T Ferkol

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Primary ciliary dyskinesia-causing mutations in amish and mennonite communities
    Thomas W Ferkol
    Departments of Pediatrics and Genetics, Washington University in St Louis, St Louis, Mo Electronic address
    J Pediatr 163:383-7. 2013
  2. doi request reprint NHLBI training workshop report: the vanishing pediatric pulmonary investigator and recommendations for recovery
    Thomas Ferkol
    Washington University School of Medicine, Campus Box 8117 660 S Euclid Ave, St Louis, MO, 63110, USA
    Lung 187:367-74. 2009
  3. ncbi request reprint Primary ciliary dyskinesia and newborn respiratory distress
    Thomas Ferkol
    Department of Pediatrics, Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Semin Perinatol 30:335-40. 2006
  4. ncbi request reprint Cystic fibrosis pulmonary exacerbations
    Thomas Ferkol
    Department of Pediatrics, Cell Biology and Physiology, Washington University School of Medicine, St Louis Children s Hospital, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Pediatr 148:259-64. 2006
  5. ncbi request reprint Targeted delivery of antiprotease to the epithelial surface of human tracheal xenografts
    Thomas Ferkol
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Am J Respir Crit Care Med 167:1374-9. 2003
  6. ncbi request reprint Transport of bifunctional proteins across respiratory epithelial cells via the polymeric immunoglobulin receptor
    T Ferkol
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Am J Respir Crit Care Med 161:944-51. 2000
  7. doi request reprint Acquired monosomy 7 myelodysplastic syndrome in a child with clinical features suggestive of dyskeratosis congenita and IMAGe association
    Sharon McDonald
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Pediatr Blood Cancer 54:154-7. 2010
  8. ncbi request reprint Lung function decline in cystic fibrosis patients and timing for lung transplantation referral
    Daniel B Rosenbluth
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Chest 126:412-9. 2004
  9. ncbi request reprint Cathepsin-G interferes with clearance of Pseudomonas aeruginosa from mouse lungs
    Julia Sedor
    Mallinkrodt Department of Pediatrics, WA University School of Medicine, St Louis, MO 63110, USA
    Pediatr Res 61:26-31. 2007
  10. ncbi request reprint NF-kappaB activation and sustained IL-8 gene expression in primary cultures of cystic fibrosis airway epithelial cells stimulated with Pseudomonas aeruginosa
    Theresa Joseph
    Department of Pediatrics, Washington University School of Medcine, St Louis, Missouri 63110, USA
    Am J Physiol Lung Cell Mol Physiol 288:L471-9. 2005

Research Grants

  1. Targeted Delivery of Interleukin-10
    Thomas Ferkol; Fiscal Year: 2004
  2. Genetic variants of primary ciliary dyskinesia
    Thomas Ferkol; Fiscal Year: 2006
  3. Delivering antiproteases to the bronchiectatic airway
    Thomas Ferkol; Fiscal Year: 2007
  4. Delivering antiproteases to the bronchiectatic airway
    Thomas Ferkol; Fiscal Year: 2009

