Research Topics
| David S GieradaSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
Quantitative CT assessment of emphysema and airways in relation to lung cancer riskDavid S Gierada
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Box 8131, St Louis, MO 63110, USA
Radiology 261:950-9. 2011..To determine whether quantitative computed tomographic (CT) measurements of emphysema and airway dimensions are associated with lung cancer risk in a screening population...
Lung cancer: interobserver agreement on interpretation of pulmonary findings at low-dose CT screeningDavid S Gierada
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63105, USA
Radiology 246:265-72. 2008..To evaluate agreement among radiologists on the interpretation of pulmonary findings at low-dose computed tomographic (CT) screening examinations for lung cancer...- Comparison of standard- and low-radiation-dose CT for quantification of emphysemaDavid S Gierada
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
AJR Am J Roentgenol 188:42-7. 2007..This study was performed to compare standard- and low-radiation-dose techniques in the CT quantification of emphysema... - CT quality assurance in the lung screening study component of the National Lung Screening Trial: implications for multicenter imaging trialsDavid S Gierada
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Campus Box 8131, St Louis, MO 63105, USA
AJR Am J Roentgenol 193:419-24. 2009..The purpose of this study was to describe the effect of implementing an imaging quality assurance program on CT image quality in the Lung Screening Study component of the National Lung Screening Trial... - Effects of diffusion time on short-range hyperpolarized (3)He diffusivity measurements in emphysemaDavid S Gierada
Mallinckrodt Institute of Radiology, Washington University, St Louis, Missouri 63105, USA
J Magn Reson Imaging 30:801-8. 2009..To characterize the effect of diffusion time on short-range hyperpolarized (3)He magnetic resonance imaging (MRI) diffusion measurements across a wide range of emphysema severity... - Effects of CT section thickness and reconstruction kernel on emphysema quantification relationship to the magnitude of the CT emphysema indexDavid S Gierada
Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, Washington University, St Louis, MO 63105, USA
Acad Radiol 17:146-56. 2010..Computed tomography (CT) section thickness and reconstruction kernel each influence CT measurements of emphysema. This study was performed to assess whether their effects are related to the magnitude of the measurement... - Emphysema quantification in inflation-fixed lungs using low-dose computed tomography and 3He magnetic resonance imagingDavid S Gierada
Mallinckrodt Institute of Radiology, Washington University, St Louis, MO 63105, USA
J Comput Assist Tomogr 34:773-9. 2010..To evaluate the use of inflation-fixed lung tissue for emphysema quantification with computed tomography (CT) and He magnetic resonance (MR) diffusion imaging... - Quantification of lung microstructure with hyperpolarized 3He diffusion MRIDmitriy A Yablonskiy
Mallinckrodt Inst of Radiology, 4525 Scott Ave, Rm 2302, St Louis, MO 63110, USA
J Appl Physiol 107:1258-65. 2009.... - The role of collateral paths in long-range diffusion of 3He in lungsMark S Conradi
Department of Physics, Washington University, Saint Louis, MO 63130, USA
Acad Radiol 15:675-82. 2008..However, no clear understanding of LRDC in healthy lungs has emerged. Here we compare LRDC measured in healthy lungs with computer simulations of diffusion along the airway tree with no collateral connections... - Accuracy of emphysema quantification performed with reduced numbers of CT sectionsThomas K Pilgram
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Campus Box 8131, St Louis, MO 63110, USA
AJR Am J Roentgenol 194:585-91. 2010..The purpose of this study was to assess the accuracy of emphysema measurements obtained from systematic samples of evenly spaced CT images compared with measurements obtained from the entire scan... - In vivo detection of acinar microstructural changes in early emphysema with (3)He lung morphometryJames D Quirk
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Ave, Campus Box 8227, St Louis, MO 63110, USA
Radiology 260:866-74. 2011.... - Cigarette smoke induces nucleic-acid oxidation in lung fibroblastsGaetan Deslee
Division of Pulmonary and Critical Care Medicine, School of Medicine, Washington University, St Louis, Missouri 63110, USA
Am J Respir Cell Mol Biol 43:576-84. 2010..Together, our results demonstrate ROS-dependent, cigarette smoke-induced nucleic-acid oxidation in alveolar fibroblasts, which may play a role in the pathogenesis of emphysema... - In vivo lung morphometry with hyperpolarized 3He diffusion MRI in canines with induced emphysema: disease progression and comparison with computed tomographyTariq S K Tanoli
Departments of Radiology, Washington University in St Louis, St Louis, Missouri, USA
J Appl Physiol 102:477-84. 2007..The observed sensitivity of our method to emphysema progression suggests that this technique has potential for the diagnosis of emphysema and tracking of disease progression or improvement via a pharmaceutical intervention... - 3He diffusion MRI of the lungMark S Conradi
Department of Physics, Washington University, Saint Louis, MO 63130, USA
Acad Radiol 12:1406-13. 2005..MR imaging of the restricted diffusion of laser-polarized 3He gas provides unique insights into the changes in lung microstructure in emphysema... - Hyperpolarized 3He MR imaging: physiologic monitoring observations and safety considerations in 100 consecutive subjectsBarbara A Lutey
Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
Radiology 248:655-61. 2008..To evaluate the safety of hyperpolarized helium 3 ((3)He) magnetic resonance (MR) imaging... - Role of collateral paths in long-range diffusion in lungsSeth Emil T Bartel
Department of Physics 1105, Washington University, One Brookings Drive, St Louis, MO 63130, USA
J Appl Physiol 104:1495-503. 2008..The role of collateral paths is supported by measurements of smaller LRADC in pigs, where collateral ventilation is known to be smaller... - Collecting 48,000 CT exams for the lung screening study of the National Lung Screening TrialKenneth W Clark
Mallinckrodt Institute of Radiology, Washington University, 510 South Kingshighway, Saint Louis, MO 63110, USA
