Research Topics
Genomes and Genes
| Brian N FinckSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
The PPAR regulatory system in cardiac physiology and diseaseBrian N Finck
Center for Human Nutrition and Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St Louis, MO 63110, USA
Cardiovasc Res 73:269-77. 2007..This review will summarize these findings and other recent studies regarding the effects of experimental PPAR activation and deactivation and its potential impact on cardiomyopathic remodeling...- The role of the peroxisome proliferator-activated receptor alpha pathway in pathological remodeling of the diabetic heartBrian N Finck
Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Curr Opin Clin Nutr Metab Care 7:391-6. 2004..Cardiovascular disease is exceptionally prevalent in patients with diabetes mellitus, which is an emerging pandemic. Unfortunately, the pathogenesis of diabetic myocardial disease is still poorly understood... - Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathwayBrian N Finck
Center for Cardiovascular Research and Washington University School of Medicine, St Louis, Missouri 63110, USA
Cell Metab 4:199-210. 2006..These results identify lipin 1 as a selective physiological amplifier of the PGC-1alpha/PPARalpha-mediated control of hepatic lipid metabolism... - Effects of PPARalpha on cardiac glucose metabolism: a transcriptional equivalent of the glucose-fatty acid cycle?Brian N Finck
Department of Medicine, Washington University School of Medicine, Center for Human Nutrition and Center for Cardiovascular Research, St Louis, MO 63110, USA
Expert Rev Cardiovasc Ther 4:161-71. 2006..Although the effects of overexpressing PPARalpha in a specific tissue obviously differ from activating PPARalpha in a systemic manner, studies such as this may influence the development of the next generation of PPAR ligands... - Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alphaBrian N Finck
Department of Animal Sciences, University of Illinois at Urbana Champaign, 390 Animal Sciences Laboratory, Urbana, Illinois 61801, USA
Am J Physiol Regul Integr Comp Physiol 282:R1429-35. 2002..Collectively, these data indicate that TNF-alpha acutely activates leptin expression and that anti-inflammatory agents can abrogate TNF-alpha-induced hyperleptinemia... 
In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapyKooresh I Shoghi
Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Circ Cardiovasc Imaging 2:373-81. 2009..We aimed to assess noninvasively the efficacy of metformin and rosiglitazone monotherapy in normalizing myocardial substrate metabolism in an animal model of type 2 diabetes mellitus...- A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetesBrian N Finck
Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cell Metab 1:133-44. 2005..These results identify PPARalpha-driven alterations in muscle fatty acid oxidation and energetics as a potential link between obesity and the development of glucose intolerance and insulin resistance... - CD36 deficiency rescues lipotoxic cardiomyopathyJohn Yang
Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
Circ Res 100:1208-17. 2007.... - Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in miceMatthew C Gropler
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 284:6763-72. 2009..Collectively, these data suggest that lipin 2 plays an important role as a hepatic PAP-1 enzyme... - Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretionZhouji Chen
Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
Arterioscler Thromb Vasc Biol 28:1738-44. 2008..We sought to evaluate the effects of lipin 1 on hepatic TAG synthesis and secretion by gain-of-function and loss-of-function approaches... - Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight lossMichelle A Croce
Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
Diabetes 56:2395-9. 2007..We sought to determine the expression of lipin 1 isoforms (lipin 1alpha and -beta) in liver and adipose tissue of obese subjects and to evaluate cellular mechanisms involved in the regulation of lipin 1 expression by physiologic stimuli... - Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and diseaseBrian N Finck
Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USA
Circulation 115:2540-8. 2007 - Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedioneZhouji Chen
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 287:23537-48. 2012..In conclusion, the beneficial pharmacology exhibited by MSDC-0602 on insulin sensitivity suggests that PPARγ-sparing TZDs are effective for treatment of type 2 diabetes with reduced risk of PPARγ-mediated side effects... - A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat contentBrian N Finck
Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 100:1226-31. 2003..These results link dysregulation of the PPARalpha gene regulatory pathway to cardiac dysfunction in the diabetic and provide a rationale for serum lipid-lowering strategies in the treatment of diabetic cardiomyopathy... - Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and womenMarleen Kars
Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Diabetes 59:1899-905. 2010..The purpose of this study was to determine the effect of TUDCA therapy on multiorgan insulin action and metabolic factors associated with insulin resistance in obese men and women... - Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restrictionErik Kirk
Center for Human Nutrition and Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, Missouri 63110, USA
Gastroenterology 136:1552-60. 2009..We determined the effects of acute and chronic calorie restriction with either a low-fat, high-carbohydrate (HC) diet or a low-carbohydrate (LC) diet on hepatic and skeletal muscle insulin sensitivity... - Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic miceAngela M Hall
Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
J Lipid Res 51:554-63. 2010..However, whereas perilipin-2 and perilipin-5 levels are primarily regulated posttranslationally, Cide family mRNA expression is induced, suggesting that these families of LDP are controlled at different regulatory checkpoints... - Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathwayJennifer G Duncan
Center for Cardiovascular Research, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
Circulation 115:909-17. 2007..We hypothesized that regulatory events involved in the control of mitochondrial function are activated in the prediabetic, insulin-resistant stage... - Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null miceCarlos Bernal-Mizrachi
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110 USA
Nat Med 9:1069-75. 2003..These results identify hepatic activation of PPAR-alpha as a mechanism underlying glucocorticoid-induced insulin resistance... - The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitusBrian N Finck
Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Clin Invest 109:121-30. 2002.... - Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic responseKari T Chambers
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 286:11155-62. 2011.... - G-protein signaling participates in the development of diabetic cardiomyopathyIan S Harris
Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Diabetes 53:3082-90. 2004..These results establish that Gq-mediated signaling plays a critical role in the pathogenesis of diabetic cardiomyopathy... - Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptorsKiran Kumar Solingapuram Sai
Division of Radiological Sciences, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
Bioorg Med Chem Lett 22:6233-6. 2012..5-fold greater radiotracer uptake in the heart of transgenic mice compared to the wild-type littermates. These results demonstrate the potential utility of PPAR-α agonists as PET radiopharmaceuticals... - Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liverAngela M Hall
Center for Human Nutrition, Washington University School of Medicine, St Louis, MO, USA
J Lipid Res 53:990-9. 2012..These data suggest that the MGAT pathway is active and dynamically regulated in human liver and could be an important target for pharmacologic intervention for the treatment of obesity-related insulin resistance and NAFLD... - OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilizationNathan E Wolins
Department of Medicine, 660 S Euclid Ave, Campus Box 8127, St Louis, MO 63110, USA
Diabetes 55:3418-28. 2006..OXPAT likely contributes to adaptive responses to the fatty acid burden that accompanies fasting, insulin deficiency, and overnutrition, responses that are defective in obesity and type 2 diabetes... - Peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heartBrian N Finck
Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
J Mol Cell Cardiol 34:1249-57. 2002..This review summarizes the regulation of cardiac substrate utilization pathways via the PPARalpha complex in the normal and diseased heart... - Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axisMayurranjan S Mitra
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Mol Cell Cardiol 51:120-8. 2011..Collectively, these data suggest that lipin 1 is the principal lipin protein in the myocardium and is regulated in response to physiologic and pathologic stimuli that impact cardiac metabolism... - PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosisTeresa C Leone
Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA
PLoS Biol 3:e101. 2005..Lastly, vacuolar lesions were detected in the central nervous system of PGC-1alpha(-/-) mice. These results demonstrate that PGC-1alpha is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life... - Hepatic expression of cell death-inducing DFFA-like effector C in obese subjects is reduced by marked weight lossAngela M Hall
Center for Human Nutrition, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Obesity (Silver Spring) 18:417-9. 2010..Moreover, the hepatic expression of CIDEC is downregulated by marked weight loss... - PGC-1 coactivators: inducible regulators of energy metabolism in health and diseaseBrian N Finck
Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 116:615-22. 2006..This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure... - Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly personsCharles P Lambert
