainment: evidence from cotwin-control analysesJulia D Grant
Midwest Alcoholism Research Center at Washington University, Washington University School of Medicine, St Louis, Missouri, USA
Alcohol Clin Exp Res 36:1412-20. 2012..We tested whether alcohol, nicotine, and illicit drug use and dependence were associated with lifetime educational attainment after controlling for familial background characteristics... - Alcohol consumption indices of genetic risk for alcohol dependenceJulia D Grant
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Biol Psychiatry 66:795-800. 2009..A high genetic correlation between these measures would suggest that a continuous measure of consumption may have a useful role in the discovery of genes contributing to dependence risk... - Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptomsArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
Alcohol Clin Exp Res 33:2047-56. 2009..In this study, we examine whether age at first drink moderates genetic and environmental influences, via gene x environment interactions, on DSM-IV alcohol dependence symptoms... - Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depressionCarolyn E Sartor
Department of Psychiatry, Yale School of Medicine, VA Connecticut Healthcare System, USA
Arch Gen Psychiatry 69:293-9. 2012.... - Initial response to cigarettes predicts rate of progression to regular smoking: findings from an offspring-of-twins designCarolyn E Sartor
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, Saint Louis, Missouri 63110, USA
Addict Behav 35:771-8. 2010..exclusively negative (physiological) responses suggests the importance of considering both dimensions in combination to characterize risk for smoking-related outcomes... - Contribution of parental psychopathology to offspring smoking and nicotine dependence in a genetically informative designHong Xian
Research Service 151JC, St Louis Veterans Affairs Medical Center, 915 North Grand Boulevard, St Louis, Missouri 63106, USA
J Stud Alcohol Drugs 71:664-73. 2010.... - A latent class analysis of DSM-IV and Fagerström (FTND) criteria for nicotine dependenceArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Nicotine Tob Res 13:972-81. 2011.... 
Genetic and environmental contributions to nicotine, alcohol and cannabis dependence in male twinsHong Xian
Research Service, St Louis Veterans Affairs Medical Center VAMC, St Louis, MO 63106, USA
Addiction 103:1391-8. 2008..To compute the common and specific genetic and environmental contributions to nicotine dependence (ND) alcohol dependence (AD) and cannabis dependence (CD)...- Subjective effects to cannabis are associated with use, abuse and dependence after adjusting for genetic and environmental influencesJeffrey F Scherrer
Research Service, St Louis Veterans Affairs Medical Center, Research Service 151 JC, 915 North Grand Blvd, St Louis, MO, United States
Drug Alcohol Depend 105:76-82. 2009..This study extends existing research by inclusion of adolescents and young adults in an offspring of twins design which makes it possible to take into account genetic and environmental risks for substance use disorder... - Patterns of use, sequence of onsets and correlates of tobacco and cannabisArpana Agrawal
Washington University School of Medicine, Dept of Psychiatry and the Midwest Alcoholism Research Center, Saint Louis, MO 63110, USA
Addict Behav 36:1141-7. 2011..In this study, we characterize patterns of cannabis and tobacco use (tobacco but not cannabis, cannabis but not tobacco or both) and compare the factors associated with onset of tobacco before cannabis and cannabis before tobacco... - Measured environmental contributions to cannabis abuse/dependence in an offspring of twins designJeffrey F Scherrer
St Louis Veterans Affairs Medical Center, Research Service 151 JC, 915 North Grand Blvd, St Louis, MO 63106, USA
Addict Behav 33:1255-66. 2008..08). Perceived sibling, friend and school peer substance use are strongly associated with CAD in young adults even after accounting for latent familial risk and for multiple measured intra-family and extra-family environmental influences... - Risk for initiation of substance use as a function of age of onset of cigarette, alcohol and cannabis use: findings in a Midwestern female twin cohortArpana Agrawal
Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
Prev Med 43:125-8. 2006..We investigated whether use and early-onset use of cigarettes, alcohol and cannabis contributed an increase in risk for initiation of subsequent psychoactive substances in women (N = 3729, mean age = 21.7)... - Deconstructing the age-prevalence curve of alcohol dependence: why "maturing out" is only a small piece of the puzzleAlvaro Vergés