Collaborators

Detail Information

Publications30

  1. pmc Primary ciliary dyskinesia-causing mutations in amish and mennonite communities
    Thomas W Ferkol
    Departments of Pediatrics and Genetics, Washington University in St Louis, St Louis, Mo Electronic address
    J Pediatr 163:383-7. 2013
    ..To determine whether individuals with primary ciliary dyskinesia (PCD) from unrelated Amish and Mennonite families harbor a single and unique founder mutation...
  2. doi request reprint NHLBI training workshop report: the vanishing pediatric pulmonary investigator and recommendations for recovery
    Thomas Ferkol
    Washington University School of Medicine, Campus Box 8117 660 S Euclid Ave, St Louis, MO, 63110, USA
    Lung 187:367-74. 2009
    ..Strategies for recruitment and retention of talented young trainees and junior faculty are proposed...
  3. ncbi request reprint Primary ciliary dyskinesia and newborn respiratory distress
    Thomas Ferkol
    Department of Pediatrics, Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Semin Perinatol 30:335-40. 2006
    ..Moreover, further evaluation is warranted in children who had transient respiratory distress in newborn period and subsequently develop persistent cough or chronic otitis media...
  4. ncbi request reprint Cystic fibrosis pulmonary exacerbations
    Thomas Ferkol
    Department of Pediatrics, Cell Biology and Physiology, Washington University School of Medicine, St Louis Children s Hospital, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Pediatr 148:259-64. 2006
  5. ncbi request reprint Targeted delivery of antiprotease to the epithelial surface of human tracheal xenografts
    Thomas Ferkol
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Am J Respir Crit Care Med 167:1374-9. 2003
    ....
  6. ncbi request reprint Transport of bifunctional proteins across respiratory epithelial cells via the polymeric immunoglobulin receptor
    T Ferkol
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Am J Respir Crit Care Med 161:944-51. 2000
    ..Thus, in cell models, this system is capable of concentrating the antiprotease of the fusion protein, in the thin film of epithelial surface fluid to a level expected to be therapeutic in the airways of many patients with CF...
  7. doi request reprint Acquired monosomy 7 myelodysplastic syndrome in a child with clinical features suggestive of dyskeratosis congenita and IMAGe association
    Sharon McDonald
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Pediatr Blood Cancer 54:154-7. 2010
    ..We considered the possibility that this patient has a defect in telomere function resulting in features of both DC and IMAGe association...
  8. ncbi request reprint Lung function decline in cystic fibrosis patients and timing for lung transplantation referral
    Daniel B Rosenbluth
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Chest 126:412-9. 2004
    ....
  9. ncbi request reprint Cathepsin-G interferes with clearance of Pseudomonas aeruginosa from mouse lungs
    Julia Sedor
    Mallinkrodt Department of Pediatrics, WA University School of Medicine, St Louis, MO 63110, USA
    Pediatr Res 61:26-31. 2007
    ..These findings suggest that cathepsin G interferes with airway defenses, showing that proteases other than neutrophil elastase have roles in the pathogenesis of suppurative airway diseases...
  10. ncbi request reprint NF-kappaB activation and sustained IL-8 gene expression in primary cultures of cystic fibrosis airway epithelial cells stimulated with Pseudomonas aeruginosa
    Theresa Joseph
    Department of Pediatrics, Washington University School of Medcine, St Louis, Missouri 63110, USA
    Am J Physiol Lung Cell Mol Physiol 288:L471-9. 2005
    ..aeruginosa stimulation. Thus, IL-8 mRNA expression was prolonged after P. aeruginosa stimulation in CF epithelial cells, and this sustained IL-8 expression may contribute to the excessive inflammatory response in CF...
  11. ncbi request reprint Single chain Fv: a ligand in receptor-mediated gene delivery
    S Gupta
    Department of Pediatrics, Case Western Reserve University School of Medicine, Biomedical Research Bldg, Rm 831, 2109, Adelbert Road, Cleveland, Ohio 44106-6006, USA
    Gene Ther 8:586-92. 2001
    ..We have expressed and purified a ligand that is efficient and specific in pIgR-mediated gene delivery...
  12. ncbi request reprint Growth hormone treatment enhances nutrition and growth in children with cystic fibrosis receiving enteral nutrition