Department of Internal Medicine, Washington University School of Medicine, Campus Box 8303, St Louis, MO 63110, USA
J Appl Physiol 105:473-8. 2008..05), but weight loss had no effect. In conclusion, exercise but not weight loss had a beneficial effect on markers of muscle inflammation and anabolism in frail obese elderly individuals... - Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) stimulates VLDL assembly through activation of cell death-inducing DFFA-like effector B (CideB)Zhouji Chen
Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 285:25996-6004. 2010..Collectively, these data suggest that PGC-1alpha plays an important role in partitioning cytoplasmic TG toward the VLDL secretory compartments and promoting VLDL secretion via transcriptional induction of CideB... - Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulationMayurranjan S Mitra
Department of Medicine, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 110:642-7. 2013.... - Time course of alterations in myocardial glucose utilization in the Zucker diabetic fatty rat with correlation to gene expression of glucose transporters: a small-animal PET investigationKooresh I Shoghi
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 49:1320-7. 2008.... - Mouse models of mitochondrial dysfunction and heart failureLaurie K Russell
Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8086, Saint Louis, MO 63110, USA
J Mol Cell Cardiol 38:81-91. 2005.... - ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndromeJochen G Schneider
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cell Metab 4:377-89. 2006..These results suggest that ATM-dependent stress pathways mediate susceptibility to the metabolic syndrome and that chloroquine or related agents promoting ATM activity could modulate insulin resistance and decrease vascular disease... - Liver regeneration is impaired in lipodystrophic fatty liver dystrophy miceVered Gazit
Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
Hepatology 52:2109-17. 2010.... - Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeedingKari T Chambers
Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS ONE 7:e52645. 2012..These results suggest that PGC-1β plays dual roles in regulating hepatic fatty acid metabolism by controlling the expression of programs of genes involved in both fatty acid oxidation and de novo fatty acid synthesis... - Sexually dimorphic effect of aging on skeletal muscle protein synthesisGordon I Smith
Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 660 South Euclid Avenue Campus, Box 8031, Saint Louis, MO 63110, USA
Biol Sex Differ 3:11. 2012..abstract:.. - Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 α (HNF4α) pathways to regulate liver lipid metabolismZhouji Chen
Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS ONE 7:e51320. 2012..Thus, the induction of lipin 1 by HNF4α may serve as a mechanism to affect promoter selection to direct HNF4α to promoters of genes encoding fatty acid oxidation enzymes... - Effect of marked weight loss on adiponectin gene expression and plasma concentrationsCarrie C Coughlin
Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Obesity (Silver Spring) 15:640-5. 2007.... - Synthesis and evaluation of a bromine-76-labeled PPARgamma antagonist 2-bromo-5-nitro-N-phenylbenzamideHsiaoju Lee
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 33:847-54. 2006..We are currently exploring second generation analogs of these lead compounds for the development of radiolabeled antagonists of the PPARgamma receptor... - The PPARalpha-PGC-1alpha Axis Controls Cardiac Energy Metabolism in Healthy and Diseased MyocardiumJennifer G Duncan
Center for Cardiovascular Research, Departments of Pediatrics and Medicine, Washington University School of Medicine, 660 S Euclid Avenue Campus Box 8031, Saint Louis, MO 63110, USA
PPAR Res 2008:253817. 2008..In this review, we detail the current understanding of the effects of the PPARalpha-PGC-1alpha axis in regulating mitochondrial energy metabolism and cardiac function in response to physiologic and pathophysiologic stimuli... - Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient miceShawn C Burgess
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
J Biol Chem 281:19000-8. 2006.... - Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemiaNandakumar Sambandam
Department of Pediatrics and Pharmacology, Univ of Alberta, Edmonton, AB, Canada
Am J Physiol Heart Circ Physiol 290:H87-95. 2006..75 +/- 9%). This study demonstrates that chronic activation of PPARalpha is detrimental to the cardiac recovery during reperfusion after ischemia... - Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liverSo Young Park
Yale University School of Medicine, Department of Internal Medicine, Section of Endocrinology and Metabolism, The Anlyan Center, S269C, P O Box 208020, 300 Cedar St, New Haven, CT 06520 8020, USA
Diabetes 54:2514-24. 2005..Additionally, age-associated hepatic insulin resistance develops in MHC-PPARalpha mice that may be due to altered cardiac metabolism, functions, and/or inflammatory cytokines...