Brian N Finck

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint The role of the peroxisome proliferator-activated receptor alpha pathway in pathological remodeling of the diabetic heart
    Brian N Finck
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Clin Nutr Metab Care 7:391-6. 2004
  2. ncbi request reprint The PPAR regulatory system in cardiac physiology and disease
    Brian N Finck
    Center for Human Nutrition and Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St Louis, MO 63110, USA
    Cardiovasc Res 73:269-77. 2007
  3. pmc The PPARalpha-PGC-1alpha Axis Controls Cardiac Energy Metabolism in Healthy and Diseased Myocardium
    Jennifer G Duncan
    Center for Cardiovascular Research, Departments of Pediatrics and Medicine, Washington University School of Medicine, 660 S Euclid Avenue Campus Box 8031, Saint Louis, MO 63110, USA
    PPAR Res 2008:253817. 2008
  4. ncbi request reprint Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway
    Brian N Finck
    Center for Cardiovascular Research and Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Metab 4:199-210. 2006
  5. ncbi request reprint Effects of PPARalpha on cardiac glucose metabolism: a transcriptional equivalent of the glucose-fatty acid cycle?
    Brian N Finck
    Department of Medicine, Washington University School of Medicine, Center for Human Nutrition and Center for Cardiovascular Research, St Louis, MO 63110, USA
    Expert Rev Cardiovasc Ther 4:161-71. 2006
  6. ncbi request reprint Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha
    Brian N Finck
    Department of Animal Sciences, University of Illinois at Urbana Champaign, 390 Animal Sciences Laboratory, Urbana, Illinois 61801, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1429-35. 2002
  7. pmc In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy
    Kooresh I Shoghi
    Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Cardiovasc Imaging 2:373-81. 2009
  8. ncbi request reprint A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes
    Brian N Finck
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Metab 1:133-44. 2005
  9. ncbi request reprint CD36 deficiency rescues lipotoxic cardiomyopathy
    John Yang
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 100:1208-17. 2007
  10. pmc Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice
    Matthew C Gropler
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 284:6763-72. 2009

Detail Information

Publications53

  1. ncbi request reprint The role of the peroxisome proliferator-activated receptor alpha pathway in pathological remodeling of the diabetic heart
    Brian N Finck
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Clin Nutr Metab Care 7:391-6. 2004
    ..Cardiovascular disease is exceptionally prevalent in patients with diabetes mellitus, which is an emerging pandemic. Unfortunately, the pathogenesis of diabetic myocardial disease is still poorly understood...
  2. ncbi request reprint The PPAR regulatory system in cardiac physiology and disease
    Brian N Finck
    Center for Human Nutrition and Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St Louis, MO 63110, USA
    Cardiovasc Res 73:269-77. 2007
    ..This review will summarize these findings and other recent studies regarding the effects of experimental PPAR activation and deactivation and its potential impact on cardiomyopathic remodeling...
  3. pmc The PPARalpha-PGC-1alpha Axis Controls Cardiac Energy Metabolism in Healthy and Diseased Myocardium
    Jennifer G Duncan
    Center for Cardiovascular Research, Departments of Pediatrics and Medicine, Washington University School of Medicine, 660 S Euclid Avenue Campus Box 8031, Saint Louis, MO 63110, USA
    PPAR Res 2008:253817. 2008
    ..In this review, we detail the current understanding of the effects of the PPARalpha-PGC-1alpha axis in regulating mitochondrial energy metabolism and cardiac function in response to physiologic and pathophysiologic stimuli...
  4. ncbi request reprint Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway
    Brian N Finck
    Center for Cardiovascular Research and Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Metab 4:199-210. 2006
    ..These results identify lipin 1 as a selective physiological amplifier of the PGC-1alpha/PPARalpha-mediated control of hepatic lipid metabolism...
  5. ncbi request reprint Effects of PPARalpha on cardiac glucose metabolism: a transcriptional equivalent of the glucose-fatty acid cycle?
    Brian N Finck
    Department of Medicine, Washington University School of Medicine, Center for Human Nutrition and Center for Cardiovascular Research, St Louis, MO 63110, USA
    Expert Rev Cardiovasc Ther 4:161-71. 2006
    ..Although the effects of overexpressing PPARalpha in a specific tissue obviously differ from activating PPARalpha in a systemic manner, studies such as this may influence the development of the next generation of PPAR ligands...
