Luigi Fontana

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi request reprint Calorie restriction and cardiometabolic health
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Eur J Cardiovasc Prev Rehabil 15:3-9. 2008
  2. ncbi request reprint Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk
    Luigi Fontana
    Division of Geriatrics and Nutritional Science and the Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 84:1456-62. 2006
  3. ncbi request reprint Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA
    Rejuvenation Res 10:225-34. 2007
  4. pmc Neuroendocrine factors in the regulation of inflammation: excessive adiposity and calorie restriction
    Luigi Fontana
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA
    Exp Gerontol 44:41-5. 2009
  5. ncbi request reprint Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 293:E197-202. 2007
  6. ncbi request reprint Impaired mononuclear cell immune function in extreme obesity is corrected by weight loss
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Rejuvenation Res 10:41-6. 2007
  7. ncbi request reprint Aging, adiposity, and calorie restriction
    Luigi Fontana
    Division of Geriatrics and Nutritional Science and Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    JAMA 297:986-94. 2007
  8. ncbi request reprint Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones
    Luigi Fontana
    Washington University School of Medicine, 4566 Scott Avenue, Campus Box 8113, St Louis, MO 63110, USA
    J Clin Endocrinol Metab 91:3232-5. 2006
  9. ncbi request reprint Low bone mass in subjects on a long-term raw vegetarian diet
    Luigi Fontana
    Section of Applied Physiology, Division of Geriatrics and Nutritional Science, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 165:684-9. 2005
  10. ncbi request reprint The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function
    Matt M Riordan
    Cardiovascular Biophysics Laboratory, Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 294:H1174-82. 2008

Collaborators

Detail Information

Publications51

  1. doi request reprint Calorie restriction and cardiometabolic health
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Eur J Cardiovasc Prev Rehabil 15:3-9. 2008
    ....
  2. ncbi request reprint Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk
    Luigi Fontana
    Division of Geriatrics and Nutritional Science and the Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 84:1456-62. 2006
    ..Western diets, obesity, and sedentary lifestyles are associated with increased cancer risk. The mechanisms responsible for this increased risk, however, are not clear...
  3. ncbi request reprint Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA
    Rejuvenation Res 10:225-34. 2007
    ..We evaluated the long-term effects of consuming a low-calorie low-protein vegan diet or performing regular endurance exercise on cardiometabolic risk factors...
  4. pmc Neuroendocrine factors in the regulation of inflammation: excessive adiposity and calorie restriction
    Luigi Fontana
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA
    Exp Gerontol 44:41-5. 2009
    ..Measuring tissue specific effects of CR using genomic, proteomic, and metabolomic techniques in humans will foster the understanding of the complex biological processes involved in the anti-inflammatory and anti-aging effects of CR...
  5. ncbi request reprint Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 293:E197-202. 2007
    ..Data from the present study provide evidence that CR- and EX-induced negative energy balance result in substantial and similar improvements in the major risk factors for CHD in normal-weight and overweight middle-aged adults...
  6. ncbi request reprint Impaired mononuclear cell immune function in extreme obesity is corrected by weight loss
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Rejuvenation Res 10:41-6. 2007
    ....
  7. ncbi request reprint Aging, adiposity, and calorie restriction
    Luigi Fontana
    Division of Geriatrics and Nutritional Science and Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    JAMA 297:986-94. 2007
    ..In rodent models, calorie restriction with adequate nutrient intake decreases the risk of developing chronic disease and extends maximum life span...
  8. ncbi request reprint Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones
    Luigi Fontana
    Washington University School of Medicine, 4566 Scott Avenue, Campus Box 8113, St Louis, MO 63110, USA
    J Clin Endocrinol Metab 91:3232-5. 2006
    ..Caloric restriction (CR) retards aging in mammals. It has been hypothesized that a reduction in T(3) hormone may increase life span by conserving energy and reducing free-radical production...
  9. ncbi request reprint Low bone mass in subjects on a long-term raw vegetarian diet
    Luigi Fontana
    Section of Applied Physiology, Division of Geriatrics and Nutritional Science, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 165:684-9. 2005
    ..Little is known regarding the health effects of a raw food (RF) vegetarian diet...
