Peter U Fischer

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc A case study of risk factors for lymphatic filariasis in the Republic of Congo
    Cédric B Chesnais
    UMI 233, Institut de Recherche pour le Developpement IRD and University of Montpellier 1, 911 Avenue Agropolis, P, O, Box 64501, 34394 Montpellier, Cedex 5, France
    Parasit Vectors 7:300. 2014
  2. pmc Impact of six rounds of mass drug administration on Brugian filariasis and soil-transmitted helminth infections in eastern Indonesia
    Taniawati Supali
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    PLoS Negl Trop Dis 7:e2586. 2013
  3. pmc Serological diagnosis of North American Paragonimiasis by Western blot using Paragonimus kellicotti adult worm antigen
    Peter U Fischer
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Trop Med Hyg 88:1035-40. 2013
  4. pmc Distribution of Brugia malayi larvae and DNA in vector and non-vector mosquitoes: implications for molecular diagnostics
    Sara M Erickson
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, Missouri, USA
    Parasit Vectors 2:56. 2009
  5. pmc Molecular characterization of the North American lung fluke Paragonimus kellicotti in Missouri and its development in Mongolian gerbils
    Peter U Fischer
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Trop Med Hyg 84:1005-11. 2011
  6. pmc Transcriptomic and proteomic analyses of a Wolbachia-free filarial parasite provide evidence of trans-kingdom horizontal gene transfer
    Samantha N McNulty
    Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 7:e45777. 2012
  7. pmc Localization of Wolbachia-like gene transcripts and peptides in adult Onchocerca flexuosa worms indicates tissue specific expression
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Parasit Vectors 6:2. 2013
  8. doi request reprint Absence of Wolbachia endobacteria in Chandlerella quiscali, an avian filarial parasite
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    J Parasitol 98:382-7. 2012
  9. pmc Tissue and stage-specific distribution of Wolbachia in Brugia malayi
    Kerstin Fischer
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Negl Trop Dis 5:e1174. 2011
  10. pmc A multicenter evaluation of a new antibody test kit for lymphatic filariasis employing recombinant Brugia malayi antigen Bm-14
    Gary J Weil
    Infectious Diseases Division, Washington University School of Medicine, St Louis, MO, USA
    Acta Trop 120:S19-22. 2011

