Will L Goff

Summary

Affiliation: Washington State University
Country: USA

Publications

  1. Goff W, Johnson W, Parish S, Barrington G, Elsasser T, Davis W, et al. IL-4 and IL-10 inhibition of IFN-gamma- and TNF-alpha-dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merozoites. Vet Immunol Immunopathol. 2002;84:237-51 pubmed
    ..However, while merozoites plus IFN-gamma induced TNF-alpha mRNA expression in MDM, NO was not produced. Both IL-4 and IL-10 inhibited expression of iNOS and production of NO in merozoite-stimulated monocytes...
  2. Goff W, McElwain T, Suarez C, Johnson W, Brown W, Norimine J, et al. Competitive enzyme-linked immunosorbent assay based on a rhoptry-associated protein 1 epitope specifically identifies Babesia bovis-infected cattle. Clin Diagn Lab Immunol. 2003;10:38-43 pubmed
    ..3% concordance). The assay appears to have the characteristics necessary for an epidemiologic and disease surveillance tool...
  3. Goff W, Johnson W, Horn R, Barrington G, Knowles D. The innate immune response in calves to Boophilus microplus tick transmitted Babesia bovis involves type-1 cytokine induction and NK-like cells in the spleen. Parasite Immunol. 2003;25:185-8 pubmed
    ..The proliferating CD8+ population consisted primarily of NK-like cells, and the expansion occurred in parallel with an increase in IL-15 mRNA expression in the spleen...
  4. Goff W, Johnson W, Molloy J, Jorgensen W, Waldron S, Figueroa J, et al. Validation of a competitive enzyme-linked immunosorbent assay for detection of Babesia bigemina antibodies in cattle. Clin Vaccine Immunol. 2008;15:1316-21 pubmed publisher
    ..8, indicating a high degree of reliability. Overall, the cELISA appears to have the attributes necessary for international application...

Detail Information

Publications4

  1. Goff W, Johnson W, Parish S, Barrington G, Elsasser T, Davis W, et al. IL-4 and IL-10 inhibition of IFN-gamma- and TNF-alpha-dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merozoites. Vet Immunol Immunopathol. 2002;84:237-51 pubmed
    ..However, while merozoites plus IFN-gamma induced TNF-alpha mRNA expression in MDM, NO was not produced. Both IL-4 and IL-10 inhibited expression of iNOS and production of NO in merozoite-stimulated monocytes...
  2. Goff W, McElwain T, Suarez C, Johnson W, Brown W, Norimine J, et al. Competitive enzyme-linked immunosorbent assay based on a rhoptry-associated protein 1 epitope specifically identifies Babesia bovis-infected cattle. Clin Diagn Lab Immunol. 2003;10:38-43 pubmed
    ..3% concordance). The assay appears to have the characteristics necessary for an epidemiologic and disease surveillance tool...
  3. Goff W, Johnson W, Horn R, Barrington G, Knowles D. The innate immune response in calves to Boophilus microplus tick transmitted Babesia bovis involves type-1 cytokine induction and NK-like cells in the spleen. Parasite Immunol. 2003;25:185-8 pubmed
    ..The proliferating CD8+ population consisted primarily of NK-like cells, and the expansion occurred in parallel with an increase in IL-15 mRNA expression in the spleen...
  4. Goff W, Johnson W, Molloy J, Jorgensen W, Waldron S, Figueroa J, et al. Validation of a competitive enzyme-linked immunosorbent assay for detection of Babesia bigemina antibodies in cattle. Clin Vaccine Immunol. 2008;15:1316-21 pubmed publisher
    ..8, indicating a high degree of reliability. Overall, the cELISA appears to have the attributes necessary for international application...