J Digit Imaging 22:667-80. 2009..The approach to large scale, multi-center trial CT image collection detailed here may serve as a useful model, while the experience reported should be valuable in the planning and execution of future equivalent endeavors... - The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysemaJeffrey J Atkinson
Washington University School of Medicine, St Louis, MO 63110, USA
Am J Respir Crit Care Med 183:876-84. 2011..Mouse models have demonstrated that excess MMP-9 production can result in permanent alveolar destruction... - Equating quantitative emphysema measurements on different CT image reconstructionsSeth T Bartel
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Med Phys 38:4894-902. 2011.... - Gadolinium-enhanced computed tomography angiography in multi-detector row computed tomography: initial observationsKyongtae T Bae
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Boulevard, St Louis, MO 63110, USA
Acad Radiol 11:61-8. 2004..CONCLUSION: Gadolinium contrast medium combined with multi-detector row computed tomography may provide clinically useful CTA. Dilution of contrast medium shortens the enhancement time but has little effect on the magnitude... - Measuring small airways in transverse CT images correction for partial volume averaging and airway tiltSusan H Conradi
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Acad Radiol 17:1525-34. 2010..This phantom study was performed to derive and test corrections to the measurements on the basis of consideration of partial volume averaging and tilt effects... - Variation in diaphragm position and shape in adults with normal pulmonary functionThitiporn Suwatanapongched
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Chest 123:2019-27. 2003..31 - 0.38). CONCLUSIONS: The substantial variability in normal diaphragm position and shape is related to weight, age, and thoracic dimensions. Consideration of these factors may be useful when evaluating chest radiographs... - Image quality assurance in the prostate, lung, colorectal, and ovarian cancer screening trial network of the National Lung Screening TrialStephen M Moore
Mallinckrodt Institute of Radiology, Washington University, St Louis, MO, USA
J Digit Imaging 18:242-50. 2005.... - Performance of a computer-aided program for automated matching of metastatic pulmonary nodules detected on follow-up chest CTKyung Won Lee
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
AJR Am J Roentgenol 189:1077-81. 2007..The purpose of this study was to evaluate the performance of a computer-aided program that allows automated matching of metastatic pulmonary nodules imaged with two serial clinical chest CT studies... 
A thoracic surgery clinic dedicated to indeterminate pulmonary nodules: too many scans and too little pathology?Nirmal K Veeramachaneni
Division of Thoracic Surgery, Washington University School of Medicine, St Louis, Mo 63110 1013, USA
J Thorac Cardiovasc Surg 137:30-5. 2009..Widespread application of computed tomographic scans has increased detection of asymptomatic pulmonary nodules. A dedicated clinic was established to encourage referral and manage large numbers of patients with such nodules...- Oxidative damage to nucleic acids in severe emphysemaGaetan Deslee
Washington University School of Medicine, Division of Pulmonary and Critical Care Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Chest 135:965-74. 2009..Oxidative stress is a key element in the pathogenesis of emphysema, but oxidation of nucleic acids has been largely overlooked. The aim of this study was to investigate oxidative damage to nucleic acids in severe emphysematous lungs... - A prospective evaluation of lung volume reduction surgery in 200 consecutive patientsRoger D Yusen
Division of Pulmonary, Washington University School of Medicine, St Louis, MO 63110, USA
Chest 123:1026-37. 2003..The primary objectives of this study were to assess long-term health-related quality of life, satisfaction, physiologic status, and survival of patients following LVRS... - MRI of piriformis syndromeEdward Y Lee
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Box 8131, St. Louis, MO 63110, USA
AJR Am J Roentgenol 183:63-4. 2004 - Radiologic assessment of emphysema for lung volume reduction surgeryDavid S Gierada
Mallinckrodt Institute of Radiology, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, MO 63110, USA
Semin Thorac Cardiovasc Surg 14:381-90. 2002.... - CT depiction of pulmonary emboli: display window settingsKyongtae T Bae
1 Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
Radiology 236:677-84. 2005..To compare computed tomographic (CT) window settings selected by radiologists with those determined by using two alternative approaches for depiction of pulmonary emboli (PE)... - Lung imaging in asthmatic patients: the picture is clearerMario Castro
Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
J Allergy Clin Immunol 128:467-78. 2011.... - Reader variability in identifying pulmonary nodules on chest radiographs from the national lung screening trialSatinder P Singh
Department of Radiology, University of Alabama Hospitals in Birmingham, 619 South 19th Street, Birmingham, AL 35233, USA
J Thorac Imaging 27:249-54. 2012..To measure reader variability related to the evaluation of screening chest radiographs (CXRs) for findings of primary lung cancer... - Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRIDmitriy A Yablonskiy
Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 99:3111-6. 2002..The technique offers promise as a clinical tool for early diagnosis of emphysema... - 19F MR imaging of ventilation and diffusion in excised lungsRichard E Jacob
Department of Physics, Washington University in St. Louis, St. Louis, MO 63130-4899, USA
Magn Reson Med 54:577-85. 2005..033 cm2/s) places it in a regime where the ADC measurement allows the surface-to-volume ratio to be determined in each voxel, a potentially valuable quantitative characterization of regional lung tissue destruction in emphysema... - Volumetric measurements of lung nodules with multi-detector row CT: effect of changes in lung volumeJin Mo Goo
Department of Radiology, Seoul National University College of Medicine, and the Institute of Radiation Medicine, SNUMRC, Jongno gu, Seoul, Korea
Korean J Radiol 7:243-8. 2006..To evaluate how changes in lung volume affect volumetric measurements of lung nodules using a multi-detector row CT...