  10. ncbi request reprint The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function
    Matt M Riordan
    Cardiovascular Biophysics Laboratory, Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 294:H1174-82. 2008
    ..13) tended to increase. We conclude that weight loss, whether induced by CR or Ex, has salutary effects on diastolic function...
  11. pmc Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Am J Clin Nutr 84:1033-42. 2006
    ..However, exercise-induced energy expenditure may further improve glucoregulation through mechanisms independent of weight loss...
  12. ncbi request reprint Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Appl Physiol (1985) 102:634-40. 2007
    ..These findings suggest that, during EX, the body adapts to maintain or even enhance physical performance capacity...
  13. ncbi request reprint Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults
    Dennis T Villareal
    Geriatrics and Nutritional Science and the Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63108, USA
    Am J Clin Nutr 84:1317-23. 2006
    ..Coronary heart disease (CHD) risk factors increase with age and body mass index (BMI; in kg/m2). However, whether lifestyle intervention ameliorates metabolic CHD risk factors in obese older adults is unknown...
  14. ncbi request reprint Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial
    Dennis T Villareal
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 166:2502-10. 2006
    ..We tested the hypothesis that EX-induced weight loss is associated with less bone loss compared with CR-induced weight loss...
  15. ncbi request reprint One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue
    Susan B Racette
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63108 2212, USA
    J Gerontol A Biol Sci Med Sci 61:943-50. 2006
    ..The objectives of this study were to determine the feasibility of prolonged CR in nonobese adults and to compare the effects of CR- and exercise-induced weight loss on body composition and abdominal adiposity...
  16. pmc Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production
    Luigi Fontana
    Washington University School of Medicine, St Louis, MO 63110, USA
    Age (Dordr) 32:97-108. 2010
    ..This impaired glucose tolerance is associated with lower circulating levels of IGF-1, total testosterone, and triiodothyronine, which are typical adaptations to life-extending CR in rodents...
  17. pmc Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Aging (Albany NY) 3:533-42. 2011
    ..Year 2 was an open label continuation. DHEA replacement improved glucose tolerance in participants who had abnormal GT initially, reduced plasma triglycerides, and the inflammatory cytokines IL6 and TNF╬▒...
  18. pmc Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans
    Andreea Soare
    Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Aging (Albany NY) 3:374-9. 2011
    ..This adaptation is likely due to CR itself, rather than to leanness, and may be involved in slowing the rate of aging...
  19. pmc Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: a randomized controlled trial
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Rejuvenation Res 11:605-9. 2008
    ..This effect does not appear to be attributable to changes in body fat mass because a comparable decrease in T(3) concentration was not observed in response to an exercise-induced fat mass reduction...
  20. pmc Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Am J Clin Nutr 89:1459-67. 2009
    ..Age-related reductions in serum dehydroepiandrosterone (DHEA) concentrations may be involved in bone mineral density (BMD) losses...
  21. pmc Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Aging Cell 7:681-7. 2008
    ....
  22. pmc Caloric restriction may reverse age-related autonomic decline in humans
    Phyllis K Stein
    HRV Laboratory, Washington University School of Medicine, St Louis, MO 63110, USA
    Aging Cell 11:644-50. 2012
    ....
  23. ncbi request reprint Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease
    Samuel Klein
    Center for Human Nutrition, Washington University School of Medicine, St Louis 63110, USA
    N Engl J Med 350:2549-57. 2004
    ..We evaluated the effect of large-volume abdominal liposuction on metabolic risk factors for coronary heart disease in women with abdominal obesity...
  24. pmc Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long-term calorie restriction with adequate nutrition
    Dennis T Villareal
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Aging Cell 10:96-102. 2011
    ..These findings suggest that markedly reduced BMD is not associated with significantly reduced bone quality in middle-aged men and women practicing long-term calorie restriction with adequate nutrition...
  25. pmc Energy requirements in nonobese men and women: results from CALERIE
    Leanne M Redman
    Pennington Biomedical Research Center, Baton Rouge, LA LMR, CKM, and ER the Duke Clinical Research Institute and Duke University Medical Center, Durham, NC WEK and MB the USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, MA SKD and SB Roberts the Department of Medicine, Washington University School of Medicine, St Louis, MO SB Racette and LF the Department of Medicine, Salerno University Medical School, Salerno, Italy LF CEINGE Biotecnologie Avanzate, Napoli, Italy LF and the USDA Agricultural Research Service, Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX WWW
    Am J Clin Nutr 99:71-8. 2014
    ..The energy intake necessary to maintain weight and body composition is called the energy requirement for weight maintenance and can be determined by using the doubly labeled water (DLW) method...
