F Gilliam

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Limitations of monotherapy trials in epilepsy
    Frank G Gilliam
    Department of Neurology, Washington University Epilepsy Program, Washington University, St. Louis, MO 63110, USA
    Neurology 60:S26-30. 2003
  2. ncbi The impact of epilepsy on subjective health status
    Frank Gilliam
    Washington University Epilepsy Program, Campus Box 8111, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Neurol Neurosci Rep 3:357-62. 2003
  3. ncbi Psychiatric comorbidity, health, and function in epilepsy
    Frank Gilliam
    Department of Neurology, Washington University, St Louis, MO, USA
    Epilepsy Behav 4:S26-30. 2003
  4. ncbi Systematic screening allows reduction of adverse antiepileptic drug effects: a randomized trial
    F G Gilliam
    Department of Neurology, Washington University, St Louis, MO, USA
    Neurology 62:23-7. 2004
  5. ncbi Tolerability of antiseizure medications: implications for health outcomes
    Frank Gilliam
    Department of Neurology, Columbia University, New York, New York, USA
    Neurology 63:S9-S12. 2004
  6. ncbi Health outcomes in persons with epilepsy
    F Gilliam
    Adult Epilepsy Center, Washington University, St Louis, Missouri 63110, USA
    Neurol Clin 19:465-75. 2001
  7. ncbi Depression in epilepsy: ignoring clinical expression of neuronal network dysfunction?
    Frank G Gilliam
    Department of Neurology, Washington University, St Louis, Missouri, USA
    Epilepsia 45:28-33. 2004
  8. ncbi What we don't learn from clinical trials in epilepsy
    Frank Gilliam
    Department of Neurology, Washington University, St Louis, Missouri 63110, USA
    Epilepsia 44:51-4. 2003
  9. ncbi Verbal retention lateralizes patients with unilateral temporal lobe epilepsy and bilateral hippocampal atrophy
    S M Sawrie
    Department of Neurology, Epilepsy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Epilepsia 42:651-9. 2001
  10. ncbi Relationships among hippocampal volumetry, proton magnetic resonance spectroscopy, and verbal memory in temporal lobe epilepsy
    S M Sawrie
    Epilepsy Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Epilepsia 42:1403-7. 2001

Research Grants

  1. Clinical Research in Epilepsy and Associated Disorders
    Frank Gilliam; Fiscal Year: 2007
  2. DEPRESSION AND HEALTH OUTCOMES IN REFRACTORY EPILEPSY
    Frank Gilliam; Fiscal Year: 2005