  6. ncbi request reprint Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha
    Brian N Finck
    Department of Animal Sciences, University of Illinois at Urbana Champaign, 390 Animal Sciences Laboratory, Urbana, Illinois 61801, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1429-35. 2002
    ..Collectively, these data indicate that TNF-alpha acutely activates leptin expression and that anti-inflammatory agents can abrogate TNF-alpha-induced hyperleptinemia...
  7. pmc In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy
    Kooresh I Shoghi
    Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Cardiovasc Imaging 2:373-81. 2009
    ..We aimed to assess noninvasively the efficacy of metformin and rosiglitazone monotherapy in normalizing myocardial substrate metabolism in an animal model of type 2 diabetes mellitus...
  8. ncbi request reprint A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes
    Brian N Finck
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Metab 1:133-44. 2005
    ..These results identify PPARalpha-driven alterations in muscle fatty acid oxidation and energetics as a potential link between obesity and the development of glucose intolerance and insulin resistance...
  9. ncbi request reprint CD36 deficiency rescues lipotoxic cardiomyopathy
    John Yang
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 100:1208-17. 2007
    ....
  10. pmc Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice
    Matthew C Gropler
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 284:6763-72. 2009
    ..Collectively, these data suggest that lipin 2 plays an important role as a hepatic PAP-1 enzyme...
  11. pmc Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion
    Zhouji Chen
    Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Arterioscler Thromb Vasc Biol 28:1738-44. 2008
    ..We sought to evaluate the effects of lipin 1 on hepatic TAG synthesis and secretion by gain-of-function and loss-of-function approaches...
  12. ncbi request reprint Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss
    Michelle A Croce
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetes 56:2395-9. 2007
    ..We sought to determine the expression of lipin 1 isoforms (lipin 1alpha and -beta) in liver and adipose tissue of obese subjects and to evaluate cellular mechanisms involved in the regulation of lipin 1 expression by physiologic stimuli...
  13. ncbi request reprint Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease
    Brian N Finck
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 115:2540-8. 2007
  14. pmc Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione
    Zhouji Chen
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:23537-48. 2012
    ..In conclusion, the beneficial pharmacology exhibited by MSDC-0602 on insulin sensitivity suggests that PPARγ-sparing TZDs are effective for treatment of type 2 diabetes with reduced risk of PPARγ-mediated side effects...
  15. ncbi request reprint Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway
    Jennifer G Duncan
    Center for Cardiovascular Research, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Circulation 115:909-17. 2007
    ..We hypothesized that regulatory events involved in the control of mitochondrial function are activated in the prediabetic, insulin-resistant stage...
  16. pmc Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 145:366-74.e1-3. 2013
    ..Insulin sensitivity was determined by using the hyperinsulinemic euglycemic clamp procedure...
  17. pmc Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 α (HNF4α) pathways to regulate liver lipid metabolism
    Zhouji Chen
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e51320. 2012
    ..Thus, the induction of lipin 1 by HNF4α may serve as a mechanism to affect promoter selection to direct HNF4α to promoters of genes encoding fatty acid oxidation enzymes...
  18. pmc Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation
    Mayurranjan S Mitra
    Department of Medicine, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 110:642-7. 2013
    ....
  19. pmc Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women
    Marleen Kars
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 59:1899-905. 2010
    ..The purpose of this study was to determine the effect of TUDCA therapy on multiorgan insulin action and metabolic factors associated with insulin resistance in obese men and women...
  20. pmc A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content
    Brian N Finck
    Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:1226-31. 2003
    ..These results link dysregulation of the PPARalpha gene regulatory pathway to cardiac dysfunction in the diabetic and provide a rationale for serum lipid-lowering strategies in the treatment of diabetic cardiomyopathy...
  21. pmc Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding
    Kari T Chambers
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e52645. 2012
    ..These results suggest that PGC-1β plays dual roles in regulating hepatic fatty acid metabolism by controlling the expression of programs of genes involved in both fatty acid oxidation and de novo fatty acid synthesis...
