R M Grady

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Role for alpha-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies
    R M Grady
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Cell Biol 1:215-20. 1999
  2. ncbi request reprint Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex
    R M Grady
    Department of Pediatrics, Washington University Medical School, St Louis, Missouri 63110, USA
    Neuron 25:279-93. 2000
  3. ncbi request reprint Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy
    R M Grady
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell 90:729-38. 1997
  4. ncbi request reprint Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction
    E D Apel
    Department of Anatomy and Neurobiology and Department of Pediatrics, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 275:31986-95. 2000
  5. pmc Subtle neuromuscular defects in utrophin-deficient mice
    R M Grady
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 136:871-82. 1997
  6. pmc Membrane targeting and stabilization of sarcospan is mediated by the sarcoglycan subcomplex
    R H Crosbie
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Cell Biol 145:153-65. 1999

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Role for alpha-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies
    R M Grady
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Cell Biol 1:215-20. 1999
    ..These results indicate that both signalling and structural functions of the DGC are required for muscle stability, and implicate alpha-dystrobrevin in the former...
  2. ncbi request reprint Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex
    R M Grady
    Department of Pediatrics, Washington University Medical School, St Louis, Missouri 63110, USA
    Neuron 25:279-93. 2000
    ..Together, these results demonstrate involvement of distinct protein complexes in the formation and maintenance of the synapse and implicate the DGC in the latter process...
  3. ncbi request reprint Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy
    R M Grady
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell 90:729-38. 1997
    ..Thus, utrophin attenuates the effects of dystrophin deficiency, and the double mutant may provide a useful model for studies of pathogenesis and therapy...
  4. ncbi request reprint Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction
    E D Apel
    Department of Anatomy and Neurobiology and Department of Pediatrics, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 275:31986-95. 2000
    ..Finally, we identify a homologous gene, syne-2, that is expressed in an overlapping but distinct pattern...
  5. pmc Subtle neuromuscular defects in utrophin-deficient mice
    R M Grady
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 136:871-82. 1997
    ..These results point to a predominant role for other molecules in the differentiation and maintenance of the postsynaptic membrane...
  6. pmc Membrane targeting and stabilization of sarcospan is mediated by the sarcoglycan subcomplex
    R H Crosbie
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Cell Biol 145:153-65. 1999
    ..In addition, the SG- SPN subcomplex functions to stabilize alpha-dystroglycan to the muscle plasma membrane. Taken together, our data provide important information about assembly and function of the SG-SPN subcomplex...