Detail Information

Publications38

  1. ncbi Limitations of monotherapy trials in epilepsy
    Frank G Gilliam
    Department of Neurology, Washington University Epilepsy Program, Washington University, St. Louis, MO 63110, USA
    Neurology 60:S26-30. 2003
    ..Despite the inherent difficulties in designing monotherapy trials in epilepsy, previous monotherapy studies have provided important information for clinical management with new treatments...
  2. ncbi The impact of epilepsy on subjective health status
    Frank Gilliam
    Washington University Epilepsy Program, Campus Box 8111, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Neurol Neurosci Rep 3:357-62. 2003
    ..Adverse medication effects and depression appear to have a strong association with subjective health status in epilepsy, independent of seizure frequency...
  3. ncbi Psychiatric comorbidity, health, and function in epilepsy
    Frank Gilliam
    Department of Neurology, Washington University, St Louis, MO, USA
    Epilepsy Behav 4:S26-30. 2003
    ..Further research is needed to increase understanding of the mechanisms of psychiatric illness in epilepsy, the effects of depression and anxiety on long-term clinical outcomes, and the most effective treatments...
  4. ncbi Systematic screening allows reduction of adverse antiepileptic drug effects: a randomized trial
    F G Gilliam
    Department of Neurology, Washington University, St Louis, MO, USA
    Neurology 62:23-7. 2004
    ..To determine the effectiveness of systematic screening with a brief 19-item self-report instrument, the Adverse Events Profile (AEP), to reduce adverse effects of antiepileptic drugs (AEDs) and improve subjective health status...
  5. ncbi Tolerability of antiseizure medications: implications for health outcomes
    Frank Gilliam
    Department of Neurology, Columbia University, New York, New York, USA
    Neurology 63:S9-S12. 2004
    ....
  6. ncbi Health outcomes in persons with epilepsy
    F Gilliam
    Adult Epilepsy Center, Washington University, St Louis, Missouri 63110, USA
    Neurol Clin 19:465-75. 2001
    ..This article reviews the issues surrounding the assessment of health outcomes from the epilepsies and the interventions used to treat recurrent seizures...
  7. ncbi Depression in epilepsy: ignoring clinical expression of neuronal network dysfunction?
    Frank G Gilliam
    Department of Neurology, Washington University, St Louis, Missouri, USA
    Epilepsia 45:28-33. 2004
    ....
  8. ncbi What we don't learn from clinical trials in epilepsy
    Frank Gilliam
    Department of Neurology, Washington University, St Louis, Missouri 63110, USA
    Epilepsia 44:51-4. 2003
    ..Patient preference may be a feasible outcome measure that allows patient-oriented validation of the results, and also inherently weighs the positive and negative effects of a treatment in a single endpoint...
  9. ncbi Verbal retention lateralizes patients with unilateral temporal lobe epilepsy and bilateral hippocampal atrophy
    S M Sawrie
    Department of Neurology, Epilepsy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Epilepsia 42:651-9. 2001
    ..To examine the lateralization utility of preoperative verbal retention in patients with and without bilateral hippocampal atrophy...
  10. ncbi Relationships among hippocampal volumetry, proton magnetic resonance spectroscopy, and verbal memory in temporal lobe epilepsy
    S M Sawrie
    Epilepsy Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Epilepsia 42:1403-7. 2001
    ..To examine the relationship between hippocampal volumes, 1H magnetic resonance spectroscopy (MRS)-identified hippocampal metabolic function, and verbal memory in patients with unilateral mesial temporal lobe epilepsy (MTLE)...
  11. ncbi Relationship between depression and intractability of seizures
    H Attarian
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, Saint Louis, MO 63110, USA
    Epilepsy Behav 4:298-301. 2003
    ..There is no relationship between the severity of depression and monthly seizure rate...
  12. ncbi Self-reported seizure frequency and time to first event in the seizure monitoring unit
    Lawrence N Eisenman
    Adult Epilepsy Center, Department of Neurology, Washington University Medical School, St Louis, Missouri, USA
    Epilepsia 46:664-8. 2005
    ..To compare seizure frequency reported in the clinic with time to first diagnostic event during video-EEG monitoring. The effect of the artificial environment of the monitoring unit on self-reported seizure frequency was explored...
  13. ncbi Video EEG monitoring prior to vagal nerve stimulator implantation
    Hrayr Attarian
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 61:402-3. 2003
    ..The authors discuss four patients who were inappropriately referred for or implanted with VNS without any previous video-EEG monitoring, in the context of their entire case experience...
  14. ncbi Selective disturbance of mental rotation by cortical stimulation
