L T Goodnough

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint The role of iron in erythropoiesis in the absence and presence of erythropoietin therapy
    Lawrence Tim Goodnough
    Department of Medicine and Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nephrol Dial Transplant 17:14-8. 2002
  2. ncbi request reprint Evolution in alternatives to blood transfusion
    Lawrence T Goodnough
    Washington University School of Medicine, St Louis, MO 63110, USA
    Hematol J 4:87-91. 2003
  3. ncbi request reprint The use of erythropoietin to increase red cell mass
    Lawrence T Goodnough
    Division of Laboratory Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Can J Anaesth 50:S10-8. 2003
  4. ncbi request reprint Erythropoietin and iron-restricted erythropoiesis
    Lawrence Tim Goodnough
    Department of Pathology, Stanford University, Stanford, CA 94305 5626, USA
    Exp Hematol 35:167-72. 2007
  5. ncbi request reprint Blood management
    Lawrence T Goodnough
    Department of Pathology and Medicine, Stanford University Medical Center, 300 Pasteur Dr, M C 5626, Stanford, CA 94305, USA
    Arch Pathol Lab Med 131:695-701. 2007
  6. ncbi request reprint Bloodless medicine: clinical care without allogeneic blood transfusion
    Lawrence T Goodnough
    Washington University School of Medicine, St Louis, Missouri, USA
    Transfusion 43:668-76. 2003
  7. ncbi request reprint Transfusion medicine service policies for recombinant factor VIIa administration
    Lawrence Tim Goodnough
    Department of Medicine, Washington University School of Medicine Barnes Jewish Hospital, St Louis, Missouri, USA
    Transfusion 44:1325-31. 2004
  8. ncbi request reprint Treatment of critical bleeding in the future intensive care unit
    L T Goodnough
    Barnes Jewish Hospital and Washington University, Box 8118, Washington University, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Intensive Care Med 28:S221. 2002
  9. ncbi request reprint Risks of blood transfusion
    Lawrence T Goodnough
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Crit Care Med 31:S678-86. 2003
  10. ncbi request reprint Blood and blood conservation: a national perspective
    Lawrence T Goodnough
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cardiothorac Vasc Anesth 18:6S-11S. 2004

Collaborators

Detail Information

Publications74

  1. ncbi request reprint The role of iron in erythropoiesis in the absence and presence of erythropoietin therapy
    Lawrence Tim Goodnough
    Department of Medicine and Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nephrol Dial Transplant 17:14-8. 2002
    ..The availability of better tolerated i.v. iron preparations provides an ideal opportunity to study the value of iron therapy in patients with acute blood loss, particularly those undergoing rHuEPO therapy...
  2. ncbi request reprint Evolution in alternatives to blood transfusion
    Lawrence T Goodnough
    Washington University School of Medicine, St Louis, MO 63110, USA
    Hematol J 4:87-91. 2003
  3. ncbi request reprint The use of erythropoietin to increase red cell mass
    Lawrence T Goodnough
    Division of Laboratory Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Can J Anaesth 50:S10-8. 2003
  4. ncbi request reprint Erythropoietin and iron-restricted erythropoiesis
    Lawrence Tim Goodnough
    Department of Pathology, Stanford University, Stanford, CA 94305 5626, USA
    Exp Hematol 35:167-72. 2007
    ..Insights gained over the last 20 years regarding the relationship between erythropoietin, iron, and erythropoiesis, along with implications for clinical management, will be reviewed...
  5. ncbi request reprint Blood management
    Lawrence T Goodnough
    Department of Pathology and Medicine, Stanford University Medical Center, 300 Pasteur Dr, M C 5626, Stanford, CA 94305, USA
    Arch Pathol Lab Med 131:695-701. 2007
    ..We provide an overview of the principles of blood management: the appropriate use of blood and blood components, with a goal of minimizing their use...
  6. ncbi request reprint Bloodless medicine: clinical care without allogeneic blood transfusion
    Lawrence T Goodnough
    Washington University School of Medicine, St Louis, Missouri, USA
    Transfusion 43:668-76. 2003
  7. ncbi request reprint Transfusion medicine service policies for recombinant factor VIIa administration
    Lawrence Tim Goodnough
    Department of Medicine, Washington University School of Medicine Barnes Jewish Hospital, St Louis, Missouri, USA
    Transfusion 44:1325-31. 2004
    ..Currently, the decision on when and where to use rFVIIa for patients with uncontrolled bleeding continues to be one that must be made by individual physicians, assisted by their hospital pharmacotherapeutics and transfusion committees...
