B D Freeman

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Tracheostomy practice in adults with acute respiratory failure
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 40:2890-6. 2012
  2. ncbi request reprint Challenges of implementing pharmacogenetics in the critical care environment
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, 660 S Euclid Avenue, Box 8109, St Louis, Missouri 63110, USA
    Nat Rev Drug Discov 3:88-93. 2004
  3. ncbi request reprint Template-directed dye-terminator incorporation with fluorescence polarization detection for analysis of single nucleotide polymorphisms associated with cardiovascular and thromboembolic disease
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Thromb Res 111:373-9. 2003
  4. ncbi request reprint A meta-analysis of controlled trials of anticoagulant therapies in patients with sepsis
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Shock 20:5-9. 2003
  5. pmc Template-directed dye-terminator incorporation with fluorescence polarization detection for analysis of single nucleotide polymorphisms implicated in sepsis
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Mol Diagn 4:209-15. 2002
  6. ncbi request reprint Coagulation inhibitors in the treatment of sepsis
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Box 8109, St Louis, MO 63110, USA
    Expert Opin Investig Drugs 11:69-74. 2002
  7. ncbi request reprint Interleukin-1 receptor antagonist as therapy for inflammatory disorders
    B D Freeman
    Department of Surgery, Section of Burn, Trauma and Surgical Critical Care, Washington University School of Medicine, St Louis, MO, USA
    Expert Opin Biol Ther 1:301-8. 2001
  8. ncbi request reprint Role of CuZn superoxide dismutase in regulating lymphocyte apoptosis during sepsis
    B D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 28:1701-8. 2000
  9. ncbi request reprint Anti-inflammatory therapies in sepsis and septic shock
    B D Freeman
    Department of Surgery, Washington University School of Medicine, Box 8109, Suite 6104, St Louis, MO 63110, USA
    Expert Opin Investig Drugs 9:1651-63. 2000
  10. ncbi request reprint A meta-analysis of prospective trials comparing percutaneous and surgical tracheostomy in critically ill patients
    B D Freeman
    Department of Surgery, Section of Burn, Trauma, Surgical Critical Care, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 118:1412-8. 2000