    Jeffrey M Zacks
    Department of Psychology, Washington University, One Brookings Drive, Saint Louis, MO 63130, USA
    Neuropsychologia 41:1659-67. 2003
    ..This marks the first instance of the use of direct cortical stimulation to investigate mental spatial transformations...
  15. ncbi Correlation of scalp EEG and 1H-MRS metabolic abnormalities in temporal lobe epilepsy
    B Maton
    Department of Neurology, Center for Nuclear Imaging Research, University of Alabama at Birmingham, USA
    Epilepsia 42:417-22. 2001
    ..1H-MRS identifies abnormalities contralateral to the predominant seizure focus more often than does EEG and may provide lateralizing information in patients with nonlateralizing interictal EEG...
  16. ncbi Optimizing health outcomes in active epilepsy
    Frank Gilliam
    Adult Epilepsy Center, Department of Neurology, Washington University, St. Louis, MO 63110, USA
    Neurology 58:S9-20. 2002
    ....
  17. ncbi What are the concerns of older adults living with epilepsy?
    Roy Martin
    UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA
    Epilepsy Behav 7:297-300. 2005
    ..The goal of this work was to examine the concerns of living with recurrent seizures as expressed by older adults with epilepsy (OAE)...
  18. ncbi Seizure frequency in children with epilepsy: factors influencing accuracy and parental awareness
    Cigdem Inan Akman
    Division of Pediatric Neurology, Department of Neurology, Columbia University College of Physician and Surgeons, New York, NY, USA
    Seizure 18:524-9. 2009
    ..The objective of this study was to ascertain the accuracy of clinical reports to determine the seizure frequency in children diagnosed with epilepsy...
  19. ncbi Pregnancy registries in epilepsy: a consensus statement on health outcomes
    K J Meador
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Neurology 71:1109-17. 2008
    ..There is a critical need for investigations to delineate the underlying mechanisms and explain the variance seen in outcomes across AEDs and within a single AED...
  20. ncbi Cognitive functioning in community dwelling older adults with chronic partial epilepsy
    Roy C Martin
    Department of Neurology, UAB Epilepsy Center Birmingham, Birmingham, Alabama 35294 0021, USA
    Epilepsia 46:298-303. 2005
    ..To examine cognitive functioning in community-dwelling older adults with chronic partial epilepsy and demographically matched healthy older adults...
  21. ncbi Optimizing epilepsy management: seizure control, reduction, tolerability, and co-morbidities. Introduction
    Frank Gilliam
    Adult Epilepsy Center Associate Professor of Neurology, Washington University, USA
    Neurology 58:S1. 2002
  22. ncbi Cortical abnormalities in epilepsy revealed by local EEG synchrony
    C A Schevon
    Department of Neurology, Columbia University Medical Center, NY, USA
    Neuroimage 35:140-8. 2007
    ....
  23. ncbi Health-related quality of life in senior adults with epilepsy: what we know from randomized clinical trials and suggestions for future research
    Roy Martin
    Department of Neurology, UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Epilepsy Behav 4:626-34. 2003
    ..The goal of this work was to review the randomized controlled trial (RCT) literature on antiepileptic medication effects on health-related quality of life in seniors with epilepsy...
  24. ncbi Conversations between community-based neurologists and patients with epilepsy: results of an observational linguistic study
    Frank Gilliam
    Comprehensive Epilepsy Center, Cornell University, New York, NY, USA
    Epilepsy Behav 16:315-20. 2009
    ..Communication gaps observed in discussions of epilepsy and its treatment warrant further exploration. Additional research is currently underway to assess the efficacy of a previsit assessment tool...
  25. ncbi Clinical assessment of Axis I psychiatric morbidity in chronic epilepsy: a multicenter investigation
    Jana E Jones
    Department of Neurology, University of Wisconsin Madison, 53792 6180, USA
    J Neuropsychiatry Clin Neurosci 17:172-9. 2005
    ..Issues regarding recognition and treatment of psychiatric morbidity in epilepsy are discussed...
  26. ncbi Modulation of cerebral GABA by topiramate, lamotrigine, and gabapentin in healthy adults
    Ruben Kuzniecky
    Department of Neurology, Center for Nuclear Imaging Research, Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neurology 58:368-72. 2002
    ..These results suggest that the mechanisms of action of anticonvulsant drugs are more complex and are likely to be multiple in nature...
  27. ncbi Health disparities in epilepsy: how patient-oriented outcomes in women differ from men
    Frank Gilliam
    Department of Neurology, Columbia University Medical Center, Comprehensive Epilepsy Center, New York 10032, USA
    Int Rev Neurobiol 83:417-9. 2008
    ..Further research and clinical implementation of improved gender-specific care is needed to optimize outcomes for women with epilepsy...