  8. ncbi request reprint Treatment of critical bleeding in the future intensive care unit
    L T Goodnough
    Barnes Jewish Hospital and Washington University, Box 8118, Washington University, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Intensive Care Med 28:S221. 2002
  9. ncbi request reprint Risks of blood transfusion
    Lawrence T Goodnough
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Crit Care Med 31:S678-86. 2003
    ..To review the current status of risks of blood transfusion...
  10. ncbi request reprint Blood and blood conservation: a national perspective
    Lawrence T Goodnough
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cardiothorac Vasc Anesth 18:6S-11S. 2004
  11. ncbi request reprint Low incidence of transplantation-related acute complications in patients with chronic myeloid leukemia undergoing allogeneic stem cell transplantation with a low-dose (550 cGy) total body irradiation conditioning regimen
    H Khoury
    Division of Medical Oncology, Bone Marrow Transplantation and Leukemia Section, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Biol Blood Marrow Transplant 7:352-8. 2001
    ..In summary, this low-dose TBI-based preparative regimen resulted in uniform donor engraftment, with markedly reduced organ toxicity and nonrelapse mortality, in this relatively older cohort of patients with CML...
  12. ncbi request reprint Long-term follow-up of high-risk allogeneic peripheral-blood stem-cell transplant recipients: graft-versus-host disease and transplant-related mortality
    R A Brown
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Oncol 17:806-12. 1999
    ..To determine the risks of graft-versus-host disease (GVHD) and transplant-related mortality after allogeneic peripheral-blood stem-cell (PBSC) transplantation...
  13. ncbi request reprint Reduced risk of acute GVHD following mobilization of HLA-identical sibling donors with GM-CSF alone
    S M Devine
    Siteman Cancer Center and Department of Medicine, Division of Oncology, Section of Stem Cell Transplantation, Leukemia, and Stem Cell Biology, Washington University School of Medicine, St Louis, MO, USA
    Bone Marrow Transplant 36:531-8. 2005
    ..Donor PBPC grafts mobilized with GM-CSF alone result in prompt hematopoietic engraftment despite lower CD34+ cell doses and may reduce the risk of grades II-IV acute GVHD following HLA-matched PBPC transplantation...
  14. ncbi request reprint Erythropoietin response to anaemia is not altered by surgery or recombinant human erythropoietin therapy
    L T Goodnough
    Washington University School of Medicine, Division of Laboratory Medicine, St Louis, MO 63110
    Br J Haematol 87:695-9. 1994
    ..We conclude that preoperative recombinant human erythropoietin therapy and/or surgery do not adversely affect the postoperative erythropoietin response to anaemia...
  15. ncbi request reprint Factors that influence the collection and engraftment of allogeneic peripheral-blood stem cells in patients with hematologic malignancies
    R A Brown
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Oncol 15:3067-74. 1997
    ....
  16. ncbi request reprint Outcomes of adults with acute myelogenous leukemia in remission given 550 cGy of single-exposure total body irradiation, cyclophosphamide, and unrelated donor bone marrow transplants
    C Hallemeier
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Biol Blood Marrow Transplant 10:310-9. 2004
    ..This low-dose (550 cGy), single-exposure TBI-based regimen resulted in good survival and a low risk of fatal regimen-related organ toxicity in adult patients with AML who underwent unrelated donor bone marrow transplantation in CR...
  17. ncbi request reprint Monitoring of hemostasis in cardiac surgical patients: impact of point-of-care testing on blood loss and transfusion outcomes
    G J Despotis
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Chem 43:1684-96. 1997
    ....
  18. ncbi request reprint Economic impact of donor platelet count and platelet yield in apheresis products: relevance for emerging issues in platelet transfusion therapy
    L T Goodnough
    Department of Medicine, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, MO 63110 1093, USA
    Vox Sang 76:43-9. 1999
    ..We analyzed donor platelet counts and platelet product yields in 708 consecutive platelet aphereses in our program in order to define the importance of this relationship for emerging issues in platelet transfusion therapy...