  22. pmc Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction
    Erik Kirk
    Center for Human Nutrition and Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 136:1552-60. 2009
    ..We determined the effects of acute and chronic calorie restriction with either a low-fat, high-carbohydrate (HC) diet or a low-carbohydrate (LC) diet on hepatic and skeletal muscle insulin sensitivity...
  23. pmc Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic mice
    Angela M Hall
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Lipid Res 51:554-63. 2010
    ..However, whereas perilipin-2 and perilipin-5 levels are primarily regulated posttranslationally, Cide family mRNA expression is induced, suggesting that these families of LDP are controlled at different regulatory checkpoints...
  24. pmc PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis
    Teresa C Leone
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 3:e101. 2005
    ..Lastly, vacuolar lesions were detected in the central nervous system of PGC-1alpha(-/-) mice. These results demonstrate that PGC-1alpha is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life...
  25. pmc Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response
    Kari T Chambers
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 286:11155-62. 2011
    ....
  26. pmc Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism
    Faidon Magkos
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 62:2757-61. 2013
    ..Plasma BCAA concentration is negatively associated with skeletal muscle insulin sensitivity, but the mechanism(s) responsible for this relationship is not known...
  27. ncbi request reprint Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice
    Carlos Bernal-Mizrachi
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110 USA
    Nat Med 9:1069-75. 2003
    ..These results identify hepatic activation of PPAR-alpha as a mechanism underlying glucocorticoid-induced insulin resistance...
  28. ncbi request reprint G-protein signaling participates in the development of diabetic cardiomyopathy
    Ian S Harris
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 53:3082-90. 2004
    ..These results establish that Gq-mediated signaling plays a critical role in the pathogenesis of diabetic cardiomyopathy...
  29. pmc The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
    Brian N Finck
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 109:121-30. 2002
    ....
  30. pmc Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors
    Kiran Kumar Solingapuram Sai
    Division of Radiological Sciences, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Bioorg Med Chem Lett 22:6233-6. 2012
    ..5-fold greater radiotracer uptake in the heart of transgenic mice compared to the wild-type littermates. These results demonstrate the potential utility of PPAR-α agonists as PET radiopharmaceuticals...
  31. pmc Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver
    Angela M Hall
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO, USA
    J Lipid Res 53:990-9. 2012
    ..These data suggest that the MGAT pathway is active and dynamically regulated in human liver and could be an important target for pharmacologic intervention for the treatment of obesity-related insulin resistance and NAFLD...
  32. pmc Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis
    Mayurranjan S Mitra
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Mol Cell Cardiol 51:120-8. 2011
    ..Collectively, these data suggest that lipin 1 is the principal lipin protein in the myocardium and is regulated in response to physiologic and pathologic stimuli that impact cardiac metabolism...
  33. ncbi request reprint OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization
    Nathan E Wolins
    Department of Medicine, 660 S Euclid Ave, Campus Box 8127, St Louis, MO 63110, USA
    Diabetes 55:3418-28. 2006
    ..OXPAT likely contributes to adaptive responses to the fatty acid burden that accompanies fasting, insulin deficiency, and overnutrition, responses that are defective in obesity and type 2 diabetes...
  34. pmc Hepatic expression of cell death-inducing DFFA-like effector C in obese subjects is reduced by marked weight loss
    Angela M Hall
    Center for Human Nutrition, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 18:417-9. 2010
    ..Moreover, the hepatic expression of CIDEC is downregulated by marked weight loss...
  35. ncbi request reprint Peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart
    Brian N Finck
    Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Mol Cell Cardiol 34:1249-57. 2002
    ..This review summarizes the regulation of cardiac substrate utilization pathways via the PPARalpha complex in the normal and diseased heart...
  36. pmc Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion
    Patrick A Vigueira
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Rep 7:2042-53. 2014
    ..Collectively, these data are consistent with a role for MPC2 in mitochondrial pyruvate import and suggest that Mpc2 deficiency results in defective pancreatic β cell glucose sensing. ..
  37. pmc Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice
    Vered Gazit
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hepatology 52:2109-17. 2010
    ..The fld mice also exhibited increased hepatic p21 expression and diminished plasma levels of the adipose-derived hormones adiponectin and leptin, which have each been implicated as regulators of liver regeneration...