    Dana S Hardin
    University of Texas Southwestern Medical School, Department of Pediatrics, Dallas 75390 9063, USA
    J Pediatr 146:324-8. 2005
    ..This study evaluates the hypothesis that adjunctive growth hormone (GH) therapy augments the growth response to nutritional supplementation...
  13. doi request reprint Baseline characteristics and factors associated with nutritional and pulmonary status at enrollment in the cystic fibrosis EPIC observational cohort
    Margaret Rosenfeld
    Department of Pediatrics, Seattle Children s Hospital and University of Washington, Seattle, Washington, USA
    Pediatr Pulmonol 45:934-44. 2010
    ..The EPIC Observational Study is an ongoing prospective cohort study investigating risk factors for and clinical outcomes associated with early Pseudomonas aeruginosa (Pa) acquisition in young children with cystic fibrosis (CF)...
  14. doi request reprint NHLBI training workshop report: The vanishing pediatric pulmonary investigator and recommendations for recovery
    Thomas Ferkol
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Pediatr Pulmonol 45:25-33. 2010
    ..Strategies for recruitment and retention of talented young trainees and junior faculty are proposed...
  15. ncbi request reprint Use of high-dose ibuprofen in a pediatric cystic fibrosis center
    Preston Blain Fennell
    Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, United States
    J Cyst Fibros 6:153-8. 2007
    ..Neither use of high-dose ibuprofen nor its cessation resulted in a significant change in the rate of decline in pulmonary function or influenced hospitalization rates...
  16. ncbi request reprint Nitric oxide deficiency contributes to impairment of airway relaxation in cystic fibrosis mice
    M J Mhanna
    Department of Pediatrics, Rainbow Babies and Childrens Hospital and MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-6010, USA
    Am J Respir Cell Mol Biol 24:621-6. 2001
    ..We conclude that the relative absence of NO compromises airways relaxation in CF, and may contribute to the bronchial obstruction seen in the disease...
  17. ncbi request reprint Growth hormone treatment improves growth and clinical status in prepubertal children with cystic fibrosis: results of a multicenter randomized controlled trial
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Texas 75390, USA
    J Clin Endocrinol Metab 91:4925-9. 2006
    ....
  18. ncbi request reprint Primary ciliary dyskinesia: recent advances in pathogenesis, diagnosis and treatment
    Hauw Lie
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Drugs 67:1883-92. 2007
    ..Multicentre collaborative efforts have been established in North America and Europe, which should help to develop standardised approaches to the diagnosis and treatment of primary ciliary dyskinesia...
  19. pmc Effect of polarized release of CXC-chemokines from wild-type and cystic fibrosis murine airway epithelial cells
    Michelle M Farberman
    Division of Pediatric Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 45:221-8. 2011
    ..aeruginosa infection of the airway epithelium induces the expression and polarized secretion of CXC-chemokines, and the increased concentration gradient across the CF airway leads to an exaggerated inflammatory response...
  20. ncbi request reprint Repetitive imaging of reporter gene expression in the lung
    Jean Christophe Richard
    Washington University School of Medicine in St Louis, MO 63110, USA
    Mol Imaging 2:342-9. 2003
    ..In conclusion, positron emission tomography is a reliable new tool to evaluate the onset and duration of reporter gene expression noninvasively in the lungs of intact animals...
  21. ncbi request reprint Repeated aerosolized AAV-CFTR for treatment of cystic fibrosis: a randomized placebo-controlled phase 2B trial
    Richard B Moss
    Department of Pediatrics, Stanford University, Stanford, CA 94305, and Division of Respiratory Diseases, Children s Hospital Boston, MA 02115, USA
    Hum Gene Ther 18:726-32. 2007
    ..Because gene transfer is the simplest, most basic way to correct the underlying genetic defect that leads to disease in CF, further research is warranted to develop an effective gene transfer agent for the treatment of CF...
  22. pmc Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis
    M M Farberman