  26. pmc Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance
    Jun Yoshino
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Metab 16:658-64. 2012
    ..These findings demonstrate that resveratrol supplementation does not have beneficial metabolic effects in nonobese, postmenopausal women with normal glucose tolerance...
  27. ncbi request reprint Long-term caloric restriction ameliorates the decline in diastolic function in humans
    Timothy E Meyer
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Coll Cardiol 47:398-402. 2006
    ..We determined whether caloric restriction (CR) has cardiac-specific effects that attenuate the established aging-associated impairments in diastolic function (DF)...
  28. pmc Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss compared with calorie restriction
    Joan C Murphy
    Department of Nutrition and Dietetics, Doisy College of Health Sciences, Saint Louis University, St Louis, MO 63104, USA
    J Appl Physiol (1985) 112:79-85. 2012
    ..64; P = 0.006). In conclusion, calorie restriction and exercise-induced weight loss both decrease IMAT and VAT volumes. However, exercise appears to result in preferential reductions in these fat depots...
  29. pmc Systemic acid load from the diet affects maximal-exercise RER
    Katherine Niekamp
    Department of Nutrition and Dietetics, Doisy College of Health Sciences, Saint Louis University, St Louis, MO, USA
    Med Sci Sports Exerc 44:709-15. 2012
    ..Because RER(max) is heavily influenced by CO2 production from acid buffering during maximal exercise, we postulated that dietary acid load, which affects acid-base regulation, might contribute to variability in RER(max)...
  30. ncbi request reprint Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
    Luigi Fontana
    Washington University School of Medicine, Campus Box 8031, 660 South Euclid Ave, St Louis, MO 63110, USA
    Diabetes 56:1010-3. 2007
    ..These data suggest that visceral fat is an important site for IL-6 secretion and provide a potential mechanistic link between visceral fat and systemic inflammation in people with abdominal obesity...
  31. pmc Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Aging Cell 11:876-84. 2012
    ..Arterial stiffness increases with age and is an independent risk factor for CVD. Therefore, the improvements observed in this study suggest that DHEA replacement might partly reverse arterial aging and reduce CVD risk...
  32. pmc Growth factors, nutrient signaling, and cardiovascular aging
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Circ Res 110:1139-50. 2012
    ..Here, we review the link between growth factors, cardiac function, and heart disease with focus on the cardioprotective and sensitizing effect of growth factors in both model organisms and humans...
  33. pmc Calorie restriction and prevention of age-associated chronic disease
    Daniela Omodei
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    FEBS Lett 585:1537-42. 2011
    ..Cancer morbidity and mortality are also diminished in CR monkeys, and data obtained from individuals practicing long-term CR show a reduction of metabolic and hormonal factors associated with increased cancer risk...
  34. pmc Modulating human aging and age-associated diseases
    Luigi Fontana
    Division of Geriatrics and Nutritional Science and Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Biochim Biophys Acta 1790:1133-8. 2009
    ..Additional studies are needed to understand the complex interactions of factors that regulate aging and age-associated chronic disease...
  35. ncbi request reprint [Nutrition, adiposity and health]
    Luigi Fontana
    Reparto di alimentazione, nutrizione e salute, Istituto Superiore di Sanita, Roma
    Epidemiol Prev 31:290-4. 2007
    ..Additional studies are needed to identify the precise calorie, protein and polyphenols intake and amount of exercise needed for optimal health in each individual, depending on his/her age, sex and genetic background...
  36. pmc Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
    Luigi Fontana
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:6659-63. 2004
    ..Based on a range of risk factors, it appears that long-term CR has a powerful protective effect against atherosclerosis. This interpretation is supported by the finding of a low carotid artery IMT...
  37. pmc Caloric restriction in humans
    John O Holloszy
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 4566 Scott Avenue, Campus Box 8113, St Louis, MO 63110, USA
    Exp Gerontol 42:709-12. 2007
    ....
  38. pmc Will calorie restriction work in humans?
