Research Topics
| J R GarbowSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
MRI measurement of liver regeneration in mice following partial hepatectomyJ R Garbow
Department of Chemistry, Washington University, St Louis, Missouri 63110, USA
Magn Reson Med 52:177-80. 2004..The success of this method will enable future studies to better elucidate the factors that affect regeneration, and help to optimize the timing and dosing of chemotherapeutics to minimize their deleterious effects on liver regeneration...- In vivo MRS measurement of liver lipid levels in miceJ R Garbow
Department of Chemistry and Alvin J Siteman Cancer Center, Washington University, St Louis, MO 63130, USA
J Lipid Res 45:1364-71. 2004.... - Detection of primary lung tumors in rodents by magnetic resonance imagingJoel R Garbow
Department of Chemistry, Washington University, St Louis, Missouri, USA
Cancer Res 64:2740-2. 2004.... 
Magnetic resonance imaging defines cervicovaginal anatomy, cancer, and VEGF trap antiangiogenic efficacy in estrogen-treated K14-HPV16 transgenic miceJoel R Garbow
Department of Radiology, Alvin J Siteman Cancer Center, Washington University in St Louis, Missouri 63110, USA
Cancer Res 69:7945-52. 2009....
Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imagingJoel R Garbow
Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Clin Cancer Res 14:1363-7. 2008..The goal of this work was to monitor quantitatively the development and progression of adenocarcinoma in a time course study of mice treated with the carcinogen urethane using in vivo small-animal magnetic resonance imaging (MRI)...- CXCR4 regulates growth of both primary and metastatic breast cancerMatthew C P Smith
Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
Cancer Res 64:8604-12. 2004..These data indicate that CXCR4 is required to initiate proliferation and/or promote survival of breast cancer cells in vivo and suggest that CXCR4 inhibitors will improve treatment of patients with primary and metastatic breast cancer... - Structure, dynamics, and stability of beta-cyclodextrin inclusion complexes of aspartame and neotameJ R Garbow
Analytical Sciences Center, Pharmacia Corporation, 800 North Lindbergh Boulevard, St Louis, Missouri 63167, USA
J Agric Food Chem 49:2053-60. 2001..Solid-state NMR experiments provide additional characterization, clearly demonstrating the formation of inclusion complexes in lyophilized solids prepared from solutions of beta-CyD and either aspartame or neotame... - Frequency-dependent viscoelastic parameters of mouse brain tissue estimated by MR elastographyE H Clayton
Department of Mechanical Engineering and Materials Science, Washington University in St Louis, 1 Brookings Drive, Campus Box 1185, Saint Louis, MO 63130, USA
Phys Med Biol 56:2391-406. 2011..Quantitative measurements of the viscoelastic parameters of brain tissue at high frequencies are also valuable for modeling and simulation of traumatic brain injury... - Orthotopic mouse lung transplantation as experimental methodology to study transplant and tumor biologyAlexander S Krupnick
Department of Surgery, Washington University School of Medicine, Campus Box 8234, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
Nat Protoc 4:86-93. 2009.... - Immunodeficient mouse strains display marked variability in growth of human melanoma lung metastasesBeatriz M Carreno
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Clin Cancer Res 15:3277-86. 2009.... - Registration of [18F]FDG microPET and small-animal MRIDouglas J Rowland
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 32:567-72. 2005..Our technique requires no manual identification of image features and makes no use of surgically implanted or external fiducial markers or stereotactic apparatus... - Molecular imaging of host-pathogen interactions in intact small animalsDavid Piwnica-Worms
Molecular Imaging Center, Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, Box 8225, Washington University, St Louis, MO 63110, USA
Cell Microbiol 6:319-31. 2004.... - MRI detection of early bone metastases in b16 mouse melanoma modelsKaren M Gauvain
Department of Pediatrics, Division of Hematology Oncology, Washington University School of Medicine, One Children s Place, Box 8116, St Louis, MO 63110, USA
Clin Exp Metastasis 22:403-11. 2005..0001) and can be used as a marker of early bone metastases. These studies demonstrate that MR imaging can detect bone marrow metastases in small animals prior to development of cortical bone loss identified by X-ray... - In vivo imaging in a murine model of glioblastomaSarah C Jost
Department of Neurosurgery, Washington University, School of Medicine, St Louis, Missouri 63110, USA
Neurosurgery 60:360-70; discussion 370-1. 2007.... - Maintenance of airway epithelium in acutely rejected orthotopic vascularized mouse lung transplantsMikio Okazaki
Department of Surgery, and The Alvin J Siteman Cancer Center, Washington University in St Louis, St Louis, Missouri, USA
Am J Respir Cell Mol Biol 37:625-30. 2007..Thus, the model of vascularized mouse lung transplantation may provide a new and more physiologic experimental tool to study the interaction between immune and nonimmune mechanisms affecting airway pathology in lung allografts... - Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbsYian Wang
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
Cancer Prev Res (Phila) 2:634-40. 2009..We found that ATB is rapidly absorbed and then distributes to various tissues including the lung. These results indicate that ATB is a potent chemopreventive agent against the development of mouse lung SCCs... - Measuring brain tumor growth: combined bioluminescence imaging-magnetic resonance imaging strategySarah C Jost
Department of Neurosurgery, Washington University School of Medicine, Saint Louis, MO 63110, USA
Mol Imaging 8:245-53. 2009.... - Diffusion effects on longitudinal relaxation in poorly mixed compartmentsJ R Anderson
Department of Chemistry, Washington University, St Louis, MO 63130, USA
J Magn Reson 211:30-6. 2011..In both cases, apparent longitudinal relaxation, though clearly multi-exponential, is well-modeled as bi-exponential... - Detection and measurement of neurofibromatosis-1 mouse optic glioma in vivoDebasish Banerjee