Department of Psychological Sciences, University of Missouri Columbia, Midwest Alcoholism Research Center, Columbia, MO, USA
J Abnorm Psychol 121:511-23. 2012.... - The effects of maternal smoking during pregnancy on offspring outcomesArpana Agrawal
Washington University School of Medicine, Dept of Psychiatry, Saint Louis, MO 63110, USA
Prev Med 50:13-8. 2010.... - H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependenceElliot C Nelson
Department of Psychiatry, Washington University School of Medicine, USA
Addict Biol 15:1-11. 2010..Our results also suggest that severe early trauma may prove to be an important clinical covariate in the treatment of alcohol dependence... - A cotwin-control analysis of drug use and abuse/dependence risk associated with early-onset cannabis useJulia D Grant
The Midwest Alcoholism Research Center at Washington University, Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addict Behav 35:35-41. 2010..In contrast to previous research, there is limited evidence for increased risk associated with early-onset use in this sample of Vietnam-era veterans... - Relationship between body mass index, alcohol use, and alcohol misuse in a young adult female twin sampleAlexis E Duncan
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Stud Alcohol Drugs 70:458-66. 2009..The aim of this study was to examine the relationships between body mass index (BMI) and alcohol use and misuse in young adulthood in a sample of black and white female twins... - Subtypes of illicit drug users: a latent class analysis of data from an Australian twin sampleMichael T Lynskey
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, United States of America
Twin Res Hum Genet 9:523-30. 2006..Aggregation of population-level data may obscure important subgroup differences in patterns of illicit drug use and psychiatric comorbidity. Further exploration of a 'self-medicating' subgroup is needed... - Psychiatric and familial predictors of transition times between smoking stages: results from an offspring-of-twins studyCarolyn E Sartor
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addict Behav 33:235-51. 2008..Findings characterize a rarely examined aspect of the course of ND development and highlight critical distinctions in risk profiles across stages of tobacco involvement... - Stimulant use and symptoms of abuse/dependence: epidemiology and associations with cannabis use--a twin studyMichael T Lynskey
Department of Psychiatry, Washington University School of Medicine, 4560 Clayton Rd, Suite 1000, St Louis, MO 63110, United States
Drug Alcohol Depend 86:147-53. 2007.... - Genetic and environmental contributions to BMI in adolescent and young adult womenAlexis E Duncan
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
Obesity (Silver Spring) 17:1040-3. 2009..Additional research is needed to better characterize the environmental and genetic factors related to BMI in persons of different races to aid understanding of the complex determinants of body weight in individuals... - A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implicationsAndrew C Heath
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Biol Psychiatry 70:513-8. 2011.... - Duration of cannabis use--a novel phenotype?Michael T Lynskey
Department of Psychiatry, Washington University School of Medicine, 4560 Clayton Rd, Suite 1000, St Louis, MO 63110, United States
Addict Behav 31:984-94. 2006..While there were high genetic correlations in both women and men, lifetime duration of cannabis may be uniquely informative in assessing components of liability to cannabis use... - Assortative mating for cigarette smoking and for alcohol consumption in female Australian twins and their spousesArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, 8134, St Louis, MO 63110, USA
Behav Genet 36:553-66. 2006..We aim to clarify the mechanisms contributing to spousal similarity for cigarette smoking and alcohol consumption... - Developing a quantitative measure of alcohol consumption for genomic studies on prospective cohortsArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
J Stud Alcohol Drugs 70:157-68. 2009..The purpose of this study was to develop a quantitative measure of alcohol consumption for gene-mapping studies... - The interpretability of family history reports of alcoholism in general community samples: findings in a midwestern U.S. twin birth cohortMary Waldron
School of Education, Indiana University, Bloomington, IN 47405, USA
