Research TopicsSpecies | Steven J FordSummaryAffiliation: Washington State University Country: USA Publications
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Publications
Length-dependent effects on cardiac contractile dynamics are different in cardiac muscle containing α- or β-myosin heavy chainSteven J Ford
Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology VCAPP, Washington State University, 205 Wegner Hall, Pullman, WA 99164, United States Electronic address
Arch Biochem Biophys 535:3-13. 2013..These data suggest a mechanism whereby greater cooperative/allosteric effects impart an enhanced length-sensitivity of XB cycling kinetics in fibers containing the slower cycling β-MHC...
The effects of slow skeletal troponin I expression in the murine myocardium are influenced by development-related shifts in myosin heavy chain isoformSteven J Ford
Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology VCAPP, Washington State University, Pullman, WA 99164, USA
J Physiol 590:6047-63. 2012....
Model representation of the nonlinear step response in cardiac muscleSteven J Ford
Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164, USA
J Gen Physiol 136:159-77. 2010....
Effects of R92 mutations in mouse cardiac troponin T are influenced by changes in myosin heavy chain isoformSteven J Ford
Department of Veterinary and Comparative Anatomy, Washington State University, Pullman, WA 99164, USA
J Mol Cell Cardiol 53:542-51. 2012..Our findings have major implications for understanding not only the divergent effects of R92 mutations on cardiac phenotype, but also the distinct effects of MHC isoforms in determining the outcome of mutations in cTnT...
Deletion of 1-43 amino acids in cardiac myosin essential light chain blunts length dependency of Ca(2+) sensitivity and cross-bridge detachment kineticsJohn Jeshurun Michael
Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164, USA
Am J Physiol Heart Circ Physiol 304:H253-9. 2013....
Interaction between myosin heavy chain and troponin isoforms modulate cardiac myofiber contractile dynamicsMurali Chandra
Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, 205 Wegner Hall, Pullman, Washington 99164, USA
Am J Physiol Regul Integr Comp Physiol 293:R1595-607. 2007..At the myofilament level, coordinated expression of complementary regulatory contractile proteins produces a functional dynamic phenotype that allows the cardiovascular systems to function effectively at different heart rates...