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Neuroimage 35:1434-7. 2007..In all cases, OPG presence or absence was correctly identified. In addition, the OPG size and shape were accurately measured in vivo, facilitating the use of this model for preclinical drug studies... - Magnetic resonance imaging of hypoxic injury to the murine placentaTracy M Tomlinson
Department of Obstetrics and Gynecology, Washington University, St Louis, Missouri, USA
Am J Physiol Regul Integr Comp Physiol 298:R312-9. 2010..Exposure to hypoxia near the end of mouse pregnancy reduces placental perfusion and clearance of contrast. MRI-based DCE imaging provides a novel tool for dynamic, in vivo assessment of placental function... - Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosityM Livia Bajenaru
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer Res 63:8573-7. 2003..This mouse model demonstrates that Nf1+/- cells contribute to the pathogenesis of gliomas in NF1 and provides a tool for the preclinical evaluation of potential therapeutic interventions for these tumors... - Optic nerve dysfunction in a mouse model of neurofibromatosis-1 optic gliomaBalazs Hegedus
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
J Neuropathol Exp Neurol 68:542-51. 2009.... - Hyperpolarized (3)He MRI of mouse lungJoseph P Dugas
Department of Physics, Washington University, St. Louis, Missouri 63110, USA
Magn Reson Med 52:1310-7. 2004..While tumors are shown to cause substantial ventilation defects in the lung, these defects appear confined to the cancerous regions and do not extend to large-scale regions of the lung distal to the tumors... - Nondestructive NMR determination of oil composition in transformed canola seedsW C Hutton
Nutrition and Consumer Sector, Monsanto, St Louis, Missouri 63167, USA
Lipids 34:1339-46. 1999..These NMR methods are nondestructive and attractive for plant-breeding programs or other studies (e.g., functional genomics) where loss of seed viability is inconvenient... - NMR studies of structure and dynamics in fruit cuticle polyestersR E Stark
Department of Chemistry, College of Staten Island and the Graduate School of the City University of New York, NY 10314, USA
Solid State Nucl Magn Reson 16:37-45. 2000.... - A mouse model for developing treatment for secondary liver tumorsShi-Rong Cai
Departmen of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Int J Oncol 27:113-20. 2005.... - Copper-64-pyruvaldehyde-bis(N(4)-methylthiosemicarbazone) for the prevention of tumor growth at wound sites following laparoscopic surgery: monitoring therapy response with microPET and magnetic resonance imagingJason S Lewis
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Cancer Res 62:445-9. 2002..001). This study demonstrates the therapeutic potential of (64)Cu-PTSM in inhibiting cancer cell implantation and growth at doses well below the maximum tolerated dose, with no signs of toxicity to the hamsters... - Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic gliomaBalazs Hegedus
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Cancer Res 68:1520-8. 2008..Collectively, these findings suggest that this Nf1 optic glioma model may be a potential preclinical benchmark for identifying novel therapies that have a high likelihood of success in human clinical trials... - A novel murine model for localized radiation necrosis and its characterization using advanced magnetic resonance imagingSarah C Jost
Department of Neurosurgery, Washington University School of Medicine, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 75:527-33. 2009..To develop a murine model of radiation necrosis using fractionated, subtotal cranial irradiation; and to investigate the imaging signature of radiation-induced tissue damage using advanced magnetic resonance imaging techniques... - A novel technology for the imaging of acidic prostate tumors by positron emission tomographyAmy L Vavere
Division of Radiological Sciences, Department of Radiology, Washington University School of Medicine, St Louis, MO, USA
Cancer Res 69:4510-6. 2009..This article introduces a novel class of noninvasive pH-selective positron emission tomography imaging agents and opens new research directions in the diagnosis of acidic solid tumors... - Natural history of neurofibromatosis 1-associated optic nerve glioma in miceM Livia Bajenaru
Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
Ann Neurol 57:119-27. 2005..Last, we observed neovascularization and microglial cell infiltration by 3 weeks of age before overt neoplastic transformation, suggesting that these cellular changes participate in the early stages of tumor formation... - Synthesis and characterization of a Gd-DOTA-D-permeation peptide for magnetic resonance relaxation enhancement of intracellular targetsAndrew M Prantner
Washington University School of Medicine, St Louis, MO 63110, USA
Mol Imaging 2:333-41. 2003.... - Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1Nicole M Warrington
Department of Pediatrics, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Developmental Biology, and Anatomy and Neurobiology, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
Cancer Res 70:5717-27. 2010..Together, these results indicate that low levels of cAMP in a susceptible Nf1 mouse strain are sufficient to promote gliomagenesis, and justify the implementation of cAMP-based stroma-targeted therapies for glioma... - Feasibility of small animal cranial irradiation with the microRT systemErich L Kiehl
Washington University School of Medicine, St Louis, Missouri 63110, USA
Med Phys 35:4735-43. 2008..To develop and validate methods for small-animal CNS radiotherapy using the microRT system... - Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain miceMarshall W Anderson
Department of Molecular Oncogenesis, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
Carcinogenesis 29:1594-600. 2008..Our results suggest a potential role for green tea extracts in preventing the progression of large, aggressive lung adenocarcinomas... - Hydrochalarones: a novel endohedral metallofullerene platform for enhancing magnetic resonance imaging contrastDarren K MacFarland
Luna nanoWorks A Division of Luna Innovations, Incorporated, 521 Bridge Street, Danville, Virginia 24541, USA
J Med Chem 51:3681-3. 2008..These new compounds can be used to visualize tissue architecture in vivo with standard MRI techniques... - Rethinking brain tumors: the fourth Mouse Models of Human Cancers Consortium nervous system tumors workshopKarlyne M Reilly
Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland 21702, USA
Cancer Res 68:5508-11. 2008