Alcohol Clin Exp Res 36:1091-8. 2012..Although there is a long tradition in alcoholism research of using family history ratings, the interpretability of family history reports of alcoholism from general community samples has yet to be established... - The association between cannabis abuse and dependence and childhood physical and sexual abuse: evidence from an offspring of twins designAlexis E Duncan
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 103:990-7. 2008.... - A candidate gene association study of alcohol consumption in young womenArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
Alcohol Clin Exp Res 35:550-8. 2011..We used data on a previously defined alcohol consumption factor score in a sample of 827 young women to investigate association with 1,014 single-nucleotide polymorphisms in genes related to addiction... - Psychiatric comorbidity and progression in drug use in adult male twins: implications for the design of genetic association studiesAlexandre A Todorov
Department of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, MO 63110 1502, United States
Addict Behav 31:948-61. 2006..We use the result of these analyses to show how the use of a particular drug disorder phenotype for selecting cases could impact final sample composition... - A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking familiesMichele L Pergadia
Department of Psychiatry, WashingtonUniversity School of Medicine, Saint Louis, MO 63110, USA
Am J Psychiatry 168:848-52. 2011..The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking... - Heritability of delay discounting in adolescence: a longitudinal twin studyAndrey P Anokhin
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
Behav Genet 41:175-83. 2011..This study provides the first evidence for heritability of DD in humans and suggests that DD can be a promising endophenotype for genetic studies of addiction and externalizing disorders... - Parent, sibling and peer associations with subtypes of psychiatric and substance use disorder comorbidity in offspringVivia V McCutcheon
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8134, St Louis, MO 63110, United States Electronic address
Drug Alcohol Depend 128:20-9. 2013..The present study examines the clustering of offspring lifetime substance use and psychiatric disorders into subtypes and characterizes them in terms of familial and non-familial influences using an offspring-of-twins design... - Suicidal behavior, smoking, and familial vulnerabilityJeffrey F Scherrer
Research Service 151 JC, St Louis Veterans Affairs Medical Center, St Louis, MO, USA
Nicotine Tob Res 14:415-24. 2012..Smoking is a well-established correlate of suicidal behavior. It is not known if familial risk factors contribute to this association... - Age and ethnic differences in the onset, persistence and recurrence of alcohol use disorderJulia D Grant
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 107:756-65. 2012..To estimate ethnic differences in three components of alcohol use disorder and alcohol dependence course (onset, persistence and recurrence) in a developmental framework... - Developmental and genetic influences on prefrontal function in adolescents: a longitudinal twin study of WCST performanceAndrey P Anokhin
Washington University School of Medicine, St Louis, MO 63110, USA
Neurosci Lett 472:119-22. 2010..The results suggest increasing influence of familial factors on frontal executive functioning during adolescence, as well as gender differences in the relative role of genetic and environmental factors... - The assessment of peer selection and peer environmental influences on behavior using pairs of siblings or twinsPamela A F Madden
Missouri Alcoholism Research Center, Washington University School, 63108, USA
Twin Res 5:38-43. 2002..Limitations of these simulations, including uncertainty about the most appropriate way to model peer selection, are discussed... - The genetics of middle-age spread in middle-class malesJames C Romeis
Health Services Research, Department of Health Management and Policy, School of Public Health, Saint Louis University, St Louis, Missouri 63104, USA
Twin Res 7:596-602. 2004..The data analysis suggests that treatments and public health interventions need to recognize the magnitude of genetic factors if short-term and long-term interventions are to be effective... - Contributions of parental alcoholism, prenatal substance exposure, and genetic transmission to child ADHD risk: a female twin studyValerie S Knopik
Center for Alcohol and Addiction Studies, Department of Community Health, Brown University Medical School, Providence, RI 02912, USA
Psychol Med 35:625-35. 2005..Little attention, however, has been directed to investigating the roles of genetic transmission and prenatal exposure simultaneously...