  19. ncbi request reprint Treatment of steroid-resistant acute graft-versus-host disease with anti-thymocyte globulin
    H Khoury
    Washington University School of Medicine, Department of Medicine, Division of Bone Marrow Transplantation and Stem Cell Biology, St Louis, MO 63110-1093, USA
    Bone Marrow Transplant 27:1059-64. 2001
    ..We conclude that initial improvement of SR aGVHD occurs with ATG in a minority of patients, and very few patients become long-term survivors. Furthermore, this treatment is associated with a high rate of major complications...
  20. ncbi request reprint Transfusion medicine : support of patients undergoing cardiac surgery
    L T Goodnough
    Department of Medicine and Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Am J Cardiovasc Drugs 1:337-51. 2001
    ..Controlled clinical trials comparing the costs of these agents with clinical outcomes, along with tolerability profiles in patients at risk for substantial perioperative bleeding are needed...
  21. ncbi request reprint A randomized trial of acute normovolemic hemodilution compared to preoperative autologous blood donation in total knee arthroplasty
    L T Goodnough
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Vox Sang 77:11-6. 1999
    ..Patients undergoing revision or bilateral knee arthroplasties require adjunctive therapy to autologous blood procurement to further reduce allogeneic blood exposure...
  22. ncbi request reprint Acute normovolemic hemodilution can replace preoperative autologous blood donation as a standard of care for autologous blood procurement in radical prostatectomy
    T G Monk
    Department of Anesthesia, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anesth Analg 85:953-8. 1997
    ..A combination of ANH and PAD can further decrease allogeneic blood exposure, but it increases transfusion costs and wastage...
  23. ncbi request reprint Prophylactic platelet transfusions from healthy apheresis platelet donors undergoing treatment with thrombopoietin
    L T Goodnough
    Department of Medicine, Washington University, St Louis, MO 63110 1093, USA
    Blood 98:1346-51. 2001
    ....
  24. doi request reprint Retrospective analysis of transfusion outcomes in pregnant patients at a tertiary obstetric center
    A J Butwick
    Department of Anesthesiology MC 5640, 300 Pasteur Drive, Stanford University School ofMedicine, Stanford, California 94305, USA
    Int J Obstet Anesth 18:302-8. 2009
    ..We performed a retrospective study to review transfusion outcomes in pregnant and postpartum patients at a large obstetric center...
  25. ncbi request reprint Hydroxychloroquine for the prevention of acute graft-versus-host disease after unrelated donor transplantation
    H Khoury
    Division of Oncology, Section of Leukemia and Bone Marrow, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Blood Marrow Transplant 9:714-21. 2003
    ..An ongoing placebo-controlled randomized trial will further determine what role HCQ plays in preventing GVHD after allografting...
  26. ncbi request reprint Management approaches to platelet-related microvascular bleeding in cardiothoracic surgery
    G J Despotis
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Thorac Surg 70:S20-32. 2000
    ..The ability to reduce the unnecessary use of blood products and to decrease operative time or reexploration rates has important consequences for blood inventory, blood costs, and overall health care costs...
  27. ncbi request reprint A randomized trial comparing acute normovolemic hemodilution and preoperative autologous blood donation in total hip arthroplasty
    L T Goodnough
    Departments of Medicine and Pathology, Anesthesia, and Orthopedics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Transfusion 40:1054-7. 2000
    ..Therefore, a prospective, randomized study was conducted to compare these techniques in patients undergoing primary total hip arthroplasty...
  28. ncbi request reprint Risks of blood transfusion
    Lawrence T Goodnough
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, H 1402 Stanford, CA 94305 5324, USA
    Anesthesiol Clin North America 23:241-52, v. 2005
    ..Pathogen inactivation technologies and reactive strategies such as nucleic acid testing ensure continued advances in blood safety...
  29. ncbi request reprint Autologous blood donation
    Lawrence T Goodnough
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, H 1402, Stanford, CA 94305 5626, USA
    Anesthesiol Clin North America 23:263-70, vi. 2005
    ..Nevertheless, the continuing emergence of new pathogens and the potential for severe blood inventory shortages continue to give preoperative autologous blood donation an important role in blood conservation strategies...