  28. ncbi Screening for major depression in epilepsy with common self-report depression inventories
    Jana E Jones
    Department of Neurology, University of Wisconsin Madison, 53792, USA
    Epilepsia 46:731-5. 2005
    ..The purpose of this study was to determine the ability of two common depressive symptom inventories to identify major depression in people with epilepsy...
  29. ncbi Epilepsy duration impacts on brain glucose metabolism in temporal lobe epilepsy: results of voxel-based mapping
    Cigdem I Akman
    Comprehensive Epilepsy Center, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Epilepsy Behav 17:373-80. 2010
    ..In this study, our aim was to use statistical parametric mapping (SPM) to test the validity of this relationship in a retrospective study of patients with temporal lobe epilepsy (TLE)...
  30. ncbi Adverse psychiatric effects of antiepileptic drugs
    Frank G Gilliam
    Epilepsy Res 68:67-9. 2006
    ..The follow-up should be long enough to differentiate between drug-related effects and the natural course of the comorbid disorder. Psychiatric problems should be defined using appropriate instruments as well as self-report...
  31. ncbi Rapid detection of major depression in epilepsy: a multicentre study
    Frank G Gilliam
    Department of Neurology, The Neurological Institute, Columbia University, New York, USA
    Lancet Neurol 5:399-405. 2006
    ..Depression is a common comorbid disorder in epilepsy but is not routinely assessed in neurology clinics. We aimed to create a rapid yet accurate screening instrument for major depression in people with epilepsy...
  32. ncbi Seizure remission and relapse in adults with intractable epilepsy: a cohort study
    Hyunmi Choi
    Department of Neurology, The Neurological Institute, Columbia University, New York, New York 10032, USA
    Epilepsia 49:1440-5. 2008
    ....
  33. ncbi Diagnosis and treatment of mood disorders in persons with epilepsy
    Frank G Gilliam
    The Neurological Institute, Columbia University, New York, New York 10032, USA
    Curr Opin Neurol 18:129-33. 2005
    ..Epilepsy is a common, disabling neurological disorder associated with increased rates of comorbid psychiatric disorders as compared with the general population...
  34. ncbi Mechanisms of depression in epilepsy from a clinical perspective
    Hrvoje Hecimovic
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Epilepsy Behav 4:S25-30. 2003
    ....
  35. ncbi Rates and risk factors for suicide, suicidal ideation, and suicide attempts in chronic epilepsy
    Jana E Jones
    Department of Neurology, University of Wisconsin Madison, Madison, WI, USA
    Epilepsy Behav 4:S31-8. 2003
    ..Assessing severity of risk helps to determine the appropriate level of intervention. The suicidality module of the Mini-International Neuropsychiatric Interview is a practical tool to help quantify current suicide risk...
  36. ncbi Consensus statement: the evaluation and treatment of people with epilepsy and affective disorders
    John J Barry
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA, USA
    Epilepsy Behav 13:S1-29. 2008
    ..Recommendations are based on the general depression literature as well as epilepsy-specific studies. It is hoped that this document will improve the overall detection and subsequent treatment of affective illnesses in PWE...
  37. ncbi Epilepsy and common comorbidities: improving the outpatient epilepsy encounter
    Frank G Gilliam
    Department of Neurology, Neurological Institute, Columbia University, New York, NY 10032, USA
    Epileptic Disord 7:S27-33. 2005
    ..Management strategies employed in the outpatient clinic to maximize overall health outcomes should include screening and treatment for the commonly coexistent conditions in persons with epilepsy...
  38. ncbi Correlation of severity of FDG-PET hypometabolism and interictal regional delta slowing in temporal lobe epilepsy
    Ebru Erbayat Altay
    Department of Neurology, Washington University in St Louis, School of Medicine, St Louis, Missouri 63110, USA
    Epilepsia 46:573-6. 2005
    ..46; p < 0.0005). CONCLUSIONS: This observation suggests related underlying pathophysiologic mechanisms for metabolic and electrical dysfunction in temporal lobe epilepsy...

Research Grants8

  1. Clinical Research in Epilepsy and Associated Disorders
    Frank Gilliam; Fiscal Year: 2007
    ..This program should allow improvement in the quality and quantity of future patient-oriented research in neuroscience through longitudinal intensive training and mentoring of junior investigators. ..
  2. DEPRESSION AND HEALTH OUTCOMES IN REFRACTORY EPILEPSY
    Frank Gilliam; Fiscal Year: 2005
    ..of the results of a positive study will support the modification of the current model of intervention for epilepsy from predominantly seizure reduction to a more comprehensive approach that includes assessment and treatment of depression ..