Research Grants

  1. PHARMACOGENETICS IN SURGICAL CRITICAL CARE
    Bradley Freeman; Fiscal Year: 2004

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Tracheostomy practice in adults with acute respiratory failure
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 40:2890-6. 2012
    ..The objective of this concise definitive review is the synthesis of current knowledge regarding tracheostomy practice in this context...
  2. ncbi request reprint Challenges of implementing pharmacogenetics in the critical care environment
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, 660 S Euclid Avenue, Box 8109, St Louis, Missouri 63110, USA
    Nat Rev Drug Discov 3:88-93. 2004
  3. ncbi request reprint Template-directed dye-terminator incorporation with fluorescence polarization detection for analysis of single nucleotide polymorphisms associated with cardiovascular and thromboembolic disease
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Thromb Res 111:373-9. 2003
  4. ncbi request reprint A meta-analysis of controlled trials of anticoagulant therapies in patients with sepsis
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Shock 20:5-9. 2003
    ..To the extent that their treatment effect is dependent upon disease severity, the safety and efficacy of these agents may be enhanced by refinement in techniques of clinical stratification...
  5. pmc Template-directed dye-terminator incorporation with fluorescence polarization detection for analysis of single nucleotide polymorphisms implicated in sepsis
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Mol Diagn 4:209-15. 2002
    ..This method has potential advantages compared with other high throughput genotyping techniques and appears well suited to clinical situations requiring analysis of large numbers of samples...
  6. ncbi request reprint Coagulation inhibitors in the treatment of sepsis
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Box 8109, St Louis, MO 63110, USA
    Expert Opin Investig Drugs 11:69-74. 2002
    ..In summary, while coagulation inhibitors may ultimately have a therapeutic role in selected subgroups of patients with sepsis, the efficacy and safety of this class of agents remain to be proven...
  7. ncbi request reprint Interleukin-1 receptor antagonist as therapy for inflammatory disorders
    B D Freeman
    Department of Surgery, Section of Burn, Trauma and Surgical Critical Care, Washington University School of Medicine, St Louis, MO, USA
    Expert Opin Biol Ther 1:301-8. 2001
    ..Nonetheless, the recent finding that IL-1ra has the ability to favourably influence a chronic inflammatory disease supports the hypothesis that inhibition of a single mediator of the immune response may have clinical impact...
  8. ncbi request reprint Role of CuZn superoxide dismutase in regulating lymphocyte apoptosis during sepsis
    B D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 28:1701-8. 2000
    ....
  9. ncbi request reprint Anti-inflammatory therapies in sepsis and septic shock
    B D Freeman
    Department of Surgery, Washington University School of Medicine, Box 8109, Suite 6104, St Louis, MO 63110, USA
    Expert Opin Investig Drugs 9:1651-63. 2000
    ....
  10. ncbi request reprint A meta-analysis of prospective trials comparing percutaneous and surgical tracheostomy in critically ill patients
    B D Freeman
    Department of Surgery, Section of Burn, Trauma, Surgical Critical Care, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 118:1412-8. 2000
    ....
  11. ncbi request reprint Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
    R S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 27:1230-51. 1999
    ..The purpose of this study was to determine whether apoptosis is a major mechanism of cell death in patients with sepsis. The activities of caspase-3 and the antiapoptotic protein, BCL-2, were investigated also...
  12. ncbi request reprint Rapid onset of intestinal epithelial and lymphocyte apoptotic cell death in patients with trauma and shock
    R S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 28:3207-17. 2000
    ..The purpose of this study was to determine whether apoptosis is a major mechanism of cell death in intestinal epithelial cells and lymphocytes in patients who sustained trauma, shock, and ischemia/ reperfusion injury...
  13. ncbi request reprint Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans
    R S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    J Immunol 166:6952-63. 2001
    ..Similar loss of lymphocytes may be occurring in critically ill patients with other disorders...
  14. ncbi request reprint A prospective, randomized study comparing percutaneous with surgical tracheostomy in critically ill patients
    B D Freeman
    Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA
    Crit Care Med 29:926-30. 2001
    ..PDT may become the procedure of choice for electively establishing tracheostomy in the appropriately selected patient who requires long-term mechanical ventilation...
  15. pmc Ethical considerations in the collection of genetic data from critically ill patients: what do published studies reveal about potential directions for empirical ethics research?
    B D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Pharmacogenomics J 10:77-85. 2010
    ..Empirical research into issues related to greater ethnic inclusivity, accuracy of substituted judgment and specimen stewardship may be essential for enabling the conduct of such trials...
  16. ncbi request reprint Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms
    A R Tabrizi
    Department of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Am J Hematol 67:144-6. 2001
    ..These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication...
  17. ncbi request reprint Evaluation of the applicability, efficacy, and safety of a thromboembolic event prophylaxis guideline designed for quality improvement of the traumatically injured patient
    Douglas J E Schuerer
    Department of Surgery, Burn, Trauma, Critical Care Section, Washington University, St Louis, Missouri, USA
    J Trauma 58:731-9. 2005
    ..Our objective was to evaluate the applicability, efficacy, and safety of this guideline in the traumatized patient, especially those admitted first to the intensive care unit (ICU)...
  18. ncbi request reprint Genetic research and testing in critical care: surrogates' perspective
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 34:986-94. 2006
    ..This study explored the perspectives of surrogate decision-makers (SDMs) for acutely ill patients with respect to social, legal, and ethical aspects of genetic testing...
  19. doi request reprint Tracheostomy protocol: experience with development and potential utility
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 36:1742-8. 2008
    ..To examine the feasibility and potential utility of a tracheostomy protocol based on a standardized approach to ventilator weaning...
  20. ncbi request reprint Is there a hidden benefit associated with early tracheostomy?
    Bradley D Freeman
    Crit Care Med 36:2688-9. 2008
  21. ncbi request reprint Relationship between tracheostomy timing and duration of mechanical ventilation in critically ill patients
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 33:2513-20. 2005
    ....
  22. ncbi request reprint A meta-analysis of controlled trials of anticoagulant therapies in patients with sepsis
    William L Macias
    Shock 20:582-3; author reply 583-4. 2003
  23. ncbi request reprint The frequency and effects of cytochrome P450 (CYP) 2C9 polymorphisms in patients receiving warfarin
    Arash Rafii Tabrizi
    Department of Surgery, Washington University School of Medicine, St Louis, MO, 63110, USA
    J Am Coll Surg 194:267-73. 2002
    ..S. patient population...

Research Grants2

  1. PHARMACOGENETICS IN SURGICAL CRITICAL CARE
    Bradley Freeman; Fiscal Year: 2004
    ..The environment for this project is Washington University School of Medicine, an institution with access to a large clinical volume and established expertise in genomic research. ..