    Division of Paediatric Allergy and Pulmonary Medicine, Dept of Paediatrics, Washington University School of Medicine, 660 South Euclid Avenue, Mailbox 8116, St Louis, MO 63110, USA
    Eur Respir J 35:410-7. 2010
    ..These results indicate that cleaved serum amyloid P component acts as an anti-opsonin and interferes with bacterial clearance from the lung...
  23. doi request reprint Airway inflammation in cystic fibrosis
    Arnon Elizur
    Department of Pediatrics, Assaf Harofeh Medical Center, Zerifin, Israel
    Chest 133:489-95. 2008
    ..Strategies for modulating the airway inflammation in patients with CF are currently under development and may offer new therapeutic options for these patients...
  24. ncbi request reprint Transmission of Panton-Valentine leukocidin-positive Staphylococcus aureus between patients with cystic fibrosis
    Arnon Elizur
    Department of Pediatrics, St Louis Children s Hospital, St Louis, Missouri, USA
    J Pediatr 151:90-2. 2007
    ..aureus, resulting in acute, life-threatening pulmonary complications in patients with cystic fibrosis. Appropriate infection control measures may be warranted to prevent similar episodes...
  25. ncbi request reprint Panton-Valentine Leukocidin-positive methicillin-resistant Staphylococcus aureus lung infection in patients with cystic fibrosis
    Arnon Elizur
    Department of Pediatrics, Washington University School of Medicine, Campus Box 8116, 660 S Euclid Ave, Saint Louis, MO 63110, USA
    Chest 131:1718-25. 2007
    ..Following two cases of patients with CF admitted with lung abscesses in association with PVL+ MRSA, we examined the incidence and the clinical characteristics of MRSA acquisition in our CF patient population...
  26. pmc Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection
    Alyssa D Gregory
    Department of Medicine, Division of Oncology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Blood 109:3235-43. 2007
    ..Collectively, these data provide new evidence that G-CSF signals play important but specific roles in the regulation of the systemic and local neutrophil response following infection...
  27. pmc Quantifying pulmonary inflammation in cystic fibrosis with positron emission tomography
    Delphine L Chen
    Department of Radiology, Washington University School of Medicine, Campus Box 8223, 660 S Euclid Ave, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 173:1363-9. 2006
    ..Positron emission tomographic imaging with [18F]fluorodeoxyglucose ([18FDG]) could be used as a noninvasive alternative to quantify lung inflammation...
  28. ncbi request reprint Energy cost of activity and exercise in children and adolescents with cystic fibrosis
    Mark R Johnson
    Department of Pediatrics, Washington University School of Medicine St Louis, MO 63011, USA
    J Cyst Fibros 5:53-8. 2006
    ..We hypothesize that alterations in ECA affects TDEE in CF...
  29. ncbi request reprint Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis
    Nada Aldallal
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Respir Crit Care Med 166:1248-56. 2002
    ..Although increased ICAM-1 and IL-8 expression are observed in some CF airway epithelial cell models, many CF cells do not exhibit significant dysregulation of these important inflammatory genes...
  30. ncbi request reprint Delivery of CFTR by adenoviral vector to cystic fibrosis mouse lung in a model of chronic Pseudomonas aeruginosa lung infection
    Anna M van Heeckeren
    Case Western Reserve Univ School of Medicine, Biomedical Research Bldg 827, 2109 Adelbert Road, Cleveland, OH 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 286:L717-26. 2004
    ..In conclusion, the observed survival advantage of adenoviral delivery of CFTR to the CF lung may be due either to CFTR expression or possibly to proinflammatory effects of the adenoviral vector, or both...

Research Grants9

  1. Targeted Delivery of Interleukin-10
    Thomas Ferkol; Fiscal Year: 2004
    ..abstract_text> ..
  2. Genetic variants of primary ciliary dyskinesia
    Thomas Ferkol; Fiscal Year: 2006
    ..Using this approach, we will define the genetic spectrum of PCD, and correlate specific genetic variants with clinical presentations of this disease, especially during the neonatal period. ..
  3. Delivering antiproteases to the bronchiectatic airway
    Thomas Ferkol; Fiscal Year: 2007
    ....
  4. Delivering antiproteases to the bronchiectatic airway
    Thomas Ferkol; Fiscal Year: 2009
    ....