  38. ncbi request reprint Mouse models of mitochondrial dysfunction and heart failure
    Laurie K Russell
    Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8086, Saint Louis, MO 63110, USA
    J Mol Cell Cardiol 38:81-91. 2005
    ....
  39. pmc PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
    Brian N Finck
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:615-22. 2006
    ..This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure...
  40. pmc Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) stimulates VLDL assembly through activation of cell death-inducing DFFA-like effector B (CideB)
    Zhouji Chen
    Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 285:25996-6004. 2010
    ..Collectively, these data suggest that PGC-1alpha plays an important role in partitioning cytoplasmic TG toward the VLDL secretory compartments and promoting VLDL secretion via transcriptional induction of CideB...
  41. pmc Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons
    Charles P Lambert
    Department of Internal Medicine, Washington University School of Medicine, Campus Box 8303, St Louis, MO 63110, USA
    J Appl Physiol (1985) 105:473-8. 2008
    ..05), but weight loss had no effect. In conclusion, exercise but not weight loss had a beneficial effect on markers of muscle inflammation and anabolism in frail obese elderly individuals...
  42. pmc Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice
    Brian J DeBosch
    MD, Department of Obstetrics and Gynecology, Washington University in St Louis School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110
    Mol Endocrinol 27:1887-96. 2013
    ..We thus establish GLUT8 as a promising target in the prevention of diet-induced obesity, metabolic syndrome, and type 2 diabetes mellitus in males. ..
  43. pmc Time course of alterations in myocardial glucose utilization in the Zucker diabetic fatty rat with correlation to gene expression of glucose transporters: a small-animal PET investigation
    Kooresh I Shoghi
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 49:1320-7. 2008
    ....
  44. ncbi request reprint ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome
    Jochen G Schneider
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Metab 4:377-89. 2006
    ..These results suggest that ATM-dependent stress pathways mediate susceptibility to the metabolic syndrome and that chloroquine or related agents promoting ATM activity could modulate insulin resistance and decrease vascular disease...
  45. pmc Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice
    Angela M Hall
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO
    Diabetes 63:2284-96. 2014
    ....
  46. pmc PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner
    Kari T Chambers
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, United States Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, United States
    Mol Metab 2:194-204. 2013
    ..These data suggest that PGC-1β-mediated coactivation of ChREBP is involved in the lipogenic response to hyperglycemia. ..
  47. pmc Sexually dimorphic effect of aging on skeletal muscle protein synthesis
    Gordon I Smith
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 660 South Euclid Avenue Campus, Box 8031, Saint Louis, MO 63110, USA
    Biol Sex Differ 3:11. 2012
    ..abstract:..
  48. ncbi request reprint Effect of marked weight loss on adiponectin gene expression and plasma concentrations
    Carrie C Coughlin
    Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Obesity (Silver Spring) 15:640-5. 2007
    ....
  49. ncbi request reprint Synthesis and evaluation of a bromine-76-labeled PPARgamma antagonist 2-bromo-5-nitro-N-phenylbenzamide
    Hsiaoju Lee
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 33:847-54. 2006
    ..We are currently exploring second generation analogs of these lead compounds for the development of radiolabeled antagonists of the PPARgamma receptor...
  50. ncbi request reprint Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver
    So Young Park
    Yale University School of Medicine, Department of Internal Medicine, Section of Endocrinology and Metabolism, The Anlyan Center, S269C, P O Box 208020, 300 Cedar St, New Haven, CT 06520 8020, USA
    Diabetes 54:2514-24. 2005
    ..Additionally, age-associated hepatic insulin resistance develops in MHC-PPARalpha mice that may be due to altered cardiac metabolism, functions, and/or inflammatory cytokines...
  51. ncbi request reprint Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia
    Nandakumar Sambandam
    Department of Pediatrics and Pharmacology, Univ of Alberta, Edmonton, AB, Canada
    Am J Physiol Heart Circ Physiol 290:H87-95. 2006
    ..75 +/- 9%). This study demonstrates that chronic activation of PPARalpha is detrimental to the cardiac recovery during reperfusion after ischemia...
  52. pmc Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice
    Shawn C Burgess
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    J Biol Chem 281:19000-8. 2006
    ....