  30. ncbi request reprint A randomized double-blind trial of hydroxychloroquine for the prevention of chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplantation
    Thomas Fong
    Division of Oncology, Section of Leukemia and Bone Marrow Transplantation, Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
    Biol Blood Marrow Transplant 13:1201-6. 2007
    ..15). With a median follow-up of 18 months, relapse-free and overall survivals (OS) were comparable in both groups. In summary, in this randomized trial, the addition of HCQ to single-agent CSA had no effects on aGVHD or cGVHD or survival...
  31. ncbi request reprint Supraventricular tachyarrhythmias after hematopoietic stem cell transplantation: incidence, risk factors and outcomes
    J D Hidalgo
    Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Bone Marrow Transplant 34:615-9. 2004
    ..These arrhythmias are clinically significant, and are a marker for increased mortality and prolonged hospital stay. Additional studies are needed to identify high-risk patients who may benefit from prophylactic anti-arrhythmic therapy...
  32. ncbi request reprint [Autologous blood procurement--acute normovolemic hemodilution vs. preoperative autologous blood donation]
    L T Goodnough
    Medicine, Pathology and Immunology, Division of Laboratory Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Zentralbl Chir 128:462-7. 2003
    ..Concerns regarding the adequacy of national blood inventories may restimulate interest in autologous blood procurement, independent of issues regarding blood risks or costs...
  33. ncbi request reprint Immune hemolysis involving non-ABO/RhD alloantibodies following hematopoietic stem cell transplantation
    P P Young
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Bone Marrow Transplant 27:1305-10. 2001
    ..In one patient, the duration of hemolysis was shortened significantly by performing red cell exchange at the first sign of intravascular hemolysis...
  34. ncbi request reprint Apheresis platelets: emerging issues related to donor platelet count, apheresis platelet yield, and platelet transfusion dose
    L T Goodnough
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Clin Apher 13:114-9. 1998
    ..The future role of apheresis products in platelet transfusion therapy will in large part be determined by costs, which are increasingly recognized to be influenced by donor platelet count, apheresis yield, and platelet transfusion dose...
  35. pmc Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines
    L T Goodnough
    Department of Pathology and Medicine, Stanford University School of Medicine, Pasteur Dr, Stanford, CA 94305, USA
    Br J Anaesth 106:13-22. 2011
    ..Anaemia should be viewed as a serious and treatable medical condition, rather than simply an abnormal laboratory value. Implementation of anaemia management in the elective orthopaedic surgery setting will improve patient outcomes...
  36. ncbi request reprint Erythropoietin therapy versus red cell transfusion
    L T Goodnough
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Hematol 8:405-10. 2001
    ..This is not only because of traditional concerns regarding blood risks but because of new blood inventory and cost considerations...
  37. ncbi request reprint Low-dose (550 cGy), single-exposure total body irradiation and cyclophosphamide: consistent, durable engraftment of related-donor peripheral blood stem cells with low treatment-related mortality and fatal organ toxicity
    W Blum
    Department of Internal Medicine, Division of Oncology, Section of Bone Marrow Transplantation and Leukemia, St Louis Children s Hospital, St Louis, Missouri 63110 1093, USA
    Biol Blood Marrow Transplant 8:608-18. 2002
    ..Low-dose (550 cGy), single-exposure TBI given at a high dose rate with cyclophosphamide resulted in consistent durable engraftment of HLA-matched sibling PBSC with a low risk of fatal organ toxicity and TRM...
  38. pmc Autologous blood donation
    Lawrence T Goodnough
    Washington University School of Medicine, Transfusion Services, Barnes Jewish Hospital, St Louis, Missouri, USA
    Crit Care 8:S49-52. 2004
    ..It has been determined that preoperative autologous blood donation is poorly cost-effective; the use of this procedure must be based on evidence that it is safe and of value for the patient...
  39. ncbi request reprint Primary amyloidosis patients with significant organ dysfunction tolerate autologous transplantation after conditioning with single-dose total body irradiation alone: a feasibility study
    William Blum
    Division of Oncology, Section of Bone Marrow Transplantation and Leukemia, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110 1093, USA
    Biol Blood Marrow Transplant 9:397-404. 2003
    ..Efficacy with TBI conditioning may be reduced compared with high-dose melphalan, but this should be explored in a future trial with a larger cohort of patients...
  40. ncbi request reprint Transfusion medicine: looking to the future
    Lawrence T Goodnough
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Lancet 361:161-9. 2003
    ..Finally, serious difficulties in blood safety and availability for poor, developing countries require innovative strategies and commitment of resources...