Collaborators

Detail Information

Publications26

  1. pmc A case study of risk factors for lymphatic filariasis in the Republic of Congo
    Cédric B Chesnais
    UMI 233, Institut de Recherche pour le Developpement IRD and University of Montpellier 1, 911 Avenue Agropolis, P, O, Box 64501, 34394 Montpellier, Cedex 5, France
    Parasit Vectors 7:300. 2014
    ..Little is known regarding risk factors for lymphatic filariasis (LF) in Central Africa. We studied the epidemiology of LF in an endemic village in the Republic of Congo...
  2. pmc Impact of six rounds of mass drug administration on Brugian filariasis and soil-transmitted helminth infections in eastern Indonesia
    Taniawati Supali
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    PLoS Negl Trop Dis 7:e2586. 2013
    ..The absence of an animal reservoir, the inefficient transmission by Anopheles mosquitoes and the high sensitivity to DEC/albendazole treatment make this species a prime candidate for elimination by mass drug administration (MDA)...
  3. pmc Serological diagnosis of North American Paragonimiasis by Western blot using Paragonimus kellicotti adult worm antigen
    Peter U Fischer
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Trop Med Hyg 88:1035-40. 2013
    ..Antibody reactivity declined after praziquantel treatment. Thus, the P. kellicotti WB appears to be superior to P. westermani WB for diagnosing Pk infections, and it may be useful for assessing responses to treatment...
  4. pmc Distribution of Brugia malayi larvae and DNA in vector and non-vector mosquitoes: implications for molecular diagnostics
    Sara M Erickson
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, Missouri, USA
    Parasit Vectors 2:56. 2009
    ..abstract:..
  5. pmc Molecular characterization of the North American lung fluke Paragonimus kellicotti in Missouri and its development in Mongolian gerbils
    Peter U Fischer
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Trop Med Hyg 84:1005-11. 2011
    ..These results demonstrate that P. kellicotti is common in Missouri crayfish. The gerbil model may be useful for research on the pathogenesis, immunology, and treatment of paragonimiasis...
  6. pmc Transcriptomic and proteomic analyses of a Wolbachia-free filarial parasite provide evidence of trans-kingdom horizontal gene transfer
    Samantha N McNulty
    Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 7:e45777. 2012
    ..flexuosa lysate and stained specific worm tissues by immunohistology. Future studies will be required to determine the exact functions of Wolbachia-like peptides and proteins in O. flexuosa and to assess their roles in worm biology...
  7. pmc Localization of Wolbachia-like gene transcripts and peptides in adult Onchocerca flexuosa worms indicates tissue specific expression
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Parasit Vectors 6:2. 2013
    ..Proteogenomic studies have shown that many of these Wolbachia-like sequences are expressed in adult worms...
  8. doi request reprint Absence of Wolbachia endobacteria in Chandlerella quiscali, an avian filarial parasite
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    J Parasitol 98:382-7. 2012
    ..Further studies of C. quiscali and other Wolbachia-free filarial species may help to clarify the reason(s) that some filarial species require Wolbachia but others do not...
  9. pmc Tissue and stage-specific distribution of Wolbachia in Brugia malayi
    Kerstin Fischer
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Negl Trop Dis 5:e1174. 2011
    ..Surprisingly, immunohistology and in situ hybridization techniques have not been widely used to monitor Wolbachia distribution during the filarial life cycle...
  10. pmc A multicenter evaluation of a new antibody test kit for lymphatic filariasis employing recombinant Brugia malayi antigen Bm-14
    Gary J Weil
    Infectious Diseases Division, Washington University School of Medicine, St Louis, MO, USA
    Acta Trop 120:S19-22. 2011
    ..It may also be a useful tool for use in LF endemic countries to monitor the progress of filariasis elimination programs and for post-MDA surveillance...
  11. pmc Comparing the mitochondrial genomes of Wolbachia-dependent and independent filarial nematode species
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    BMC Genomics 13:145. 2012
    ..Comparisons between the mitochondrial genome sequences of Wolbachia-dependent and independent filarial worms may reveal differences indicative of altered mitochondrial function...
  12. pmc Laboratory and field evaluation of a new rapid test for detecting Wuchereria bancrofti antigen in human blood
    Gary J Weil
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Am J Trop Med Hyg 89:11-5. 2013
    ..Based on its increased sensitivity and other practical advantages, we believe that the test strip represents a major step forward that will be welcomed by the GPELF and the filariasis research community...
  13. pmc Systems biology studies of adult paragonimus lung flukes facilitate the identification of immunodominant parasite antigens
    Samantha N McNulty
    The Genome Institute at Washington University, St Louis, Missouri, United States of America
    PLoS Negl Trop Dis 8:e3242. 2014
    ..Hence, the purpose of this study was to use a systems biology approach to identify key parasite proteins that may be useful for development of improved diagnostic tests...
  14. pmc Inter and intra-specific diversity of parasites that cause lymphatic filariasis
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, United States
    Infect Genet Evol 14:137-46. 2013
    ..Improved information on filarial genetic diversity may increase the chances of success for lymphatic filariasis elimination programs...