    Edda Cava
    Division of Geriatrics and Nutritional Science and Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63130, USA
    Aging (Albany NY) 5:507-14. 2013
    ..More studies are needed to understand the interactions between CR, diet composition, exercise, and other environmental and psychological factors on metabolic and molecular pathways that regulate health and longevity. ..
  39. pmc Multiple dietary supplements do not affect metabolic and cardio-vascular health
    Andreea Soare
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63130, USA
    Aging (Albany NY) 6:149-57. 2014
    ..In summary, supplementation with a combination of popular dietary supplements has no cardiovascular or metabolic effects in non-obese relatively healthy individuals. ..
  40. pmc Serum from humans on long-term calorie restriction enhances stress resistance in cell culture
    Daniela Omodei
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63130, USA
    Aging (Albany NY) 5:599-606. 2013
    ....
  41. pmc Long-term effects of calorie restriction on serum sex-hormone concentrations in men
    Roberto Cangemi
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO, USA
    Aging Cell 9:236-42. 2010
    ..More studies are needed to understand the role of this CR-mediated reduction in sex hormones in modulating the pathogenesis of age-associated chronic diseases such as cancer and the aging process itself...
  42. pmc Extending healthy life span--from yeast to humans
    Luigi Fontana
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 328:321-6. 2010
    ..We discuss these findings and their potential application to prevention of age-related disease and promotion of healthy aging in humans, and the challenge of possible negative side effects...
  43. ncbi request reprint The scientific basis of caloric restriction leading to longer life
    Luigi Fontana
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Gastroenterol 25:144-50. 2009
    ..The present review discusses the current state of knowledge regarding the effects of calorie restriction in modulating metabolism and aging...
  44. pmc Postprandial plasma incretin hormones in exercise-trained versus untrained subjects
    Edward P Weiss
    1Department of Nutrition and Dietetics, Saint Louis University, St Louis, MO 2Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St Louis, MO 3Department of Biology, Saint Louis University, St Louis, MO 4Department of Medicine, Salerno University Medical School, Salerno, ITALY and 5CEINGE Biotecnologie Avanzate, Napoli, Italy
    Med Sci Sports Exerc 46:1098-103. 2014
    ..We evaluated the hypothesis that low postprandial plasma insulin levels in lean exercise-trained individuals are associated with low concentrations of incretin hormones...
  45. pmc Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans
    Brian D Muegge
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA
    Science 332:970-4. 2011
    ..These results illustrate the value of characterizing vertebrate gut microbiomes to understand host evolutionary histories at a supraorganismal level...
  46. pmc Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans
    Tim Hofer
    Department of Aging and Geriatrics, Division of Clinical Research, and Genomics and Biomarkers Core of The Institute on Aging, University of Florida, 210 East Mowry Road, Gainesville, FL 32611, USA
    Rejuvenation Res 11:793-9. 2008
    ....
  47. ncbi request reprint Oxidative stress and antioxidant defence in a healthy nonagenarian population
    Emanuela Balbis
    Department of Experimental Medicine, Section of General Pathology, University of Genova, Italy
    Redox Rep 12:59-62. 2007
    ....
  48. ncbi request reprint Excessive adiposity, calorie restriction, and aging
    Luigi Fontana
    JAMA 295:1577-8. 2006
  49. ncbi request reprint Anti malondialdehyde-adduct immunological response as a possible marker of successful aging
    Nicola Traverso
    Department of Experimental Medicine, Section of General Pathology, University of Genova, Genova, Italy
    Exp Gerontol 38:1129-35. 2003
    ..The low level of protein carbonyl might reflect the more efficient removal of damaged proteins...
  50. ncbi request reprint Assessment of autonomic function in untreated adult coeliac disease
    Gian Marco Giorgetti
    Department of Internal Medicine, Clinical Nutrition Unit, S Eugenio Hospital, Rome, Italy
    World J Gastroenterol 10:2715-8. 2004
    ..The aim of our study was to investigate whether autonomic nervous system was altered in untreated and unselected coeliac disease patients...
  51. doi request reprint Favourable response to infliximab in a case of bilateral refractory Mooren's ulcer
    Luigi Fontana
    Clin Experiment Ophthalmol 35:871-3. 2007
    ....