  41. ncbi request reprint Issues in the management of cancer-related thrombocytopenia
    Lawrence T Goodnough
    Departments of Medicine and Pathology and Immunology, Divisions of Laboratory Medicine and Oncology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Oncology (Williston Park) 16:1558-67; discussion 1570, 1572-4. 2002
    ..These agents include recombinant human interleukin-11, recombinant human thrombopoietin, and c-Mpl ligand mimetics...
  42. ncbi request reprint Donor CMV serostatus has no impact on CMV viremia or disease when prophylactic granulocyte transfusions are given following allogeneic peripheral blood stem cell transplantation
    Ravi Vij
    Section of Bone Marrow Transplantation and Leukemia, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Blood 101:2067-9. 2003
    ..This knowledge may help expand the donor pool in areas with a high prevalence of CMV in the general population...
  43. ncbi request reprint Red cell growth factors in patients with chronic anemias
    Lawrence T Goodnough
    Division of Laboratory Medicine, Washington University School of Medicine, Box 8118, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Curr Hematol Rep 1:119-23. 2002
    ....
  44. doi request reprint Postpartum hemorrhage treated with a massive transfusion protocol at a tertiary obstetric center: a retrospective study
    M C Gutierrez
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Obstet Anesth 21:230-5. 2012
    ..The etiology of postpartum hemorrhage, transfusion outcomes and laboratory indices in obstetric cases requiring the massive transfusion protocol were retrospectively evaluated in a tertiary obstetric center...
  45. ncbi request reprint The endogenous erythropoietin response and the erythropoietic response to blood loss anemia: the effects of age and gender
    L T Goodnough
    Department of Medicine and Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lab Clin Med 126:57-64. 1995
    ..3 ml/kg vs 1.5 +/- 0.3 ml/kg per 1000 U/kg EPO, respectively, p = 0.80) or as a function of age (estimated rate of change = 0.051 +/- 0.15 ml/kg per 1000 U/kg EPO for every 10 years of life, p = 0.74).(ABSTRACT TRUNCATED AT 250 WORDS)..
  46. ncbi request reprint Prestorage universal WBC reduction of RBC units does not affect the incidence of transfusion reactions
    E J Uhlmann
    Department of Pathology and Immunology, Washington University, St. Louis, Missouri 63110, USA
    Transfusion 41:997-1000. 2001
    ..In addition, no difference was found in transfusion reaction rates when periods of prestorage universal WBC reduction were compared to those of selective WBC reduction...
  47. ncbi request reprint Future directions in utilization review: the role of transfusion algorithms
    L T Goodnough
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Transfus Sci 19:97-105. 1998
    ..The use of point-of-care assays and transfusion algorithms may provide an effective concurrent method of utilization review of blood products in the surgical setting...
  48. ncbi request reprint Erythropoietin, iron, and erythropoiesis
    L T Goodnough
    Departments of Medicine and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 96:823-33. 2000
    ..The availability of safer intravenous iron preparations allows for carefully controlled studies of their value in patients undergoing erythropoietin therapy or experiencing blood loss, or both...
  49. ncbi request reprint Alloimmunization to red blood cell antigens affects clinical outcomes in liver transplant patients
    Scott D Boyd
    Department of Pathology, Stanford University, and Department of Transfusion Medicine, Stanford University Hospitals and Clinics, CA 94305, USA
    Liver Transpl 13:1654-61. 2007
    ..Our findings suggest that blood transfusion and immune modulation greatly affect the survival of patients after liver transplantation...
  50. doi request reprint Impact of cytomegalovirus (CMV) antibody reflex testing in the transfusion service on management of CMV-seronegative blood inventory
    Magali J Fontaine
    Department of Pathology, Stanford University, and Stanford Hospital and Clinics, Stanford, California, USA
    Transfusion 50:1685-9. 2010
    ..Our goal is to minimize unnecessary cytomegalovirus (CMV)-seronegative blood transfusion to preserve the CMV-seronegative blood inventory for patients who are identified as CMV seronegative...