  15. pmc Genetic characterization of atypical Mansonella (Mansonella) ozzardi microfilariae in human blood samples from northeastern Peru
    Luis A Marcos
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Trop Med Hyg 87:491-4. 2012
    ..All atypical microfilariae were clustered into the Mansonella group and indistinguishable from M. ozzardi based on these DNA markers...
  16. doi request reprint Brugia malayi: Effects of nitazoxanide and tizoxanide on adult worms and microfilariae of filarial nematodes
    Ramakrishna U Rao
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Parasitol 121:38-45. 2009
    ..Neither NTZ nor TZ cleared adult worms or microfilariae in infected gerbils. These results show that NTZ and TZ have potent effects on B. malayi nematodes in vitro. However, they were not effective in vivo...
  17. doi request reprint Molecular identification of Schistosoma mattheei from feces of Kinda (Papio cynocephalus kindae) and grayfoot baboons (Papio ursinus griseipes) in Zambia
    Anna H Weyher
    Department of Anthropology, Washington University in St Louis, One Brookings Drive, St Louis, Missouri 63130, USA
    J Parasitol 96:184-90. 2010
    ..Schistosoma mattheei is typically a parasite of bovids, but it can also infect humans. Schistosoma mattheei in baboons in Zambia may affect other wildlife species and humans that live in close proximity to baboons...
  18. pmc Targeting protein-protein interactions for parasite control
    Christina M Taylor
    Department of Genetics, The Genome Center, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 6:e18381. 2011
    ..malayi (H. sapiens parasite), which have extremely different modes of parasitism. As more genomes of pathogens are sequenced and PPI databases expanded, this methodology will become increasingly applicable...
  19. pmc High pressure freezing/freeze substitution fixation improves the ultrastructural assessment of Wolbachia endosymbiont-filarial nematode host interaction
    Kerstin Fischer
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 9:e86383. 2014
    ....
  20. pmc Filarial antigenemia and Loa loa night blood microfilaremia in an area without bancroftian filariasis in the Democratic Republic of Congo
    Didier K Bakajika
    Programme national de lutte contre l onchocercose, Kinshasa, Democratic Republic of Congo Centre de Recherche en Maladies Tropicales de l Ituri, Ituri, Congo, Democratic Republic of Congo Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri
    Am J Trop Med Hyg 91:1142-8. 2014
    ..Periodicity studies revealed atypical patterns, with no significant diurnal periodicity in some individuals. Thus, methods routinely used for LF mapping may not be reliable in areas in central Africa that are highly endemic for loiasis. ..
  21. pmc The impact of two semiannual treatments with albendazole alone on lymphatic filariasis and soil-transmitted helminth infections: a community-based study in the Republic of Congo
    Sebastien D S Pion
    Unité Mixte Internationale 233, Institut de Recherche pour le Développement and University of Montpellier 1, Montpellier, France Centre for Research on Filariasis and Other Tropical Diseases CRFilMT, Yaounde, Cameroon Programme National de Lutte contre l Onchocercose, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri
    Am J Trop Med Hyg 92:959-66. 2015
    ..6% (91% reduction), with less impressive effects on Ascaris and Trichuris. These preliminary results suggest that semiannual community MDA with ALB is a promising strategy for controlling LF and STH in areas with coendemic loiasis...
  22. doi request reprint Conventional parasitology and DNA-based diagnostic methods for onchocerciasis elimination programmes
    Melanie M Lloyd
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA Electronic address
    Acta Trop 146:114-8. 2015
    ..qPCR could be a useful tool for detecting residual O. volvulus infections in human populations as prevalence decreases in areas following community-directed treatment with ivermectin. ..
  23. ncbi request reprint Localization of gender-regulated gene expression in the filarial nematode Brugia malayi
    Daojun Jiang
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Int J Parasitol 38:503-12. 2008
    ..Thus, ISH provides a means to independently confirm differential expression of genes identified by other methods. In addition, localization patterns provide insight regarding the function of known or novel genes in the parasite...
  24. pmc Endosymbiont DNA in endobacteria-free filarial nematodes indicates ancient horizontal genetic transfer
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 5:e11029. 2010
    ..The mechanisms behind this interdependence are not understood. Interestingly, a minority of filarial species examined to date are naturally Wolbachia-free...
  25. doi request reprint Brugia malayi: whole genome amplification for genomic characterization of filarial parasites
    Samantha N McNulty
    Internal Medicine Infectious Diseases Division, Washington University School of Medicine, Campus Mailbox 8051, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Exp Parasitol 119:256-63. 2008
    ..MDA is useful for whole genome amplification of filarial DNA from very small amounts of starting material. This technology will permit detailed studies of genetic diversity that were not previously feasible...
  26. pmc A review of factors that influence individual compliance with mass drug administration for elimination of lymphatic filariasis
    Alison Krentel
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 7:e2447. 2013
    ..This paper reports results from a comprehensive review of factors that affect compliance with MDA...