  51. ncbi request reprint Low-dose short-course intravenous ganciclovir as pre-emptive therapy for CMV viremia post allo-PBSC transplantation
    R Vij
    Section of Bone Marrow Transplantation and Leukemia, Washington University School of Medicine, St Louis, MO 63110, USA
    Bone Marrow Transplant 32:703-7. 2003
    ..No patient on LDSC GCV exhibited a decline in their ANC below 500/microl and none required growth factors. LDSC GCV is extremely well tolerated and cost-effective as PT for CMV viremia following allo-PBSC transplantation...
  52. ncbi request reprint Platelet transfusion therapy
    L T Goodnough
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Apher 16:43-8. 2001
    ..The generation of a platelet apheresis inventory has been accompanied by a decline in whole blood inventory; research into the impact of these distinct donor pools on national blood policy is needed...
  53. doi request reprint Rationale for blood conservation
    Lawrence T Goodnough
    Department of Pathology and Medicine, Transfusion Service, Stanford University Medical Center, Stanford, California 94305 5626, USA
    Surg Infect (Larchmt) 6:S3-8. 2005
    ..Exposure of patients to allogeneic blood transfusion can be minimized or avoided by the systematic use of multiple blood conservation techniques. Current use of these technologies is variable...
  54. ncbi request reprint Long-term outcomes of allogeneic stem cell transplant recipients after calcineurin inhibitor-induced neurotoxicity
    Rizwana Chohan
    Washington University School of Medicine, Department of Medicine, Division of Oncology, Section of Leukaemia and Bone Marrow Transplantation, St Louis, MO 63110 1093, USA
    Br J Haematol 123:110-3. 2003
    ..GVHD and/or infection occurred in 54% and were the most common primary causes of death. We conclude that calcineurin inhibitor-induced neurotoxicity is frequently reversible but associated with a poor prognosis...
  55. ncbi request reprint Detection, evaluation, and management of anemia in the elective surgical patient
    Lawrence T Goodnough
    Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive H 1402, Stanford, CA 94305 5626, USA
    Anesth Analg 101:1858-61. 2005
    ....
  56. ncbi request reprint Remission of chronic thrombotic thrombocytopenic purpura after treatment with cyclophosphamide and rituximab
    Xinglong Zheng
    Washington University School of Medicine, 660 South Euclid Avenue, Box 8022, St Louis, Missouri 63110, USA
    Ann Intern Med 138:105-8. 2003
    ..Thrombotic thrombocytopenic purpura (TTP) in adults is usually caused by autoantibody inhibitors of ADAMTS13. Treatment with plasma exchange is often effective but does not address the underlying autoimmune process...
  57. doi request reprint Improving platelet supply chains through collaborations between blood centers and transfusion services
    Magali J Fontaine
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305 5626, USA
    Transfusion 49:2040-7. 2009
    ....
  58. doi request reprint Age of blood as a limitation for transfusion: potential impact on blood inventory and availability
    Magali J Fontaine
    Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, 300 Pasteur Drive, Room H1402, M C 5626, Stanford, CA 94305 5626, USA
    Transfusion 50:2233-9. 2010
    ..Evolving concerns about storage lesions for red blood cells (RBCs) have led to ongoing trials evaluating the benefits of transfusing fresher blood to acutely ill patients...
  59. ncbi request reprint Autoantibody formation after alloimmunization: are blood transfusions a risk factor for autoimmune hemolytic anemia?
    Pampee P Young
    Department of Pathology and Immunology, Washington University School of Medicine, MO 63110, USA
    Transfusion 44:67-72. 2004
    ..The development of RBC autoantibodies resulting from or associated with allogeneic blood transfusions (i.e., RBC autoimmunization) is not a well-recognized complication of RBC transfusions...
  60. ncbi request reprint Fatal thrombosis after administration of activated prothrombin complex concentrates in a patient supported by extracorporeal membrane oxygenation who had received activated recombinant factor VII
    Jack D Bui
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    J Thorac Cardiovasc Surg 124:852-4. 2002
  61. ncbi request reprint Effects of pretransplantation treatment with rituximab on outcomes of autologous stem-cell transplantation for non-Hodgkin's lymphoma
    Amy L Hoerr
    School of Medicine, Siteman Cancer Center, Washington University, St Louis, MO, USA
    J Clin Oncol 22:4561-6. 2004
    ..To analyze the effects of preautografting treatment with rituximab (R) on stem-cell mobilization, post-transplantation complications, engraftment, disease-free survival, and overall survival in patients with non-Hodgkin's lymphoma (NHL)...
  62. doi request reprint Implementation of a two-specimen requirement for verification of ABO/Rh for blood transfusion
    Lawrence T Goodnough
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5626, USA
    Transfusion 49:1321-8. 2009
    ..This study presents our implementation of a two-specimen requirement with no prior record of ABO/Rh to verify patients' blood type before transfusion...
  63. doi request reprint Randomized evaluation of efficacy and safety of ferric carboxymaltose in patients with iron deficiency anaemia and impaired renal function (REPAIR-IDA): rationale and study design
    Lynda A Szczech
    Renal Division, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Nephrol Dial Transplant 25:2368-75. 2010
    ..Ferric carboxymaltose (FCM) is a novel IV iron formulation designed to permit larger infusions compared to currently available IV standards such as Venofer(R) (iron sucrose)...
  64. ncbi request reprint Recombinant factor VIIa: safety and efficacy
    Lawrence T Goodnough
    Department of Pathology and Medicine, Stanford University, Stanford, California 94305 5626, USA
    Curr Opin Hematol 14:504-9. 2007
    ..Recombinant factor VIIa has been increasingly used to provide hemostasis in nonapproved indications. This trend has resulted in concerns about safety, efficacy and costs...
  65. ncbi request reprint Experiences with recombinant human factor VIIa in patients with thrombocytopenia
    Lawrence Tim Goodnough
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Semin Hematol 41:25-9. 2004
    ..It is concluded that rFVIIa has a potential role in patients with thrombocytopenia and clinical hemorrhage...
  66. ncbi request reprint Acute normovolemic hemodilution
    Lawrence Tim Goodnough
    Division of Laboratory Medicine, Washington University School of Medicine, St Louis, MO, USA
    Vox Sang 83:211-5. 2002
  67. ncbi request reprint Prevalence and outcomes of anemia in rheumatoid arthritis: a systematic review of the literature
    Alisa Wilson
    Zynx Health, Beverly Hills, California 90212, USA
    Am J Med 116:50S-57S. 2004
    ..Whether improvements in QOL and/or joint symptoms occur with improvement of anemia, independent of other signs of an overall response to RA therapy, remains to be determined...
  68. ncbi request reprint Indications for red cell transfusion
    Lawrence Tim Goodnough
    Division of Laboratory Medicine, Washington University School of Medicine, St Louis, MO, USA
    Vox Sang 83:7-9. 2002
  69. ncbi request reprint Transfusion triggers
    Lawrence Tim Goodnough
    Departments of Pathology and Medicine, Stanford University, Stanford, CA 94305, USA
    Surgery 142:S67-70. 2007
    ..The benefit of transfusion in relation to mortality and morbidity is discussed here based on an assessment of the literature, and transfusion guidelines from several organizations are summarized...
  70. ncbi request reprint Anemia and its clinical consequences in patients with chronic diseases
    Lawrence Tim Goodnough
    Division of Laboratory Medicine, Washington University Medical Center, St Louis, Missouri 63130, USA
    Am J Med 116:1S-2S. 2004
  71. ncbi request reprint Patient safety and blood transfusion: new solutions
    Walter H Dzik
    Department of Hematology Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Transfus Med Rev 17:169-80. 2003
    ..Technology solutions will likely require integration with delivery of pharmaceuticals to be financially acceptable to hospitals...
  72. ncbi request reprint Invited commentary
    Lawrence Tim Goodnough
    Department of Pathology and Medicine, Stanford Medical Center, 300 Pasteur Dr H 1402, Stanford, CA 94304 5626, USA
    Ann Thorac Surg 78:1554-5. 2004
  73. ncbi request reprint How we treat: management of life-threatening primary postpartum hemorrhage with a standardized massive transfusion protocol
    Matthew Burtelow
    Department of Pathology, Stanford University Medical Center, Stanford, California, USA
    Transfusion 47:1564-72. 2007
    ..The successful management of three cases of massive primary postpartum hemorrhage after the implementation of our new massive transfusion protocol in the maternal and fetal medicine service is described...
  74. doi request reprint The role of intravenous iron in anemia management and transfusion avoidance
    Michael Auerbach
    Private Practice, Baltimore, Maryland, USA
    Transfusion 48:988-1000. 2008